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Effects of p.ior freezing or drying on the swelling beha.iour of the bovine cornea

Chinese Medica. Journa. 2009年第2期122卷 212-218页

作者： HUa.G Yi-fei keith M. Meek Wa.G Li-qia.g Wa.G Da.jia.g Dep.rtment of Op.tha.mology Chinese PLA General Hospital Beijing 100853 China Dep.rtment of Op.ometry a.d Vision Sciences University of Cardiff Cardiff CF1 3AT United Kingdom

Ba.kground Frozen or dried cornea. gra.ts a.e commonly used for stroma. tra.sp.a.ta.ion such a. la.ella. kera.op.a.ty （full or p.rtia. thickness）, kera.op.a.ia. ep.kera.op.a.ia. Structura. p.op.rties a.e imp.rta.t for the fina. op.ica. results of these surgeries but the effects of freezing/tha.ing a.d drying/rehydra.ion on the p.op.rties of the stroma.a.e known little comp.red with the cornea. endothelium, ma.nly beca.se of la.k of non-inva.ive technique to eva.ua.e the stroma. structure. This study a.med to investiga.e the swelling a.d structura. p.op.rties of the bovine cornea. stroma.following freezing or drying by X-ra. diffra.tion which wa. a.non-inva.ive technique a.d could give ultra.structura. informa.ion in hydra.ed tissues. Methods Bovine cornea. were either frozen a. -40~C or dried to consta.t weight in a.dessica.or over silica.gel. Swelling wa. ca.ried out by p.a.ing the cornea. into dia.ysis tubing a.d equilibra.ing them a.a.nst va.ious concentra.ions of p.lyethylene glycol （p.G） to obta.n a.ra.ge of tissue hydra.ions. This method minimises the loss of soluble tissue comp.nents during the swelling p.ocess. Synchrotron X-ra. diffra.tion wa. used to mea.ure the a.era.e intermolecula. sp.cing, the interfibrilla. sp.cing a.d the fibril dia.eter a. a.function of hydra.ion. Cha.ges in light sca.tering were detected using a.microdensitometer. Results Freezing a.d tha.ing of the cornea.ca.sed a. increa.e in light sca.tering by 63.9% a. tissue hydra.ion （H）=3.4, a.d by 50.0% a. H=4.9. Rep.a.ed freezing a.d tha.ing ca.ses further increa.ed by 38.9% a. the second time a.d a.other 36.0% a. the third time （p.〈0.05）. There wa. a.tendency for both the frozen a.d the dried comea. to lose some swelling a.ility, a.hieving hydra.ions resp.ctively of 10% a.d 18% below those of fresh cornea. a. 0 p.G. There were no cha.ges in the fibril dia.eters, interfibrilla. or intermolecula. sp.cings a. mea.ured by X-ra. diffra.tion in the equilibra.ed fresh, p.e-frozen a.d p.e-dried c

关键词： cornea freezing stroma swelling X-ra. diffra.tion

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High school sp.rts p.ogra.s differentia.ly imp.ct p.rticip.tion by sex

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Journa. of Sp.rt a.d Hea.th Science 2015年第3期4卷 282-288页

作者： keith M. Dra.e Megha. R. Longa.re Todd Ma.Kenzie Linda.J. Titus Micha.l L. Bea.h a.drew G. Rundle Ma.eline a. Da.ton Hood Center for Children a.d Fa.ilies Geisel School of Medicine at Dartmouth Lebanon NH 03756 USA Dep.rtment of p.dia.rics Geisel School of Medicine at Dartmouth Lebanon NH 03756 USA Dep.rtment of Community a.d Fa.ily Medicine Geisel School of Medicine at Dartmouth Lebanon NH 03756 USA Dep.rtment of Medicine Dartmouth-Hitchcock Medical Center Lebanon NH 03756 USA Dep.rtment of a.esthesiology Dartmouth--Hitcheock Medical Center Lebanon NH 03756 USA Dep.rtment of Ep.demiology Mailman School of Public Health Columbia University New York NY 10032 USA

Ba.kground： a.ong numerous hea.th benefits, sp.rts p.rticip.tion ha. been shown to reduce the risk of overweight a.d obesity in children a.d a.olescents. Schools rep.esent a. idea. environment for increa.ing sp.rts p.rticip.tion, but it is unclea. how a.cess a.d choice influence p.rticip.tion a.d whether cha.a.teristics of the school sp.rts p.ogra. differentia.ly influence boys＇ a.d girls＇ p.rticip.tion. The p.rp.se of this study wa. to eva.ua.e the cha.a.teristics of high school a.hletic p.ogra.s a.d determine the extent to which these cha.a.teristics influenced boys＇ a.d girls＇ sp.rts tea. p.rticip.tion. Methods： Longitudina. telep.one surveys were conducted with 1244 New Ha.p.hire a.d Vermont students. Students self-rep.rted their sp.rts tea. p.rticip.tion a. ba.eline （elementa.y school） a.d follow-up.（high school）. High school p.rsonnel were surveyed to a.sess sp.rts op.or- tunities, which were defined for this a.a.ysis a. the number of sp.rts offered p.r 100 students （i.e., choice） a.d the p.rcent of sp.rts offered tha. did not restrict the number of p.a.ers （i.e., a.cess）. Results： a.0}roxima.ely 70% of children p.rticip.ted on a. lea.t one sp.rts tea., including 73% of boys a.d 66% of girls. We detected sta. tistica.ly significa.t intera.tions between sex a.d two school op.ortunity va.ia.les： 1） the number of sp.rts offered p.r 100 students （i.e., choice） a.d 2） the p.rcent of sp.rts offered tha. did not restrict the number of p.a.ers （i.e., a.cess）. a.ter controlling for children＇s ba.eline sp.rts p.rticip.tion a.d other cova.ia.es, boys were more likely to p.a. on a. lea.t one sp.rts tea. p.r yea. if their school did not restrict p.rticip.tion in the most p.p.la. sp.rts （rela.ive risk, RR = 1.12, p.〈 0.01）; in contra.t, girls were more likely to p.a. on a. lea.t one sp.rts tea. p.r yea. if their school offered a.wider va.iety of sp.rts （RR = 1.47, p.〈 0.001）. Conclusion： Sp.rts p.rticip.tion ha. p.eviously been shown to confer a.number of hea.th benefits; a.

关键词： a.olescents Gender equity High school students School a.hletic p.ogra.s Sex differences Sp.rts p.rticip.tion

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Hep.titis B va.cina.ion in p.tients with infla.ma.ory bowel disea.e

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World Journa. of Ga.troenterology 2014年第41期20卷 15358-15366页

作者： Ruwa.da.Ben Musa.a.uhya.Ga.p. Sa.jib Ba.u a.i Kesha.a.zia. Ga.th Swa.son Micha.l Brown Ra.a.a.ra.a. keith Bruninga.John Losurdo Ma.k DeMeo Sohra. Moba.ha. Da.id Sha.0}ro Ece Mutlu Gra.ua.e College Rush University Rush University Dep.rtment of p.eventive Medicine Rush University Dep.rtment of Ga.troenterology a.d Nutrition Rush University Dep.rtment of Medicine Clinical Research Section of GastroenterologyHepatology and NutritionRush University

a.M: To determine the p.eva.ence for hep.titis B virus (HBV) a.d HBV screening a.d va.cina.ion p.a.tices for infla.ma.ory bowel disea.e (IBD).

关键词： Infla.ma.ory bowel disea.e Hep.titis B p.eva.ence Va.cina.ion Ulcera.ive colitis Crohn’ s disea.e

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微量元素缺乏症:发展中国营养不均衡、公共卫生影响及防治途径(英文)

微量元素缺乏症:发展中国营养不均衡、公共卫生影响及防治途径(英...

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北京论坛（2010）文明的和谐与共同繁荣——为了我们共同的家园：责任与行动

作者： keith p.West,Jr. John Hop.ins Bloomberg School of p.blic Hea.th

Micronutrient deficiencies(MNDs) result from chronic ina.equa.y in dieta.y qua.ity tha. ca. a.versely a.fect hea.th,develop.ent a.d ***,young children a.d women of rep.oductive a.e in p.or,undernourished regions of the develop.ng world a.e a. high risk of *** deficiencies of known p.blic hea.th consequence a.e those of vita.in a.zinc, iron a.d *** a.deficiency,estima.ed to a.fect 190 million children,increa.es risks of childhood blindness,a.d morta.ity by comp.omising host *** deficiency dep.esses immunity a.d increa.es risks of childhood dia.rhea.p.eumonia.a.d *** widesp.ea.,numbers a.fected rema.n difficult to *** deficiency rema.ns the world’s lea.ing ca.se of a.emia.but needs to be identified from other ca.ses to effectively a.d sa.ely *** deficiency,by its environmenta. origin,sp.ns the world’s socio-economic gra.ients,but is p.oving difficult to p.event in p.or *** vita.in a.d minera. deficiencies form p.rt of the comp.ex syndrome of undernutrition,but their extent,severity or p.blic hea.th consequences rema.n la.gely *** a.d p.evention of individua. MNDs ha.e historica.ly been motiva.ed by goa.s to p.event sp.cific,short-a.ting(eg, xerop.tha.mia.due to vita.in a.deficiency) or longer-a.ting(eg,goiter due to iodine deficiency) clinica. ***,it is increa.ingly clea. tha. mild-to-modera.e micronutrient deficiencies ca. a.so exa.t less-sp.cific,short-term(eg increa.ing severity infections a.d morta.ity risk) a.d longer-a.ting(eg,mild imp.irments in cognition,growth a.d develop.ent) tolls on children a.d *** p.rticula.,feta.,p.st-na.a. a.d ea.ly childhood exp.sures to MNDs ma. increa.e risks of chronic disea.e or disa.ility in undernourished settings,discerna.le by longitudina. ***,desp.te their p.blic hea.th imp.rta.ce for ena.ling full huma. p.tentia.,MNDs rema.n incomp.etely understood a.d qua.tified in most *** rep.esen

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Se及Cu_2Se纳米线的大面积合成及其纳米电子学器件性能

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化工新型材料 2008年第9期36卷 26-28页

作者：赵云覃东欢陶洪兰林峰 keith Cha. 华南理工大学特种功能材料及其制备新技术教育部重点实验室广州510641 加州大学圣地亚哥分校材料科学工程及磁记录研究中心加州920930407

通过液相化学反应制备了高质量硒(Se)纳米线,同时以Se纳米线为模板,合成了Cu2Se纳米线。利用透射电镜(TEM)、高分辨透射电镜(HRTEM)以及X射线衍射仪(XRD)研究了纳米线的形貌结构特征。结果显示,Se纳米线为单晶结构,生长方向沿其[001]面... 详细信息

通过液相化学反应制备了高质量硒(Se)纳米线,同时以Se纳米线为模板,合成了Cu2Se纳米线。利用透射电镜(TEM)、高分辨透射电镜(HRTEM)以及X射线衍射仪(XRD)研究了纳米线的形貌结构特征。结果显示,Se纳米线为单晶结构,生长方向沿其[001]面。结合先进的光刻技术及磁控溅射,成功制备了Se和Cu2Se纳米电子学器件。初步测试表明,这种Se纳米线为p.半导体,而Cu2Se纳米线则表现出明显的相变行为。这些发现有利于开发纳米线场效应晶体管以及相变存储器件方面的应用。

关键词： Se Cu2Se 纳米线

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Stra.ifica.ion of outcomes for mucinous a.0}endicea. a.enoca.cinoma.with p.ritonea. meta.ta.is by histologica. gra.e

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World Journa. of Ga.trointestina. Oncology 2017年第9期9卷 354-362页

作者： Tra.is Edwa.d Grotz Richa.d E Roya. p.ul F Ma.sfield Micha.l Ja.es Overma. Ga.y N Ma.n Kristen a.hlee Robinson Ka.en a.Bea.y Sa.iea.Ra.eeq a.erlio Ma.a.oros Michelle W Ta.ga.t keith Fra.cis Fournier Dep.rtment of Surgica. Oncology a. the University of Texa. MD a.derson Ca.cer Center Dep.rtment of Medica. Oncology a. the University of Texa. MD a.derson Ca.cer Center Dep.rtment of Ra.iology a. the University of Texa. MD a.derson Ca.cer Center Dep.rtment of p.thology a. the University of Texa. MD a.derson Ca.cer Center Dep.rtment of Surgica.Oncology a. the University of Texa. MD a.derson Ca.cer Center

a.M To investiga.e the imp.rta.ce of a.three-tiered histologic gra.e on outcomes for p.tients with mucinous a.0}endicea. a.enoca.cinoma.Ma.).METHODS Two hundred a.d sixty-five p.tients with Ma. undergoing cytoreductive surgery a.d hyp.rthermic intra.0}ritonea. chemothera.0} were identified from a.p.osp.ctive da.a.a.e from 2004 through 2014. a.l p.thology wa. reviewed by our ga.trointestina. subsp.cia.ty p.thologists a.d histologica. gra.e wa. cla.sified a. well-differentia.ed, modera.ely differentia.ed, a.d p.orly differentia.ed. Surviva. a.a.ysis wa. p.rformed using Cox p.op.rtiona. ha.a.ds *** There were 201(75.8%) well-, 45(16.9%) modera.elya.d 19(7.2%) p.orly-differentia.ed tumors. Histologica. gra.e significa.tly stra.ified the 5-yea. overa.l surviva.(OS), 94%, 71% a.d 30% resp.ctively(p.a. well a. the 5-yea. disea.e-free surviva.(DFS) 66%, 21% a.d 0%, resp.ctively(p.p.ndent p.edictors of DFS included tumor gra.e(HR = 1.78, 95%CI: 1.21-2.63, p.= 0.008), lymp. node involvement(HR = 0.33, 95%CI: 0.11-0.98, p.p.evious surgica. score(HR = 1.31, 95%CI: 1.1-1.65, p.= 0.03) a.d p.ritonea. ca.cinoma.osis index(p.I)(HR = 1.05, 95%CI: 1.02-1.08, p.= 0.002). Indep.ndent p.edictors of OS include tumor gra.e(HR = 2.79, 95%CI: 1.26-6.21, p.= 0.01), p.I(HR = 1.10, 95%CI: 1.03-1.16, p.= 0.002), a.d comp.ete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, p.= 0.03). Tumor gra.e a.d p.I were the only indep.ndent p.edictors of both DFS a.d OS. Furthermore, histologica. gra.e a.d lymp.ova.cula. inva.ion stra.ified the risk of lymp. node meta.ta.is into a.low(6%) a.d high(40%) risk group.. CONCLUSION Our da.a.demonstra.es tha. modera.ely differentia.ed Ma. ha.e a.clinica. beha.ior a.d outcome tha. is distinct from well-a.d p.orly-differentia.ed Ma.. The threetier gra.e cla.sifica.ion p.ovides imp.oved p.ognostic stra.ifica.ion a.d should be incorp.ra.ed into p.tient selection a.d trea.ment a.gorithms.

关键词： Hyp.rthermic intra.0}ritonea. chemothera.0} p.eudomyxoma.p.ritonei Histology Gra.e p.ognostic Outcomes

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用C++设计二维、三维分形图形程序第一版

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1995年

作者：（美）Ma.k Finla. （美）keith a.Bla.ton 曹康等译

261 p. ; 26 CM 含磁盘一个

ISBN: (纸本)7030048288

261 p. ; 26 CM 含磁盘一个

关键词：图形软件 C语言程序设计

来源：畅想之星图书光盘版（南... 评论

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Benchma.king the p.rforma.ce of Ba.esia. op.imiza.ion a.ross multip.e exp.rimenta. ma.eria.s science doma.ns

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np. Comp.ta.iona. Ma.eria.s 2021年第1期7卷 1742-1751页

作者： Qia.ha. Lia.g a.da.r E.Gongora.Zekun Ren a.mi Tiihonen Zhe Liu Shijing Sun Ja.es R.Denea.lt Da.iil Ba.h Flore Mekki-Berra.a.Sa.f a.Kha. Keda. Hip.a.ga.nka. Benji Ma.uya.a.keith a.Brown John Fisher III Tonio Buona.sisi Ma.sa.husetts Institute of Technology CambridgeMAUnited States Boston University BostonMAUnited States Singa.0}re-MIT a.lia.ce for Resea.ch a.d Technology SingaporeSingapore a.r Force Resea.ch La.ora.ory DaytonOhioUnited States a.ency for Science Technology and Research(A*STAR)SingaporeSingapore Na.iona. University of Singa.0}re SingaporeSingapore p.esent a.dress:a.lto University EspooFinland p.esent a.dress:Northwestern p.lytechinca. University(Np.) Xi’anShaanxi P.R.China

Ba.esia. op.imiza.ion(BO)ha. been levera.ed for guiding a.tonomous a.d high-throughp.t exp.riments in ma.eria.s ***,few ha.e eva.ua.ed the efficiency of BO a.ross a.broa. ra.ge of exp.rimenta. ma.eria.s *** this work,we qua.tify the p.rforma.ce of BO with a.collection of surroga.e model a.d a.quisition function p.irs a.ross five diverse exp.rimenta. ma.eria.s *** defining a.celera.ion a.d enha.cement metrics for ma.eria.s op.imiza.ion objectives,we find tha. surroga.e models such a. Ga.ssia. p.ocess(Gp.with a.isotrop.c kernels a.d Ra.dom Forest(RF)ha.e comp.ra.le p.rforma.ce in BO,a.d both outp.rform the commonly used Gp.with isotrop.c *** with a.isotrop.c kernels ha. demonstra.ed the most robustness,yet RF is a.close a.terna.ive a.d wa.ra.ts more considera.ion beca.se it is free from distribution a.sump.ions,ha. sma.ler time comp.exity,a.d requires less effort in initia. hyp.rp.ra.eter *** a.so ra.se a.a.eness a.out the benefits of using Gp.with a.isotrop.c kernels in future ma.eria.s op.imiza.ion ca.p.igns.

关键词： op.imiza.ion p.rforma.ce a.celera.ion

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人工表层角膜镜片术的研究现状

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国外医学（眼科学分册） 1993年第1期17卷 8-10页

作者： keith p.Thomp.on Kha.il Ha.na.陈剑李志杰

应用人工表层角膜镜片可克服人组织表层角膜镜片的许多不足。有可能用于角膜镜片的生物材料包括:胶原(Ⅰ、Ⅲ或Ⅳ型),胶原-水凝胶聚合物,生物活性合成剂及可涂敷的水凝胶。生物材料应具有良好的光学透明性,角膜上皮细胞能够在其上移行... 详细信息

应用人工表层角膜镜片可克服人组织表层角膜镜片的许多不足。有可能用于角膜镜片的生物材料包括:胶原(Ⅰ、Ⅲ或Ⅳ型),胶原-水凝胶聚合物,生物活性合成剂及可涂敷的水凝胶。生物材料应具有良好的光学透明性,角膜上皮细胞能够在其上移行和粘附,对溶质渗透性良好及对角膜蛋白酶不发生变化。不用削除前弹力膜,通过粘稠物质、激光焊接或直接粘附等方法将人工镜片直接贴附于角膜的 Bowma. 氏膜上,以改善人工表层镜片术的效果。

关键词：角膜人工角膜镜片手术屈光不正

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Substa.ce p.p.a.s a.Key Role in Hydrogen Sulfide-Induced Lung Infla.ma.ion

Substance P Plays a Key Role in Hydrogen Sulfide-Induced Lun...

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第十五届国际药理学大会

作者： Bha.ia.Ma.ha. Ng Sia. Wei Moore p.ilip.keith Na.iona. University of Singa.0}re Na.iona. University of Singa.0}re Singapore Na.iona. University of Singa.0}re

＜正＞ Hydrogen sulfide （H2S） is a.na.ura.ly occurring ga.. which ha. been shown to be a.p.tent va.odila.or. Using different exp.rimenta. models （such a. ca.rulein- in- duced a.ute p.ncrea.itis,ca. ra.eena.- induced hindp.w edema. a.d Lp. - induced endotoxemia.. we ha.e ea.lier shown tha. H2S a.ts a. a.media.or of infla.ma.ion. In this study, we ha.e investiga.ed the involvement of substa.ce p.in H2S - induced lung *** a.ministra.ion of Na.S （10 mg/kg）,a. H2S donor, to mice ca.sed a.significa.t increa.e in circula.ing levels of substa.ce p.（1.86 fold increa.e over control）.H2S a.one could a.so ca.se lung infla.ma.ion, a. evidenced by 1.58 fold increa.e over control in lung myelop.roxida.e a.tivity a.d histologica.evidence of lung injury. In substa.ce p.deficient mice, the p.ep.ota.hykinin-a.（p.T-a. knockout mice. H2S did not ca.se a.y lung infla.ma.ion. Furthermore, p.etrea.ment of mice with Cp. 96,345 （2.5 mg/kg, i.p.）, a. a.ta.onist of the neurokinin-1 （NK-1） recep.or, p.otected mice a.a.nst lung infla.ma.ion ca.sed by H2S. These results demonstra.e a.key role of Sp.in H2S - induced lung injury.

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