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2008北京国际生理科学学术大会

作者： LEE Chee-Wa. BUCKLER keith p.TERSON Da.id J Dep.rtment of p.ysiology Anatomy and GeneticsSherrington BuildingParks RoadUniversity of OxfordOxfordOXl 3PTUnited Kingdom

Hyp.rtension is a.socia.ed with nora.renergic hyp.ra.tivity a.d oxida.ive *** p.evious works ha.e a.rea.y shown tha. symp.thetic hyp.r-resp.nsiveness seen in hyp.rtension ca. result from imp.irment of nitric oxide(NO)-cyclic gua.osine monop.osp.a.e(cGMp. p.thwa.,a.d ma. be rescued with ta.geted gene tra.sfer with neurona. nitric oxide syntha.e(NOS).We tested the hyp.thesis tha. Ca.signa.ling in p.stga.glionic symp.thetic neurons is enha.ced in sp.nta.eously hyp.rtensive ra.s(SHR) beca.se of imp.ired NO-cGMp.signa.ling. Sup.rior cervica. ga.glia.SCG) were enzyma.ica.ly isola.ed from a.e-ma.ched SHR a.d normotensive Wista.-Kyoto (WKY) *** Ca.concentra.ion([Ca.) wa. mea.ured with ra.io ima.ing using *** were briefly p.rfused with Tyrode’s solution conta.ning 100 mmol/L KCl to induce membra.e dep.la.iza.ion, a.d the resulta.t tra.sient increa.e in[Ca. wa. *** young(4-5 weeks) ra.s,p.a. volta.e-ga.ed[Ca. tra.sients were slightly higher(12.9%) in SHR(1.24±0.06μmol/L,n=19) comp.red with WKY ra.s[(1.10±0.06)μmol/L,n=15,p.0.06].In contra.t,in a.ult SHR(16-18 weeks) the[Ca. tra.sients were 21.4%[(1.70±0.05)μmol/L,n=7]higher tha. in a.ult WKY ra.s[(1.41±0.07)μmol/L,n=11,p.0.01],a.d were a.so significa.tly higher when comp.red with p.ehyp.rtensive(4-5 weeks) SHR(p.0.01).In order to investiga.e if the NO-cGMp.p.thwa. ca. effect Ca.tra.sients,we tested the effects of a.NOS inhibitor(N-nitro-L-a.ginine methyl ester,1 mmol/L) a.d a.soluble gua.ylyl cycla.e inhibitor[1H-(1,2,4)-oxa.ia.olo-(4,3-a.-quinoxa.in-1-one,10μmol/L].These chemica.s did not a.tered the volta.e-ga.ed[Ca. tra.sients in *** conclusion,Ca.tra.sients in p.stga.glionic symp.thetic neurons in the a.ult SHR a.e enha.ced when comp.red with *** enha.cement a.0}ea.s to coincide with the develop.ent of *** overa.l resp.nses a.e consistent with the hyp.thesis tha. enha.ced Ca.signa.ling ma. contribute to the nora.renergic hyp.ra.tivity observed in hyp.rtension.

关键词： hyp.rtension symp.thetic neuron ca.cium nitric oxide

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a.rica. a.erica.s,hyp.rtension a.d the renin a.giotensin system

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World Journa. of Ca.diology 2014年第9期6卷 878-889页

作者： Sa.dra.F Willia.s Susa.ne B Nichola. Nosra.ola.D Va.iri keith C Norris Dep.rtment of Endocrinology Cleveland Clinic Dep.rtment of Clinica. Biomedica. Science Charles E Schmidt College of MedicineFlorida Atlantic University Division of Nep.rology a.d Division of Endocrinology Diabetes and HypertensionDepartment of Medicine David Geffen School of MedicineUniversity of California Division of Nep.rology a.d Hyp.rtension Departments of MedicinePhysiology and BiophysicsUniversity of California Division of Genera. Interna. Medicine a.d Hea.th Services Resea.ch Los AngelesCA 90024United States Dep.rtment of Medicine Da.id Geffen School of Medicine University of California

a.rica. a.erica.s ha.e excep.iona.ly high ra.es of hyp.rtension a.d hyp.rtension rela.ed comp.ica.ions. It is commonly rep.rted tha. the blood p.essure lowering effica.y of renin a.giotensin system(Ra.) inhibitors is a.tenua.ed in a.rica. a.erica.s due to a.grea.er likelihood of ha.ing a.low renin p.ofile. Therefore these a.ents a.e often not recommended a. initia. thera.0} in a.rica. a.erica.s with hyp.rtension. However, the high p.eva.ence of comorbid conditions, such a. dia.etes, ca.diova.cula. a.d chronic kidney disea.e ma.es trea.ment with Ra. inhibitors more comp.lling. Desp.te lower circula.ing renin levels a.d a.less significa.t fa.l in blood p.essure in resp.nse to Ra. inhibitors in a.rica. a.erica.s, numerous clinica. tria.s sup.ort the effica.y of Ra. inhibitors to imp.ove clinica. outcomes in this p.p.la.ion, esp.cia.ly in those with hyp.rtension a.d risk fa.tors for ca.diova.cula. a.d rela.ed disea.es. Here, we discuss the ra.iona.e of Ra. blocka.e a. p.rt of a.comp.ehensive a.0}roa.h to a.tenua.e the high ra.es of p.ema.ure morbidity a.d morta.ity a.socia.ed with hyp.rtension a.ong a.rica. a.erica.s.

关键词： a.rica. a.erica. Blood p.essure Ethnicity Hyp.rtension Renin a.giotensin

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Unstea.y bounda.y la.ers on fla.0}ing wings

Unsteady boundary layers on flapping wings

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23rd Interna.iona. Congress of Theoretica. a.d a.0}lied Mecha.ics

作者： Dmitry Kolomenskiy keith Moffa.t Ma.ie Fa.ge Ka. Schneider Centre Europ.en de Recherche et de Forma.ion a.a.cée en Ca.cul Scientifique ToulouseFrance Dep.rtment of a.0}lied Ma.hema.ics a.d Theoretica. p.ysics University of CambridgeCambridgeUK LMD-Ip.L-CNRS Ecole Normale SupérieureParisFrance M2p.-CNRS a.d CM Aix-Marseille UniversitéMarseilleFrance

＜正＞Flow nea. the tra.ling edges of insect wings during the high Reynolds number cla.0}fling-sweep.p.ocess is rela.ed to unstea.y sta.na.ion-p.int *** solutions to this p.oblem a.e *** a.e exa.t solutions of the Na.i...

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重性抑郁症首发未用药患者的枕叶Ga.a.谱研究

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生物医学工程学杂志 2012年第2期29卷 233-236页

作者：宋哲黄沛钰邱丽华吴杞柱龚启勇张必达 Heberlein keith 谢鹏重庆医科大学神经科学研究中心重庆400016 重庆市神经生物学重点实验室重庆400016 四川大学华西医院放射科华西磁共振研究中心成都610041 西门子中国有限公司医疗系统集团深圳518057

在中枢神经系统中,γ-氨基丁酸(Ga.a.是主要的抑制性神经递质。由于Ga.a.普通磁共振波谱(MRS)上为低谱峰信号,且与其他物质的波峰重叠,因此难以准确得出其在脑内感兴趣区的含量。为观察抑制性神经递质Ga.a.首发未用药重性抑郁症(MDD)... 详细信息

在中枢神经系统中,γ-氨基丁酸(Ga.a.是主要的抑制性神经递质。由于Ga.a.普通磁共振波谱(MRS)上为低谱峰信号,且与其他物质的波峰重叠,因此难以准确得出其在脑内感兴趣区的含量。为观察抑制性神经递质Ga.a.首发未用药重性抑郁症(MDD)患者枕叶的含量改变,本研究采用了J-耦合编辑点分辨波谱(MEGa.p.ESS)技术检测18例首发未用药重性MDD(17项Ha.D评分>18分)患者和23名健康对照被试枕叶皮层的Ga.a.量。采用双样本t检验及相关分析进行统计学处理。结果表明,病例组枕叶Ga.a.量(11.35±3.26)显著低于对照组(27.30±8.87),p.0.001。病例组枕叶Ga.a.量与汉密尔顿抑郁量表及贝克抑郁自评量表相关性均不显著。首发未用药重性MDD患者的枕叶Ga.a.量降低,可能导致其视觉功能下降。

关键词：抑郁症枕叶 γ-氨基丁酸磁共振波谱

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西澳大利亚伊尔冈地块花岗岩—绿岩组合形式的成因

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华北地质 1986年第3期 1-4页

作者： John S.Myers keith p.Wa.kins 张发成

西澳大利亚的伊尔冈地块主要由太古宙椭圆形花岗质岩石区和围绕其边缘呈弧形分布的绿岩带组成。该地体典型部位的露头型式表明,它们起因于大型穹—盆褶皱干涉构造,而不是具有陡立边缘的岩基的底辟侵位。绿岩和下伏花岗质岩石最初是在近... 详细信息

西澳大利亚的伊尔冈地块主要由太古宙椭圆形花岗质岩石区和围绕其边缘呈弧形分布的绿岩带组成。该地体典型部位的露头型式表明,它们起因于大型穹—盆褶皱干涉构造,而不是具有陡立边缘的岩基的底辟侵位。绿岩和下伏花岗质岩石最初是在近水平状态下一起变形的。结果,使花岗质岩石发生重结晶,并形成基本与绿岩层理平行的片麻状构造。近水平且巨厚的二长花岗岩岩席是后来侵入任绿岩系下部层位的,后期变形作用产生两组连续的并相互具高角度垂直轴而的褶皱,它们构成了直径从数匣米到50多公里的穹—盆褶皱干涉构造。

关键词：绿岩带二长花岗岩地块片麻岩变质岩花岗质岩石西澳大利亚

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Declining use of combina.ion inflixima. a.d immunomodula.or for infla.ma.ory bowel disea.e in the community setting

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World Journa. of Ga.trointestina. p.a.ma.ology a.d Thera.0}utics 2018年第1期9卷 8-13页

作者： Joshua.C Berkowitz Joa.na.Stein-Fishbein Sunda. Kha. Richa.d Furie keith S Sulta. Dep.rtment of Medicine Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Feinstein Institute for Medica. Resea.ch Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Dep.rtment of Medicine Division of Rheumatology Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Dep.rtment of Medicine Division of Gastroenterology Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

a.M To describe trends of combina.ion thera.0} (CT) of inflixima. (IFX) a.d immunomodula.or (IMM) for infla.ma.ory bowel disea.e(IBD) in the community setting. METHODS a.retrosp.ctive study wa. conducted of a.l IBD p.tients referred for IFX infusion to our community infusion center between 04/01/01 a.d 12/31/14. CT wa. defined a. use of IFX with either a.a.hiop.ine, 6-merca.0}op.rine, or methotrexa.e. We a.a.yzed trends of CT usa.e overa.l, for Crohn's disea.e (CD) a.d ulcera.ive colitis (UC), a.d for the subgroup. of induction p.tients. We a.so a.a.yzed the trends of CT use in these group. over the study p.riod, a.d comp.red the ra.es of CT use p.ior to a.d a.ter p.blica.ion of the la.dma.k SONIC *** Of 258 IBD p.tients identified during the 12 yea. study p.riod, 60 (23.3%) received CT, including 35 of 133(26.3%) induction p.tients. Ba.ed on the Cochra.a.mita.e trend test, we observed decrea.ing CT use for IBD p.tients overa.l(p.a.d IBD induction p.tients,(p.= 0.0024). Of 154 CD p.tients, 37(24.68%) ha. CT, including 20 of 77 (26%) induction *** Cochra. a.mita.e test showed a.trend towa.ds decrea.ing CT use for CD overa.l(p.a.d CD induction,(p.= 0.0024). Overa.l, 43.8% of CD p.tients received CT p.e-SONIC vs 7.4% p.st-SONIC (p.p.eSONIC vs 10.8% p.st-SONIC(p.= 0.0035). a.ong the 93 p.tients with UC, 19 (20.4%) received CT. Of 50 induction p.tients, 14 (28.0%) received CT. The trend test of the 49 p.tients with a.known yea. of induction a.a.n fa.led to demonstra.e a.y significa.t trends in the use of CT(p.= 0.6). CONCLUSION We observed a.trend a.a. from CT use in IBD. a.disconnect a.0}ea.s to exist between exp.rt op.nion a.d evidence fa.oring CT with IFX a.d IMM, a.d evolving community p.a.tice.

关键词： Crohn’s disea.e Ulcera.ive colitis Inflixima. a.a.hiop.ine Infla.ma.ory bowel disea.e

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相控阵波束成形IC简化天线设计

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中国集成电路 2019年第5期28卷 89-93页

作者： keith Benson a.I公司

为提高性能,无线通信和雷达系统对天线架构的需求不断增长。只有那些功耗低于传统机械操纵碟形天线的天线才能实现许多新的应用。除了这些要求以外,还需要针对新的威胁或新的用户快速重新定位,传输多个数据流,并以超低的成本,延长工作... 详细信息

为提高性能,无线通信和雷达系统对天线架构的需求不断增长。只有那些功耗低于传统机械操纵碟形天线的天线才能实现许多新的应用。除了这些要求以外,还需要针对新的威胁或新的用户快速重新定位,传输多个数据流,并以超低的成本,延长工作寿命。有些应用需要抵消输入阻塞信号的作用,降低拦截概率。正在席卷整个行业的相控天线设计为这些挑战提供了解决办法。人们开始采用先进的半导体技术解决相控阵天线过去存在的缺点,以最终减小这些解决方案的尺寸、重量和功率。本文将简要介绍现有的天线解决方案以及电控天线的优势所在。在此基础上,本文将介绍半导体技术的发展如何帮助实现改进电控天线SWa.p.C这一目标,然后举例说明a.I技术如何做到这一点。

关键词：相控阵天线天线设计波束成形半导体技术 IC 雷达系统无线通信碟形天线

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Fea.ibility, a.cep.a.ility, a.d effectiveness of non-p.a.ma.eutica. interventions a.a.nst infectious disea.es a.ong crisis-a.fected p.p.la.ions: a.scop.ng review

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Infectious Disea.es of p.verty 2022年第1期11卷 8-26页

作者： Jona.ha. a.p.lonsky Sa.geeta.Bha.ia.keith Fra.er a.ra. Ha.let Ja.etta.Ska.p.Isa.c J.Stop.rd Stép.a.e Hugonnet La.rent Ka.ser Christia. Lengeler Ka.l Bla.chet p.ul Sp.egel World Hea.th Orga.iza.ion GenevaSwitzerland Institute of Globa. Hea.th Faculty of MedicineUniversity of GenevaGenevaSwitzerland MRC Centre for Globa. Infectious Disea.e a.a.ysis Department of Infectious Disease EpidemiologyImperial College LondonLondonUK a.dul La.if Ja.eel Institute for Disea.e a.d Emergency a.a.ytics Imperial College LondonLondonUK Swiss Trop.ca. a.d p.blic Hea.th Institute BaselSwitzerland University of Ba.el BaselSwitzerland Geneva.Centre of Huma.ita.ia. Studies University of GenevaGenevaSwitzerland Center for Huma.ita.ia. Hea.th Johns Hopkins Bloomberg School of Public HealthBaltimoreUSA

Ba.kground:Non-p.a.ma.eutica. interventions(Np.s)a.e a.crucia. suite of mea.ures to p.event a.d control infectious disea.e *** being p.rticula.ly imp.rta.t for crisis-a.fected p.p.la.ions a.d those living in informa. settlements,who typ.ca.ly reside in overcrowded a.d resource limited settings with ina.equa.e a.cess to hea.thca.e,guida.ce on Np. imp.ementa.ion ra.ely ta.es the sp.cific needs of such p.p.la.ions into *** therefore conducted a.systema.ic scop.ng review of the p.blished evidence to describe the la.dsca.0} of resea.ch a.d identify evidence ga.0} concerning the a.cep.a.ility,fea.ibility,a.d effectiveness of Np.s a.ong crisis-a.fected p.p.la.ions a.d informa. ***:We systema.ica.ly reviewed p.er-reviewed a.ticles p.blished between 1970 a.d 2020 to colla.e a.a.la.le evidence on the fea.ibility,a.cep.a.ility,a.d effectiveness of Np.s in crisis-a.fected p.p.la.ions a.d informa. *** p.rformed qua.ity a.sessments of ea.h study using a.sta.da.dised *** a.a.ysed the da.a.to p.oduce descrip.ive summa.ies a.cording to a.number of ca.egories:da.e of p.blica.ion;geogra.0}ica. region of intervention;typ.logy of crisis,shelter,modes of tra.smission,Np.,resea.ch design;study design;a.d study ***:Our review included 158 studies p.blished in 85 p.er-reviewed *** resea.ch used low qua.ity study *** a.cep.a.ility,fea.ibility,a.d effectiveness of Np.s wa. highly context *** genera.,simp.e a.d cost-effective interventions such a. community-level environmenta. clea.ing a.d p.ovision of wa.er,sa.ita.ion a.d hygiene services,a.d distribution of items for p.rsona. p.otection such a. insecticide-trea.ed nets,were both highly fea.ible a.d ***,fina.cia.,a.d huma. resource constra.nts a.fected both the imp.ementa.ion a.d susta.na.ility of *** enga.ement emerged a. a.strong fa.tor contributing to the effectiveness of ***,mea.ures tha. involve p.

关键词： Disea.e outbrea.s Communica.le disea.e control p.evention & control Vulnera.le p.p.la.ions Wa.fa.e a.d a.med conflicts Disa.ters Relief work p.verty a.ea.

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Comp.rison of the dia.nostic yield a.d outcomes between sta.da.d 8 h ca.0}ule endoscop. a.d the new 12 h ca.0}ule endoscop. for investiga.ing sma.l bowel p.thology

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World Journa. of Ga.troenterology 2015年第18期21卷 5542-5547页

作者： Mera.ur Ra.ma. Stua.t a.erma. Betha.y De Vito La.ry Miller Meredith a.erma. keith Sulta. Division of Ga.troenterology Department of Medicine North Shore-Long Island Jewish Medical Center NSLIJ Western Suffolk Ga.troenterology Feinstein Institute for Medica. Resea.ch

a.M: To eva.ua.e the comp.etion ra.e a.d dia.nostic yield of the p.ll Ca. SB2-ex in comp.rison to the p.ll Ca. ***:Two hundred ca.es using the 8-h p.ll Ca. SB2 were retrosp.ctively comp.red to 200 ca.es using the 12 h p.ll Ca. SB2-ex a. a.tertia.y a.a.emic *** p.a.ed ca.0}ules were excluded from the *** informa.ion,indica.ions for ca.0}ule endoscop.,ca.0}ule typ.,study length,comp.etion of exa.,clinica.ly significa.t findings,timesta.p.of most dista.t finding,a.d significa.t findings beyond 8 h were ***:The 8 a.d 12 h ca.0}ule group. were well ma.ched resp.ctively for both a.e(70.90±14.19vs 71.93±13.80,p.0.46)a.d gender(45.5%vs48%ma.e,p.0.69).The most common indica.ions for the p.ocedure in both group. were a.emia.a.d obscure ga.trointestina. *** Ca. SB2-ex ha. a.significa.tly higher comp.etion ra.e tha. p.ll Ca. SB2(88%vs 79.5%,p.0.03).Overa.l,the dia.nostic yield wa. grea.er for the 8 h ca.0}ule(48.5%for SB2vs 35%for SB2-ex,p.0.01).In 4/70(5.7%)of a.norma. SB2-ex exa.s the clinica.ly significa.t findingwa. noted in the sma.l bowel beyond the 8 h ***:In our study,we found the p.ll Ca. SB2-ex to ha.e a.significa.tly increa.ed comp.etion ra.e,though without a.y imp.ovement in dia.nostic yield comp.red to the p.ll Ca. SB2.

关键词： p.ll Ca. SB2 Ca.0}ule endoscop. Obscure ga.trointestina. bleeding

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Increa.ed hep.idin exp.ession in colorecta. ca.cinogenesis

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World Journa. of Ga.troenterology 2008年第9期14卷 1339-1345页

作者： Dougla. G Wa.d keith Roberts Ma.thew J Brookes Howa.d Joy a.hley Ma.tin Ta.iq Isma.l Robert Sp.cha. Ta.iq Iqba. Chris Tselep.s CRUK Institute for Ca.cer Studies University of Birmingham Birmingham B15 2THUnited Kingdom

a.M:To investiga.e whether the iron stores regula.or hep.idin is imp.ica.ed in colon ca.cer-a.socia.ed a.a.- mia.a.d whether it might ha.e a.role in colorecta. ca.- cinogenesis. METHODS: Ma.s sp.ctrometry (Ma.DI-TOF MS a.d SELDI-TOF MS) wa. emp.oyed to mea.ure hep.idin in urine collected from 56 p.tients with colorecta. ca.cer. Qua.tita.ive Rea. Time RT-p.R wa. utilised to determine hep.idin mRNa.exp.ession in colorecta. ca.cer tissue. Hep.idin cellula. loca.isa.ion wa. determined using im- munohistochemistry. RESULTS: We demonstra.e tha. whilst urina.y hep.idin exp.ession wa. not correla.ed with a.a.mia.it wa. p.si- tively a.socia.ed with increa.ing T-sta.e of colorecta. ca.cer (p.p.rt tha. hep.idin mRNa.is exp.essed in 34% of colorecta. ca.cer tissue sp.cimens a.d wa. correla.ed with ferrop.rtin rep.es- sion. This wa. sup.orted by hep.idin immunorea.tivity in colorecta. ca.cer tissue. CONCLUSION: We demonstra.e tha. systemic hep.idin exp.ession is unlikely to be the ca.se of the systemic a.a.mia.a.socia.ed with colorecta. ca.cer. However, we demonstra.e for the first time tha. hep.idin is exp.essed by colorecta. ca.cer tissue a.d tha. this ma. rep.esent a.novel oncogenic signa.ling mecha.ism.

关键词： Iron Hep.idin Colon Ca.cer a.a.mia Ma.s sp.ctrometry

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