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In Vitro Antioxidant and Radio Protective Activities of Lycopene from Tomato Extract against Radiation—Induced DNA Aberration

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Journal of Biosciences and Medicines 2024年第2期12卷 202-213页

作者： Safaiatul Islam Abu Hena Mostofa Kamal Md. Ziaur Rahman protul kumar roy A.Y.K. Md. Masud Rana Molecular Radiobiology and Biodosimetry Division Institute of Food and Radiation Biology Bangladesh Atomic Energy Commission Savar Bangladesh

Background: The accumulation of free radicals is linked to a number of diseases. Free radicals can be scavenged by antioxidants and reduce their harmful effects. It is therefore essential to look for naturally occurring antioxidants that come from plants, as synthetic antioxidants are toxic, carcinogenic and problematic for the environment. Lycopene is one of the carotenoids, a pigment that dissolves in fat and has antioxidant properties. Materials and Methods: The antioxidant and free radical scavenging activity were assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The impact of lycopene on bacteria (E. coli) susceptibility to γ-radiation was examined by radio sensitivity assay. The study also examined the induction of strand breaks in plasmid pUC19 DNA and how lycopene extract protected the DNA from γ-radiation in vitro. Results: At varying concentrations, lycopene demonstrated its ability to scavenge free radicals such as 2, 2-diphenyl-1-picrylhydrazyl (DPPH). IC50 for lycopene was determined at 112 μg/mL which was almost partial to IC50 of standard antioxidant L-ascorbic acid. The D10 value 180 Gy of E. coli was found to be >2-fold higher in the extract-containing lycopene sample than in the extract-free controls. The lycopene extracts inhibited the radiation-induced deterioration of the plasmid pUC19 DNA. At an IC50 concentration, lycopene provided the highest level of protection. Conclusion: Lycopene functions as an efficient free radical scavenger and possible natural antioxidant source. For cancer patients and others who frequently expose themselves to radiation, lycopene may be a useful plant-based pharmaceutical product for treating a variety of diseases caused by free radicals.

关键词： Radio Protective Antioxidants Free Radical DNA Damage pUC19 Plasmid Gamma Irradiation DPPH

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Appraisal of pollution and health risks associated with coal mine contaminated soil using multimodal statistical and Fuzzy-TOPSIS approaches

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 101-115页

作者： Sumit kumar Sonali Banerjee Saibal Ghosh Santanu Majumder Jajati Mandal Pankaj kumar roy Pradip Bhattacharyya Agricultural and Ecological Research Unit Indian Statistical InstituteGiridih815301India Department of Life and Environmental Sciences Bournemouth University(Talbot Campus)Fern BarrowPooleBH12 5BBUK School of Sciences Engineering & EnvironmentUniversity of SalfordSalfordM5 4QJUK School of Water Resource Engineering Jadavpur UniversityKolkata700032India School of Environmental Studies Jadavpur UniversityKolkata700032India

The present study assesses the concentration,probabilistic risk,source classification,and dietary risk arising from heavy metal(HMs)pollution in agricultural soils affected by coal mining in eastern part of *** of soil and rice plant indicated significantly elevated levels of HMs beyond the permissible limit in the contaminated zones(zone 1:PbSoil:108.24±72.97,CuSoil:57.26±23.91,CdSoil:8.44±2.76,CrSoil:180.05±46.90,NiSoil:70.79±25.06 mg/kg;PbGrain:0.96±0.8,CuGrain:8.6±5.1,CdGrain:0.65±0.42,CrGrain:4.78±1.89,NiGrain:11.74±4.38 mg/*** 2:PbSoil:139.56±69.46,CuSoil:69.89±19.86,CdSoil:8.95±2.57,CrSoil:245.46±70.66,NiSoil:95.46±22.89 mg/kg;PbGrain:1.27±0.84,CuGrain:7.9±4.57,CdGrain:0.76±0.43,CrGrain:8.6±1.58,NiGrain:11.50±2.46 mg/kg)compared to the uncontaminated zone(zone 3).Carcinogenic and non-carcinogenic health risks were computed based on the HMs concentration in the soil and rice grain,with Pb,Cr,and Ni identified as posing a high risk to human *** Carlo simulation,the solubility-free ion activity model(FIAM),and severity adjusted margin of exposure(SAMOE)were employed to predict health *** hazard quotient(HQ)values for Ni,Cr,Cd,and Pb were>1,indicating a significant non-carcinogenic ***(risk thermometer)results for contaminated zones ranged from low to moderate risk(CrSAMOE:0.05,and NiSAMOE:0.03).Fuzzy-TOPSIS and variable importance plots(from random forest)showed that Ni and Cr were mostly responsible for the toxicity in the rice plant,respectively.A self-organizing map for source classification revealed common origin for the studied HMs with zone 2 exhibiting the highest *** positive matrix factorization model for the source apportionment identified coal mining and transportation as the predominant sources of *** distribution analysis indicated higher contamination near mining sites as compared to distant sampling ***,this study will aid environmental scientists and policymakers controllin

关键词： Coal mine Free ion activity model Monto Carlo Simulation Pollution and Health risk Fuzzy-TOPSIS

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Earliest megafossils of scandent calamoid palms from the Deccan Intertrappean Beds of Central India and their paleobiogeographic implications

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Journal of Palaeogeography 2024年第3期13卷 509-527页

作者： Sanchita kumar Kaustav roy Robert A.Spicer Mahasin Ali Khan Palaeobotany and Palynology Laboratory Department of BotanySidho-Kanho-Birsha UniversityRanchi RoadPurulia-723104India CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303Yunnan ProvinceChina School of Environment Earth and Ecosystem SciencesThe Open UniversityMilton KeynesMK76AAUK State Key Laboratory of Tibetan Plateau Earth System Resources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Two well-preserved petrified palm stems from the latest Maastrichtian(Late Cretaceous) to earliest Danian(Early Paleocene) sediments of the Deccan Intertrappean Beds of Madhya Pradesh, Central India are described. Their significant anatomical characteristics include a Calamus-type general stem pattern,the presence of well-preserved fibrovascular bundles(fvbs) with two wide metaxylem vessel elements(230 μm-250 μm) and one phloem strand, uniform density of fvbs, lack of continuity between protoxylem and metaxylem vessel elements, and an absence of centrifugal differentiation of sclerenchymatous fibrous *** features reveal a close resemblance to those of extant genera of scandent Calamoideae. The permineralized stems are described as a new species namely, Palmoxylon calamoides kumar, roy et Khan sp. *** fossils represent the oldest reliable fossil records of this family, supporting their Gondwanan origin, their importance in tracing their migration pathways from India to Europe and other continents after the docking of the Indian subcontinent with Eurasia during the Paleocene, and an “Out-of-India” dispersal hypothesis. Today the subfamily Calamoideae is disjunctly occurred in Africa, Asia, Australia, Europe, and South America, but the poor deep-time fossil record of this subfamily with a small number of Cenozoic fossils makes hypotheses concerning its origin and dispersal difficult to evaluate. The present study has significant implications for the origin and migration of this subfamily and the paleoclimate.

关键词： Scandent Calamoideae Stem anatomy K-Pg Paleobiogeography Paleoclimate Central India

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A hierarchical clustering approach for colorectal cancer molecular subtypes identification from gene expression data

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Intelligent Medicine 2024年第1期4卷 43-51页

作者： Shivangi Raghav Aastha Suri Deepika kumar Aakansha Aakansha Muskan Rathore Sudipta roy Department of Computer Science&Engineering Bharati Vidyapeeth’s College of EngineeringNew DelhiIndia Artificial Intelligence&Data Science Jio InstituteNavi Mumbai410206India

Background Colorectal cancer(CRC)is the second leading cause of cancer fatalities and the third most common human *** molecular subgroups of CRC and treating patients accordingly could result in better therapeutic success compared with treating all CRC patients *** have highlighted the significance of CRC as a major cause of mortality worldwide and the potential benefits of identifying molecular subtypes to tailor treatment strategies and improve patient *** This study proposed an unsupervised learning approach using hierarchical clustering and feature selection to identify molecular subtypes and compares its performance with that of conventional *** proposed model contained gene expression data from CRC patients obtained from Kaggle and used dimension reduction techniques followed by Z-score-based outlier *** hierarchy clustering was used to identify molecular subtypes,with a P-value-based approach for feature *** performance of the model was evaluated using various classifiers including multilayer perceptron(MLP).Results The proposed methodology outperformed conventional methods,with the MLP classifier achieving the highest accuracy of 89%after feature *** model successfully identified molecular subtypes of CRC and differentiated between different subtypes based on their gene expression *** This method could aid in developing tailored therapeutic strategies for CRC patients,although there is a need for further validation and evaluation of its clinical significance.

关键词： Machine learning Colorectal cancer Feature selection Classification Clustering

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Performance validation of High Mountain Asia 8-meter Digital Elevation Model using ICESat-2 geolocated photons

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Journal of Mountain Science 2024年第8期21卷 2562-2578页

作者： Giribabu DANDABATHULA Subham roy Omkar Shashikant GHATAGE Vaibhav Balaso KOLASE Shwetambari SATPUTE Koushik GHOSH Sahibnoor KAUR Satyanarayana PONDARI Apurba kumar BERA Sushil kumar SRIVASTAV Regional Remote Sensing Centre-West National Remote Sensing CentreIndian Space Research OrganisationJodhpur 342005India Department of Geography School of Earth SciencesBharathidasan UniversityTiruchirappalli 620024India Centre for Climate Change and Water Research Suresh Gyan Vihar UniversityJaipur 302017India Department of Geography Panjab UniversityChandigarh 160014India National Remote Sensing Centre Indian Space Research OrganisationHyderabad 500037India Regional Centres National Remote Sensing CentreIndian Space Research OrganisationNew Delhi 110049India

High Mountain Asia(HMA),recognized as a third pole,needs regular and intense studies as it is susceptible to climate *** accurate and high-resolution Digital Elevation Model(DEM)for this region enables us to analyze it in a 3D environment and understand its intricate role as the Water Tower of *** science teams of NASA realized an 8-m DEM using satellite stereo imagery for HMA,termed HMA 8-m *** this research,we assessed the vertical accuracy of HMA 8-m DEM using reference elevations from ICESat-2 geolocated photons at three test sites of varied topography and land *** were made from statistical quantifiers and elevation *** the world’s highest mountain,Mount Everest,and its surroundings,Root Mean Squared Error(RMSE)and Mean Absolute Error(MAE)resulted in 1.94 m and 1.66 m,respectively;however,a uniform positive bias observed in the elevation profiles indicates the seasonal snow cover change will dent the accurate estimation of the elevation in this sort of test *** second test site containing gentle slopes with forest patches has exhibited the Digital Surface Model(DSM)features with RMSE and MAE of 0.58 m and 0.52 m,*** third test site,situated in the Zanda County of the Qinghai-Tibet,is a relatively flat terrain bed,mostly bare earth with sudden river cuts,and has minimal errors with RMSE and MAE of 0.32 m and 0.29 m,respectively,and with a negligible ***,in one more test site,the feasibility of detecting the glacial lakes was tested,which resulted in exhibiting a flat surface over the surface of the lakes,indicating the potential of HMA 8-m DEM for deriving the hydrological *** results accrued in this investigation confirm that the HMA 8-m DEM has the best vertical accuracy and should be of high use for analyzing natural hazards and monitoring glacier surfaces.

关键词： High Mountain Asia Digital Elevation Model ICESat-2 geolocated photons Accuracy assessment

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Spatio-temporal variation and relationship between agricultural efficiency and irrigation intensity in a semi-arid region of India

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Regional Sustainability 2024年第2期5卷 123-139页

作者： Shibu DAS Kaushal kumar SHARMA Suranjan MAJUMDER Debabrata DAS Indrajit roy CHOWDHURY Centre for the Study of Regional Development School of Social SciencesJawaharlal Nehru UniversityNew Delhi110067India Department of Geography&Applied Geography University of North BengalDarjeeling734013India Geography Department of Krishnagar Government College Krishnagar741101India

A surging population in Karnataka State,a semi-arid region in India,poses a threat to both food security and livelihood sustainability,necessitating a concentrated effort to bolster agricultural efficiency and achieve United Naton’s Sustainable Development Goal 2(zero hunger).Therefore,in order to address the pressing issue of food scarcity in Karnataka,this study meticulously examined the spatio-temporal variation of agricultural efficiency and irrigation intensity in Karnataka,uncovering its significant dependence of agricultural efficiency on irrigation ***,this study used a one-way analysis of variance(ANOVA)to ascertain significant differences in the means of agricultural efficiency and irrigation intensity during 2004-2005 and *** study showed that the maximum improvement in agricultural efficiency index was recorded in Belgaum(40.24),Gulbarga(24.77),and Yadgir districts(22.92)between 2004-2005 and 2018-2019,which indicated the progressing trend and better scope for agriculture *** the contrary,some districts expressed threat(a decline of above 20.00 of agricultural efficiency index)and needed special care for the improvement of agricultural efficiency in four northern districts(Bagalkot,Bidar,Raichur,and Bijapur),three southern districts(Chitradurga,Chikballapur and Hassan),and two southern districts(Koppal and Gadag)in *** 2004-2005,irrigation intensity varied from 3.19%to 56.39%,with the lowest irrigation intensity in Kodagu District and the highest irrigation intensity in Shimoga *** 2018-2019,irrigation intensity changed from 0.77%to 72.77%,with the lowest irrigation intensity in Kodagu District and the highest in Dakshin Kannad ***,the research scrutinized the complex relationship between agricultural efficiency and irrigation intensity,with the correlation coefficient increased from 0.162 during 2004-2005 to 0.255 during *** implies that in both periods,a low positive

关键词： Agricultural efficiency Irrigation intensity One-way analysis of variance(ANOVA) Food security Karnataka

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Artificial Intelligence for Maximizing Agricultural Input Use Efficiency: Exploring Nutrient, Water and Weed Management Strategies

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1569-1598页

作者： Sumit Sow Shivani Ranjan Mahmoud F.Seleiman Hiba M.Alkharabsheh Mukesh kumar Navnit kumar Smruti Ranjan Padhan Dhirendra kumar roy Dibyajyoti Nath Harun Gitari Daniel O.Wasonga Department of Agronomy Dr.Rajendra Prasad Central Agricultural UniversityPusaSamastipurBihar848125India Department of Plant Production College of Food and Agriculture SciencesKing Saud UniversityRiyadh11451Saudi Arabia Department of Crop Sciences Faculty of AgricultureMenoufia UniversityShibin El-Kom32514Egypt Department of Water Resources and Environmental Management Faculty of Agricultural TechnologyAl Balqa Applied UniversitySalt19117Jordan Division of Agronomy ICAR-Indian Agricultural Research InstitutePusa CampusNew Delhi110012India Department of Soil Science Dr.Rajendra Prasad Central Agricultural UniversityPusaSamastipurBihar848125India Department of Agricultural Science and Technology School of Agriculture and Environmental SciencesKenyatta UniversityNairobi43844Kenya Department of Crop Sciences University of Illinois Urbana-ChampaignUrbanaIL 61801USA

Agriculture plays a crucial role in the economy,and there is an increasing global emphasis on automating agri-cultural *** the tremendous increase in population,the demand for food and employment has also increased signiﬁ*** methods traditionally used to meet these requirements are no longer ade-quate,requiring solutions to issues such as excessive herbicide use and the use of chemical *** of technologies such as the Internet of Things,wireless communication,machine learning,artiﬁcial intelligence(AI),and deep learning shows promise in addressing these ***,there is a lack of comprehensive documentation on the application and potential of AI in improving agricultural input efﬁ*** address this gap,a desk research approach was used by utilizing peer-reviewed electronic databases like PubMed,Scopus,Goo-gle Scholar,Web of Science,and Science Direct for relevant *** of 327 initially identiﬁed articles,180 were deemed pertinent,focusing primarily on AI’s potential in enhancing yield through better management of nutrients,water,and *** into account researchﬁndings worldwide,we found that AI technologies could assist farmers by providing recommendations on the optimal nutrients to enhance soil quality and deter-mine the best time for irrigation or herbicide *** present status of AI-driven automation in agricul-ture holds signiﬁcant promise for optimizing agricultural input utilization and reducing resource waste,particularly in the context of three pillars of crop management,i.e.,nutrient,irrigation,and weed management.

关键词： Agriculture artiﬁcial intelligence crop management nutrient irrigation weed management resource use efﬁciency

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Recharge and vulnerability assessment of groundwater resources in North west India:Insights from isotope-geospatial modelling approach

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Geoscience Frontiers 2024年第1期15卷 247-262页

作者： Annadasankar roy Sitangshu Chatterjee Uday kumar Sinha Anil kumar Jain Hemant Mohokar Ajay Jaryal Tirumalesh Keesari Harish Jagat Pant Isotope and Radiation Application Division Bhabha Atomic Research CentreTrombayMumbai–400085India Homi Bhabha National Institute Mumbai 400094India Central Ground Water Board AhmedabadGujaratIndia

Recent studies indicate dwindling groundwater quantity and quality of the largest regional aquifer system in North West India,raising concern over freshwater availability to about 182 million population residing in this *** agricultural activities have resulted severe groundwater pollution in this area,demanding a systematic vulnerability assessment for proactive *** vulnerability assessment models encounter drawbacks due to subjectivity,complexity,data-prerequisites,and spatial-temporal *** study incorporates isotopic information into a weighted-overlay framework to overcome the above-mentioned limitations and proposes a novel vulnerability assessment *** isotope methodology provides crucial insights on groundwater recharge mechanisms(18O and 2H)and dynamics(3H)-often ignored in vulnerability *** characterisation of precipitation helped in establishing Local Meteoric Water Line(LMWL)as well as inferring contrasting recharge mechanisms operating in different *** aquifer(depth<60 m)showed significant evaporative signature with evaporation loss accounting up to 18.04%based on Rayleigh distillation ***-aquifer connections were apparent from Kernel Density Estimate(KDE)and isotope correlations.A weighted overlay isotope-geospatial model was developed combining 18O,3H,aquifer permeability,and water level *** central and northern parts of study area fall under least(0.29%)and extremely(1.79%)vulnerable zones respectively,while majority of the study area fall under moderate(42.71%)and highly vulnerable zones(55.20%).Model validation was performed using groundwater NO3-concentration,which showed an overall accuracy up to 82%.Monte Carlo Simulation(MCS)was performed for sensitivity analysis and permeability was found to be the most sensitive input parameter,followed by 3H,18O,and water *** the vulnerability map with Land Use Land Cover(LULC)and population density maps

关键词： Agricultural pollution Data scarcity Recharge mechanism Rayleigh distillation Isotope-geospatial model Vulnerability assessment

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Textile dyeing wastewater negatively influences the hematological profile and reproductive health of male Swiss albino mice

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Asian pacific Journal of Reproduction 2024年第4期13卷 169-177页

作者： Md.Taimur Islam Nusrat Binte Rafique Mohosina Mou Dipu roy Robius Sani Sadi Ziban Chandra Das Anup kumar Talukder Minhaz Ahmed MdMizanur Rahman MdGolam Haider Department of Pathobiology Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Department of Gynecology Obstetrics and Reproductive HealthBangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Department of Agroforestry and Environment Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Department of Physiology and Pharmacology Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh

Objective:To determine the effects of textile dyeing industrial wastewater on the hematological parameters and reproductive health including histoarchitecture of male gonad(testes)of ***:Twenty-four Swiss albino mice at 4-weeks old were divided into four groups(n=6 per group).Mice of group 1 supplied with normal drinking water were served as the control *** of group 2,3 and 4 were supplied normal drinking water mixed with textile dyeing wastewater at 5%,10% and 20% concentration,*** completing 24 weeks of treatment,different hematological profile,weight of testes,gonadosomatic index(GSI),sperm concentration and morphology were ***,histopathological changes in testes were ***:Hematocrit value and hemoglobin concentrations were decreased in all groups of wastewater-treated mice compared to the control ***,weight of testes,GSI and sperm concentration were decreased significantly in wastewater-treated mice in comparison to the control *** percentage of morphologically healthy epididymal sperm was significantly reduced in wastewater-treated *** examination revealed degenerative changes in seminiferous tubules,a smaller number of spermatogenic cells,elongation of seminiferous tubules and degenerative changes of seminiferous tubules in wastewater-treated ***:Textile dyeing wastewater has harmful effects on hematological profile and reproductive health of male mice.

关键词： Textile dyeing wastewater Gonads Hematology Histopathology Mice

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Two-Stent Strategy for Bifurcation Lesions in Percutaneous Transluminal Coronary Angioplasty: Real-World Evidence

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World Journal of Cardiovascular Diseases 2024年第3期14卷 140-156页

作者： Dilip kumar Amit Malviya Animesh Mishra Rabin Chakraborty Sanjeev S. Mukherjee Soumya Patra Arindam Pande Rana Rathor roy Debopriyo Mondal Ashesh Halder Sumit Shanker Medica Superspecialty Hospital 127 Eastern Metropolitan Bypass Nitai Nagar Mukundapur Kolkata West Bengal India North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences (NEIGRIHMS) Mawdiangdiang Shillong Meghalaya India

Background: Bifurcation lesions pose a high risk for adverse events after percutaneous coronary intervention (PCI). Evidence supporting the benefits of the two-stent strategy (2SS) for treating coronary bifurcation lesions in India is limited. This study aimed to evaluate the clinical outcomes of various 2SSs for percutaneous transluminal coronary angioplasty for bifurcation lesions in India. Materials and Methods: This retrospective, observational, multicentric, real-world study included 64 patients over 8 years. Data on demographics, medical history, PCI procedures, and outcomes were recorded. Descriptive statistics were computed using the SPSS software. Results: Patients (n = 64) had an average age of 65.3 ± 11.1 years, with 78.1% males. Acute coronary syndrome was reported in 18.8%, chronic stable angina in 40.6%, and unstable angina in 34.4% of participants. Two-vessel disease was observed in 98.4% of patients, and 99.4% had true bifurcation lesions. The commonly involved vessels were the left anterior descending artery (50%), left circumflex coronary artery (34.4%), and first diagonal artery (43.8%). Mean percent diameter stenosis was 87.2% ± 10.1%. The mean number of stents used was 2.00 ± 0.34. The 2SS techniques included the T and small protrusion (TAP) (39.1%), double kissing (DK) crush (18.8%), and the culotte techniques (14.1%). Procedural and angiographic success rate was 92.18%. Major adverse cardiovascular events at 1-year follow-up occurred in 7.8% of cases. Conclusion: The 2SS for bifurcation lesions showed favorable in-hospital and follow-up outcomes. Findings can serve as a resource for bifurcation angioplasty in India. Larger real-world studies with robust methodology are needed to validate these results.

关键词： Bifurcation Stenting Coronary Bifurcation Lesions Percutaneous

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