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Involvement of haptoglobin in disease development

World Journal of Hematology 2024年第2期11卷 1-7页

作者： Romaric Tuono De Manfouo JosuéSimo Louokdom Bernard Claude Chetcha Larissa Michelle BakamMagoua prosper cabral biapa nya Constant Anatole Pieme Claude Tayou Tagny Department of Microbiology ParasitologyHematologyand Infectious DiseasesHematology UnitFaculty of Medicine and Biomedical SciencesUniversity of Yaoundé1Yaoundé296Cameroon Higher Institute of Health Sciences Universitédes MontagnesBangangté296Cameroon Public Health and Biotechnology Research Laboratory(LAPHER-Biotech) Faculty of SciencesUniversity of Yaoundé1Yaoundé296Cameroon Faculty of Sciences Universitéde DschangDschang 296Cameroon Department of Biochemistry Faculty of Medicine and Biomedical SciencesUniversity of Yaoundé1Yaoundé296Cameroon

Haptoglobin(HP)is a liver glycoprotein that is actively synthesized during in-flammatory and hemolytic *** also has pro-oxidant and proinflam-matory properties,which are a function of its *** genetic polymorp-hism of the chains leads to synthesis of three phenotypes/proteins,which are related to the number and type of chains and their molecular weight,namely HP1-1,HP1-2 and *** with HP2-2 have more vascular complications,while those with HP1-1 have *** is involved in the worsening of diseases,such as HP2-2 in aggravation of vaso-occlusive crises in sickle cell disease,and worsening of the pathophysiology of other *** contrast,HP1-1 confers better protection against *** of this suggests that further studies should be conducted,including experimental and analytical studies focused on de-monstrating the influence of different HP genotypes on individual clinical and hematological *** would help in understanding the role played by this genetic polymorphism in the pathophysiology of diseases.

关键词： Haptoglobin Protein Properties Polymorphism Diseases

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Larvicidal activities of hydro-ethanolic extracts of three Cameroonian medicinal plants against Aedes albopictus

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Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 931-936页

作者： Tankeu Nzufo Francine biapa nya prosper cabral Pieme Constant Anatole Moukette Moukette Bruno Nanfack Pauline Ngogang Yonkeu Jeanne Laboratory of Biochemistry Department of Biochemistry and Physiological Sciences Faculty of Medicine and Biomedical Sciences University of Yaoundé I Laboratory of Sustainable Management of the Agro-ecosystems ENEA-Italian National Agency for New Technologies Energy and Sustainable Economic Development Laboratory of Medicinal Plant Biochemistry Food Science and Nutrition Department of Biochemistry Faculty of ScienceUniversity of Dschang

Objective: To investigate the larvicidal activity of Syzygium guineense(Myrtaceae)(S. guineense), Monodora myristica and Zanthoxylum heitzii(Rutaceae)(Z. heitzii) extracts against Aedes albopictus(Ae. albopictus).Methods: The larvicidal activity of the hydro-ethanolic extracts from these plant species was assessed at three different concentrations(50, 100 and 200 mg/L) on first-instar of Ae. albopictus larvae in comparison with untreated controls. Mortality rate was recorded daily for a period of 12 days. The values of LC_(50) and lethal time killing 50% of the tested individuals(LT_(50)) were calculated using the log-probit ***: The root extract of S. guineense exhibited the best activity with 100% mortality after 8 days of treatment at 200 mg/L, followed by the fruit extract of Z. heitzii with83.33% mortality at the same concentration. Nonetheless, larvae were most susceptible to the fruit extract of Z. heitzii both in terms of LC_(50)(39.89 mg/L) and LT_(50)(145.68 h). A statistically significant difference between the control and the group treated at 200 mg/L was noticed in all the ***: The present study shows that the hydro-ethanolic extracts of S. guineense,Monodora myristica and Z. heitzii tested have significant larvicidal activity. These preliminary results are of great interest and some of these plant species can be proposed for the formulation of new bioinsecticides to control Ae. albopictus populations.

关键词： Aedes albopictus Larvicides Plant extracts Syzygium guineense Zanthoxylum heitzii

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