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Baseline Laboratory Profile of HIV Positive Patients on Antiretroviral Therapy in Jos North Central Nigeria: Implications for Pre-vention, Treatment, Care and Support

引用

World Journal of AIDS 2015年第4期5卷 328-334页

作者： Christian Ogoegbunem Isichei Mercy Wakili Isichei Jean Emile Njab Johnson Ibidun Rotimi Tinuade Abimbola Oyebode Charles Ujunwa Anyaka Kenneth Emeka Enwerem Ayuba Ishiaku Affi Lucius Chidiebere Imoh Alexander Ogielu Abu Solomon Abiola Asorose Noel Omuya Amadu propser ihenacho okonkw. Ngozi Ijeoma Okoro Department of Chemical Pathology Faculty of Medical Sciences University of Jos Jos University Teaching Hospital Jos Nigeria Faith Alive Foundation Jos Nigeria Department of Surgery Faculty of Medical Sciences University of Jos Jos University Teaching Hospital Jos Nigeria Department of Chemical Pathology Bingham University Jos Campus Jos Nigeria Department of Obstetrics and Gynaecology Faculty of Medical Sciences University of Jos Jos Nigeria AIDS Prevention Initiative in Nigeria (APIN) Abuja Nigeria

Background: We characterized baseline laboratory data of patients to identify priority treatment areas, most affected populations, anticipated clinical complications and assessed the potential burden of retention in care in Jos, Plateau State—North Central Nigeria. Methods: This study was a cross-sectional design from January 2004 to December 2005 at Faith Alive Foundation (FAF). All participants were HIV-positive and underwent pre-antiretroviral therapy counseling based on the national antiretroviral therapy (ART) guidelines and baseline laboratory testing. Data were captured on Microsoft Excel, validated on Epi Info and analyzed on SPSS version 21 at P < .05 level of significance. Results: Total of 1499 (463 men and 1036 women) participants were evaluated in this study. The age and sex related distribution of participants showed that majority (80.3% for males and 92.5% for females) were 16 - 45 years old. Amylase and creatinine were significantly higher in males than females (P = .02). Anaemia was the most common baseline abnormality (63% for females and 58% for males), while baseline CD4 count was significantly lower in males than females (P < .02) and at one-third had elevated liver enzymes (AST and ALT). Conclusion: The baseline laboratory profile of most HIV positive patients in Jos and environs of North Central–Nigeria was characterized by anaemia, elevated creatinine, and abnormal liver transaminase levels (AST and ALT). This pre-ART laboratory result suggests that HIV-positive individuals have multiple clinical abnormalities which may require more extensive care than just treating the HIV disease.

关键词： Baseline Laboratory Profile HIV-Positive Patients PEPFAR HTC Nigeria

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