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Origin of and therapeutic approach to cardiac syndrome X:Results of the proton pump inhibitor therapy for angina-like lingering pain trial (PITFALL trial)

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World Journal of Gastroenterology 2008年第42期14卷 6506-6512页

作者： Christoph G Dietrich Susanne Laupichler Sven Stanzel Ron Winograd Oliver Al-Taie carsten Gartung Andreas Geier Department of Gastroenterology Aachen University Aachen 52074 Germany Department of Gastroenterology Klinikum Aschaffenburg Aschaffenburg 63739 Germany Department of Medical Statistics AachenUniversity Aachen 52074 Germany Department of Gastroenterology University Hospital Zurich Zurich 8091 Switzerland

AIM: To investigate the frequency of gastroen-terological diseases in the etiology and the efficacy of proton pump inhibitors (PPIs) in the treatment of cardiac syndrome X (CSX) as a subform of non-cardiac chest pain (NCCP). METHODS: We investigated 114 patients with CSX using symptom questionnaires. A subgroup of these patients were investigated regarding upper gastrointestinal disorders (GIs) and treated with PPI. Patients not willing to participate in investigation and treatment served as control group. RESULTS: Thirty-six patients denied any residual symptoms and were not further evaluated. After informed consent in 27 of the remaining 78 patients, we determined the prevalence of disorders of the upper GI tract and quantifi ed the effect of treatment with pantoprazole. We found a high prevalence of gastroenterological pathologies (26/27 patients, 97%)with gastritis, gastroesophageal reflux disease (GERD) and acid reflux as the most common associated disorders. If treated according to the study protocol, these patients showed a significant improvement in the symptom score. Patients treated by primary care physicians, not according to the study protocol had a minor response to treatment (n = 19, -43%), while patients not treated at all (n = 26) had no improvement of symptoms (-0%). CONCLUSION: Disorders of the upper GI tract are a frequent origin of CSX in a German population and can be treated with pantoprazole if given for a longer period.

关键词： Non-cardiac chest pain Gastroesophageal reflux disease Proton pump inhibitor Cardiac syndrome X

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In-situ LDHs growth on PEO coatings on AZ31 magnesium alloy for active protection:Roles of PEO composition and conversion solution

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镁合金学报(英文) 2023年第7期11卷 2376-2391页

作者： Gen Zhang Liang Wu Maria Serdechnova Aitao Tang Cheng Wang carsten Blawert Fusheng Pan Mikhail L.Zheludkevich Nuclear Power Institute of China ChengduSichuan 610213China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Institute of Surface Science Helmholtz-Zentrum HereonMax-Planck Str.1Geesthacht 21502Germany National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China Institute for Materials Science Faculty of EngineeringUniversity of KielKaiserstraße 2Kiel 24143Germany

In this work,plasma electrolytic oxidation(PEO)coatings were produced on magnesium alloy AZ31 in aluminate,silicate and phosphate-based electrolytes,and followed by hydrothermal treatments in order to synthesis layered double hydroxides(LDHs)based *** synthesis was done in three different growth solutions(deionized water,sodium nitrate and aluminum nitrate containing solution).In frame of this work it was shown,that it was difficult to form LDHs on Si-based PEO coating,due to more stable silicate phases in comparison with aluminate and phosphate phases in respective PEO *** obtained hybrid LDH/PEO coatings were characterized using SEM,EDS and GDOES,and then the corrosion protection was further investigated by *** on the obtained results,it was confirmed that,the hydrothermal treatments in Al^(3+)containing solution played an important role on overall corrosion resistance for phosphate and silicate-based PEO coatings,but not for Al-based PEO coatings.

关键词： Layered double hydroxides Plasma electrolytic oxidation Corrosion resistance Magnesium alloys

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商业评论 2024年第8期 164-169页

作者：卡斯滕·伦·彼泽森托马斯·里特陈媛熙哥本哈根信息技术大学商业信息技术系哥本哈根商学院

我们喜欢客户,并且用职业生涯的大部分时间来研究他们.在开展研究、教学和咨询项目的过程中,我们一再敦促高管们倾听客户的声音.然而,我们也逐渐认识到一个尴尬的事实:有些客户对你毫无益处,甚至可能会毁掉你的企业.因此,开掉他们反而...

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Polo-like kinase 1 expression is a prognostic factor in human colon cancer

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World Journal of Gastroenterology 2005年第36期11卷 5644-5650页

作者： Wilko Weichert Glen Kristiansen Mathias Schmidt Volker Gekeler Aurelia Noske Silvia Niesporek Manfred Dietel carsten Denkert Institute of Pathology Charité University Hospital Berlin 10117 Germany Altana Pharma AG Konstanz 78467 Germany

AIM：To clarify the expression patterns and prognostic implications of the mitotic regulator Polo-like kinase 1 （PLK1） in colon cancer. METHODS： Expression of PLK1 was investigated by immunohistochemistry （158 cases） and immunoblotting in tissue of colon adenomas and adenocarcinomas. PLK1 expression patterns were correlated with clinicopathological parameters and patient prognosis. In addition, expression of PLK1 was evaluated by immunoblot and PCR in colon carcinoma cell lines, and coexpression of PLK1 with the proliferation marker Ki-67 was investigated. RESULTS： Weak PLK1 expression was observed in normal colon mucosa and adenomas. In contrast, 66.7% of carcinomas showed strong expression of PLK1. Overexpression of PLK1 correlated positively with Dukes stage （P〈0.001）, tumor stage （P = 0.001） and nodal status （P〈0.05）. Additionally, PLK1 expression was a prognostic marker in univariate survival analysis （P〈0.01） and had independent prognostic significance （RR = 3.3, P = 0.02） in patients with Iocoregional disease. Expression of PLK1 mRNA and protein was detected in all cell lines investigated. Coexpression of PLK1 and Ki-67 was observed in the majority of colon cancer cells, but a considerable proportion of cells showed PLK1 positivity without Ki-67 expression. CONCLUSION： PLK1 is a new prognostic marker for colon carcinoma patients and may be involved in tumorigenesis and progression of colon cancer. Strategies focusing on PLK1 inhibitionin vivo might therefore represent a promising new therapeutic approach for this tumor entity. 2005 The WIG Press and Elsevier Inc. All rights reserved

关键词： Polo-like kinase Colon carcinoma Survival Immunohistochemistry, Mitosis

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Statistical Analysis of Excitonic Transitions in Single,Free-Standing GaN Nanowires:Probing Impurity Incorporation in the Poissonian Limit

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Nano Research 2010年第12期3卷 881-888页

作者： carsten Pfuller Oliver Brandt Timur Flissikowski Caroline Cheze Lutz Geelhaar Holger T.Grahn Henning Riechert Paul-Drude-Institut für Festkörperelektronik 5-7 HausvogteiplatzBerlin 10117Germany

Single,free-standing GaN nanowires grown by plasma-assisted molecular-beam epitaxy have been investigated with low temperature *** quantitative analysis of the luminescence spectra of around 100 nanowires revealed that each nanowire exhibits its own individual spectrum.A significant fraction of nanowires exclusively emits at energies corresponding to either surface-donor-bound or free excitons,demonstrating that optical properties of individual nanowires are determined by a few impurity atoms *** number of impurities per nanowire and their location within the nanowires varies according to Poissonian statistics.

关键词： Single nanowires impurities doping excitonic luminescence scaling

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Testicular expression of survivin and human telomerase reverse transcriptase(hTERT)associated with spermatogenic function in infertile patients

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Asian Journal of Andrology 2006年第1期8卷 95-100页

作者： Steffen Weikert Frank Christoph Wolfgang Schulze Hans Krause carsten Kempkensteffen Martin Schostak Kurt Miller Mark Schrader Department of Urology Charité-Universittsmedizin BerlinCampus B.FranklinD-12200 BerlinGermany Department of Andrology University of HamburgD-20246 HamburgGermany

Aim： To characterize the coexpression of survivin, an inhibitor of apoptosis （IAF）, and human telomerase reverse transcriptase （hTERT） in human testes with varying spermatogenic function. Methods： Transcript levels of survivin mRNA and hTERT mRNA were determined in normal testes （n = 11） and testes with defective spermatogenesis （n = 28） using real-time reverse-transcription polymerase chain reaction （RT-PCR）. The histological work-up was performed according to a modified Johnsen score. Results： Expressions of both survivin and hTERT were highest at median levels of 96.8 and 709 in normal spermatogenesis and dropped to 53.3 and 534 in testes with postmeiotic spermatogenic arrest （n = 10）. In severe spermatogenic failure （n = 18）, survivin expression was lacking in most specimens （n = 16）, whereas at least low levels of testicular hTERT expression were largely detectable with a normalized expression of 73 in premeiotic spermatogenic arrest （n = 7） and 45 in patients with Sertoli cell-only syndrome （SCOS）（n = 3）. Both survivin and hTERT expressions increased with a progressing Johnsen score （P for trend = 0.001）. Conclusion： Although both survivin and hTERT are correlated with spermatogenic function, they show different expression patterns in testes of infertile patients. These findings substantiate results from studies in the rodent testis suggesting a predominant expression of survivin in meiotically dividing germ cells. （Asian J Andro12006 Jan; 8： 95-100）

关键词： survivin human telomerase reverse transcriptase apoptosis azoospermia male infertility spermatogenesis

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MgAl-V_(2)O_7 ^(4-)LDHs/(PEI/MXene)_(10) composite film for magnesium alloy corrosion protection

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Journal of Materials Science & Technology 2021年第32期91卷 28-39页

作者： Yulong Wu Liang Wu Mikhail L.Zheludkevich Yanning Chen Maria Serdechnova Wenhui Yao carsten Blawert Andrej Atrens Fusheng Pan State Key Laboratory of Mechanical Transmission College of Materials Science and EngineeringChongqing UniversityChongqing 400044China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China Institute of Surface Science Helmholtz-Zentrum HereonMax-Planck Str.121502 GeesthachtGermany School of Mechanical and Mining Engineering The University of QueenslandBrisbaneQld 4072Australia

In this study,MgAl-V_(2) O_7^(4-) LDHs/(poly(ethyleneimine)(PEI)/MXene)_n composite films were synthesized via(ⅰ) in-situ hydrothermal growth of Mg-AL layered double hydroxides(LDHs) on AZ31 alloy followed by vanadate intercalation reactions,and(ⅱ) the as-prepared MgAL-V_(2) O7^(4-) LDHs film was covered by layerby-layer assembly using(PEI/MXene)_n,where n=5,10,and *** characterization revealed that the outer layers(PEI/MXene) were assembled on the surface by electrostatic interaction and provided a good coverage of LDHs ***,microcracks appeared gradually on the surface and destroyed the film integrity with increasing number of PEI/MXene *** corrosion tests indicated that the MgAl-V_(2) O_7^(4-)LDHs/(PEI/MXene)_(10) composite films provided a better corrosion protection ability than that of n=5 *** outer layers(PEI/MXene) had a corrosion inhibition protective effect on MgAl-V_(2) O_7^(4-) LDHs *** work opened a new perspective of the MXene materials for anticorrosion application via a layer-bylayer assembly method.

关键词： Magnesium alloys Layered double hydroxides Vanadate MXene Layer-by-Layer Corrosion resistance

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Dysregulated expression and distribution of Kif5αin neurites of wobbler motor neurons

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Neural Regeneration Research 2023年第1期18卷 150-154页

作者： Kilian Kürten Anne-Christin Gude Aimo Samuel Christian Epplen Jan Stein carsten Theiss Veronika Matschke Department of Cytology Institute of AnatomyMedical FacultyRuhr University BochumBochumGermany

Impaired axonal transport has been observed in patients with amyotrophic lateral sclerosis(ALS)and in animal models,suggesting that transport proteins likely play a critical role in the pathological mechanism of *** of Kinesin-family-member 5α(Kif5α),a neuron-specific isoform of heavy chain kinesin family,has been described in several neurological disorders,in humans and animal models,including *** this study,we determined Kif5αexpression by gene sequencing,quantitative reverse transcription-polymerase chain reaction,and western blot assay in the cervical spinal cord of wobbler mice and immunofluorescence staining in dissociated cultures of the ventral ***,we observed the distribution of Kif5αand mitochondria along motor neuronal branches by confocal *** results showed that Kif5αexpression was greatly dysregulated in wobbler mice,which resulted in altered distribution of Kif5αalong motor neuronal branches with an abnormal mitochondrial ***,our results indicate that dysregulation of Kif5 and therefore abnormal transport in motor neuronal branches in this ALS model could be causative for several pathological findings at the cellular level,like misallocation of cytoskeletal proteins or organelles like mitochondria.

关键词： amyotrophic lateral sclerosis cell culture kinesin mitochondria neurodegeneration spinal cord transport

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A Very Simple Model Concerning the Unified Field Theory Basing on the Kronig-Penney-Model

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Journal of High Energy Physics, Gravitation and Cosmology 2019年第3期5卷 941-952页

作者： carsten Wochnowski Independent Researcher Karlsfeld Germany

In this paper, a very simple novel model is presented concerning the unified field theory (“theory of everything”). In the scope of this novel theory, it is assumed that matter, space and time are quantized. It is assumed that the space is subdivided into cubic elementary cells (space quanta), and in each of its eight corners a Delta potential is positioned. That means the Delta potentials are equidistantly arranged, so that the Delta potentials are forming a lattice similar to a crystal lattice in solid state physics. The novel theory is analogue to the Kronig-Penney model well-known in solid state physics: a crystal lattice comprises Delta potentials arranged equidistantly to one another, so the lattice space can be considered as being quantized by an array of equally spaced Delta potentials or the lattice space is divided into cubic elementary cells (space quanta). But instead of electrons, material quanta are inserted into the cubic elementary cells or space quanta. So the material quanta are not freely vibrating (unbound state), but are vibrating in a bound state with discrete energy levels separated by an energy gap. This is due to the presence of the array of Delta potentials. In the frame of this novel theory the Schr?dinger Equation for the Kronig-Penney-Model is not solved by differentiation, but the Schr?dinger Equation is integrated yielding the formula , by whose discussion the existence of an energy gap is revealed. This energy gap is responsible if the material quantum occurs as light quantum (photon) or mass quantum.

关键词： String Theory Loop Quantum Gravity Theory Unified Field Theory

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Feature size below 100 nm realized by UVLEDbased microscope projection photolithography

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Light(Advanced Manufacturing) 2023年第4期4卷 72-81页

作者： Lei Zheng Tobias Birr Urs Zywietz carsten Reinhardt Bernhard Roth Hannover Centre for Optical Technologies Leibniz University Hannover30167 HannoverGermany Cluster of Excellence PhoenixD(Photonics Opticsand Engineering-Innovation Across Disciplines)30167 HannoverGermany Laboratory of Nano and Quantum Engineering 30167 HannoverGermany Bremen University of Applied Science 28199 BremenGermany

The demand for miniaturization and integration of optical elements has fostered the development of various micro-and nanofabrication *** this work,we developed a low-cost UV-LED-based microscope projection photolithography system for rapid and high-resolution *** system can be easily implemented using off-the-shelf *** allows for micro-and nanostructuring within *** optimizing the process,a minimum feature size down to approximately 85 nm was successfully *** addition,investigations on fabrication of the same structures using both costly and economic microscope objectives were *** sizes below 100 nm can be stably *** demonstrated approach extends the technology capabilities and may find applications in fields such as nanophotonics,biophotonics sensing and material science.

关键词： Microfabrication Nanofabrication Subwavelength structuring Projection lithography UV-LED lithography

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