检索结果-南通市图书馆

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

引用

Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of TiO_2 Functionalization on Nano-Porous Silicon for Selective Alcohol Sensing at Room Temperature

引用

Journal of Materials Science & Technology 2017年第6期33卷 516-522页

作者： priyanka Dwivedi Saakshi Dhanekar Samaresh Das Sudhir chandra Centre for Applied Research in Electronics Indian Institute of Technology(IIT)

Room temperature operated sensor for detection of alcohol vapours in low ppm range based on TiO_2 functionalized nano-porous silicon（PSi） is demonstrated. The effect of functionalization by TiO_2 on PSi is investigated using SEM, EDX, Raman spectroscopy, XRD and contact angle measurements. Sensing is accomplished by measuring change in resistance of the sensing layer using Cr-Au inter-digitatedelectrode（IDE） structure formed on top of the functionalized PSi layer. The sensors were tested for volatile organic compounds（VOCs） and water vapours in the wide range of 5–500 ppm concentration at room temperature. Functionalization of the nanostructured PSi by sputter deposited TiO_2 results in significant enhancement of sensitivity and inverse change in selectivity. PSi sensors have displayed strong response to water vapours whereas after functionalization, selective sensing to ethanol is depicted. Minimum detection by PSi sensors is portrayed at 100 ppm and that of functionalized sensors is at 10 ppm. Sensing mechanism is explained on the basis of surfaces and structures of both PSi and TiO_2. This study incites the importance of surface treatment of PSi for tuning the sensing properties and is useful in the development of selective alcohol sensors.

关键词： Functionalization Porous silicon Selectivity Sensor Titanium dioxide(TiO2)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Strategies to mitigate the adverse effect of drought stress on crop plants-influences of soil bacteria:A review

引用

Pedosphere 2021年第3期31卷 496-509页

作者： priyanka.chandra Amoolya WUNNAVA Pooja VERMA Amaresh chandra Rakesh Kumar SHARMA Indian Council of Agricultural Research(ICAR) Central Soil Salinity Research InstituteKarnalHaryana 132001India Department of Biosciences Manipal University JaipurRajasthanJaipur 303007India Indian Council of Agricultural Research(ICAR) Indian Institute of Sugarcane ResearchUttar PradeshLucknow 226002India

Drought stress affects plant growth and causes significant issues in meeting global demand for food crops and *** can cause physiological,physicochemical,and morphological changes in plants,which negatively affects plant growth and *** combat this under the increasing global threat of water shortage and rapid population expansion,it is crucial to develop strategies to meet global food *** growth-promoting rhizobacteria(PGPR)may provide a safe solution to enhancing crop yields through various *** soil bacteria can provide drought tolerance to crop plants,allowing them to survive and thrive in water-scarce *** of phytohormones,free radical-scavenging enzymes,and stress-combating enzymes that can increase tolerance to drought-induced stress are key features of plant-associated microbial *** review summarizes the beneficial properties of microbes that help plants tolerate water scarcity and highlights the bacterial mechanisms that enhance drought tolerance in plants.

关键词： abiotic stress agricultural yield drought tolerance food crops microbe PGPR rhizobactoria water deficit

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Patients with Cirrhosis of Liver Operated for Non-transplant Surgery: A Retrospective Analysis

引用

Journal of Clinical and Translational Hepatology 2019年第1期7卷 9-14页

作者： Kishore Kumar Kuduva Subramanian Manish Tandon chandra Kant Pandey priyanka Jain Department of Anaesthesiology Institute of Liver and Biliary SciencesNew DelhiIndia Department of Research Institute of Liver&Biliary Sciences(ILBS)New DelhiIndia

Background and Aims:Patients with cirrhosis of the liver have high mortality after *** investigated the mortality in patients with cirrhosis of the liver who underwent surgery other than liver transplant and applied the Mayo clinic model to predict mortality and compare with the observed *** also studied the association of the observed mortality with the Child-Turcotte-Pugh(CTP)class and the model for end-stage liver disease(MELD)and model for end-stage liver disease-sodium(MELD-Na)***:The electronic records database of our hospital was accessed to analyze the data of 133 cirrhotic patients who underwent various surgeries under general anesthesia from October 2009 to June *** Mayo risk score was applied to each and used to calculate predicted mortality;the MELD and MELD-Na scores were also *** interview was performed with the patients and or their relative to ascertain survival or time of death after surgery,when the information was not available from the hospital ***:The all-cause observed mortality rates at postoperative days 30 and 90 and at 1 year were 12%,20.3%and 26.3%*** area under the receiver operating characteristic curve values for the Mayo model as a predictor of 30-day,90-day and 1-year mortality were 0.836,0.828 and 0.744 *** correlation was seen for observed mortality with CTP class and with MELD and MELD-Na ***:The Mayo model for predicting postoperative mortality in patients with cirrhosis of the liver demonstrated good correlation in this *** strength of prediction of mortality by Mayo risk score calculation was similar at postoperative days 30 and 90 but decreased at 1-year after the *** correlation was seen for the observed mortality with MELD,MELD-Na and CTP scores.

关键词： Cirrhosis of the liver Mayo risk model CTP score MELD score

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pathogenicity of Vibrio harveyi and its biocontrol using bacteriophages

引用

Systems Microbiology and Biomanufacturing 2023年第4期3卷 552-570页

作者： Smita Ghosh priyanka Kar Sudipta Chakrabarti Shrabani Pradhan Keshab chandra Mondal Kuntal Ghosh Department of Biological Sciences Midnapore City CollegeMidnaporeWest BengalIndia Biodiversity and Environmental Studies Research Center Midnapore City CollegeVidyasagar UniversityMidnaporeWest BengalIndia Department of Microbiology Vidyasagar UniversityMidnaporeWest BengalIndia

Vibrio harveyi is a Gram-negative,rod-shaped,polar flagellate,facultatively anaerobic,halophilic,bioluminescent marine bacteria that belongs to the family of Vibrionaceae,class,*** pathogenic organism is responsible for various diseases of vertebrates and invertebrates in marine habitats,including shrimp *** symptoms like lesions,gastroenteritis,skin ulcers,eye lesions,and tail rot have been observed due to *** *** pathogenic-ity mechanism of *** involves endotoxin lipopolysaccharide,extracellular proteases,and bacteriophage *** genes encoded extracellular hemolysin-like phospholipase B toxin could inactivate fish species via the caspase inactivation pathway,ultimately leading to *** addition,VBNC(viable but nonculturable)cells are another basis of vibriosis outbreaks in the shrimp aquaculture *** extensive amount of antibiotic use promotes the generation of multidrug-resistant ***,as an alternative strategy to combat *** infection,bacteriophages are utilized as a biocontrol ***,there is a lack of research on the immobilization and development of encapsulation strategies of ***-infecting bacteriophages which need to be studied *** conclusion,the pathogenicity of *** and its biocontrol by bacteriophages has been documented in this review.

关键词： Shrimp Antibiotic resistance Bacteriophage Bioluminescence Biofilm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bianchi Type-Ⅱ Inflationary Models with Stiff Matter and Decaying Cosmological Term

引用

Chinese Physics Letters 2014年第7期31卷 27-31页

作者： Shri Ram, priyanka Department of Mathematical Sciences Indian Institute of Technology Banaras Hindu University Varanasi 221 005 India

We deal with Einstein＇s field equations with a time-decaying cosmological term of the forms （i） ∧=β（a/a）＋ α/a62 and （ii）∧ = α/a^2, where a is the average scale factor of the universe, α and β are constants for a spatially homogeneous and anisotropic LRS Bianchi type-Ⅱ spacetime. Exact solutions of the field equations for stiff matter are obtained by applying a special law of variation for the Hubble parameter. Anisotropic cosmological models are presented with a constant negative deceleration parameter which corresponds to the accelerated phase of the present universe. The cosmological constant A is obtained as a decreasing function of time that is approaching a small positive value at the present epoch, which is corroborated by the consequences from recent supernovae Ia observations. The physical and kinematical behaviors of the models are also discussed.

关键词： INFLATIONARY universe BIANCHI groups PARTICLE decays COSMOLOGY MATHEMATICAL models SPACE & time HUBBLE constant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Seismic analysis of nailed vertical excavation using pseudo-dynamic approach

引用

Earthquake Engineering and Engineering Vibration 2016年第4期15卷 621-631页

作者： Piyush Sarangi priyanka Ghosh Department of Civil Engineering Indian Institute of Technology

An attempt has been made to study the behavior of nailed vertical excavations in medium dense to dense cohesionless soil under seismic conditions using a pseudo-dynamic approach. The effect of several parameters such as angle of internal friction of soil （φ）, horizontal （kh） and vertical （kv） earthquake acceleration coefficients, amplification factor （fa）, length of nails （L）, angle of nail inclination （a） and vertical spacing of nails （S） on the stability of nailed vertical excavations has been explored. The limit equilibrium method along with a planar failure surface is used to derive the formulation involved with the pseudo-dynamic approach, considering axial pullout of the installed nails. A comparison of the pseudo-static and pseudo-dynamic approaches has been established in order to explore the effectiveness of the pseudo-dynamic approach over pseudo-static analysis, since most of the seismic stability studies on nailed vertical excavations are based on the latter. The results are expressed in terms of the global factor of safety （FOS）. Seismic stability, i.e., the FOS of nailed vertical excavations is found to decrease with increase in the horizontal and vertical earthquake forces. The present values of FOS are compared with those available in the literature.

关键词： earthquake factor of safety pseudo-dynamic approach soil nailing vertical excavation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ion Conduction in Superionic Glassy Electrolytes:An Overview

引用

Journal of Materials Science & Technology 2013年第3期29卷 193-208页

作者： Angesh chandra Alok Bhatt Archana chandra Department of Applied Physics Shri Shankaracharya Institute of Prof.Manag.& Tech.Raipur 492015C.G.India Department of Applied Physics M.P Christian College of Engg.& Tech.Bhilai 490026C.G.India

The various theoretical and experimental models for ion conduction mechanism of fast ion conducting （FIC） glass electrolytes have been reported in the present review paper. Some characterization techniques of FIC glasses are presented. The experimental methods for determination of some ion transport parameters viz ionic conductivity （σ）, ionic mobility （μ）, mobile ion concentration （n）, ionic drift velocity （Vd）, ionic transference number （tion） and activation energies of FIC glasses are explained. The solid state battery fabrication by using some FIC glasses is also reported.

关键词： Ion conduction Glassy solid electrolyte Fast ion conducting (FIC) glass Superionic solid Relaxation phenomenon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Using Markov chains to predict the natural progression of diabetic retinopathy

引用

International Journal of Ophthalmology(English edition) 2015年第1期8卷 132-137页

作者： priyanka Srikanth Jaslok Hospital & Research Centre

AIM: To study the natural progression of diabetic retinopathy in patients with type 2 ***: This was an observational study of 153 cases with type 2 diabetes from 2010 to 2013. The state of patient was noted at end of each year and transition matrices were developed to model movement between years. Patients who progressed to severe non-proliferative diabetic retinopathy(NPDR) were *** Chains and Chi-square test were used for statistical ***: We modelled the transition of 153 patients from NPDR to blindness on an annual basis. At the end of year 3, we compared results from the Markov model versus actual data. The results from Chi-square test confirmed that there was statistically no significant difference(P =0.70) which provided assurance that the model was robust to estimate mean sojourn times. The key finding was that a patient entering the system in mild NPDR state is expected to stay in that state for 5y followed by 1.07 y in moderate NPDR, be in the severe NPDR state for 1.33 y before moving into PDR for roughly8 y. It is therefore expected that such a patient entering the model in a state of mild NPDR will enter blindness after 15.29 ***: Patients stay for long time periods in mild NPDR before transitioning into moderate ***, they move rapidly from moderate NPDR to proliferative diabetic retinopathy(PDR) and stay in that state for long periods before transitioning into blindness.

关键词： diabetes mellitus diabetic retinopathy Markov Chains Chi-square test transition probability matrix

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PEO-PVP BLENDED Na^+ION CONDUCTING SOLID POLYMERIC MEMBRANES

引用

Chinese Journal of Polymer Science 2013年第11期31卷 1538-1545页

作者： Angesh chandra Department of Applied Physics Shri Shankaracharya Institute of Professional Management & Technology

Polyethylene oxide （PEO）-polyvinylpyrrolidone （PVP） blended Na＋ ion conducting solid polymeric membranes：（1-x） [75PEO：25NaPO3] ＋ x PVP, where 0 〈 x 〈 12 wt%, are reported. The polymeric blending was done using a solvent- free hot-press method. Two orders of conductivity enhancement （σca. 1.07× 10^-5 S·cm^-1） have been achieved with 3 wt% of PVP （i.e. the composition： [97（75PEO：25NaPO3）＋ 3PVP]）, from that of the pure host：（75PEO：25NaPO3）. The conductivity enhancement in PEO-PVP blended solid polymeric membranes have been explained by the ionic conductivity, ionic mobility and mobile ion concentration measurements. Materials characterization and polymer-salt complexation were done with the help of X-ray diffraction （XRD）, scanning electron microscopy （SEM）, differential scanning calorimetry （DSC） and thermo gravimetric analysis （TGA） studies. The temperature dependent conductivity studies have also been done to compute the activation energy （Ea） values from lgσ-1/TArrhenius plots. A solid state polymeric battery was fabricated by using optimum conducting composition of solid polymer electrolyte （SPE OCC）, and some important cell parameters were also calculated from the discharge profile of the cell.

关键词： Polymer blending Activation energy Ionic conductivity SEM XRD DSC TGA.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：