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Simultaneous enantioseparation and simulation studies of atenolol,metoprolol and propranolol on Chiralpak^■IG column using supercritical fluid chromatography

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Journal of Pharmaceutical Analysis 2021年第6期11卷 746-756页

作者： Pranav A.Pandya priyanka A.Shah Pranav S.Shrivastav Department of Chemistry School of SciencesGujarat UniversityAhmedabad380009India

Enantioseparation of threeβ-blockers,i.e.,atenolol,metoprolol and propranolol,was studied on amylose tris(3-chloro-5-methylphenylcarbamate)immobilized chiral stationary phase using supercritical fluid chromatography(SFC).The effect of organic modifiers(methanol,isopropanol and their mixture),column temperature and back pressure on chiral separation ofβ-blockers was *** chromatographic separation with respect to resolution,retention,and analysis time was achieved using a mixture of CO_(2) and 0.1%isopropyl amine in isopropanol:methanol(50:50,V/V),in 75:25(V/V)*** the optimized conditions,the resolution factors(Rs)and separation factors(a)were greater than3.0 and 1.5,***,with increase in temperature(25-45℃)and pressure(100-150 bars)there was corresponding decrease in retention factors(k),a and ***,a reverse trend(a and Rs)was observed for atenolol with increase in *** thermodynamic data from van’t Hoff plots revealed that the enantioseparation was enthalpy driven for metoprolol and propranolol while entropy driven for *** understand the mechanism of chiral recognition and the elution behavior of the enantiomers,molecular docking studies were *** binding energies obtained from simulation studies were in good agreement with the elution order found experimentally and also with the free energy *** method was validated in the concentration range of 0.5-10μg/m L for all the *** limit of detection and limit of quantitation ranged from 0.126 to 0.137μg/m L and 0.376-0.414μg/m L,*** method was used successfully to analyze these drugs in pharmaceutical preparations.

关键词： Enantioseparation Supercritical fluid chromatography β-blockers Chiralpak^(■)IG column Molecular docking Binding energy

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Synthesis and electroluminescence properties of tris-[5-choloro-8-hydroxyquinoline]aluminum Al(5-Clq)_3

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Journal of Semiconductors 2015年第6期36卷 35-38页

作者： Rahul Kumar Parag Bhargava Ritu Srivastava priyanka Tyagi Indian Institute of Technology Bombay National Physical Laboratory

A new electroluminescent material tris- [5-choloro-8-hydroxyquinoline] aluminum has been synthesized and characterized. Solution of this material AI（5-Clq）3 in toluene showed absorption maxima at 385 nm which was attributed to the moderate energy （π-π＊） transitions of the aromatic rings. The photoluminescence spectrum of AI（5-Clq）3 in toluene solution showed a peak at 522 nm. This material shows thermal stability up to 400 ℃. The structure of the device is ITO/0.4 wt%F4-TCNQ doped α-NPD （35 nm） / AI（5-Clq）3 （30 nm） / BCP （6 nm）/ Alq3 （30 nm） / LiF （1 nm） / A1 （150 nm）. This device exhibited a luminescence peak at 585 nm （CIE coordinates, x = 0.39, y = 0.50）. The maximum luminescence of the device was 920 Cd/m2 at 25 V. The maximum current efficiency of OLED was 0.27 Cd/A at 20 V and maximum power efficiency was 0.04 lm/W at 18 V.

关键词： organometallic compounds chemical synthesis vapour deposition photoluminescence spectroscopy electrical properties luminescence

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Gastric electrical stimulation: An emerging therapy for children with intractable gastroparesis

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World Journal of Gastroenterology 2019年第48期25卷 6880-6889页

作者： Aniruddh Setya priyanka Nair Sam Xianjun Cheng Department of Pediatric Gastroenterology Hepatology and Nutrition University of Florida

Management of gastroparesis remains challenging,particularly in pediatric *** care and pharmacological therapies for symptoms remain the mainstay *** they are effective for mild and some moderately severe cases,often time they do not work for severe *** are a few prokinetics available,yet the use of these drugs is limited by a lack of persistent efficacy and/or safety ***,the only modality for adult patients with severe intractable gastroparesis is surgery,e.g.,pyloroplasty and partial gastrectomy,however,this option is generally considered too radical for a growing *** therapeutic approaches,particularly those which are less invasive,are *** article explores gastric electrical stimulation(GES),a new therapy for *** others,it neither needs medications nor gastrectomy;rather,it treats through the use of microelectrodes to deliver high-frequency low energy electric stimulation to the pacemaker area of the ***,it is tolerated and safe in *** in adult patients,GES appears to work in releasing symptoms,improving nutrition,and enhancing the quality of life;it also helps wean off medications and eliminate many needs for *** the transient nature of gastroparesis in children in many occasions,GES is considered a“bridging”therapy after failed medical interventions and before surgery.

关键词： Gastroparesis Gastric electrical stimulation Nausea Vomiting Prokinetics

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Extracellular synthesis of silver nanoparticles by Pseudomonas sp. THG-LS1.4 and their antimicrobial application

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Journal of Pharmaceutical Analysis 2018年第4期8卷 258-264页

作者： Hina Singh Juan Du priyanka Singh Tae Hoo Yi Department of Oriental Medicine Biotechnology College of Life Science Kyung Hee University Global Campus College of Food and Bioengineering Zhengzhou University of Light Industry Henan Province Collaborative Innovation Center for Food Production and Safety

Silver nanoparticles（Ag NPs） are known to have bacteriostatic and bactericidal effects. The present study highlights the extracellular synthesis of Ag NPs and its antibacterial properties. The Ag NPs were synthesized using Pseudomonas sp. THG-LS1.4 strain which had been isolated from soil. The Ag NPs were characterized by field emission-transmission electron microscopy（FE-TEM）, X-ray diffraction（XRD）,Fourier transform-infrared（FT-IR） spectroscopy, and particle size distribution（DLS）. The Ag NPs displayed maximum absorbance at 412 nm and were irregular in shape ranging from 10 to 40 nm. The XRD spectroscopy results demonstrated the crystalline nature of nanoparticles. The Ag NPs showed antimicrobial activity against Bacillus cereus, Staphylococcus aureus, Candida tropicalis, Vibrio parahaemolyticus, Escherichia coli and Pseudomonas aeruginosa. Furthermore, the Ag NPs were also evaluated for their increased antibacterial activities with various antibiotics against Escherichia coli, Pseudomonas aeruginosa and Salmonella enterica. Additionally, Ag NPs showd biofilm inhibition activity. The biosynthesized Ag NPs were found to be a potent agent against tested pathogens. More importantly, we highlight the applications of Ag NPs as an antimicrobial agent.

关键词： Extracellular synthesis Silver nanoparticles Pseudomonas sp.THG-LS1.4 Antimicrobial activity

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A new 'superassemblage' model explaining proximal-to-distal and lateral facies changes in fluvial environments,based on the Proterozoic Sanjauli Formation(Lesser Himalaya,India)

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Journal of Palaeogeography 2016年第4期5卷 391-408页

作者： Ananya Mukhopadhyay priyanka Mazumdar A.J. (Tom) van Loon Department of Earth Sciences Indian Institute of Engineering Science & Technology Shibpur Howrah West Bengal 711103 India Geocom Consulting Valle del Portet 17 03726 Benitachell Spain

Facies analysis of fluvial deposits of the Proterozoic Sanjauli Formation in the Lesser Himalaya was combined with an architectural analysis. On this basis, a model was developed that may be applied to other fluvial systems as well, whether old or recent. The new model, which might be considered as an assemblage of previous models, explains lateral variations in architecture and facies but is not in all respects consistent with the standard fluvial models. The Sanjauli fluvial model is unique in that it deals with lateral facies variations due to shifts of the base-level along with fluctuations in accommodation space owing to changes in palaeoclimate.

关键词： Ftuvial model Braided river Sanjauli Formation Simta Basin Proterozoic Lesser Himalaya India

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Effect of forest fire on soil microbial biomass and enzymatic activity in oak and pine forests of Uttarakhand Himalaya, India

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Ecological Processes 2021年第1期10卷 394-407页

作者： Devanshi Singh priyanka Sharma Ujjwal Kumar Achlesh Daverey Kusum Arunachalam School of Environment and Natural Resources Doon UniversityDehradunUttarakhand 248012India

Background:Forest fire incidences in the Himalayan region of Uttarakhand,India are very common in *** and oak are the principal and dominant species of Himalayan subtropical forest and Himalayan temperate forest,*** vegetation influences the physicochemical and biological properties of soil and forest fire in pine and oak forests may have a different effect on the physicochemical and biological properties of ***,the present study was carried out to assess the impact of forest fire on soil microbial properties,enzymatic activity,and their relationship with soil physicochemical properties in the advent of forest fire in the pine and oak forests of the Garhwal region of Uttarakhand Himalaya,***:The soil microbial biomass carbon and nitrogen,soil basal respiration,and acid phosphatase activity decreased,whereas dehydrogenase activity increased at burnt sites of both forest *** overall change in soil microbial biomass carbon was 63 and 40%at the burnt oak forest and burnt pine forest,*** activity and acid phosphatase activity showed a strong positive correlation with soil organic matter(r=0.8)and microbial indices,*** ratio of soil microbial biomass carbon/nitrogen was reduced at burnt sites of both forest *** analysis results showed that fire had a significant impact on soil *** soil basal respiration was linked with macro-and micronutrients at burnt sites,whereas at control sites,it was linked with physicochemical properties of soil along with ***:Forest fire had a significant impact on soil properties of both forest *** impact of forest fire on soil microbial biomass carbon was stronger in the oak forest than in the pine *** type influenced soil enzymatic activity at burnt *** bacterial community was dominated over fungi in burnt sites of both *** microbial indices can be used as a selective measure to assess

关键词： Microbial indices Soil enzymes Microbial biomass Forest fire Pine forest Oak forest

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Application of source biasing technique for energy efficient DECODER circuit design: memory array application

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Journal of Semiconductors 2018年第4期39卷 49-54页

作者： Neha Gupta priyanka Parihar Vaibhav Neema Department of Electronics and Telecommunication Engineering Institute of Engineering and Technology Devi Ahilya University

Researchers have proposed many circuit techniques to reduce leakage power dissipation in memory cells. If we want to reduce the overall power in the memory system, we have to work on the input circuitry of memory architecture i.e. row and column decoder. In this research work, low leakage power with a high speed row and column decoder for memory array application is designed and four new techniques are proposed. In this work, the comparison of cluster DECODER, body bias DECODER, source bias DECODER, and source coupling DE- CODER are designed and analyzed for memory array application. Simulation is performed for the comparative analysis of different DECODER design parameters at 180 nm GPDK technology file using the CADENCE tool. Simulation results show that the proposed source bias DECODER circuit technique decreases the leakage current by 99.92% and static energy by 99.92% at a supply voltage of 1.2 V. The proposed circuit also improves dynamic power dissipation by 5.69%, dynamic PDP/EDP 65.03% and delay 57.25% at 1.2 V supply voltage.

关键词： SRAM leakage current delay SLEEP transistor

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Targeting metabolic vulnerabilities to overcome resistance to therapy in acute myeloid leukemia

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Cancer Drug Resistance 2023年第3期6卷 567-589页

作者： priyanka Sharma Gautam Borthakur Department of Leukemia Section of Molecular Hematology and TherapeuticsThe University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Malignant hematopoietic cells gain metabolic plasticity, reorganize anabolic mechanisms to improve anabolic output and prevent oxidative damage, and bypass cell cycle checkpoints, eventually outcompeting normal hematopoietic cells. Current therapeutic strategies of acute myeloid leukemia (AML) are based on prognostic stratification that includes mutation profile as the closest surrogate to disease biology. Clinical efficacy of targeted therapies, e.g., agents targeting mutant FMS-like tyrosine kinase 3 (FLT3) and isocitrate dehydrogenase 1 or 2, are mostly limited to the presence of relevant mutations. Recent studies have not only demonstrated that specific mutations in AML create metabolic vulnerabilities but also highlighted the efficacy of targeting metabolic vulnerabilities in combination with inhibitors of these mutations. Therefore, delineating the functional relationships between genetic stratification, metabolic dependencies, and response to specific inhibitors of these vulnerabilities is crucial for identifying more effective therapeutic regimens, understanding resistance mechanisms, and identifying early response markers, ultimately improving the likelihood of cure. In addition, metabolic changes occurring in the tumor microenvironment have also been reported as therapeutic targets. The metabolic profiles of leukemia stem cells (LSCs) differ, and relapsed/refractory LSCs switch to alternative metabolic pathways, fueling oxidative phosphorylation (OXPHOS), rendering them therapeutically resistant. In this review, we discuss the role of cancer metabolic pathways that contribute to the metabolic plasticity of AML and confer resistance to standard therapy;we also highlight the latest promising developments in the field in translating these important findings to the clinic and discuss the tumor microenvironment that supports metabolic plasticity and interplay with AML cells.

关键词： OXPHOS DHODH leukemia stem cells mesenchymal stromal cells IDH

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A review of the～1600 Ma sedimentation,volcanism,and tectono-thermal events in the Singhbhum craton,Eastern India

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Geoscience Frontiers 2013年第3期4卷 277-287页

作者： priyanka Chatterjee Shuvabrata De Marinah Ranaivoson Rajat Mazumder Makoto Arima Department of Geology University of Calcutta35 B.C.RoadKolkata 700019India Geological Studies Unit Indian Statistical Institute203 B.T.RoadKolkata 700108India Graduate School of Environment and Information Science Yokohama National University79-7TokiwadaiHodogaya Yokohama 240-8501Japan School of Biology Earth and Environmental SciencesUniversity of New South WalesKensingtonSydney NSW 2052Australia

The Palaeoproterozoic-Mesoproterozoic transition （ -1600 Ma） is a significant event in the Earth history as a global thermal perturbation affected the pre-1600 Ma landmasses. Like other cratonic blocks of the world, lithospheric thinning, sedimentation, magmatism, metamorphism and crustal melting/anatexis are associated with this significant geological event in the Singhbhum cratonic province of India. This paper is a review of sedimentological, magmatic and tectono-thermal events in the Singhbhum craton at 1600 Ma. The Palaeo-Mesoproterozoic sedimentation and volcanism in the Singhbhum craton took place in a terrestrial intracontinental rift setting. The available geochronological data are indicative of late Palaeoproterozoic to Neoproterozoic tectono-thermal events in the Chhotanagpur Granite Gneissic Complex （CGGC）, an east-west trending arcuate belt of granite gneisses, migmatites and metasedi- mentary rocks. A detailed multidisciplinary geo-scientific investigation of the Dalma volcanic belt and the area to its north （Chandil Formation） and further north in CGGC will enable us to constrain the extant surface processes and crust-mantle interactions, the collision events between the North and South Indian cratonic blocks, and the position of India in the Columbia supercontinent.

关键词： Late Palaeoproterozoic Mesoproterozoic Sedimentation Volcanism Geochronology Singhhhum

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Genome-wide association study in historical and contemporary *** wheats identifies heightreducing loci

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The Crop Journal 2020年第2期8卷 243-251页

作者： Sintayehu D.Daba priyanka Tyagi Gina Brown-Guedira Mohsen Mohammadi Department of Agronomy Purdue UniversityWest LafayetteIN 47907USA Department of Crop and Soil Sciences North Carolina State UniversityRaleighNC 27695USA U.S.Department of Agriculture Agricultural Research ServicesSoutheast AreaPlant Science ResearchRaleighNC 27695USA

Plant height has been a major target for selection of high-yielding varieties in *** height-reducing loci(Rht-B1 and Rht-D1)have been widely used since the Green ***,these genes also negatively affect other agronomic traits such as kernel *** alternative height-reducing loci could benefit wheat *** study focused on the genetics of plant height in 260 historical and contemporary winter wheat accessions via genome-wide association studies using 38,693 single nucleotide polymorphism(SNP)markers generated through genotyping by sequencing,two Kompetitive Allele Specific Polymorphismmarkers,and phenotypic data recorded in two seasons(2016 and 2018).The 260 accessions showed wide variation in plant *** accessions developed after 1960 were shorter than earlier *** broad-sense heritability for plant height was high(H2=0.82),whichwas also supported by a high correlation(r=0.82,P<0.0001)between heights from the two *** detected a total of 16 marker–trait associations(MTAs)for plant height at–lg(P)≥4.0 on chromosomes 1A,2B,2D,3B,4D,5A,5D,6A,6B,7A,and *** detected three of the MTAs(QPLH-2D,QPLH-4B.2,and QPLH-4D)consistently in individual-year and combined-year *** MTAs individually explained 10%–16%of phenotypic *** heightreducing alleles at these threeMTAs appeared after 1960 and increased in frequency *** the genes near these loci were gibberellic acid insensitive(GAI)and GRAS transcription factor(GIBBERELLIC-ACID INSENSITIVE(GAI),REPRESSOR of GAI(RGA),and SCARECROW(SCR)).The evidence from this study and previous reports suggests that QPLH-2D is Rht8.A gene encoding a GRAS transcription factor is located near *** of the QPLH-2D locus and associated candidate genes awaits further study.

关键词： GWAS Marker-trait associations Rht-B1 Rht-D1 Candidate genes Position-dependent procedures

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