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Open Journal of Obstetrics and Gynecology 2017年第2期7卷 235-244页

作者： Jean Marc Lamine Dia Eric Bohoussou Edouard Nguessan Mouhideen Oyelade privat guié Simplice Anongba Gynecology Obstetrics University Hospital of Treichville Abidjan C&ocirc te d’Ivoire

Objectives: This study aimed to clarify the etiology of women infertility and describe their management in our service with limited technical equipment. Methodology: We conducted a retrospective and descriptive study on 175 women treated for infertility and followed in the gynecology services of the university Hospital center of Treichville from 1st January 2012 to 31st December 2014. Results: During the study, we recorded 12072 consultations in gynecology including 1582 (13.1%) cases of infertility, but only 175 cases were selected for this study. The patients had an average age of 31.3 years and an average socio-economic level in general (78.9%). The etiologies were found in 79.4% of patients, dominated by classical abnormalities: uterine (fibroids: 41.8%), hormonal, tubo peritoneal (5%). We also found some unusual pathologies related to cultural practices (female genital mutilation, caustic stenosis of the vagina). The surgery was performed in several patients, including myomectomy by laparotomy (46.6%), laparoscopy, hysteroscopy and vaginal surgeries. As to drug treatment, they were various combinations, and the ovarian stimulation practices (62.3%) and induction of ovulation (47.2%) were common. The result of this support has been marked by the occurrence of 74 pregnancies (42.3%), with the birth of healthy children in the majority of cases (95.9%). Conclusion: The management of infertile women was frequent and yielded encouraging results despite our limited technical equipment.

关键词： Women Infertility Etiologies Treatment

Mother-to-Child HIV Transmission Factors in Exposed Children at University Hospital Center of Treichville (Abidjan, Cote d’Ivoire)

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Open Journal of Obstetrics and Gynecology 2017年第12期7卷 1198-1208页

作者： Edouard N’Guessan Jean Marc Lamine Dia Mouhideen Oyelade Ignace Yao privat guié Simplice Anongba Department of Obstetrics and Gynecology University Hospital of Treichville Abidjan Cote d’Ivoire

Background: The elimination of HIV transmission from mother to child is currently possible. Cote d’Ivoire, which has a 4.6% HIV prevalence among women, is one of 22 pilot countries for the elimination of mother-to-child transmission of HIV. Since 2015, Cote d’Ivoire has adopted new strategies according to the WHO B+ guidelines. Objective: To identify factors associated with mother-to-child HIV transmission in children born of seropositive mothers managed at Treichville university hospital. Material and methods: A case-control study was conducted in the obstetrics department at Treichville university hospital, between January 2013 and December 2015. It involved children born to mothers infected with HIV, whose first PCR (Polymerase Chain Reaction) result was available during this period. A standardized questionnaire on data related to exposed children and their mother was used. Factors associated with mother-to-child HIV transmission were investigated using logistic regression. Results: A total of 214 HIV-exposed children were included in the study with a sex ratio of 0.9. The majority of the children were born by vaginal route (52.8%) and received post-exposure prophylaxis (88.3%) and replacement feed (51.9%). Their mothers received antiretroviral therapy during pregnancy in 45.3% of the cases. The first PCR was performed at the sixth week of life in 52.3% of cases. The prevalence of HIV infection in exposed children was 7.5% (95% CI = 4.5% - 11.8%). In multivariate analysis, the absence of antiretroviral prophylaxis in children [aOR = 4.3, 95% (1.2 to 15.6), p = 0.03], the mixed feed [aOR = 3.8, 95% (1.1 - 13.1), p < 0.03], the failure to take antiretroviral regimen during pregnancy [aOR = 8.0, 95% CI (1.9 - 32.4), p < 0.003], were associated with mother-child HIV transmission. Conclusion: The mother-to-child HIV transmission rate remains high in our practice. Strategies to reduce situations that do not comply with current recommendations should be considered to pr

关键词： HIV-Exposed Children Mother-to-Child Transmission DBS/PCR

Occurrence Delays of Metastatic Relapses of Breast Cancers Treated at University Hospital of Treichville (Abidjan-Cote d’Ivoire)

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Journal of Cancer Therapy 2017年第11期8卷 924-932页

作者： Lydie Estelle Djanhan Jean Marc Dia Boston Mian Mouhideen Oyelade Aboulaye Diallo privat guié Simplice Anongba Department of Gynecology and Obstetrics University Hospital of Bouaké Bouake Cote d’Ivoire Department of Gynecology and Obstetrics University Hospital of Treichville Abidjan Cote d’Ivoire Department of Gynecology and Obstetrics University Hospital of Cocody Abidjan Cote d’Ivoire

Objective: Describe the occurrence delays of metastatic relapses of breast cancer based on the characteristics of the original tumor. Methodology: This is a retrospective and cohort study conducted from January 2000 to December 2015 on patients with metastatic relapse of breast cancer. Results: Out of 178 patients collected, the metastatic relapses were estimated at 49%, occurring in patients with an average age of 53.4 years. The majority of the patients was educated (91.6%) and did not have a high socioeconomic level (88.2%). The initial tumors were mainly at a clinical stage III (47.8%), SBR grade III (47.2%), high index Ki 67 (46.5%), negative RH (79.3%) and HER2 negative (58%). Metastases were unique in general (62.9%), dominated by bone locations (36.6%), with an average age of occurrence of 2.4 years. After the occurrence of these metastases, the cumulative survival rate was 5% at 3 years, and zero to 5 years. Conclusion: Metastatic relapses were common with poor prognosis.

关键词： Breast Cancer Risk Factors Metastatic Relapses

Epidemiological Aspects of Metastatic Relapse of Breast Cancer in an African Context

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Open Journal of Obstetrics and Gynecology 2017年第5期7卷 552-561页

作者： Jean Marc Dia Corneille Saki Oyeladé Mouhideen Eric Bohoussou Moctar Touré Gerard Okon privat guié Simplice Anongba Gynecology Department of the University and Hospital Center of Treichville (CHUT) Abidjan C&ocirc te d’Ivoire Cancerology Department of the University and Hospital Center of Treichville (CHUT) Abidjan C&ocirc te d’Ivoire

Objectives: This study aimed to describe the epidemiological characteristics of metastatic relapse in breast cancer at the University and Hospital Center of Treichville. Methodology: This is a cohort and retrospective study conducted from January 2000 to December 2015 on 178 patients with metastaticrelapse in breast cancer. Results: The prevalence of metastatic relapses was 49% and the patients had an average age of 53.4 years and among them, 91.6% received school education and 88.2% did not have a high socioeconomic level. The majority of initial tumors were in Stage III (47.8%), SBR III (47.2%), High Ki 67 (46.5%), Negative RH (79.3%), and HER2 negative (58%). Metastases were generally unique (62.9%), dominated by bone sites (36.6%), with an average occurrencedelay of 2.4 years. After the occurrence of metastases, the cumulative survival rate was 5% at 3 years, and nil at 5 years. Conclusion: Metastatic relapses were common with poor prognosis.

关键词： Breast Cancer Risk Factors Metastatic Relapses

Management of Giant Ano-Vulvar Condyloma in a Structure with Limited Resources

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Open Journal of Obstetrics and Gynecology 2017年第11期7卷 1124-1131页

作者： Mian Dehi Boston Dia Jean Marc Djanhan Lydie N’Guessan Koffi guié privat Abauleth Yao Raphael Kouakou Firmin Boni Serges Department of Gynecology and Obstetrics University and Hospital Center of Cocody (CHUC) Abidjan Cote d’Ivoire Department of Gynecology and Obstetrics University and Hospital Center of Treichville (CHUT) Abidjan Cote d’Ivoire Department of Gynecology and Obstetrics University and Hospital Center of Bouaké (CHUB) Bouaké Cote d’Ivoire

Buschke-Lowenstein Tumor (BLT) or Giant Acuminate Condyloma (GAC) is an uncommon clinical entity rarely published in Cote d’Ivoire and Africa. It is a viral infection with increasing sexual transmission due to the resurgence of HIV infection. This observation is the first case recorded in our service in three decades. The treatment is resolutely surgical, in our context of sub-medicalization, in the absence of other therapeutic means. Most of the time the progression is favorable, but the prognosis can be aggravated by the HIV coinfection. Through this observation, the authors insist on the prevention of all sexually transmitted infections, particularly, with HPV and HIV, by sexual education (abstinence, fidelity, port of condom) and the systematic vaccination before any sexual activity.

关键词： Giant Ano-Vulvar Condyloma HIV HPV

Management of Inflammatory Breast Cancers in Subsaharian Africa Context

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Open Journal of Obstetrics and Gynecology 2018年第1期8卷 20-30页

作者： Jean Marc Dia Lydie Estelle Djanhan C. Saki Mouhideen Oyéladé Gérard Okon Abdoulaye Camara Abdoulaye Diallo privat guié Simplice Anongba Department of Gynecology and Obstetrics University Hospital of Treichville Abidjan Cote d’Ivoire Department of Gynecology and Obstetrics University Hospital of Bouaké Bouake Cote d’Ivoire

Objective: To report the experience of Gynecology Department of the University Hospital of Treichville in the management of the inflammatory breast cancers. Methodology: We conducted a retrospective and descriptive study on cases of the inflammatory breast cancers managed in the Gynecology Department of the University Hospital of Treichville, from January 2011 to December 2015. Results: We collected 44 cases of inflammatory breast cancer representing 17.9% of all breast cancers. The average age of patients was 46.5 years (32 - 70 years) and among them, the majority had inadequate socioeconomic level (90.9%). The risk factor for cancer found in the majority of patients was the age of first menstrual periods before the age of 12 years (52.3%). The average consultation time was long (10 months) and several patients had extensive inflammatory signs (38.6%), with lymph node involvement (84.1%) and metastases (36.4%). At the histological analysis, the most common type was invasive ductal carcinoma (81.8%), SBR grade III (54.5%). Regarding treatment, mastectomy according to Patey associated with a chemotherapy was performed in 22.7% cases. The evolution has been marked by an overall 5-year survival of 20%. Conclusion: The management of inflammatory breast cancers was late and incomplete in our service making poor prognosis.

关键词： Inflammatory Brest Cancers Epidemiology Diagnosis Treatment

Ovarian Pregnancy: Diagnosis and Management of a Rare Case of Ectopic Pregnancy

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Open Journal of Obstetrics and Gynecology 2024年第11期14卷 1671-1678页

作者： Gerard Okon Roland Adjoby Stephane Kume Corneille Saki Fahimat Tijani Abdoulaye Diallo Mouhideen Oyelade Aude-Lima Djiro Isaac Kouamé Dominique N’Zi Youssouf Diabaté Eric Bohoussou privat guié Gynecology Department of the University and Hospital Center of Treichville (CHUT) Abidjan Cte dIvoire Gynecology Department of the University and Hospital Center of Angr (CHUA) Abidjan Cte dIvoire

Ectopic pregnancy (EP) is a common gynecological emergency, with ovarian pregnancy (OP) being a rare form, representing about 3% of EP cases. OP poses diagnostic and therapeutic challenges due to its often-asymptomatic progression and nonspecific clinical presentation. We report the case of a 32-year-old primiparous woman diagnosed with an ovarian pregnancy by ultrasound. The patient frequently used emergency contraceptives and presented with intermittent pelvic pain and secondary amenorrhea with positive urinary β-HCG tests. Ultrasound revealed a lateral uterine gestational sac attached to the left ovary, containing a living fetus of 15 weeks + 6 days, with moderate fluid accumulation. Upon admission, the patient was in shock with severe anemia and hemoperitoneum, necessitating emergency laparotomy. The laparotomy revealed a hemoperitoneum of 1400 mL and a hyper vascularized mass involving the left ovary, requiring left adnexectomy. The mass contained a deceased male fetus of 16 weeks. This case highlights the need for heightened vigilance and precise diagnostic and therapeutic approaches for rare forms of EP to prevent severe complications.

关键词： Ovarian Pregnancy Ultrasound Diagnosis Surgical Complications

A NEW EXPLANATION OF DEWET TING PHENOMENA

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Chinese Science Bulletin 1990年第15期35卷 1261-1265页

作者： E.TRoNEL·PEYROZ J.M.DOUILLARD R.BENNES M.privat GU Ti-ren Physico-Chimie des Systemes Polyphases U.R.A 330.C.N.R.S.Route de MendeBP 505134033 Montpellier CédexFrance Department of Chemistry and Institute of Physical Chemistry Peking UniversityBeijing 100871PRC

In our studies concerning the structure of liquid-vapour interfaces with aqueous mixtures of alcohols,we have shown the importance of local composition fluctuations for superficial mixture *** have observed a correlation between the contact angle of the three-phase system liquid-vapour-solid,the variation of the surface tension,and the surface structure factor,whihc is elrated to the local comPosition fluctuations in the transition layer.

关键词： dewetting local composition fluctuation surface tension fluctuation.

Determinants of mechanical restraint in an acute psychiatric care unit

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World Journal of Psychiatry 2021年第10期11卷 854-863页

作者： Khadija El-Abidi Antonio R Moreno-Poyato Alba Toll privat David Corcoles Martinez Rosa Acena-Dominguez Victor Perez-Sola Anna Mane Department of Psychiatry Institut de Neuropsiquiatria i AddiccionsParc de Salut MarBarcelona 08003Spain Public Health Mental and Maternal and Child HealthSchool of NursingFaculty of Medicine and Health SciencesUniversity of BarcelonaBarcelona 08907Spain Biomedical Research Institut Hospital del Mar d'Investigacions MediquesBarcelona 08003Spain Biomedical Research Center for Biomedical Research in Mental Health NetworkBarcelona 08003Spain Department of Psychiatry Institut de Neuropsiquiatria i AddiccionsCentre FòrumBarcelona 08019Spain

BACKGROUND Despite numerous attempts to reduce the use of mechanical restraint(MR),this technique continues to be widely applied in many acute psychiatric care *** order to reduce MR,a better understanding of the variables associated with its use and duration in different clinical environments is *** To determine the proportion of patients subjected to MR and the duration thereof in two acute care psychiatric units;and to identify the variables associated with the use and duration of *** Descriptive study of all patients admitted to the acute psychiatric units at the Parc de Salut Mar(Barcelona,Spain)in the year *** number and percentage of patients subjected to MR,as well as the duration of each episode were *** following data were also registered:sociodemographic characteristics,psychiatric diagnosis,and presence of cultural and/or language *** analyses were performed to assess determinants of MR and its *** Of the 464 patients,119(25.6%)required MR,with a median of 16.4 h per *** factors-a diagnosis of psychotic disorder[Odds ratios(OR)=0.22;95%CI:0.06-0.62;P=0.005]and the presence of a language barrier(OR=2.13;95%CI:1.2-3.7;P=0.007)-were associated with a significantly higher risk of *** sex was associated with a longer duration of MR(B=-19.03;95%CI:-38.06-0.008;P=0.05).CONCLUSION The presence of a language barrier and a psychotic disorder diagnosis are associated with a significantly higher risk of ***,male sex is associated with a longer duration of *** restraint protocols that include the required tools are necessary to ultimately limit the use of mechanical restraint.

关键词： Mechanical restraint Prolonged restraint Determining factors Psychiatric acute unit

Phytochemical analyses, antimicrobial and antioxidant activities of stem bark extracts of Distemonanthus benthamianus H. Baill. and fruit extracts of Solanum torvum Sw. from Gabon

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Asian Pacific Journal of Tropical Biomedicine 2019年第5期9卷 209-216页

作者： Cédric Sima Obiang Rick Léonid Ngoua Meye Misso Guy Roger Ndong Atome Joseph privat Ondo Louis Clément Obame Engonga Edouard Nsi Emvo Laboratory of Research in Biochemistry University of Sciences and Technology of Masuku Laboratory of Natural Substances and Organometallic Synthesis University of Sciences and Technology of Masuku

Objective: To evaluate the phytochemical constituents, antimicrobial and antioxidant activities of the extracts of Distemonanthus benthamianus(D. benthamianus) stem bark and Solanum torvum(S. torvum) fruit which have been used as traditional medicinal herbs in Gabon. Methods: Plant extracts were subjected to a qualitative study(phytochemical screening) and a quantitative(dosing) study of secondary metabolites. Antioxidant activity was tested by 1,1-diphenyl-2-picrylhydrazyl and 2,2'-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid assay. Bacteria and fungi susceptibility tests were performed on Mueller Hinton medium and solid Sabouraud, respectively, using the diffusion method, while minimum inhibitory concentration, minimum fungicidal concentration and minimum bactericidal concentration were evaluated by microdilution ***: The total phenol and tannin contents were significantly higher in the water-ethanol extract compared to the other extracts of D. benthamianus and S. torvum. The water-ethanol and water-acetone extracts showed significantly higher antioxidant activity than the aqueous extracts of the two medicinal plants. However, the extracts presented weak antioxidant activities compared to standards(Vitamin C, BHA). The water-acetone and water-ethanol extracts of S. torvum showed the highest antimicrobial activity against Bacillus cereus LMG 13569 BHI, Shigella dysenteriae 5451 CIP, Shigella dysenteriae and Neisseria gonorrhoeae. Conclusions: Our results show that D. benthamianus and S. torvum can be promising sources of natural products with potential antimicrobial and antioxidant activities.

关键词： Antioxidants Phytochemical Antimicrobial Distemonanthus benthamianus Solanum torvum