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Telbivudine vs tenofovir in hepatitis B e antigen-negative chronic hepatitis B patients: OPTIMA roadmap study

World Journal of Hepatology 2016年第32期8卷 1402-1413页

作者： Zahari Krastev Diana Petrova Iskren Kotzev Mustafa Kemal Celen Meryl Mendelson Richa Chandra priti pandey Kamal Hamed Clinic of Gastroenterology St.Ivan Rilsky University HospitalMedical University Department of Gastroenterology University Hospital Alexandrovska Clinic of Hepatogastroenterology University Hospital St Marina Infectious Disease Clinic Dicle University Novartis Pharmaceuticals Corporation East Hanover Novartis Healthcare Pvt. Ltd.

AIM To make efficacy and safety comparison of telbivudineraodmap and tenofovir-roadmap in hepatitis B e antigen(HBe Ag)-negative chronic hepatitis B(CHB) *** This was the first prospective, randomised, two-arm, open-label, non-inferiority study in HBe Ag-negative CHB patients that compared telbivudine and tenofovir administered as per roadmap concept. Patients were treated up to 24 wk and, depending on virologic response, continued the same therapy or received addon therapy up to 104 wk. Eligible patients received an additional 52 wk of treatment in the extension period(i.e., up to 156 wk). Patients who developed virologic breakthrough(VB) while on monotherapy also received add-on therapy. The primary efficacy endpoint was the rate of patients achieving hepatitis B virus(HBV) DNA < 300 copies/m L at week 52. Secondary efficacy endpoints included the rates of HBV DNA < 300 and < 169 copies/m L, HBV DNA change from baseline, alanine aminotransferase normalisation, hepatitis B surface antigen(HBs Ag) loss, HBs Ag seroconversion, VB, and emergence of resistance at various timepoints throughout the study. Safety and estimated glomerular filtration rate(e GFR) were also *** A total of 241 patients were randomised. Non-inferiority of telbivudine arm to tenofovir arm was demonstrated at week 52(± 7 d window), with over 91% of patients in each treatment arm achieving HBV DNA level < 300 copies/m L. Both arms were similar in terms of key secondary efficacy variables at weeks 104 and 156. The percentage of patients achieving HBV DNA < 300 copies/m L remained high and was similar in the telbivudine and tenofovir arms at both weeks 104 and 156. Over 82% of patients in both arms achieved alanine aminotransferase normalisation at week 52, and this percentage remained high at weeks 104 and 156. Telbivudine treatment progressively reduced serum HBs Ag levels from baseline while no change was reported in quantitative HBs Ag during therapy with tenofovir. Bot

关键词：长期的肝炎 B Glomerular 过滤率 Telbivudine Tenofovir 路线图概念

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Biomedical Perspective of Electrochemical Nanobiosensor

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Nano-Micro Letters 2016年第3期8卷 193-203页

作者： priti Singh Shailendra Kumar pandey Jyoti Singh Sameer Srivastava Sadhana Sachan Sunil Kumar Singh Department of Biotechnology Motilal Nehru National Institute of Technology Department of Chemical Engineering Motilal Nehru National Institute of Technology

Electrochemical biosensor holds great promise in the biomedical area due to its enhanced specificity, sensitivity, label-free nature and cost effectiveness for rapid point-of-care detection of diseases at bedside. In this review, we are focusing on the working principle of electrochemical biosensor and how it can be employed in detecting biomarkers of fatal diseases like cancer, AIDS, hepatitis and cardiovascular diseases. Recent advances in the development of implantable biosensors and exploration of nanomaterials in fabrication of electrodes with increasing the sensitivity of biosensor for quick and easy detection of biomolecules have been elucidated in detail. Electrochemical-based detection of heavy metal ions which cause harmful effect on human health has been discussed. Key challenges associated with the electrochemical sensor and its future perspectives are also addressed.

关键词： Biomarkers Point-of-care detection Nanomaterials Electroactive species Potentiometric Amperometric Implantable

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Saponin synthesis and cotton growth is antagonistically regulated by solar UV-B radiation

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Journal of Cotton Research 2018年第3期1卷 30-40页

作者： DEHARIYA priti KATARIA Sunita GURUPRASAD Kadur Narayan pandey Govind Prakash School of Life Sciences Devi Ahilya University School of Biochemistry Devi Ahilya University Shri Vaishnav Vidyapeeth Vishwavidyalaya

Background: Earlier we have reported that the exclusion of solar UV-B increased the growth and yield of cotton plants as compared with ambient UV-B. The UV-B radiation effects on the saponins and the impact of ambient and reduced UV-B on the accumulation of saponins has not been investigated yet. Thus a field experiment was conducted to study the influence of solar UV-B on the growth response and saponin synthesis in cotton(Gossypium hirsutum) var. Vikram plants by the exclusion of UV-B. The cotton plants were grown in specially designed iron chambers, wrapped with filters that excluded UV-B(<315 nm), or transmitted ambient ***: Exclusion of ambient UV-B enhanced the growth of cotton plants in terms of plant height and leaf *** plant height in UV-B excluded plants was due to elongated internode and more number of *** in growth was accompanied by a decrease in the accumulation of saponins, which was quantified by the spectrophotometric, TLC and HPLC methods. Solvent extraction of saponins from the internodes and leaves were used for the bioassay of Amaranthus hypocotyl growth and expansion of cucumber cotyledons. Extracts obtained from the UV-B excluded plants(leaves and internodes) promoted the growth to a larger extent as compared with the extracts obtained from ambient grown ***: The result indicates that solar UV-B may possibly suppress the plant growth by regulating the synthesis of natural growth inhibitor’s like saponin.

关键词： Bioassay Cotton Growth Inhibitor Saponin UV radiation

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