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Antifertility effect of chronically administered Tabernaemontana divaricata leaf extract on male rats

Asian Pacific Journal of Tropical Medicine 2012年第7期5卷 547-551页

作者： Sachin Jain Ankit Jain pritesh paliwal Shailendra Singh Solanki Department of Pharmacognosy College of PharmacyIPS AcademyRajendra NagarIndore(MP) India 452012

Objective:To investigate the antifertility effect of chronically administered Tabernaemontana divarkala(***) leaf extract on male ***:The effect of 50%ethanol extract of *** leaves on reproduction was studied on male *** study was divided into four groups of five animals *** first groups(1) received vehicle alone to serve as control. The second,third and fourth groups(Ⅱ,ⅡandⅣ) of animals were administered the leaf extract daily at 50 mg/kg body weight,p.o.,100 nig/kg body weight,p.o.,and 200 mg/kg body weight, p.o.,respectively,for a period of 60 ***:Significant decreases in the weight of testes, epididymis,seminal vesicle and ventral prostate were observed.A dose related reduction in the testicular sperm count,epididymal sperm count and motility,number of fertile male,ratio between delivered and inseminated females and numbers of pups were *** testis showed a clear correlation between the dose and severity of lesions of seminiferous epithelium. In general,the seminiferous tubules appear reduced in size with a frequently filled eosinophilic *** arrested at the secondary spermatocyte *** spermatocytes were undergoing *** and sloughing of immature germ cell were visible. Leydinf cells were *** morphological changes were observed in Sertoli *** reduction in serum concentration of luteinizing hormone and testosterone were *** distinct change in serum FSH concentration was *** final body weights of all groups were elevated *** alterations were recorded in any hematologiocal parameters. Conclusions:It is concluded that the 50%ethanol extract of *** leaf produced dose related effect on male reproduction without altering general bodv metabolism.

关键词： Tabernaemontana divaricata Anti-fertility Male rats 50%ethanol extract Reproduction Hormone levels

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