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New-onset diabetes in COVID-19 and clinical outcomes: A systematic review and meta-analysis

World Journal of Virology 2021年第5期10卷 275-287页

作者： Dhan Bahadur Shrestha Pravash Budhathoki Sumit Raut Sugat Adhikari prinska ghimire Sabin Thapaliya Ali A Rabaan Bibodh Jung Karki Department of Internal Medicine Mount Sinai HospitalChicagoIL 60608United States Department of Internal Medicine BronxCare Health SystemBronxNY 10457United States Department of Emergency Medicine Kathmandu Medical CollegeKathmandu 44600Nepal Department of Internal Medicine Nishtar Medical UniversityMultan 59330Pakistan Department of Internal Medicine Tribhuvan UniversityKathmandu 44600Nepal Department of Internal Medicine Tribhuvan University Teaching HospitalKathmandu 44600Nepal Molecular Diagnostic Laboratory Johns Hopkins Aramco HealthcareDhahran 34465Saudi Arabia Department of Public Health&Nutrition The University of HaripurHaripur 22620Pakistan Division of Infectious Diseases University of LouisvilleLouisvilleKY 40292United States

BACKGROUND Diabetes mellitus(DM)is associated with adverse clinical outcomes and high mortality in patients with coronavirus disease 2019(COVID-19).The relationship between diabetes and COVID-19 is known to be *** To analyze the rate of new-onset diabetes in COVID-19 patients and compare the clinical outcomes of new-onset diabetes,pre-existing diabetes,hyperglycemic,and non-diabetes among COVID-19 *** We used the Meta-analysis of Observational Studies in Epidemiology statement for the present *** databases were searched for all peerreviewed articles published until November 6,*** were screened using Covidence and data *** analysis was done using comprehensive *** the 128 studies detected after thorough database searching,seven were included in the quantitative *** proportion was reported with 95%confidence interval(CI)and heterogeneity was assessed using *** Analysis showed that 19.70%(CI:10.93-32.91)of COVID-19 patients had associated DM,and 25.23%(CI:19.07-32.58)had associated *** overall mortality rate was 15.36%(CI:12.57-18.68)of all COVID-19 cases,irrespective of their DM *** mortality rate was 9.26%among non-diabetic patients,10.59%among patients with COVID-19 associated hyperglycemia,16.03%among known DM patients,and 24.96%among COVID-19 associated DM *** overall occurrence of adverse events was 20.52%(CI:14.21-28.70)among COVID-19 patients in the included studies,15.29%among non-diabetic patients,20.41%among patients with COVID-19 associated hyperglycemia,20.69%among known DM patients,and 45.85%among new-onset *** showed an increasing rate of mortality among new hyperglycemic patients,known diabetics,and new-onset DM patients in comparison to those without *** A significantly higher rate of new onset DM and hyperglycemia was *** mortality rates and adverse events were seen in patients with

关键词： Acute respiratory distress syndrome COVID-19 Diabetes mellitus Hyperglycemia Mortality

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