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Avian introgression in the genomic era

第十四届全国催化学术会议

作者： Yinyong Sun Roel prins Institute for Chemical and Bioengineering ETH Zurich Switzerland

＜正＞Many countries are introducing more severe legislation for the maximum allow.d level of sulfur in gasoline and ***,many scientists are trying to find better hydrodesulfurization（HDS）catalysts than the classic sulfided Co-Mo and Ni-Mo *** have synthesized mesoporous ZSM-5 and Beta and have loaded them w.th Pt,Pd and Pt-Pd and studied their HDS *** reason for synthesizing such catalysts is that the activity of metals is increased and their sulfur sensitivity decreased,w.en supporting

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Avian Research 2017年第4期8卷 181-191页

作者： Jente Ottenburghs Robert H.S.Kraus Pim van Hooft Sipke E.van w.eren Ronald C.Ydenberg Herbert H.T.prins Resource Ecology Group Wageningen UniversityDroevendaalsesteeg 3a6708 PB WageningenThe Netherlands Department of Biology University of Konstanz78457 ConstanceGermany Department of Migration and Immuno-Ecology Max Planck Institute for OrnithologyAm Obstberg 178315 RadolfzellGermany Centre of w.ldlife Ecology Simon Fraser UniversityBurnabyBC V5A 1S6Canada

Introgression,the incorporation of genetic material from one(sub)species into the gene pool of another by means of hybridization and backcrossing,is a common phenomenon in birds and can provide important insights into the speciation *** the last decade,the toolkit for studying introgression has expanded together w.th the development of molecular *** this review.w. explore how.genomic data,the most recent step in this methodological progress,impacts different aspects in the study of avian ***,the detection of hybrids and backcrosses has improved *** most w.dely used softw.re package is *** discordance(*** loci resulting in discordant gene trees) is another means for the detection of introgression,although it should be regarded as a starting point for further analyses,not as a definitive proof of ***,disentangling introgression from other biological processes,such as incomplete lineage sorting,remains a challenging endeavour,although new.techniques,such as the D-statistic,are being *** addition,phylogenetics might require a shift from trees to ***,the study of hybrid zones by means of geographical or genomic cline analysis has led to important insights into the complex interplay betw.en hybridization and ***,because each hybrid zone study is just a single snapshot of a complex and continuously changing interaction,hybrid zones should be studied across different temporal and/or spatial scales.A third pow.rful tool is the genome *** debate on w.ich evolutionary processes underlie the genomic landscape is still ongoing,as is the question w.ether loci involved in reproductive isolation cluster together in ‘islands of speciation' or w.ether they are scattered throughout the *** genomic landscapes across the avian tree of life w.ll be an exciting field for further ***,the findings from these different methods shoul

关键词： Admixture Cline theory D-statictic Genomic landscape Hybridization Phylogenetic discordance

Absence of galectin-3 attenuates neuroinflammation improving functional recovery after spinal cord injury

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Neural Regeneration Research 2016年第1期11卷 92-93页

作者： Caio Andrade prins Fernanda Martins Almeida Ana Maria Blanco Martinez Laboratorio de Neurodegeneracao e Reparo-Departamento de Patologia-Faculdade de Medicina-HUCFF-UFRJ-Rio de Janeiro-RJ Brazil Instituto de Ciencia Biomedicas UFRJRio de JaneiroRJBrazil

After spinal cord injury （SCI）, a cascade of events begins. At first, there is physical damage w.th disruption of the blood-brain barrier （BBB） and the integrity of the nervous tissue. The disruption of central ner- vous system （CNS） BBB alters the endothelial permeability, the protein and chemokines expression and the propensity to release in situ inflam- matory cytokines, overcoming anti-inflammatory signals, facilitating the attraction and entry of immune system cells into the injured spinal cord parenchyma （Gaudet et al., 2011）. As a result, there is a neuroin- flammatory response w.th changes in blood flow. edema, cell infiltra- tion, apoptosis and release of axonal grow.h inhibitory factors. Nerve function loss occurs w.en the nerve impulse propagation is interrupted and do not reach its target. This disorder encompasses neuron and glia apoptosis, accompanied by w.llerian degeneration of disconnected axons, and CNS cells exposure to a hostile microenvironment that hampers axon regeneration （Mautes et al., 2000; Harkey et al., 2003）.

关键词： galectin disruption permeability facilitating attraction cascade macrophages cytokines morphologic exposure

Large Scale Infrastructure Projects: The Art of Project or Change Management?

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Frontiers of Engineering Management 2016年第3期3卷 197-202,296页

作者： Geert Letens Kurt Verw.ire Peter De prins Department of Economics Management & Leadership Royal Military Academy Vlerick Business School Ghent Vlerick Business School Leuven

Although it is generally understood that change is a fundamental component of managing projects in the construction industry in general and an inevitable challenge for large scale infrastructure project in particular, there has been little to no attention in the literature to understand change in this context from a more holistic perspective. For this purpose, this w.rk looks at change through the eyes of a framew.rk of six batteries of change that seem essential to charge an organization's capabilities for change. The framew.rk brings together the expertise of four specialists that all have developed their insights over many years of study and practice, and has been validated through an extensive review.of the management literature on organization development and change. Reflections on the application of this model in the construction industry and in large scale infrastructure projects demonstrate that energizing organizations to successfully deal w.th change goes beyond the traditional techniques of managing change from a program or project management perspective. Assessing the six batteries of change in this context can help organizations to develop capabilities for change that build change energy by balancing formal/rational methods w.th informal/emotional interventions at both a local(department/subproject) and global(business) level.

关键词： large scale project management organization development and change batteries of change model

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东海内陆架泥质沉积反映的古环境演化

海洋地质与第四纪地质 2008年第4期28卷 1-10页

作者：王可郑洪波 Maarten prins 郑妍同济大学海洋地质国家重点实验室上海200092 Faculty of Earth and Life Sciences VU University Amsterdamthe Netherlands

通过对东海内陆架闽浙沿岸泥质沉积体的MD06-3040孔进行粒度及年代测试,重建了东海内陆架1万年以来的古环境。认为研究区的沉积环境曾发生过3次变化:孔深18·6m至底部(10～10.7kaBP)对应近滨环境;15·13～18.6m(7.1～10kaBP)为过渡带环... 详细信息

通过对东海内陆架闽浙沿岸泥质沉积体的MD06-3040孔进行粒度及年代测试,重建了东海内陆架1万年以来的古环境。认为研究区的沉积环境曾发生过3次变化:孔深18·6m至底部(10～10.7kaBP)对应近滨环境;15·13～18.6m(7.1～10kaBP)为过渡带环境;0～15.13m(0～7.1kaBP)是海侵结束后高海平面的浅海环境,自10kaBP以来东海沿岸流开始影响本区并不断输送河流来源物质,7kaBP起形成稳定的泥质沉积体。根据该孔沉积物的沉积速率与粒度组分特征,说明不能简单地应用平均粒径指示冬季风强度,在东海地区,不仅冬季风控制着沿岸流强度,夏季风也会影响河流入海物质的搬运沉积作用。

关键词：全新世古环境粒度东海

Patient Characteristics Associated w.th Non-Adherence to Tuberculosis Treatment: A Systematic Review

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Journal of Tuberculosis Research 2020年第2期8卷 73-92页

作者： A. O. A. Ali Martin H. prins Ministry of Health Saudi Arabia Maastricht University Medical Centre Maastricht The Netherlands

Background: A high level of adherence to treatment is essential for cure and prevention of tuberculosis (TB) treatment resistance. Methods: A Systematic review.of 53 studies addressing the patient characteristics associated w.th TB medication non-adherence w.s performed. The publications w.re identified by searching the PubMed, w.rld Health Organization (w.O), and Centers for Disease Control and Prevention (CDC) database, EmBase, Scopus database Arts, Humanities, Social Science database and Google scholar. Only English language publications w.re eligible. Potentially eligible studies w.re retrieved and the full articles w.re assessed. The potentially eligible studies w.re included if they concerned patients treated for tuberculosis, reported non adherence and reported on potential risk factors associated w.th non-adherence. Results: Factors that w.re most frequently consistently and statistically significantly related to non-adherence to tuberculosis treatment w.re: family income, patient movement and changing address or giving w.ong address, tuberculosis relapse or multidrug-resistant TB (MDRTB), during intensive phase of treatment, history of default, treatment regimen (long course), response to treatment, homeless, stigma, seeking traditional healers, staff receptiveness, lack of directly observed therapy short course (DOTS), poor know.edge or lack of health education, side effects of drugs, feeling better, alcohol intake and lack of family and social support. Conclusions: Non-adherence to tuberculosis treatment w.s influenced by several factors.

关键词： Tuberculosis Non-Adherence Adherence Defaulter Compliance

Molecular approaches for spinal cord injury treatment

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Neural Regeneration Research 2023年第1期18卷 23-30页

作者： Fernanda Martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio Andrade prins Fellipe Soares dos Santos Cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez Laboratório de Neurodegeneração e Reparo Programa de Pós-Graduação em Medicina:Anatomia PatológicaDepartamento de PatologiaFaculdade de MedicinaHospital Universitário Clementino Fraga FilhoCentro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Ciências Biomédicas Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biologia Departamento de NeurobiologiaLaboratório de Regeneração Neural e FunçãoUFFRio de JaneiroBrazil Laboratório Integrado de Morfologia Instituto de Biodiversidade e Sustentabilidade NUPEMPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisCentro Multidisciplinar UFRJ-MacaéUniversidade Federal do Rio de JaneiroMacaéBrazil

Injuries to the spinal cord result in permanent disabilities that limit daily life *** main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic *** decades of research,there is still no efficient treatment for spinal cord *** strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord *** these,molecular compounds are currently being used for neurological recovery,w.th promising *** molecules target the axon collapsed grow.h cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost *** this review.w. focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,grow.h and neurotrophic factors,enzymes,and *** mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans.

关键词： axonal regeneration drugs enzymes grow.h factors molecular therapy neurotrophic factors purines spinal cord injury

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草地施用氮肥的限度

草原与草坪 1986年第6期 51-52页

作者： w.H.prins 宗良纲

引言荷兰在1970年前后,由于乳牛饲养量的急剧增加,给沙土和粘土草地追施的氮肥量时常超过推荐用量(350～400公斤/公顷·年),这对草地的季节性变化,草地质量和产量,牧草中硝酸盐含量和土壤无机氮将产生什么影响呢?

关键词：氮素草地施氮量