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Scientific Validation of the Ethnomedicinal Properties of the Ayurvedic Drug Triphala:A Review

Chinese Journal of Integrative Medicine 2012年第12期18卷 946-954页

作者： Manjeshwar Shrinath Baliga Sharake Meera Benson Mathai Manoj Ponadka Rai Vikas Pawar princy louis palatty Department of Research and Development Father Muller Medical CollegeKankanadyMangaloreKarnataka(575002)India Sanjeevini Ayurvedic Chikitsalaya MallikatteMangaloreKarnataka(575003)India Department of Pharmacology St.John's Pharmacy CollegeVijayanagar Ⅱ StageBangaloreKarnataka(560040)India Unilever R&D No.64Main RoadWhitefieldBangaloreKarnataka(560066)India Department of Pharmacology Father Muller Medical CollegeKankanadyMangaloreKarnataka(575002)India

Triphala, a herbal formula composed of the three fruits of Terminalia chebula Retz. （Haritaki, Family： Combretaceae）, Terminalia bellirica Roxb. （Bibhitaki, Family： Combretaceae） and Phyllanthus emblica Linn. or Emblica officinalis Gaertn. （Amalaki or the Indian gooseberry, Family： Euphorbiaceae） is considered to be a universal panacea in the traditional Indian system of medicine the Ayurveda. It has been described in the Ayurveda text as a ＂Ftasayana＂ and to rejuvenat the debilitated organs. Ayurvedic physicians use Triphala for many ailments but most importantly to treat various gastrointestinal disorders. Scientific studies carried out in the past two decades have validated many of the ethnomedicinal claims and researches have shown Triphala to possess free radical scavenging, antioxidant, antiinflammatory, antipyretic, analgesic, antibacterial, antimutagenic, wound healing, anticariogenic, antistress, adaptogenic, hypoglycaemic, anticancer, chemoprotective, radioprotective and chemopreventive effects. Clinical studies have also shown that Triphala was found to have good laxative property, to improve appetite and reduce gastric hyperacidity. Studies have also shown that Triphala was effective in preventing dental caries and that this effect was equal to that of chlorhexidine. The current review addresses the validated pharmacological properties of Triphala and also emphasizes on aspects that need further investigation for its future clinic application.

关键词： Ayurveda Rasayana Triphala Terminalia chebula Terminalia bellerica and Phyllanthus emblicaand Emblica officina/is

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Remediation of Hepatotoxic Effect of Tamoxifen with Ginger in Rat Model

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Journal of Pharmacy and Pharmacology 2022年第3期10卷 79-86页

作者： Vanditha.S princy louis palatty Malini Eapen Thennavan.A Manjeshwar.S.Baliga Greeshma.C.Ravindran Department of Pharmacology Amrita School of MedicineAmrita Vishwa VidyapeethamKochiIndia Department of Pathology Amrita School of MedicineAmrita Vishwa VidyapeethamKochiIndia Veterinary Medicine Department Amrita School of MedicineAmrita Vishwa VidyapeethamKochiIndia Mangalore Institute Of Oncology MangaloreIndia Department of Biostatistics Amrita School of MedicineAmrita Vishwa VidyapeethamKochiIndia

Background:Tamoxifen is a non-steroidal oestrogen receptor *** has strong anti-estrogenic activity on oestrogen receptor 2 in the breast *** is the treatment of choice in breast cancer cases following surgery and radiotherapy,it is the most potent weapon against breast *** stages of hormone-dependent breast cancer are currently treated with ***-term tamoxifen therapy may cause hepatotoxicity which would perclude the use of *** this study was done to determine whether ginger has a role in protecting liver toxicity caused by ***:Twenty female albino rats(SD)were divided into 4 *** group formed of five rats:Group I:Serves as control group received normal rodent diet and water,GroupⅡ:Received ginger powder(200 mg/kg)dissolved in normal saline,orally daily for 6 weeks,GroupⅢ:received TAM at a dose of 20 mg/kg daily for 6 weeks orally GroupⅣ:Received TAM(20 mg/kg)then after 2 hrs they are orally given Ginger powder(200 mg/kg)daily for 6 ***:Tamoxifen 20 mg/kg/day caused hepatotoxicity in *** ginger is added to tamoxifen there is no development of hepatotoxic features like:marked sinusoidal congestion in the lobules and lab parameters showed decrease in serum AST and ALT levels when compared to tamoxifen group ***:Ginger supplementation would reduce the incidence of hepatotoxicity&related adverse drug reactions among breast cancer patient on therapy.

关键词： Breast cancer tamoxifen ginger raised liver enzyme levels hepatotoxicity hepatic sinusoidal congestion

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