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全身性感染时的组织氧合第2部分:动物和人体研究的评价(二)

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中国危重病急救医学 1999年第6期11卷 329-331页

作者： Gavin Joynt charles D Gomersall Department of Anaesthesia and Intensive Care Chinese University of Hong Kong Prince of Wales Hospital Sha Tin Hong Kong

２组织氧合的局部测定我们已经发现，在全身水平上未能显示组织氧供缺乏。我们现在需要对单一器官和组织进行观察，因为全身性测定仅仅是全身氧合情况的简单平均，此时一些重要组织可能严重缺氧，而其他组织则存在氧供剩余。在局部水平... 详细信息

２组织氧合的局部测定我们已经发现，在全身水平上未能显示组织氧供缺乏。我们现在需要对单一器官和组织进行观察，因为全身性测定仅仅是全身氧合情况的简单平均，此时一些重要组织可能严重缺氧，而其他组织则存在氧供剩余。在局部水平，由于组成器官的细胞死亡或功能不全...

关键词：全身性感染组织氧合动物实验人体研究

全身性感染时的组织氧合(第1部分:评价方法)

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中国危重病急救医学 1999年第4期11卷 199-202页

作者： Gavin Joynt charles D Gomersall Department of Anaesthesia and Intensive Care Chinese University of Hong Kong prince of Wales Hospital Sha TinHong Kong

在加强医疗（Ｉｎｔｅｎｓｉｖｅｃａｒｅ）中的常规监测技术反映了全身性感染患者血流动力学的总体情况。但是，它们并不反映组织水平上的氧供、氧需和氧耗的平衡〔１〕。现有的很多技术能够直接测定组织氧合状况，但都不适宜临床常规... 详细信息

在加强医疗（Ｉｎｔｅｎｓｉｖｅｃａｒｅ）中的常规监测技术反映了全身性感染患者血流动力学的总体情况。但是，它们并不反映组织水平上的氧供、氧需和氧耗的平衡〔１〕。现有的很多技术能够直接测定组织氧合状况，但都不适宜临床常规应用〔２〕。因此，全身性氧输送和氧...

关键词：全身性感染组织氧合氧合测定

Movable typing of full-lumen personalized Vein-Chips to model cerebral venous sinus thrombosis

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Aggregate 2023年第6期4卷 153-162页

作者： Yunduo charles Zhao Yingqi Zhang Arian Nasser Tianbo Hong Zihao Wang Allan Sun Laura Moldovan Leon S Edwards Freda Passam Ken S Butcher Timothy Ang Lining Arnold Ju School of Biomedical Engineering University of SydneyDarlingtonNew South WalesAustralia charles Perkins Centre University of SydneyCamperdownNew South WalesAustralia The University of Sydney Nano Institute(Sydney Nano) University of SydneyCamperdownNew South WalesAustralia Heart Research Institute CamperdownNew South WalesAustralia Department of Neurosciences Gosford HospitalNorth GosfordNew South WalesAustralia Sydney Brain Centre Ingham Institute for Applied Medical ResearchLiverpoolNew South WalesAustralia South Western Sydney Clinical School University of New South WalesLiverpoolNew South WalesAustralia Department of Haematology Royal Prince Alfred HospitalCamperdownNew South WalesAustralia Central Clinical School Faculty of Medicine and HealthUniversity of SydneyCamperdownNew South WalesAustralia prince of Wales Clinical School Prince of Wales HospitalRandwickNew South WalesAustralia Departments of Interventional Neuroradiology Neurology Royal Prince Alfred HospitalCamperdownNew South WalesAustralia

Cerebral venous sinus thrombosis(CVST)is a type of stroke associated with COVID-19 vaccine-induced immune thrombotic *** precise etiology of CVST often remains elusive due to the highly heterogeneous nature of its governing mechanisms,specifically,Virchow’s triad that involves altered blood flow,endothelial dysfunction,and hypercoagulability,which varies substantially amongst *** diagnostic and monitoring approaches lack the capability to reflect the combination of these patient-specific thrombotic *** response to this challenge,we introduce a Vein-Chip platform that recapitulates the CVST vascular anatomy from magnetic resonance venography and the associated hemodynamic flow profile using the“Chinese Movable Type-like”soft stereolithography *** resultant full-lumen personalized Vein-Chips,functionalized with endothelial cells,enable in-vitro thrombosis assays that can elucidate distinct thrombogenic scenarios between normal vascular conditions and those of endothelial *** former displayed minimal platelet aggregation and negligible fibrin deposition,while the latter presented significant fibrin extrusion from platelet *** low-cost movable typing technique further enhances the potential for commercialization and broader utilization of personalized Vein-Chips in surgical labs and at-home *** research and development in this direction will pave the way for improved management and prevention of CVST,ultimately benefiting both patients and healthcare systems.

关键词： 3D printing cerebral venous sinus thrombosis mechanobiology Organ on chip platelet Virchow’s triad

Current and future molecular diagnostics in colorectal cancer and colorectal adenoma

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World Journal of Gastroenterology 2014年第14期20卷 3847-3857页

作者： Andy Hin-Fung Tsang Ka-Ho Cheng Apple Siu-Ping Wong Simon Siu-Man Ng Brigette Buig-Yue Ma charles Ming-Lok Chan Nancy Bo-Yin Tsui Lawrence Wing-Chi Chan Benjamin Yat-Ming Yung Sze-Chuen Cesar Wong Department of Health Technology and Informatics Faculty of Health and Social SciencesHong Kong Polytechnic University Department of Surgery Prince of Wales Hospital State Key Laboratory in Oncology in South China Sir Y K Pao Centre for CancerDepartment of Clinical OncologyHong Kong Cancer Institute and Prince of Wales HospitalThe Chinese University of Hong Kong

Colorectal cancer(CRC)is one of the most prevalent cancers in developed *** the other hand,CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or *** CRC develops slowly from precancerous lesions,early detection can reduce both the incidence and mortality of the *** occult blood test is a widely used non-invasive screening tool for *** fecal occult blood test is simple and cost-effective in screening CRC,there is room for improvement in terms of the accuracy of the *** dysregulations have been found to play an important role in CRC *** better understanding of the molecular basis of CRC,there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for *** this review,the molecular basis of CRC development,the characteristics and applications of different non-invasive molecular biomarkers,as well as the technologies available for the detection were *** review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state,colorectal adenoma.

关键词： Colorectal cancer Colorectal adenoma Molecular diagnostics Fecal occult blood test Non-invasive

血管性认知损害诊断的进一步规范化：血管性认知损害分类共识研究组指南

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国际脑血管病杂志 2018年第4期26卷 241-250页

作者： Olivia A. Skrobot Sandra E. Black Christopher Chen charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂徐俊 Translational Health Sciences University of Bristol Bristol UK Sunnybrook Research Institute University of Toronto Ontario Canada Department of Pharmacology National University of Singapore Singapore Department of Neurology and Center for Neuroscience University of California at Davis Sacramento California USA Neurology University of Helsinki and Helsinki University Hospital Helsinki Finland Divison of Medical Sciences Oxford University Oxford UK Institute of Neuroscience Newcastle University Newcastle UK Department of Psychiatry University of Cambridge School of Clinical Medicine Cambridge UK NEUROFARBA Department University of FlorenceFlorence Italy Inserm U1171 University of Lille Lille France Methodist Neurological Institute Houston Texas USA Memory Clinic at Department of Neuropsychiatry Sahlgrenska University Hospital Molndal Sweden Institute of Neuroscience and Physiology Sahlgrenska AcademyUniversity of Gothenburg Sweden School of Psychiatry University of New South WalesSydney Australia Neuropsychiatric Institute Prince of Wales Hospital Randwick New South WalesAustralia Population Health Sciences University of Bristol Bristol UK Institute of Institute of Clinical Sciences Block B Queens University Belfast Belfast UK 116044 大连医科大学 116044 苏北人民医院神经内科扬州225001 首都医科大学附属北京天坛医院神经内科北京100069

引言血管性认知损害（vascular cognitive impairment,VCI）诊断共识的缺乏（体现为多种不同评估方案的使用）,妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究（Vascular Impair... 详细信息

引言血管性认知损害（vascular cognitive impairment,VCI）诊断共识的缺乏（体现为多种不同评估方案的使用）,妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究（Vascular Impairment of Cognition Classification Consensus Study,VICCCS）,旨在就VCI的诊断原则（VICCCS-1）和诊断方案（VICCCS-2）达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲（Delphi）调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65～79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网（National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN）发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作.

关键词：血管性认知损害血管性痴呆指南标准共识德尔菲法

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid