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Use of recombin.n. microRn.s as an.imetabolites to in.ibit human.n.n.small cell lun. can.er

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Acta Pharmaceutica Sin.ca B 2023年第10期13卷 4273-4290页

作者： Yixin.Chen.Mei-Juan.Tu Fan.wei Han.Zhen.hen.Liu n.elu Batra primo n.lara Hon.-Wu Chen.Huichan. Bi Ai-Min. Yu Departmen. of Biochemistry an. Molecular Medicin. School of MedicineUC DavisSacramentoCA 95817USA School of Pharmaceutical Scien.es Sun Yat-sen UniversityGuangzhou 510006China School of Public Health UNT Health Science CenterFort WorthTX 76107USA Departmen. of In.ern.l Medicin. School of MedicineUC DavisSacramentoCA 95817USA

Durin. the developmen. of therapeutic microRn.s(miRn.s or miRs),it is essen.ial to defin. their pharmacological ***,miRn. research an. therapy main.y use miRn. mimics syn.hesized in.*** experimen.al screen.n. of un.que recombin.n. miRn.s produced in.vivo,three lead an.iproliferative miRn.s again.t human.n.CLC cells,miR-22-3p,miR-9-5p,an. miR-218-5p,were revealed to target folate metabolism by bioin.ormatic *** miR-22-3p,miR-9-5p,an. miR-218-5p were shown.to regulate key folate metabolic en.ymes to in.ibit folate metabolism an. subsequen.ly alter amin. acid metabolome in.n.CLC A549 an. H1975 *** tracin. studies further con.irmed the disruption.of on.-carbon.tran.fer from serin. to folate metabolites by all three miRn.s,in.ibition.of glucose uptake by miR-22-3p,an. reduction.of serin. biosyn.hesis from glucose by miR-9-5p an.-218-5p in.n.CLC *** greater activities to in.errupt n.CLC cell respiration.glycolysis,an. colon. formation.than.miR-9-5p an.-218-5p,recombin.n. miR-22-3p was effective to reduce tumor growth in.two n.CLC patien.-derived xen.graft mouse models without causin. an. *** results establish a common.an.ifolate mechan.sm an. differen.ial action. on.glucose uptake an. metabolism for three lead an.ican.er miRn.s as well as an.itumor efficacy for miR-22-3p n.n.medicin.,which shall provide in.ight in.o developin. an.imetabolite Rn. therapies.

关键词： Rn. therapy Folate metabolism Amin. acid Glycolysis miR-22 miR-9 miR-218 Lun. can.er

Photolumin.scen.e emission. of Ca_(1-x)WO_(4):xEu^(3+):Bridgin. between.experimen. an. DFT calculation.

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Journ.l of Rare Earths 2022年第10期40卷 1527-1534页

作者： Aman.a Fern.n.es Gouveia Marcelo Assis lara Kelly Ribeiro Alin. Estefan. Bran.ao Lima Eduardo de Oliveira Gomes Dan.ele Souza Yara Gobato Galvao Ieda Lucia Vian. Rosa Geraldo Eduardo da Luz jr Eva Guillamón.Elson.Lon.o Juan.An.rés Miguel An.el San.Miguel Departmen. of Physical an. An.lytical Chemistry University Jaume I(UJI)12071CastelloSpain In.titute of Chemistry State University of Campinas(Unicamp)13083-970CampinasSPBrazil CDMF Federal University of S?o Carlos(UFSCar)P0.Box 67613565-905Sao CarlosSao PauloBrazil Departamen.o de Química Federal University of Piauí(UFPI)64049-550TeresinaPiautBrazil Physics Departmen. Federal University of S?o Carlos(UFSCar)P.0.Box 67613565-905Sao CarlosSao PauloBrazil

In.this work,the impact of the dopin. process on.the photolumin.scen.e emission.of CaWO_(4) as a fun.tion.of the con.en.ration.of Eu^(3+) cation.0.01 mol%,0.02 mol%,0.04 mol%,0.06 mol%,0.08 mol%,an. 0.10 mol%) is discussed in.***_(1-x)WO~4:xEu^(3+) samples were successfully syn.hesized by a simple coprecipitation.method followed by microwave *** blue shift in.the absorption.edge con.irms the quan.um con.in.men. effect an. the ban. gap en.rgy covers the ran.e from 3.91 to 4.18 eV,as the amoun. of Eu^(3+) cation. *** experimen.al results are sustain.d by first-prin.iples calculation.,at the den.ity fun.tion.l theory level,to decipher the geometry an. electron.c properties,thereby en.blin. a more accurate an. direct comparison.between.theory an. experimen. for the Ca_(1-x)WO_(4):xEu^(3+) structure.

关键词： Ca_(1-x)WO_(4):xEu^(3+) DFT calculation. Photolumin.scen.e emission. Rare earths

不稳定型心绞痛和PTCA术后患者血小板和白细胞的黏附和激活

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世界核心医学期刊文摘（心脏病学分册） 2005年第9期1卷 50-50页

作者： Serran. jr. C.V. Rocha Giraldez R. De lara Fern.n.es J. 孙凯 Heart In.titute(In.or) Univ. of S. Paulo Medical School Av. Dr. E. de Carvalho Aguiar 44 So Paulo SP-05403-000 Brazil

Backgroun.: Un.table atherosclerotic plaques activate blood cells which may adhere to the coron.ry en.othelium causin. vessel occlusion. However, it is un.n.wn.if differen. clin.cal syn.romes associated with plaque rupture in.uce similar blood cell activation.an. adhesion.to the en.othelium. Methods: We studied chan.es in.adhesion.molecule expression.of platelets(GPIIb/IIIa), n.utrophils -CD18, CD11b an. L-selectin.-an. mon.cytes(CD14) after in.eraction.with active lesion. of patien.s with stable an.in. subjected to PTCA an. patien.s with un.table an.in.(UA). Gen.ration.of superoxide(SO) radicals from PMn. an. PMn.sequestration.in.the coron.ry circulation.were also assessed. Blood samples were collected from the aorta(Ao) an. coron.ry sin.s(CS) before an. 15 min.after PTCA(n.13) an. within.the first 48 h of UA(n.12). Results: PTCA in.uced a marked up-regulation.of CD18, CD11b, CD14 an. GPIIb/IIIa with L-selectin.sheddin. an. reduced SO formation. whereas on.y min.r L-selectin.down.regulation.an. decreased SO production.in.icated activation.in.UA. However, a sign.fican. decrease in.n.utrophil coun. in.the CS compared to the Ao was on.y observed in.UA. Con.lusion.: The magn.tude of cellular activation.depen.s on.the un.erlyin. clin.cal settin. an. just partially con.ributes to cell adhesion.to the en.othelium which might be modulated by differen. exten. of vascular occlusion.an. shear forces.

关键词：不稳定型心绞痛 PTCA术选择素冠状动脉循环稳定斑块斑块破裂黏附分子冠状窦临床综合征中性粒细胞