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Genistein improves the vaginal epithelium thickness in a rat model of vaginal atrophy through modulation of hormone and heat shock protein 70 levels

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Asian pacific Journal of Reproduction 2020年第4期9卷 192-196页

作者： pribakti budinurdjaja I Wayan Arsana Wiyasa Ika Kustiyah Oktaviyanti Djanggan Sargowo Doctoral Program in Medicine Faculty of MedicineUniversitas BrawijayaMalangEast JavaIndonesia Department of Obstetric and Gynecology Faculty of Medicine Universitas Lambung Mangkurat/Ulin General HospitalBanjarmasinSouth KalimantanIndonesia Department of Obstetric and Gynecology Faculty of Medicine Universitas Brawijaya/dr.Saiful Anwar General HospitalMalangEast JavaIndonesia Department of Cardiology and Vascular Medicine Faculty of Medicine Universitas Brawijaya/dr.Saiful Anwar General HospitalMalangEast JavaIndonesia

Objective: To investigate whether administration of genistein can improve hormonal changes [estradiol and follicle stimulating hormone (FSH)] , heat shock protein 70 (Hsp70) expression, and thickness of vaginal epithelial cells in a rat model of vaginal atrophy. Methods: Twenty-five multiparous female rats were divided into five groups, namely the control group (without ovariectomy), the ovariectomy only group, and the ovariectomy groups 1, 2 and 3 receiving genistein at the doses of 0.045, 0.090 and 0.180 mg/kg body weight/day, respectively. Estradiol, FSH, and Hsp70 expression were analyzed by using the immunoassay technique. Analysis of the thickness of the vaginal epithelium was performed by histology. Results: Ovariectomy significantly decreased estradiol levels compared to the control group (P0.05). Ovariectomy significantly increased parabasal cell Hsp70 expression compared to the control group (P0.05). Conclusions: Genistein is able to increase the thickness of the vaginal epithelium through hormone modulation and cellular stress suppression. Genistein is beneficial in the form of a herbal or alternative food for improvement of vaginal atrophy due to menopause.

关键词： Vagina Cellular stress Hypoestrogen Pelvic organ prolapse

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