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阴茎胶样变性

世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 39-39页

作者： preston p.w. Orpin S.D. Muc R. Zaki I. 任建文 Department of Dermatology Solihull HospitalHeart ofEngland NHS TrustLode LaneSolihullWest MidlandsB91 2JLUnited Kingdom Dr.

Colloid degeneration is a rare but well-recognized entity,usually occurring on chronically sun-exposed *** report acase occurring on penile skin with no history of such exposure.

关键词：阴茎男生殖器

E-selectin ligand complexes adopt an extended high-affinity conformation

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Journal of Molecular Cell Biology 2016年第1期8卷 62-72页

作者： Roland C.preston Roman p.Jakob Florian p.C.Binder Christoph p.Sager Beat Ernst Timm Maier Institute of Molecular pharmacy Universitat Basel4056 BaselSwitzerland Biozentrum Universitat Basel4056 BaselSwitzerland

E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewisx(sLex).Efficient leukocyte recruitment under vascular flow conditions depends on an increased lifetime of E-selectin/ligand complexes under tensile force in a so-called catch-bond binding ***-crystal structures of a representative fragment of the extracellular E-selectin region with sLex and a glycomimetic antagonist thereof reveal an extended E-selectin conformation,which is identified as a high-affinity binding state of E-selectin by molecular dynamics ***-angle X-ray scattering experiments demonstrate a direct link between ligand binding and E-selectin conformational transition under static conditions in *** permits tracing a series of concerted structural changes connecting ligand binding to conformational stretching as the structural basis of E-selectin catch-bond-mediated leukocyte *** detailed molecular view of the binding site paves the way for the design of a new generation of selectin *** is of special interest,since their therapeutic potentialwas recently demonstrated with the pan-selectin antagonists GMI-1070(Rivipansel).

关键词： inﬂammation leukocyte adhesion E-selectin glycomimetic antagonist sialyl Lewisx conformational change

Roles and Representations of women in Early Chinese philosophy: A Survey

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Frontiers of philosophy in China 2020年第2期15卷 198-222页

作者： Sarah Craddock John preston Department of philosophy University of ReadingReading RG66UDUK

An understanding of the roles and representations of women in classical Chinese philosophy is here derived from central texts such as the Analects,the Lienii Zhuan,and the I *** argue that the roles of women during the classical period of Chinese philosophy tended to be as part of the "inner," working domestically as a housewife and *** will be shown from three passages from the *** were represented as submissive and passive,as with the qualities ascribed to yin energy,and therefore as rightfully subordinate to ***,despite representations of women in philosophy being thus at this time,there were exceptions,specific women who could take a male "outer" political *** story of Jing Jiang from the Lienii Zhuan suggests that although women being involved in "outer" affairs were looked down on,there were still women who would be and who would occasionally get praised for doing *** shows that it was realized,explicitly or otherwise,that women were capable of taking those roles,but also that they were not allowed to take such roles at that time.

关键词： women roles yin-yang early Chinese philosophy distinctions

Increased β-Cyanoalanine Nitrilase Activity Improves Cyanide Tolerance and Assimilation in Arabidopsis

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Molecular plant 2014年第1期7卷 231-243页

作者： Brendan O'Leary GaU M. preston Lee J. Sweetlove Department of plant Sciences University of Oxford Oxford UK

plants naturally produce cyanide （CN） which is maintained at low levels in their cells by a process of rapid assimilation. However, high concentrations of environmental CN associated with activities such as industrial pollution are toxic to plants. There is thus an interest in increasing the CN detoxification capacity of plants as a potential route to phytoremediation. Here, Arabidopsis seedlings overexpressing the pseudomonas fluorescens β-cyanoalanine nitrilase pinA were compared with wild-type and a β-cyanoalanine nitrilase knockout line （△Atnit4） for growth in the presence of exogenous CN. After incubation with CN, ＋pfpinA seedlings had increased root length, increased fresh weight, and decreased leaf bleaching compared with wild-type, indicating increased CN tolerance. The increased tolerance was achieved without an increase in β-cyanoalanine synthase activity, the other enzyme in the cyanide assimilation pathway, suggesting that nitrilase activity is the limiting factor for cyanide detoxification. Labeling experiments with [^13C] KCN demonstrated that the altered CN tolerance could be explained by differences in flux from CN to Asn caused by altered β-cyanoalanine nitrilase activity. Metabolite profiling after CN treatment provided new insight into downstream metabolism, revealing onward metabolism of Asn by the photorespiratory nitrogen cycle and accumulation of aromatic amino acids.

关键词： cyanide β-cyanoalanine cyanide detoxification asparagine metabolism nitrilase

Optical haze of transparent and conductive silver nanowire films

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Nano Research 2013年第7期6卷 461-468页

作者： Colin preston Yunlu Xu Xiaogang Han Jeremy N. Munday Liangbing Hu Department of Materials Science and Engineering University of Maryland College Park College Park Maryland 20742 USA Department of Electrical and Computer Engineering University of Maryland College Park Maryland 20742 USA The Institute for Research in Electronics and Applied physics University of Maryland College Park Maryland 20742 USA

Contemporary nanostructured transparent electrodes for use in solar cells require high transmittance and high conductivity, dictating nanostructures with high aspect ratios. Optical haze is an equally important yet unstudied parameter in transparent electrodes for solar cells that is also determined by the geometry of the nanostructures that compose the electrode. In this work, the effect of the silver nanowire diameter on the optical haze values in the visible spectrum was investigated using films composed of wires with either small diameters （N60 nm） or large diameters （~150 nm）. Finite difference time domain （FDTD） simulations and experimental transmittance data confirm that smaller diameter nanowires form higher performing transparent conducting electrode （TCE） films according to the current figure of merit. while maintaining near constant transmittance and conductivity for each film, however, it was observed experimentally that films composed of silver nanowires with larger diameters have a higher haze factor than films with smaller diameters. This confirms the FDTD simulations of the haze factor for single nanowires with similarly large and small diameters. This is the first record of haze properties for Ag Nws that have been simulated or experimentally measured, and also the first evidence that the current figure of merit for TCEs is insufficient to evaluate their performance in solar cell devices.

关键词： solar cell transparent conducting electrode silver nanowire haze factor light trapping

M13 Bacteriophage-polymer Nanoassemblies as Drug Delivery Vehicles

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Nano Research 2011年第5期4卷 483-493页

作者： Nisaraporn Suthiwangcharoen Tao Li Kai Li preston Thompson Shaojin You Qian wang Department of Chemistry and Biochemistry and Nanocenter University of South Carolina Columbia SC 29208 USA Histo-pathology Core Atlanta VA Medical Center 1670 Clairmont Road Decatur GA 30033 USA

poly（caprolactone-b-2-vinylpyridine）（pCL-p2Vp） coated with folate-conjugated M13 （FA-M13） provides a nanosized delivery system which is capable of encapsulating hydrophobic antitumor drugs such as doxorubicin （DOX）. The DOXqoaded FA-M13-pCL-p2Vp assemblies had an average diameter of approximately 200 nm and their structure was characterized using transmission electron microscopy, scanning electron microscopy, and dynamic light scattering. The particles were stable at physiological pH but could be degraded at a lower pH. The release of DOX from the nanoassemblies under acidic conditions was shown to be significantly faster than that observed at physiological pH. In addition, the DOX-loaded FA-M13-pCL-p2Vp particles showed a distinctly greater cellular uptake and cytotoxicity against folate-receptor-positive cancer cells than folate-receptor-negative cells, indicating that the receptor facilitates folate uptake via receptor-mediated endocytosis. Furthermore, the DOX-loaded particles also had a significantly higher tumor uptake and selectivity compared to free DOX. This study therefore offers a new way to fabricate nanosized drug delivery vehicles.

关键词： Bacteriophage M13 nanoassemblies doxorubicin drug delivery polymer

Transcriptional and epigenetic regulation of immune tolerance:roles of the NF-κB family members

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Cellular & Molecular Immunology 2019年第4期16卷 315-323页

作者： Lei Zhang Xiang Xiao preston R.Arnold Xian C.Li Immunobiology and Transplant Science Center and Department of Surgery Houston Methodist HospitalHoustonTXUSA Department of Surgery Weill Cornell Medical CollegeCornell UniversityNew YorkNYUSA

Immune tolerance is a highly regulated state and involves diverse *** to the induction of tolerance is the targeted modulation of T-cell activities(both effector and regulatory),in which transcription factors play a significant *** nuclear factor kappa-B(NF-κB)family is a family of transcription factors that not only are critically involved in diverse T-cell responses but also are regulated by many mechanisms to maintain tolerance and T-cell ***-κB,as a transcription factor,has been extensively studied in recent decades,and the molecular mechanisms that regulate NF-κB activities have been well ***,recent studies have revealed exciting new roles for NF-κB;in addition to its transcriptional activity,NF-κB can also activate diverse epigenetic mechanisms that mediate extensive chromatin remodeling of target genes to regulate T-cell *** this review article,we highlight recent discoveries and emerging opportunities in targeting NF-κB family members as well as their associated chromatin modifiers in the induction of immune tolerance and in the clinical treatment of immune diseases.

关键词： Immune tolerance NF-κB chromatin modifiers

Mechanisms of inducible resistance against Bacillus thuringiensis endotoxins in invertebrates

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Insect Science 2005年第5期12卷 319-330页

作者： GANG MA MUHAMMAD SARJAN CHRISTOpHER preston SASSAN ASGARI OTTO SCHMIDT plant and pest Science Faculty of Sciences the University of Adelaide Glen Osmond South Australia Australia Faculty of Agriculture University of Mataram Lombok Indonesia School of Integrative Biology University of Queensland St Lucia Queensland Australia

Resistance in insect pests against the endotoxin of Bacillus thuringiensis （Berliner）（Bt） is a major threat to the usefulness of this biopesticide, both used as traditional formulations and in transgenic crops. A crucial requirement for the development of successful resistance management strategies is a molecular understanding of the nature and inheritance of resistance mechanisms. This information can be used to design management strategies that will delay or counteract Bt resistance. The best known Bt resistance mechanism is inactivation of brush border membrane receptors. This type of resistance has a largely recessive mode of inheritance, which has enabled the design of resistance management approaches involving high dose and refuge strategies. Recent observations suggest that other resistance mechanisms are possible, including a mechanism that sequesters the toxin in the gut lumen through inducible immune reactions. The elevated immune status associated with tolerance to the toxin can be transmitted to subsequent generations by a maternal effect, which has implications for resistance management in the field. The high dose/refuge strategy may not be appropriate for the management of these alternative resistance mechanisms and other strategies have to be developed if inducible dominant resistance or tolerance mechanisms occur frequently in the field.

关键词： Bacillus thuringiensis crystal toxin innate immunity melanization resistance mechanism

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The Obsidian chamber

The Obsidian chamber