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Genetic ＆ Epigenetic alterations in Gliomas with special reference to age related differences:Indian experience

Genetic ＆ Epigenetic alterations in Gliomas with special re...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Chitra Sarkar prerana jha Pankaj Pathak Vaishali Suri MC Sharma Vikas Sharma Ashish Suri AK Mahapatra Department of Pathology and Neurosurgery* All India Institute of Medical Sciences

This study was undertaken to evaluate age-related differences in histopathologic and molecular profile of glioblastomas（GBMs） at various age groups,with special reference to TP53 mutation,epidermal growth factor receptor（EGFR） amplification,EGFR vIII mutant,PTEN deletion,IDH1 mutation and MGMT promoter *** GBM incidence was calculated over a period of 5 years（2005 to 2009）.Seventy-five GBMs were selected for molecular *** of cases were in the age group of 41 to 60 years,and mean age was 43.6 *** of all 75 cases selected for molecular profiling was *** adult GBMs showed EGFR amplification and PTEN deletion in majority（37.3% and 54.9%,respectively）.TP53 and IDH1 mutations were rare（11.8% cases each）.In secondary GBMs,TP53（66.7%） and IDH1 mutations（44.4%） were most frequent while PTEN deletion was seen in 33.3% and none had EGFR *** GBMs（＜18 year） harbored frequent TP53 mutations（46.7%） and PTEN deletion in 40%.However,characteristics feature was absence of IDH1 mutations and EGFR *** molecular profile of primary GBMs in young adults（19 to 40 year） was distinctly different from that of adults older than 40 years in that TP53 mutation was present in 20% of *** frequency of EGFR amplification（13.3%） and PTEN deletion（33.3%） was significantly low（P=0.028 and 0.046,respectively）.IDH1 mutation,which is rare in primary adult GBMs,was however present in this age group in 40% of *** promoter methylation showed no difference with reference to age or any genetic *** was noted in about 50% of both paediatric and adult GBM ***,molecular heterogeneity exists within GBMs of different age *** molecular profile of GBMs in young adults is distinctly ***,there is a strong need for further studies in various age groups to provide guidelines for therapeutic targeting and define prognostic markers.

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