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Garcinol suppresses the growth of human hepatocellular carcinoma by inducing abrogation of STAT3 phosphorylation,acetylation and dimerization

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中国药理学与毒理学杂志 2015年第S1期29卷 82-83页

作者： Muthu K SHANMUGAM Snehajyoti CHATTERJEE Peramaiyan RAJENDRAN Feng LI Parijat SENAPATI Kwong Fai WONG Alan prem kumar John MLUK Kam Man HUI Gautam SETHI Tapas K KUNDU Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 117957 Jawaharlal Nehru Centre for Advanced Scientific Research Molecular Biology and Genetics Unit Transcription and Disease Laboratory Jakkur P.O. Bangalore 560064 India Cancer Science Institute of Singapore National University of Singapore Singapore 117456 School of Biomedical Sciences Faculty of Health Sciences Curtin University Western Australia Division of Cellular and Molecular Research Humphrey Oei Institute of Cancer Research National Cancer Centre Singapore 169610 Institute of Molecular and Cell Biology Singapore 138673

OBJECTIVE Hepatocellular carcinoma(HCC)is the fifth most common malignancy worldwide and the third cause of global cancer *** of signal transducer and activator of transcription 3(STAT3)is commonly observed in tumor cells and is a critical mediator of on cogenic signaling in HCC and controls the expression of several genes involved in proliferation,survival,metastasis and *** drug-targeted therapies,besides being expensive,are associated with serious side effects and ***,novel agents that can suppress STAT3 activation have potential for both prevention and treatment of *** the present report,we investigated whether the potent HAT/KAT inhibitor,garcinol,(apolyisoprenylatedbenzophenone),could suppress STAT3 activation in HCC cells and in nude mice *** The effect of garcinol on HCC cell lines wasdetermined by MTT assay,immunoblotting,DNA binding assays,immuno-fluorescenceand immune-histochemical *** effect of garcinolon the inhibition of tumor growth in vivo was also investigated using HCCxenograft tumor modelin athymic nu/nu *** We found that garcinol could inhibit constitutive STAT3 activation in a dose-and time-dependent manner both by inhibiting STAT3 phosphorylation and acetylation in HCC *** investigated for molecular mechanism(s),we found that garcinol interferes with the dimer formation of STAT3 thereby inhibits its nuclear *** modeling showed that garcinol could bind to the SH2 domain of STAT3 and suppresses its dimerization in *** understand the cellular mechanism(s)of inhibition of STAT3 function by garcinol,we observed that upon inhibition of STAT3 dimerization bygarcinol,STAT3 DNA binding ability gets *** inhibition of STAT3 activation by garcinol led to the suppression of various gene products involved in proliferation,survival,and ***,when administered i.p.,garcinol inhibited the growth of human HCC xenograft tumors in

关键词： STAT3 HCC garcinol acetylation dimerization nude m

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识别和降低系统级风险,确保连接汽车的安全

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电子产品世界 2017年第5期24卷 23-24页

作者： prem kumar Arora 美高森美公司

自动驾驶作为汽车工业发展的又一方向,ADAS、V2V、V2X等相关技术已经得到了一定的发展,但是,自动驾驶的安全问题仍然未能完全解决。本文针对V2X网络安全问题,介绍了硅IC生物签名和公钥基础设施(PKI)系统两种解决方法。

关键词：自动驾驶 V2X 硅IC生物签名 PKI

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Spectrum of Upper GI Endoscopy in Pediatric Population at a Tertiary Care Centre in Pakistan

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Open Journal of Pediatrics 2014年第3期4卷 180-184页

作者： Muhammad Rehan Khan Shakeel Ahmed Syed Rehan Ali prem kumar Maheshwari Muhammad Saad Jamal Department of Pediatrics and Child Health The Aga Khan University Hospital Karachi Pakistan

Although upper GI endoscopy is considered to be a gold standard in diagnosis of many pediatric gastrointestinal disorders, there is limited data about its utility from developing countries. We carried out this retrospective study at Aga khan University Hospital, Karachi, Pakistan from 2008-2012. During the study period, a total of 200 procedures were performed. Mean age of patients was 8.5 years. 66% of patients received general anesthesia for the procedure. Failure to thrive with suspected coeliac disease was the most common indication for the procedure, seen in 31% of patients. Gastritis was the most common abnormal endoscopic finding, seen in 14.5% of patients. Gastritis was the most common histopathological finding on biopsy, seen in 31% of the patients (n = 62). Findings?were consistent with coeliac disease in 18% (n = 36), duodenitis, 10.5% (n = 21) and esophagitis, 4%?(n = 8) of patients. No immediate post procedure complication was noted in our study.

关键词： Upper GI Endoscopy Children Indications

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Contrast-enhanced multidetector computed tomography features and histogram analysis can differentiate ameloblastomas from central giant cell granulomas

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World Journal of Radiology 2022年第9期14卷 329-341页

作者： Adarsh Ghosh Meyyappan Lakshmanan Smita Manchanda Ashu Seith Bhalla prem kumar Ongkila Bhutia Asit Ranjan Mridha Department of Radiology Children's Hospital of PhiladelphiaPhiladelphiaPA 19104United States Department of Radiology All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029India Department of Oral&Maxillofacial Surgery All India Institute of Medical SciencesNew Delhi 110029India Department of Pathology All India Institute of Medical SciencesAnsari NagarNew Delhi 110029India

BACKGROUND No qualitative or quantitative analysis of contrast-enhanced computed tomography(CT)images has been reported for the differentiation between ameloblastomas and central giant cell granulomas(CGCGs).AIM To describe differentiating multidetector CT(MDCT)features in CGCGs and ameloblastomas and to compare differences in enhancement of these lesions qualitatively and using histogram *** MDCT of CGCGs and ameloblastomas was retrospectively reviewed to evaluate qualitative imaging *** analysis was used to compare the extent of enhancement of the soft ***’s exact tests and Mann–Whitney U test were used for statistical analysis(P49.05 HU in the tumour providing 100%sensitivity and 85%specificity in identifying a *** A multilocular,lytic sclerotic lesion with significant hyperenhancement in soft tissue,which spares the angle of the mandible and has matrix mineralization,should indicate prospective diagnosis of CGCG.

关键词： Ameloblastoma Granuloma Giant cell Multidetector CT

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栽培条件对黑翅跳甲为害胡椒的影响

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世界热带农业信息 1989年第3期 23-24页

作者： T. prem kumar 王石永

在喀拉拉邦进行了不同栽培条件对胡椒黑翅跳甲为害胡椒的影响的大田试验。位于平原的植地,害虫为害果实最严重,而在海拔较高的植地则无虫害。果实受害率有荫蔽比无荫蔽的严重。有荫蔽支柱的椒蔓受害程度比无荫蔽支柱的大。卡露瓦里种在... 详细信息

在喀拉拉邦进行了不同栽培条件对胡椒黑翅跳甲为害胡椒的影响的大田试验。位于平原的植地,害虫为害果实最严重,而在海拔较高的植地则无虫害。果实受害率有荫蔽比无荫蔽的严重。有荫蔽支柱的椒蔓受害程度比无荫蔽支柱的大。卡露瓦里种在北喀拉拉邦和南加里孟塔对虫害的敏感性最低。

关键词：胡椒栽培条件受害率果实跳甲为害程度相对敏感性支柱受害程度海拔高度

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Proximate Composition,Mineral Content and Fatty Acids Analyses of Aromatic and Non-Aromatic Indian Rice

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Rice science 2017年第1期24卷 21-31页

作者： Deepak kumar VERMA prem Prakash SRIVASTAV Agricultural and Food Engineering Department Indian Institute of TechnologyKharagpur 721302India

Awareness on nutritive value and health benefits of rice is of vital importance in order to increase the consumption of rice in daily diet of the human beings. In this study, a total of six aromatic and two non-aromatic rice accessions grown in India were analysed for their nutritional quality attributes including proximate composition, mineral contents and fatty acids. Data with three replications were used to measure Pearson＇s simple correlation co-efficient in order to establish the relationship among various nutritional quality attributes. The result on proximate composition showed that Govind Bhog had the highest moisture（13.57%） and fat（0.92%） content, which signifies its tasty attribute. Badshah Bhog exhibited the highest fibre content（0.85%）, carbohydrate content（82.70%） and food energy（365.23 k Cal per 100 g）. Among the minerals, the higher Ca（98.75 mg/kg）, Zn（17.00 mg/kg） and Fe（31.50 mg/kg） were in Gopal Bhog, whereas the highest Na（68.85 mg/kg） was in Badshah Bhog, the highest K（500.00 mg/kg） was in Swetganga, Khushboo and Sarbati. The highest contents of unsaturated fatty acids viz. oleic acid（49.14%）, linoleic acid（46.99%） and linolenic acid（1.27%） were found in Sarbati, whereas the highest content of saturated fatty acids viz. myristic acid（4.60%） and palmitic acid（31.91%） were found in Govind Bhog and stearic acid（6.47%） in Todal. The identified aromatic rice accessions Gopal Bhog, Govind Bhog and Badshah Bhog and non-aromatic rice accession Sarbati were found nutritionally superior among all eight tested accessions. The nutritional quality oriented attributes in this study were competent with recognized prominent aromatic and non-aromatic rice accessions as an index of their nutritional worth and recommend to farmers and consumers which may be graded as export quality rice with good unique nutritional values in international market.

关键词： aromatic unsaturated nutritional proximate accession carbohydrate oleic vital competent attribute

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Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers

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中国药理学与毒理学杂志 2015年第S1期29卷 80-80页

作者： Feng Li Muthu K. Shanmugam Kodappully Sivaraman Siveen Fan Wang Tina H. Ong Ser Yue Loo Mahadeva M.M. Swamy Somnath Mandal Alan prem kumar Boon Cher Goh Tapas Kundu Kwang Seok Ahn Ling Zhi Wang Kam Man Hui Gautam Sethi Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 117957 Cancer Science Institute of Singapore Centre for Translational Medicine Singapore 117957 Division of Cellular and Molecular Research Humphrey Oei Institute of Cancer Research National Cancer Centre Singapore 169610 Genome Institute of Singapore Agency for Science Technology and Research (A*STAR) Singapore Jawaharlal Nehru Centre for Advanced Scientific Research Molecular Biology and Genetics Unit Transcription and Disease Laboratory Bangalore 560064 India School of Biomedical Sciences Faculty of Health Sciences Curtin University Western Australia 6009 Australia Department of Biological Sciences University of North Texas Denton Texas 76203 Department of Haematology-Oncology National University Health System Singapore 117957 College of Korean Medicine Kyung Hee University Seoul 130-701 Republic of Korea

OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to *** The effect of garcinol and cisplatin on HNSCC was assessed by MTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse *** We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by *** the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and *** pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,*** Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers.

关键词： HNSCC chemoresistance NF-κB proliferation garcinol

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A New High Performance Realization of Hyperchaotic Modified Canonical Chua Circuit Using JFETs

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Chinese Physics Letters 2008年第8期25卷 2803-2805页

作者： prem Bhushan Mital Umesh kumar R.S. Prasad IEC College of Engineering and Technology GB Nagar Pin-201 306 India Indian Institute of Technology Delhi Pin-110016 India Inderprastha Eng. College Sahibabad Ghaziabad (UP) India

A new implementation of hyperchaotic modified canonical Chua circuit using junction field-effect transistors （JFETs） is proposed. The design is based on a source coupled JFET circuit to approximate a smooth cubic nonlinearity and a two-terminal negative resistance element containing a p-n-p silicon transistor and an n-channel JFET. The realization is supported by Orcad Pspice simulation and numerical MATLAB results. The hyperchaotic nature is confirmed by two positive Lyapunov exponents associated with the attractor which is a fractal with a Lyapunov dimension between 3 and 4.

关键词： OSCILLATOR

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Sugar-Hormone Cross-Talk in Seed Development： Two Redundant Pathways of IAA Biosynthesis Are Regulated Differentially in the Invertase- Deficient miniature 1 （mn 1） Seed Mutant in Maize

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Molecular Plant 2010年第6期3卷 1026-1036页

作者： prem S. Chourey Qin-Bao Li Dibyendu kumar USDA-ARS Center for Medical Agricultural and Veterinary Entomology Gainesville FL 32608-1069 USA Interdisciplinary Center for Biotechnology Research University of Florida Gainesville FL 32610 USA

The miniature1 （mn1） seed phenotype is a loss-of-function mutation at the Mnl locus that encodes a cell wall invertase; its deficiency leads to pleiotropic changes including altered sugar levels and decreased levels of IAA throughout seed development. To understand the molecular details of such a sugar-hormone relationship, we have initiated studies on IAA biosynthesis genes in developing seeds of maize. Two tryptophan-dependent pathways of IAA biosynthesis, tryptamine （TAM） and indole-3-pyruvic acid （IPA）, are of particular interest. We report on molecular isolation and characterization of an endosperm-specific ZmTARelatedl （ZmTarl） gene of the IPA branch; we have also reported recently on ZmYucl gene in the TAM branch. Comparative gene expression analyses here have shown that （1） the ZmTarl transcripts were approximately 10-fold higher levels than the ZmYucl; （2） although both genes showed the highest level of expression at 8-12 d after pollination （DAP） coincident with an early peak in IAA levels, the two showed highly divergent （antagonistic） response at 12 and 16 DAP but similar patterns at 20 and 28 DAP in the Mnl and ran1 endosperm. The Western blot analyses for the ZmTAR1 protein, however, displayed disconcordant protein/transcript expression patterns. Overall, these data report novel observations on redundant trp-dependent pathways of auxin biosynthesis in developing seeds of maize, and suggest that homeostatic control of IAA in this important sink is highly complex and may be regulated by both sucrose metabolism and developmental signals.

关键词： Seed development IAA biosynthesis tryptophan-aminotransferase 1 ZmYUCCA1 gene expression q-PCR maize.

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Structural build-up model for three-dimensional concrete printing based on kinetics theory

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 998-1014页

作者： Prabhat Ranjan prem P.S.AMBILY Shankar kumar Greeshma GIRIDHAR Dengwu JIAO Advanced Materials Laboratory CSIR-Structural Engineering Research CentreChennai 600113India Department of Architecture and Civil Engineering City University of Hong KongHong Kong 999077China

The thixotropic structural build-up is crucial in extrusion-based three-dimensional(3D)concrete *** paper uses a theoretical model to predict the evolution of static and dynamic yield stress for printed *** model employs a structural kinetics framework to create a time-independent constitutive link between shear stress and shear *** model considers flocculation,deflocculation,and chemical hydration to anticipate structural *** reversible and irreversible contributions that occur throughout the build-up,breakdown,and hydration are defined based on the proposed structural ***,detailed parametric studies are conducted to evaluate the impact of model *** is revealed that the proposed model is in good agreement with the experimental results,and it effectively characterizes the structural build-up of 3D printable concrete.

关键词： structural build-up rheology thixotropy 3D printable concrete kinetics theory ultra high performance concrete

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