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Efficacy and safety of vedolizumab in elderly patients with inflammatory bowel disease:a matched case-control study

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Gastroenterology Report 2020年第4期8卷 306-311,I0002页

作者： preeti shashi Dharmesh Gopalakrishnan Malav P.Parikh Bo Shen Gursimran Kochhar Center for Inflammatory Bowel Disease Digestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOHUSA Department of Internal Medicine The Cleveland Clinic FoundationClevelandOHUSA Department of Gastroenterology Allegheny General HospitalPittsburghPAUSA

Background:Vedolizumab was demonstrated to be safe and effective in adults with moderately to severely active inflammatory bowel disease(IBD)in clinical ***,there are limited data regarding its efficacy and safety in elderly ***:This was a case-control study comparing the efficacy(measured by rates of mucosal healing and need for IBD surgery)and safety of vedolizumab in IBD among patients65 years of age(the elderly group)vs those0.05).Conclusions:In a real-world setting,vedolizumab was demonstrated to have an efficacy and safety profile among elderly IBD patients that were comparable to younger controls.

关键词： inflammatory bowel disease vedolizumab elderly patients mucosal healing safety

Influence of scattering of SH-waves in dynamic interaction of shear wall with soil layers

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Earthquake Engineering and Engineering Vibration 2020年第3期19卷 583-595页

作者： shashi Kumar Swapan Kumar Chakraborty Department of Mathematics Sarala Birla UniversityRanchi 835103India Department of Applied Mathematics Cambridge Institute of TechnologyRanchi 835103India Department of Mathematics Birla Institute of TechnologyMesraRanchi 835215India

The dynamic soil-structure interaction of a shear wall embedded in elastic isotropic and homogeneous soil layers underlain by bedrock,subjected to SH waves,is modeled in the present *** soil layers consist of irregular interfaces and it has been shown that the scattering due to the roughness of the layers has significant effect on the displacement of both the foundation and the shear *** demonstrate the phenomena indirect boundary element method(IBEM)has been used on the basis of its validation in previous problems of similar *** system response is compared with the analytical solution of the same type of model for vertically propagating incident SH *** is observed that for the low frequency of wave,displacement is abruptly high,and as a result the combination of shear wall and foundation perceives *** thickness of the soil layer,mass of the shear wall,stiffness of the bedrock and the soil layers all affects the system frequency and displacement.

关键词： soil dynamic interaction

New Chain Imputation Methods for Estimating Population Mean in the Presence of Missing Data Using Two Auxiliary Variables

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Communications in Mathematics and Statistics 2023年第2期11卷 325-340页

作者： shashi Bhushan Abhay Pratap Pandey Department of Mathematics and Statistics Dr.Shakuntala Misra National Rehabilitation UniversityLucknowIndia Department of Statistics Ramanujan College University of DelhiNew DelhiIndia

This article deals with some new chain imputation methods by using two auxiliary variables under missing completely at random(MCAR)*** proposed generalized classes of chain imputation methods are tested from the viewpoint of optimality in terms of *** proposed imputation methods can be considered as an efficient extension to the work of Singh and Horn(Metrika 51:267-276,2000),Singh and Deo(Stat Pap 44:555-579,2003),Singh(Stat A J Theor Appl Stat 43(5):499-511,2009),Kadilar and Cingi(Commun Stat Theory Methods 37:2226-2236,2008)and Diana and Perri(Commun Stat Theory Methods 39:3245-3251,2010).The performance of the proposed chain imputation methods is investigated relative to the conventional chain-type imputation *** theoretical results are derived and comparative study is conducted and the results are found to be quite encouraging providing the improvement over the discussed work.

关键词： Missing data Imputation MCAR

Comparison of eigensensitivity and ANN based methods in model updating of an eight-story building

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Earthquake Engineering and Engineering Vibration 2015年第3期14卷 453-464页

作者： Prabakaran K Ashok Kumar shashi Kant Thakkar Department of Civil Engineering PSG College of Technology Department of Earthquake Engineering IIT Roorkee

Analytical models prepared from field drawings do not generally provide results that match with experimental *** error may be due to uncertainties in the property of materials,size of members and errors in the modelling *** is important to improve analytical models using experimentally obtained *** the past several years,data obtained from ambient vibration testing have been successfully used in many cases to update and match dynamic behaviors of analytical models with real *** paper presents a comparison between artificial neural network(ANN) and eigensensitivity based model updating of an existing multi-story building.A simple spring-mass analytical model,developed from the structural drawings of the building,is considered and the corresponding spring stiffness and lumped mass of all floors are chosen as updating *** advantages and disadvantages of these updating methods are *** advantage is that both methods ensure a physically meaningful model which canbe further employed in determining structural response and health monitoring.

关键词： ambient vibration measurement model updating artif

Geographic patterns of genetic diversity and fertility restoration ability of Asian and African origin pearl millet populations

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The Crop Journal 2022年第2期10卷 468-477页

作者： K.Sudarshan Patil shashi Kumar Gupta International Crops Research Institute for the Semi-Arid Tropics(ICRISAT) PatancheruHyderabad 502324TelanganaIndia Professor Jayashankar Telangana State Agricultural University(PJTSAU) RajendranagarHyderabad 500030TelanganaIndia

A set of 45 diverse Asian and African origin/bred populations of pearl millet were investigated multi-locationally for morphological traits including grain yield and assessed for their fertility restoration ability on three cytoplasmic male sterility(CMS) systems in two contrasting seasons. Significant genetic variation was found for all the yield linked traits. Multivariate analysis for grain yield and its component traits grouped these populations into five clusters. Most of the Asian origin populations grouped into single cluster(Cluster III) and separated from the rest of the African origin populations indicating the presence of correspondence between clustering pattern and geographical origin of the populations. Clusters dominated with Asian populations(As-As) had linkages with early flowering, short plant height, more number of tillers, small and thin panicles, small seeded and low grain yield compared to the clusters dominated by African populations(Af-Af) or African origin and Asian bred(Af-As) *** related populations having common parentage were found grouped in same *** restoration/maintainer frequency of 45 populations on three diverse CMS systems revealed that overall fertility restoration frequency was highest for A1(86%) followed by A4(37%) and for A5(7%) CMS system. Five populations were identified as potential sources for developing maintainer lines for all three CMS systems and eight populations were identified specifically for A;and A;CMS systems. A set of 11 and four populations were identified for restorer line development exclusively for A;and A;CMS system,respectively. Six populations were identified for the development of dual restorers for both A;and A;CMS system.

关键词： CMS systems Fertility restoration Morphological diversity Pearl millet Populations

Optimality Conditions and Duality for Nondifferentiable Multiobjective Semi-Infinite Programming Problems with Generalized(C,α,ρ,d)-Convexity

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Journal of Systems Science & Complexity 2015年第1期28卷 47-59页

作者： MISHRA shashi Kant JAISWAL Monika HOAI AN Le Thi Department of Mathematics Banaras Hindu University Laboratory of Theoretical and Applied Computer Science LITA UFR MIMUniversity of Lorraine

This paper obtains sufficient optimality conditions for a nonlinear nondifferentiable multiobjective semi-infinite programming problem involving generalized(C,α,ρ,d)-convex *** authors formulate Mond-Weir-type dual model for the nonlinear nondifferentiable multiobjective semiinfinite programming problem and establish weak,strong and strict converse duality theorems relating the primal and the dual problems.

关键词： Duality generalized convexity optimality conditions semi-infinite programming.

GENERALIZED INVEXITY-TYPE CONDITIONS IN CONSTRAINED OPTIMIZATION

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Journal of Systems Science & Complexity 2011年第2期24卷 394-400页

作者： shashi K. MISHRA Norma G. RUEDA Department of Mathematics Faculty of Science Banaras Hindu University Varanasi 221005 India.Norma G. RUEDA Department of Mathematics Merrimack College North Andover MA 01845 USA.

This paper defines a new class of generalized type I functions, and obtains Kuhn-Tucker necessary and sumcient conditions and duality results for constrained optimization problems in the presence of the aforesaid weak... 详细信息

关键词： Constrained optimization duality results type I functions.

Synthesis,characterization and application of Lagerstroemia speciosa embedded magnetic nanoparticle for Cr(Ⅵ)adsorption from aqueous solution

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Journal of Environmental Sciences 2017年第5期29卷 283-293页

作者： Shalini Srivastava shashi Bhushan Agrawal Monoj Kumar Mondal Department of Botany Institute of Science Banaras Hindu University Varanasi 221005 India Department of Chemical Engineering and Technology Indian Institute of Technology Banaras Hindu University Varanasi 221005 Uttar Pradesh India

Lagerstroemia speciosa bark（LB） embedded magnetic nanoparticles were prepared by co-precipitation of Fe2＋ and Fe3＋ salt solution with ammonia and LB for Cr（Ⅵ） removal from aqueous *** native LB,magnetic nanoparticle（MNP）,*** embedded magnetic nanoparticle（MNPLB） and Cr（Ⅵ） adsorbed MNPLB particles were characterized by SEM-EDX,TEM,BET-surface area,FT-IR,XRD and TGA *** analysis confirmed nearly spherical shape of MNP with an average diameter of 8.76 nm and the surface modification did not result in the phase change of MNP as established by XRD analysis,while led to the formation of secondary particles of MNPLB with diameter of 18.54 *** results revealed covalent binding between the hydroxyl group of MNP and carboxyl group of LB particles and further confirmed its physico-chemical nature favorable for Cr（Ⅵ） *** Cr（Ⅵ） adsorption on to MNPLB particle as an adsorbent was tested under different contact time,initial Cr（Ⅵ） concentration,adsorbent dose,initial pH,temperature and agitation *** results of the equilibrium and kinetics of adsorption were well described by Langmuir isotherm and pseudo-second-order model,*** thermodynamic parameters suggest spontaneous and endothermic nature of Cr（Ⅵ）adsorption onto *** maximum adsorption capacity for MNPLB was calculated to be 434.78 mg/g and these particles even after Cr（Ⅵ） adsorption were collected effortlessly from the aqueous solution by a *** desorption of Cr（Ⅵ）-adsorbed MNPLB was found to be more than 93.72%with spent MNPLB depicting eleven successive adsorption-desorption cycles.

关键词： Lagerstroemia speciosa Magnetic nanoparticles Co-precipitation Cr(Ⅵ) ions Adsorption capacity

User behaviour analysis using data analytics and machine learning to predict malicious user versus legitimate user

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High-Confidence Computing 2022年第1期2卷 9-18页

作者： Rohit Ranjan shashi Shekhar Kumar Thapar Institute of Engineering and Technology Thapar UniversityPatialaIndia Indian Institute of Information Technology Allahabad IIIT AllahabadPrayarajIndia

Research-based on user behavior analysis for authentication is the motivation for this *** move ahead using a behavioral approach to identify malicious users and legitimate *** this paper,we have explained how we have applied big data analytics to application-layer logs and predicted malicious users by employing a Machine Learning algorithm based on certain metrics explained later in the *** Learning would present a list of IP addresses or user identification tokens(UIT),deduced from live data which would be performing a malicious activity or are suspected of malicious activity based on their browsing *** have created an e-commerce web application and induced vulnerabilities intentionally for this *** have hosted our setup on LAMP[1]stack based on AWS cloud[2].This method has a huge potential as any organization can imply this to monitor probable attackers thus narrowing down on their efforts to safeguard their *** idea is based on the fact that the browsing pattern,as well as the access pattern of a genuine user,varies widely with that of a *** patterns would be used to sort out the incoming traffic from and list out IP addresses and UIT that are the most probable cases of hack attempts.

关键词： Application security Big data analytics Machine learning Random forest Behavioral analysis Prediction