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Analyzing variations in spatial critical gaps at two-way stop controlled intersections using parametric and non-parametric techniques

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第1期8卷 129-138页

作者： Digvijay S.Pawar Gopal R.patil Department of Civil Engineering Indian Institute of Technology HyderabadKandi 502285India Department of Civil Engineering Indian Institute of Technology BombayPowai 400076India

At two-way stop controlled(TWSC)intersections drivers on minor stream are generally at risk because of the difficulty in judging safe gap between major stream *** misjudgment by the driver while choosing gap may result in a collision with major stream *** paper provides important insights for determining and analyzing spatial critical gaps of drivers at high speed and medium speed TWSC *** critical gap line(CGL)fitted for the accepted and rejected gaps using parametric(binary logit model-BLM)and non-parametric(support vector machines-SVM)techniques gives critical gap values at 15 th,50 th and 85 th percentile *** evaluation of spatial critical gap with respect to major road vehicle(conflicting vehicle)speed makes it easier to understand the impact of variation in speed on spatial gaps accepted by the drivers on the minor *** logit models developed revealed that the probability of accepting gap decreases with increase in the speed of the conflicting vehicle and it increases with increase in the distance of conflicting *** spatial critical gaps estimated using support vector machines were found in close approximation with those estimated using binary logit *** study results showed that SVMs have very good potential to be an alternative tool for the estimation of driver's critical *** spatial critical gaps corresponding to 15 th,50 th and 85 th percentile speeds for medium speed intersections were 32 m,38 m and 46 m respectively and for high speed intersections these values were 64 m,76 m and 104 m *** increase in the magnitude of gap value with respect to the percentile speed clearly states the effect of speed on spatial *** insights from the study can be used to suggest various measures to improve the safety of crossing drivers at uncontrolled intersections.

关键词： Traffic engineering Spatial critical gaps Uncontrolled intersections Logit model SVM Driver behavior

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MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα

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Cellular & Molecular Immunology 2019年第5期16卷 495-507页

作者： Anant Jaiswal Sukka Santosh Reddy Mohita Maurya preeti Maurya Manoj Kumar Barthwal Division of Pharmacology Council of Scientific and Industrial Research-Central Drug Research Institute(CSIR-CDRI)Lucknow 226031 U.P.India Academy of Scientific and Innovative Research New Delhi 110025India

In human adipose tissue and obesity,miR-99a expression is negatively correlated with ***,the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation.M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and M1 ***-switching experiments established an association between upregulated miR-99a expression and the M2 *** of miR-99a prevented M1 phenotype activation and attenuated bactericidal ***,knockdown of miR-99a abolished M2 phenotype *** means of in silico target prediction tools and a luciferase reporter assay,TNFαwas identified as a direct target of *** of TNFαrecapitulated the effect of miR-99a overexpression in M1 *** a db/db mice model,miR-99a expression was reduced in eWAT and F4/80+*** overexpression of miR-99a in db/db mice attenuated adipocyte hypertrophy with increased CD301 and reduced CD86 *** cytometry analysis also showed an increased M2 and a reduced M1 macrophage *** of miR-99a also improved the diabetic dyslipidemia and insulin signaling in eWAT and liver,with an attenuated expression of gluconeogenesis and cholesterol metabolism genes in the ***,adoptive transfer of miR-99a-overexpressing macrophages in the db/db mice recapitulated in vivo miR-99a mimic effects with increased M2 and reduced M1 macrophage populations and improved systemic glucose,insulin sensitivity,and insulin signaling in the eWAT and *** present study demonstrates that miR-99a mimics can regulate macrophage M1 phenotype activation by targeting TNFα.miR-99a therapeutics in diabetic mice reduces the adipose tissue inflammation and improves insulin sensitivity.

关键词： inflammation macrophage CD86

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Fluorimetric study of the interaction between ATP and ciprofloxacin-Y^(3+) complex and its application

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Journal of Rare Earths 2010年第3期28卷 329-332页

作者： Shailaja R.patil Umesh S.Mote Shivajirao R.patil Sang-Hak Lee Govind B.Kolekar Fluorescence Spectroscopy Research Laboratory Department of ChemistryShivaji UniversityKolhapur-416 004MaharashtraIndia Department of Chemistry Kyungpook National UniversityDaeguS.Korea 133-791)

A simple spectrofluorimetric method was developed for determination of trace amount of adenosine disodium triphosphate(ATP).Under the optimum conditions,we studied the interaction between CIP-Y3+-ATP complex by using absorption and fluorescence *** was observed that ATP remarkably enhanced the fluorescence intensity of the CIP-Y3+ complex at λem=415 nm and the enhanced fluorescence intensity of Y3+ ion remained proportional to the concentration of *** developed method was successfully applied for...

关键词： adenosine disodium triphosphate(ATP) ciprofloxacin(CIP) yttrium(Y3+) spectrofluorimetric method rare earths

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An effective digital audio watermarking using a deep convolutional neural network with a search location optimization algorithm for improvement in Robustness and Imperceptibility

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High-Confidence Computing 2023年第4期3卷 47-59页

作者： Abhijit J.patil Ramesh Shelke Computer Engineering Pacific Academy of Higher Education and Research UniversityUdaipur 313003India Electronics and Telecommunications University of MumbaiMumbai 400032India

Watermarking is the advanced technology utilized to secure digital data by integrating ownership or copyright *** of the traditional extracting processes in audio watermarking have some restrictions due to low reliability to various ***,a deep learning-based audio watermarking system is proposed in this research to overcome the restriction in the traditional *** implication of the research relies on enhancing the performance of the watermarking system using the Discrete Wavelet Transform(DWT)and the optimized deep learning *** selection of optimal embedding location is the research contribution that is carried out by the deep convolutional neural network(DCNN).The hyperparameter tuning is performed by the so-called search location optimization,which minimizes the errors in the *** experimental result reveals that the proposed digital audio watermarking system provides better robustness and performance in terms of Bit Error Rate(BER),Mean Square Error(MSE),and Signal-to-noise *** BER,MSE,and SNR of the proposed audio watermarking model without the noise are 0.082,0.099,and 45.363 respectively,which is found to be better performance than the existing watermarking models.

关键词： Search location optimization algorithm Deep convolutional neural network DWT Robustness Imperceptibility

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Gene set enrichment analysis of alpha-glucosidase inhibitors from Ficus benghalensis

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Asian Pacific Journal of Tropical Biomedicine 2019年第6期9卷 263-270页

作者： Pukar Khanal B.M.patil Department of Pharmacology and Toxicology KLE College of Pharmacy Belagavi KLE Academy of Higher Education and Research (KAHER)

Objective:To identify alpha-glucosidase inhibitors from Ficus benghalensis and analyze gene set enrichment of regulated protein ***:The phytoconstituents of Ficu.s *** were queried for inhibitors of alphaglucosidase,also identified as aldose reductase *** score,absorption,distribution,metabolism,excretion and toxicity profile,biological spectrum,and gene expression were predicated for each *** study was performed to predict the binding affinity with alpha-glucosidase and aldose reductase and compared with clinically proven *** Encyclopedia of Genes and Genomes pathway analysis was performed for the regulated genes to identify the modulated ***:Apigenin,3,4’,5,7-tetrahydroxy-3’-methoxyflavone,and kaempferol were identified as inhibitors of alpha-glucosidase and aldose *** was predicted to possess the highest binding affinity with both *** p53 signaling pathway was predicted to modulate the majority of protein molecules in diabetes *** the alpha-glucosidase inhibitors were also predicted as membrane integrity agonist and anti-mutagenic ***:The current study indicates alpha-glucosidase inhibitors from Ficus benghale,nsis can act as aldose reductase inhibitors after absorption from the intestinal ***,these phytoconstituents are involved in the regulation of numerous protein molecules and ***,the anti-diabetic efficacies of these compounds are due to their action on multiple protein molecules and synergistic effects which should be confirmed by future investigations.

关键词： Ficus benghalensis Gene set enrichment Kaempferol Network pharmacology Type 2 diabetes mellitus

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Effect of Ipomea carnea Jacq. flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats

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Chinese Journal of Natural Medicines 2014年第3期12卷 161-166页

作者： Jain Smita patil U.K. Department of Pharmacognosy VNS Institute of Pharmacy Department of Pharmaceutical Sciences Dr. H.S. Gour Central University

AIM： To investigate the active chloroform fraction of the ethanol extract oflpomoea carnea flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats. METHOD： Except for the control group, all of the rats were sensitized with intranasal application of 5 μL of 10% toluene diiso- cyanate （TDI） for 7 days. One week after second sensitization, all of the rats were provoked with 5 ~tL of 5% TDI to induce airway hypersensitivity. After the last challenge, blood and bronchoalvelor lavage （BAL） fluid were collected and subjected to total and differential leucocytes count. Flash chromatography was performed on the most active chloroform fraction to isolate an individual component. RESULTS： Treatment with the ethanolic extract and its chloroform fraction at an oral dose of 200 mg·kg^ -1 showed a significant decrease in circulating neutrophil and eosinophil in blood and BAL as compared with standard dexamethasone （DEXA）. The structure of the compound obtained from chloroform fraction oflpomea carnea was elucidated as stigmast-5, 22-dien-3β-ol on the basis of spectral data analysis. CONCLUSION： The chloroform fraction was found to be more effective to suppress airway hyper reactivity symptoms, and de- creased count of both total and differential inflammatory cells.

关键词： Ipomea carnea Toluene diisocyanate Bronchoalvelor lavage Neutrophils Stigmasterol

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Improved region growing segmentation for breast cancer detection:progression of optimized fuzzy classifier

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International Journal of Intelligent Computing and Cybernetics 2020年第2期13卷 181-205页

作者： Rajeshwari S.patil Nagashettappa Biradar Department of Electronics and Communication BLDEA’s V P Dr PG Halakatti College of Engineering and TechnologyBijapurIndia Department of Electronics and Communication Bheemanna Khandre Institute of TechnologyBidarIndia

Purpose-Breast cancer is one of the most common malignant tumors in women,which badly have an effect on women’s physical and psychological health and even danger to ***,mammography is considered as a fundamental criterion for medical practitioners to recognize breast ***,due to the intricate formation of mammogram images,it is reasonably hard for practitioners to spot breast cancer ***/methodology/approach-Breast cancer is one of the most common malignant tumors in women,which badly have an effect on women’s physical and psychological health and even danger to ***,mammography is considered as a fundamental criterion for medical practitioners to recognize breast ***,due to the intricate formation of mammogram images,it is reasonably hard for practitioners to spot breast cancer ***-The performance analysis was done for both segmentation and *** the analysis,the accuracy of the proposed IAP-CSA-based fuzzy was 41.9%improved than the fuzzy classifier,2.80%improved than PSO,WOA,and CSA,and 2.32%improved than GWO-based fuzzy ***,the accuracy of the developed IAP-CSA-fuzzy was 9.54%better than NN,35.8%better than SVM,and 41.9%better than the existing fuzzy ***,it is concluded that the implemented breast cancer detection model was efficient in determining the normal,benign and malignant ***/value-This paper adopts the latest Improved Awareness Probability-based Crow Search Algorithm(IAP-CSA)-based Region growing and fuzzy classifier for enhancing the breast cancer detection of mammogram images,and this is the first work that utilizes this method.

关键词： Mammogram Breast cancer detection Optimized region growing Membership optimized-fuzzy classifier Improved crow search algorithm

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Population Structure and Marker-Trait Association in Indigenous Aromatic Rice

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Rice science 2017年第3期24卷 145-154页

作者： preeti Rekha TALUKDAR Sunayana RATHI Khanin PATHAK Sanjay Kumar CHETIA Ramendra Nath SARMA Department of Plant Breeding and Genetics Assam Agricultural University Jorhat 785013 India Biochemistry & Agricultural Chemistry Assam Agricultural University Jorhat 785013 India Regional Agricultural Research Station Assam Agricutural University Jorhat 785013 India

Joha rice of Assam is a class of rice with aroma, good cooking qualities and excellent palatability, which are grown in different places of Assam with their adaptability to local situations. A total of 143 simple sequence repeat markers were used in this study to reveal sufficient genetic variations among the 40 Joha and 14 non-Joha rice genotypes. Polymorphism information content of these markers were from 0.17 to 0.88, where the average of 3.7 alleles were observed. The model-based population assignment and dendrogram analysis identified three distinct groups in the 54 rice accessions, which established a clear identity of Joha accessions from the Basmati accessions, indicating high diversity and strong population structure in Joha rice. Furthermore, a total of 29 significant marker-trait associations(P < 0.05) for 10 characters were detected. The QTLs related with yield and grain quality can be used effectively in crop improvement programs and for further fine mapping and validation of specific genes to develop gene-based perfect markers in rice breeding and for mining of better alleles of these genes in Joha rice collections.

关键词： Joha rice genetic diversity association mapping population structure quantitative trait locus aroma

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Phytoplankton abundance and community structure in the Antarctic polar frontal region during austral summer of 2009

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Chinese Journal of Oceanology and Limnology 2013年第1期31卷 21-30页

作者： SHRAMIK patil RAHUL Mohan SUHAS Shetye SAHINA Gazi National Centre for Antarctic and Ocean Research

The Antarctic polar front region in the Southern Ocean is known to be most productive. We studied the phytoplankton community structure in the Indian sector at this frontal location during late austral summer (February, 2009) onboard R/V Akademic Boris Petrov. We used the phytoplankton and microheterotrophs abundance, as also the associated physico-chemical parameters to explain the low phytoplankton abundance in the study region. This study emphasizes the shift of phytoplankton, from large (>10 μm) to small (10 μm) phytoplankton abundance during the late austral summer. This study highlights the highly productive polar front nevertheless becomes a region of low phytoplankton abundance, due to community shifts towards pico-phytoplankton (<10 μm) during late austral summer.

关键词： Southern Ocean polar front diatom ciliate dinoflagellate

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Estimation of lung cancer burden in Australia,the Philippines,and Singapore:an evaluation of disability adjusted life years

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Cancer Biology & Medicine 2017年第1期14卷 74-82页

作者： Suman Morampudi Neha Das Arun Gowda Anand patil Phamax Analytic Resources Pvt.Ltd. Bengaluru 560095India

Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billion on a global scale in 2008. This paper aims to understand the economic burden of lung cancer in terms of disability adjusted life years(DALY) in Australia, the Philippines, and ***: The years of life lost(YLL) and years lost due to disability(YLD) were calculated using the formula developed by Murray and Lopez in 1996 as part of a comprehensive assessment of mortality and disability for diseases, injuries and risk factors in 1990 and projected to 2020. The same formula is represented in the Global Burden of Disease template provided by the World Health Organization. Appropriate assumptions were made when data were unavailable and projections were performed using regression analysis to obtain data for ***: The total DALYs due to lung cancer in Australia, the Philippines, and Singapore were 91,695, 38,584, and 12,435,respectively, and the corresponding DALY rates per a population of 1,000 were 4.0, 0.4, and 2.2, respectively, with a discount rate of 3%. When researchers calculated DALYs without the discount rate, the burden of disease increased substantially; the DALYs were 117,438 in Australia, 50,977 in the Philippines, and 16,379 in Singapore. Overall, YLL or premature death accounted for more than 95% of DALYs in these ***: Strategies for prevention, early diagnosis, and prompt treatment must be devised for diseases where the major burden is due to mortality.

关键词： Lung cancer DALY YLD YLL burden of disease DALY rate discount rate

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