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Hepatobiliary & Pancreatic Diseases International 2010年第1期9卷 27-32页

作者： praveen sharma Barjesh Chander sharma Shiv Kumar Sarin Department of Gastroenterology G.B.Pant Hospital

BACKGROUND:Minimal hepatic encephalopathy (MHE) impairs quality of life and predicts overt hepatic encephalopathy (HE) in cirrhotic *** of MHE requires cumbersome *** is effective in the treatment of *** study aimed to evaluate the use of critical flicker frequency (CFF) for the diagnosis of MHE in cirrhotic patients after ***:One hundred and ten patients were evaluated by psychometry (number connection tests A,B or figure connection tests A,B),P300 auditory event related potential (P300ERP),venous ammonia,and CFF for *** was diagnosed by abnormal psychometry (>2SD age matched controls) and *** patients were treated with lactulose for one *** was defined by normalization (<2SD of matched controls) of both psychometry and ***:Of the 110 patients [Child Turcott Pugh score A:B:C 39:42:29,(age 41.6±11.6 years,M:F 82:28)],75 (68%) had abnormal results of psychometric tests,and 74 (67%) had prolonged *** (20%) patients with abnormal results of psychometric tests had normal *** sixty (54.5%) patients were diagnosed as having *** treatment for one month,34 (57%) recovered while 26 (43%) continued to have abnormal resents of psychometric or P300ERP *** was <39 Hz in 72 (65.4%) patients before treatment and in 20 (33.3%) after *** sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy for the assessment of recovery of MHE were 65%,91%,85%,77% and 80%,***:CFF is a simple,relatively reliable,and accurate test without any dependence on age or literacy in the diagnosis and assessment of recovery of patients with MHE.

关键词： minimal hepatic encephalopathy critical flicker frequency lactulose

Identification and Validation of Reference Sites in the Andhi Khola River,Nepal

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Journal of Resources and Ecology 2015年第1期6卷 30-36页

作者： praveen sharma Subodh sharma Smriti GURUNG 加德满都大学理学院环境科学与工程系加德满都大学理学院水生生态学中心

Reference conditions having no or only minor anthropogenic disturbances, are a basic requirement for ecological studies in rivers. To study ecological impact of a dam, two sites were pre-classiifed as reference or least disturbed in the Andhi Khola River, Nepal, using Rapid Field Bioscreening （RFB） protocol. Biological （macroinvertebrates） and physico-chemical samples were collected in the month of January and February 2013. Multi-habitat sampling （MHS） was employed in sample collection of macro-invertebrates fauna. Validation of the pre-classiifed sites was done using several indices viz. Nepalese biotic score （NEPBIOS）, Biological monitoring working party （BMWP）, Hindu-Kush Himalayan biotic score （HKHBIOS）, Hilsenhoff （HILSENHOFF）＆ National Sanitation Foundation Water Quality Index （NSFWQI）. The NEPBIOS, HKHBIOS, HILSENHOFF, RFB ＆ NSFWQI indices predicted the river quality at al two sites as good with quality class Ⅱ. Only BMWP/ASPT water quality index predicted the river quality at al two sites as Excelent with quality class Ⅰ. Hence preselected sites with quality of rank Ⅱ i.e. good qualities were validated as reference sites. The study demonstrated that the multi-metric approach is suitable for application in the monitoring and assessment of rivers where dams are built to produce hydropower.

关键词： reference macro-invertebrates dams indices validation

Downregulation of miRNA-21 and cancer stem cells after chemotherapy results in better outcome in breast cancer patients

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World Journal of Stem Cells 2022年第4期14卷 310-313页

作者： Shailendra Dwivedi Puneet Pareek Jeewan Ram Vishnoi praveen sharma Sanjeev Misra Biochemistry All India Institute of Medical Sciences Gorakhpur IndiaGorakhpur 273008Uttar PradeshIndia Department of Radiation Oncology All India Institute of Medical SciencesJodhpur 342005RajasthanIndia Surgical Oncology All India Institute of Medical SciencesJodhpur 342005RajasthanIndia Department of Biochemistry All India Institute of Medical SciencesJodhpur 342005RajasthanIndia Department of Surgical Oncology All India Institute of Medical SciencesJodhpur 342005RajasthanIndia King George’s Medical University Lucknow 226003Uttar PradeshIndia

Epigenetic modifications have been observed as a decline in miRNA-21 expression and breast cancer stem cell(CSC)population after 3 cycles of standard *** epigenetic response(miRNAs expression)and CSCs are also correlated in patients with Breast *** patients who tolerated chemotherapy well,miRNA-21(non-coding RNA)expression decreased significantly after three cycles of *** miRNA-21 expression in breast cancer tissue was quantified by quantitative PCR(real-time PCR)using the standard *** addition,breast CSCs(CD44+/CD24-)were also decreased in these *** miRNA-21 regulates cell division,proliferation,and autophagy of cancerous cells(as it targets phosphatase and tensin homolog/AKT/transcription factor EB/programmed cell death 4/autophagy-related protein 5 and chemotherapy also produces similar effects),thereby contributing to these ***,when all of the targets on genes have been explored by mimic miRNA,chemotherapy combined with anti-miRNA21 therapy may prove useful in the care of cancer patients.

关键词： Epigenetic modification miRNA-21 Breast carcinoma Autophagy Chemotherapy Breast cancer stem cells

Performance of Non-invasive Blood Parameters for Ruling Out Significant Liver Fibrosis in Patients with Chronic Hepatitis B

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Journal of Clinical and Translational Hepatology 2020年第2期8卷 143-149页

作者： Shivam Khare Anil Arora praveen sharma Shashi Dhawan Naresh Bansal Vikas Singla Ashish Kumar Institute of Liver Gastroenterology&Pancreatico-Biliary SciencesSir Ganga Ram HospitalNew DelhiIndia Department of Histopathology Sir Ganga Ram HospitalNew DelhiIndia

Background and Aims:Evaluation of significant liver fibro-sis is important for treatment decision and treatment re-sponse evaluation in patients with chronic hepatitis B. Since liver biopsy is invasive and transient elastography (TE) has limited availability, various non-invasive blood parameters need evaluation for their capabilities for detection of signifi-cant fibrosis. Methods:In this retrospective study, records of patients who had undergone liver biopsy for treatment-na?ve chronic hepatitis B were evaluated to obtain various non-in-vasive blood parameters (aspartate aminotransferase-to-pla-telet ratio index [referred to as APRI], Fibrosis-4 score [referred to as FIB-4], gamma-glutamyl transpeptidase-to-platelet ratio [referred to as GPR], and gamma-glutamyl transpeptidase-to-albumin ratio [referred to as GAR]), in ad-dition to TE, to assess significant liver fibrosis and compare these to fibrosis stage in liver biopsy. Results:A total of 113 patients were included in the study (median age 33 [inter-quartile range: 11-82 years], 74% males). Most (75%) pa-tients were HBeAg-negative. The liver biopsy revealed significant fibrosis (Ishak ≥3) in 13% of the patients and nil or mild fibrosis (Ishak<3) in 87%of the patients. TE findings were available for 85 patients, APRI and FIB-4 for 95 patients, GPR for 79 patients, and GAR for 78 patients. The median values of all the parameters were significantly higher in pa-tients with significant fibrosis, as compared to patients with non-significant fibrosis, and all the blood parameters as well as TE were able to identify patients with significant fibrosis significantly well (p<0.05). All non-invasive parameters had low positive predictive value but negative predictive value above 92%. Compared to TE, all the non-invasive blood pa-rameters had similar area under the curve for detecting sig-nificant fibrosis, with excellent negative predictive value (≥93%). Conclusions: Non-invasive blood parameters (APRI, FIB-4, GPR, and G

关键词： Hepatitis B Liver fibrosis Cirrhosis Transient elastography APRI FIB-4 GPR GAR

Correlation of transient elastography with hepatic venous pressure gradient in patients with cirrhotic portal hypertension: A study of 326 patients from India

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World Journal of Gastroenterology 2017年第4期23卷 687-696页

作者： Ashish Kumar Noor Muhammad Khan Shrihari Anil Anikhindi praveen sharma Naresh Bansal Vikas Singla Anil Arora Institute of Liver Gastroenterologyand Pancreatico-Biliary SciencesGanga Ram Institute for Postgraduate Medical Education and ResearchSir Ganga Ram HospitalNew Delhi 110060India

AIMTo study the diagnostic accuracy of transient elastography (TE) for detecting clinically significant portal hypertension (CSPH) in Indian patients with cirrhotic portal *** retrospective study was conducted at the Institute of Liver, Gastroenterology, and Pancreatico-Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, on consecutive patients with cirrhosis greater than 15 years of age who underwent hepatic venous pressure gradient (HVPG) and TE from July 2011 to May 2016. Correlation between HVPG and TE was analyzed using the Spearman’s correlation test. Receiver operating characteristic (ROC) curves were prepared for determining the utility of TE in predicting various stages of portal hypertension. The best cut-off value of TE for the diagnosis of CSPH was obtained using the Youden *** study included 326 patients [median age 52 (range 16-90) years; 81% males]. The most common etiology of cirrhosis was cryptogenic (45%) followed by alcohol (34%). The median HVPG was 16.0 (range 1.5 to 30.5) mmHg. Eighty-five percent of patients had CSPH. A significant positive correlation was noted between TE and HVPG (rho 0.361, P < 0.001). The area under ROC curve for TE in predicting CSPH was 0.740 (95%CI: 0.662-0.818) (P < 0.01). A cut-off value of TE of 21.6 kPa best predicted CSPH with a positive predictive value (PPV) of 93%.CONCLUSIONTE has a fair positive correlation with HVPG; thus, TE can be used as a non-invasive modality to assess the degree of portal hypertension. A cut-off TE value of 21.6 kPa identifies CSPH with a PPV of 93%.

关键词： Portal hypertension Cirrhosis Clinically significant portal hypertension Liver stiffness Transient elastography FibroScan

Association of Overt Diabetes Mellitus with the Non-CC but not the CC Genotype of Interleukin-28B in Hepatitis C Virus Infected Patients

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Journal of Clinical and Translational Hepatology 2016年第1期4卷 26-31页

作者： Ashish Kumar Varun Gupta praveen sharma Naresh Bansal Vikas Singla Anil Arora Institute of Liver Gastroenterology & Panceatico-Biliary Sciences Sir Ganga Ram Hospital New Delhi India

Background:Interleukin-28B (IL-28B) polymorphism is an important predictor for hepatitis C virus (HCV) treatment *** IL-28b genotypes also influence other nontreatment related clinical parameters is ***:Patients with HCV-related chronic liver diseases who attended our department during 2012-2014 were retrospectively *** single nucleotide polymorphisms (SNPs) of rs12979860 (IL-28B) were correlated with various clinical *** also compared these parameters in patients with and without overt diabetes to identify possible ***:A total of 115 patients were included (median age 48,range 15-76 years;70% males).Overall,43/115(37%) patients had chronic hepatitis,while the remaining 72/115 (63%) had *** most common IL-28B genotype was CC,which was found in 53% of patients (61/115),while the remaining 47% were nonCC [CT 42% (48/115) and T-r 5% (6/115)].Clinical and laboratory parameters like Hb,white blood cell (WBC),platelets,bilirubin,transaminases,and albumin were similar in the CC and nonCC *** diabetes mellitus was present in 22% (25/115) of *** with nonCC genotype had significantly higher prevalence of overt diabetes mellitus than patients with CC genotype (31% [17/54] versus 13% [8/61];p < 0.05).When parameters were compared in patients with and without overt diabetes mellitus,only IL-28B and age were significantly associated with overt diabetes mellitus (p < 0.05).Conclusion:In HCV patients,overt diabetes mellitus was more commonly associated with the nonCC genotype of IL-28B than the CC *** of the T-allele of SNP rs12979860 were more likely to have insulin resistance than CC homozygotes,and this finding may explain the higher prevalence of diabetes in non-CC ***,an IL-28B test may be useful in patients of HCV in order to determine their likelihood of developing diabetes mellitus.

关键词： Chronic hepatitis C Diabetes mellitus Cirrhosis IL-28B Chronic liver disease Insulin resistance

On the Stationary Convection of Thermohaline Problems of Veronis and Stern Types

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Applied Mathematics 2010年第5期1卷 400-405页

作者： Joginder S. Dhiman praveen K. sharma Poonam sharma 不详

The stability of thermohaline convection problems of Veronis and Stern types for stationary convection is studied for quite general nature of boundaries. It is shown by means of an appropriately chosen linear transformation, that in case of stationary convection the equations describing the eigenvalue problem for thermohaline convection problems are identical to equations describing the eigenvalue problem for classical Bénard convection problem. As a consequence, the values of the critical Rayleigh numbers for the onset of stationary convection in thermohaline convection problems are obtained. Also, necessary conditions for the validity of principle of exchange of stabilities for thermohaline convection problems are derived using variational principle.

关键词： Thermohaline Convection Stationary Convection Eigenvalue Problem Principle of Exchange of Stabilities Rayleigh Number

马蹄花叶提取物在雄性白化病小鼠体内的抗炎作用(英文)

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中国天然药物 2013年第5期11卷 472-476页

作者： Sachin Jain praveen sharma Santosh Ghule Ankit Jain Nitesh Jain College of Pharmacy IPS AcademyRajendra NagarAB RoadIndore MP India 452012 Department of Pharmacy Oriental University

AIM:To study the in vivo anti-inflammatory activity of Tabernaemontana divaricata leaf extract on male albino ***:Aqueous decoction and methanol leaf extracts were tested for their ability to reduce croton oil-induced edema in the mouse ear after topical *** methanol leaf extract dose-dependently inhibited the croton oil-induced ear edema in mice(ID50<500μg·cm 2).A bioassay-guided liquid–liquid fractionation of this methanol extract gave four active fractions:water insoluble(F1),hexane(F2),ethyl acetate(F3)and water(F4).RESULTS:The hexane fraction showed a very high activity(42.1%inhibition at0.7μg·cm 2)as compared to the *** other fractions were less active(F1:56.1%at 506.2μg·cm-2;F3:57.3%at 289.3μg·cm 2;and F4:31.9%for 203.8μg·cm 2)while indomethacin gave 48.8%of inhibition at 90μg·cm *** activity of F1 and F3 may be at least in part explained by the presence of anti-inflammatory flavonoids,while the activity was not correlated to the tannin *** compounds were detected in the most active F2 ***:The results give a rational support to the traditional use of *** in tropical India as anti-inflammatory agent.

关键词： Tabernaemontana divaricata Anti-inflammatory Mouse ear edema Quercitrin Plant extract Traditional medicine

Convective stability analysis of a micropolar fluid layer by variational method

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Theoretical & Applied Mechanics Letters 2011年第4期1卷 47-52页

作者： Joginder S.Dhiman praveen K.sharma Gurdeep Singh Department of Mathematics Himachal Pradesh UniversityShimla 171005India

This paper studies Rayleigh-B’enard convection of micropolar fluid layer heated from below with realistic boundary conditions.A specific approach for stability analysis of a convective problem based on variational principle is applied to characterize the Rayleigh number for quite general nature of bounding *** analysis consists of replacing the set of field equations by a variational principle and the expressions for Rayleigh number are then obtained by using trial function satisfying the essential boundary ***,the values of the Rayleigh number for particular cases of large and small values of the microrotation coefficient have been *** effects of wave number and micropolar parameter on the Rayleigh numbers for onset of stationary instability for each possible combination of the bounding surfaces are discussed and illustrated *** present analysis establishes that the nature of bounding surfaces combination and microrotation have significant effect on the onset of convection.

关键词： critical Rayleigh number Rayleigh-B'enard convection micropolar fluid eigenvalue problem variational principle

Deep Learning-Based Speech Emotion Recognition: Leveraging Diverse Datasets and Augmentation Techniques for Robust Modeling

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Journal of Harbin Institute of Technology(New series) 2024年

作者： Ayush Porwal praveen Kumar Tyagi Ajay sharma Dheeraj Kumar Agarwal Department of Electronics and Instrumentation Engineering， Shri G.S.Institute of Technology and Science Department of Electronics and Communication Engineering， Maulana Azad National Institute of Technology School of Computing Science and Engineering， VIT Bhopal University

In recent years， Speech Emotion Recognition (SER) has developed into an essential instrument for interpreting human emotions from auditory data. The proposed research focused on the development of a SER system employing deep learning and multiple datasets containing samples of emotive speech. The primary objective of this research endeavor is to investigate the utilization of Convolutional Neural Networks (CNNs) in the process of sound feature extraction. Stretching， pitch manipulation， and noise injection are a few of the techniques utilized in this study to improve the data quality. The investigation includes coverage of these methods. Feature extraction methods including Zero Crossing Rate， Chroma＿stft， MFCC， RMS， and MelSpectogram are used to train a model. By using these techniques， audio signals can be transformed into recognized features that can be utilized to train the model. Ultimately， the study will produce a thorough evaluation of the model’s performance. When this method was applied， the model achieved an impressive accuracy of 94.57% on the test dataset. Proposed work also validated on EMO-BD and IEMOCAP dataset. These consist of further data augmentation， feature engineering， and hyperparameter optimization. By following these development paths， SER systems will be able to be implemented in real-world scenarios with greater accuracy and resilience.

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