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Genes linked to obesity-related infertility:bridging the knowledge gap

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Reproductive and Developmental Medicine 2024年第2期8卷 121-129页

作者： praveen Kumar Chandra Sekar Ramakrishnan Veerabathiran Human Cytogenetics and Genomics Laboratory Faculty of Allied Health SciencesChettinad Academy of Research and EducationKelambakkamTamil Nadu 603103India

Genetic factors play a pivotal role in the complex relationship between obesity and *** article delves into the genetics of obesity-related infertility,focusing on the essential genes and mechanisms in both *** explored infertility factors in obese females,focusing on polycystic ovary syndrome(PCOS)and the influence of genes like insulin receptor(INSR),androgen receptor(AR),and follicle-stimulating hormone receptor(FSHR).Epigenetic changes are believed to contribute to PCOS-related *** impact of adipokines and inflammation on obesity-related infertility has been discussed,with genes such as fat mass and obesity(FTO)and melanocortin-4-receptor(MC4R)playing significant *** factors affecting sperm quality and function,including nuclear receptor subfamily 3 group C member 1(NR3C1)and methylenetetrahydrofolate reductase(MTHFR),have been investigated in obesity-related infertility in *** dysregulation influenced by genetic markers,such as leptin receptor(LEPR),tumor necrosis factor-alpha(TNF-α),and interleukin-6(IL-6),was also *** factors play a vital role in obesity-related infertility in both *** involved in metabolism,hormonal regulation,and inflammation contribute to the complex association between obesity and *** changes further complicate the *** these genetic mechanisms is essential to address obesity-related infertility and develop personalized interventions.

关键词： Obesity Infertility PCOS DNA methylation Epigenetics

DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice

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Genes & Diseases 2024年第4期11卷 368-380页

作者： Dafei Chai Xu Wang praveen Neeli Shan Zhou Xingfang Yu Kanaga Sabapathy Yong Li Department of Medicine Section of Epidemiology and Population SciencesDan L Duncan Comprehensive Cancer CenterBaylor College of MedicineHoustonTX 77030USA Division of Cellular&Molecular Research Humphrey Oei Institute of Cancer ResearchNational Cancer Centre SingaporeSingapore 168583Singapore

tThe tumor suppressor p53 is the most common mutated gene in cancer,with the R175H as the most frequent p53 missense ***,there are currently no approved targeted therapies or immunotherapies against mutant ***,we characterized and inves-tigated a monoclonal antibody(mAb)that recognizes the mutant p53-R175H for its affinity,specificity,and activity against tumor cells in *** then delivered DNA plasmids expres-sing the anti-R175H mAb or a bispecific antibody(BsAb)into mice to evaluate their therapeutic *** results showed that the anti-R175H mAb specifically bound to the p53-R175H an-tigen with a high affinity and recognized the human mutant p53-R175H antigen expressed on HEK293T or MC38 cells,with no cross-reactivity with wild-type *** cultured cells,the anti-R175H mAb showed higher cytotoxicity than the control but did not induce antibody-dependent cellular *** made a recombinant MC38 mouse cell line(MC38-p53-R175H)that overexpressed the human p53-R175H after knocking out the endogenous mutant p53 *** vivo,administration of the anti-R175H mAb plasmid elicited a robust anti-tumor effect against MC38-p53-R175H in *** administration of the anti-R175H BsAb plasmid showed no therapeutic effects,yet potent anti-tumor activity was observed in combination with the anti-PD-1 *** results indicate that targeting specific mutant epitopes using DNA-delivered mAbs or BsAbs presents a form of improved natural immunity derived from tumor-infiltrating B cells and plasma cells against intracellular tumor antigens.

关键词： BsAb Cytotoxicity mAb Mutant p53 PD-1 R175H

A Novel Multi-objective Protection Coordination Scheme for a Microgrid with Optimal Deployment of Dual-setting ROCOV Based Relays

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Protection and Control of Modern Power Systems 2024年第4期9卷 23-38页

作者： praveen Kumar Gupta Priyanshul Niranjan Niraj Kumar Choudhary Nitin Singh Ravindra Kumar Singh the Department of Electrical Engineering Motilal Nehru National Institute of Technology AllahabadPrayagraj 211004India

Relay coordination is crucial in electrical power systems to protect against malfunctions and damage caused by unexpected events like short *** address the challenge associated with the reverse direction of fault current,dual-setting(DS)directional over-current relays have evolved but failed to provide proper coordination during changes of load,generation,and *** the meantime,with the increasing number of DS relays,the total relay operating time tends to ***,this paper proposes a protection scheme based on the optimal deployment of conventional and dual-setting rate of change of voltage(DS-ROCOV)relays in distribution *** holds true for varying network topologies and is unaffected by variations in load and *** objective of the proposed scheme is to ensure reliable and efficient protection against faults in distribution systems by minimizing the overall operating time with the optimal number of DS-ROCOV *** proposed protection scheme’s performance is evaluated for different coordination time interval values as well as in different microgrid *** paper outlines the design and implementation of the proposed protection scheme which is validated on the modified IEEE 14-bus system using simulations in Matlab/Simulink.

关键词： Coordination time interval DS-ROCOV relay multi-objective optimization optimal-deployment protection coordination

Severe acute kidney injury due to oxalate crystal induced severe interstitial nephritis:A case report

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World Journal of Nephrology 2024年第2期13卷 24-30页

作者： Maulik K Lathiya praveen Errabelli Sasmit Roy Neeharik Mareedu Department of Emergency Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Centra Lynchburg General HospitalLynchburgVA 24551United States Department of Nephrology UPMC Western MarylandCumberlandMD 21502United States

BACKGROUND Acute kidney injury(AKI)due to interstitial nephritis is a known condition primarily attributed to various *** medication-induced interstitial nephritis is common,occurrences due to non-pharmacological factors are *** report presents a case of severe AKI triggered by intratubular oxalate crystal deposition,leading to interstitial *** aim is to outline the case and its management,emphasizing the significance of recognizing uncommon causes of interstitial *** SUMMARY A 71-year-old female presented with stroke-like symptoms,including weakness,speech difficulties,and cognitive *** hypertension had been managed with hydrochlorothiazide(HCTZ)for over two *** admis-sion,severe hypokalemia and AKI were noted,prompting discontinuation of HCTZ and initiation of prednisolone for acute interstitial *** investigations,including kidney biopsy,confirmed severe acute interstitial nephritis with oxalate crystal deposits as the underlying *** treatment,initial renal function showed minimal ***,with prednisolone therapy and supportive measures,her condition gradually improved,high-lighting the importance of comprehensive *** This case underscores the importance of a thorough diagnostic approach in identifying and addressing uncommon causes of interstitial *** occurrence of interstitial nephritis due to oxalate crystal deposition,especially without typical risk factors,emphasizes the need for vigilance in clinical practice.

关键词： Acute kidney injury Interstitial nephritis Oxalate crystal Hydrochlorothiazide Hypokalemia Case report

Improving hydrogen evolution reaction efficiency through lattice tuning

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Nano Research 2024年第7期17卷 5907-5913页

作者： Zipeng Zhao Haotian Liu Wenpei Gao praveen Kolla Wang Xue Zeyan Liu Jinghua Guo Sanjeev Mukerjee Xiaoqing Pan Qingying Jia Xiangfeng Duan Yu Huang Department of Materials Science and Engineering University of CaliforniaLos AngelesCalifornia 90095USA Department of Chemical Engineering and Materials Science University of CaliforniaIrvineCalifornia 92697USA Materials Science and Engineering North Carolina State UniversityRaleighNorth Carolina 27695USA Department of Chemistry and Chemical Biology Northeastern UniversityBostonMassachusetts 02115USA Department of Chemistry and Biochemistry University of CaliforniaLos AngelesCalifornia 90095USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720USA Department of Chemistry and Biochemistry University of CaliforniaSanta CruzCalifornia 95064USA Department of Physics and Astronomy University of CaliforniaIrvineCalifornia 92697USA California Nanosystems Institute University of CaliforniaLos AngelesCalifornia 90095USA

The intermittent nature of renewable energy sources sets a requirement for efficient energy storage to mitigate the conflict between energy supply and *** is a promising choice for energy storage due to its high energy ***,the conversion of electrical energy to chemical energy stored in hydrogen through water electrolysis suffers from low efficiency,and the electricity cost dominates the total cost of hydrogen ***,we report the study of improving the hydrogen evolution reaction activity of Pt-based catalysts by building a nanoscale surface NiO and Pt interface,further optimizing the performance via tuning the lattice parameter of the core of nanoparticles,which can be achieved by varying the dealloying annealing *** optimized PtCuNi-O/C and PtNi-O/C catalysts are demonstrated to be one of the best catalysts,with a mass activity(MA)of 9.1 and 8.7 mA/μgPt,which is 9.9-fold and 9.5-fold of that of Pt/C,respectively.

关键词： lattice tuning Pt-based catalyst hydrogen evolution reaction electrocatalysis

Quality indicators in respiratory therapy

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World Journal of Critical Care Medicine 2024年第2期13卷 116-125页

作者： Manjush Karthika Sureshkumar Vanajakshy Kumaran praveen Beekanahaali Mokshanatha Research and Innovation Council Srinivas Institute of Medical Sciences and Research CenterSrinivas UniversityMangalore 574146India Department of Health and Medical Sciences Liwa CollegeAbu DhabiUnited Arab Emirates Healthcare Management Tata Institute of Social SciencesMumbai 400088India Medical Administration NS Memorial Institute of Medical SciencesKollam 691020India Research and Innovation Council Srinivas UniversityMangalore 574146India

Quality indicators in healthcare refer to measurable and quantifiable parameters used to assess and monitor the performance,effectiveness,and safety of healthcare *** indicators provide a systematic way to evaluate the quality of care offered,and thereby to identify areas for improvement and to ensure that patient care meets established standards and best *** therapists play a vital role in areas of clinical administration such as infection control practices and quality improvement *** indicators serve as essential metrics for respiratory therapy departments to assess and enhance the overall quality of *** systematically tracking and analyzing indicators related to infection control,treatment effectiveness,and adherence to protocols,respiratory care practitioners can identify areas to improve and implement evidence-based *** article reviewed how to identify,implement,and monitor quality indicators specific to the respiratory therapy departments to set benchmarks and enhance patient outcomes.

关键词： Healthcare Quality indicators Structure Process Outcome Respiratory therapy Department Respiratory therapists

Analysis and Review of Downregulated Actin Cytoskeletal Proteins in Non-Small Cell Lung Cancer

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Journal of Biosciences and Medicines 2024年第4期12卷 89-115页

作者： Hala M. Abdel Mageed praveen Sahu Raji Sundararajan School of Engineering Technology Purdue University West Lafayette USA National Institute of Standards Al Haram Egypt

Actin, a highly conserved protein, plays a dominant role in Non-small cell lung cancer (NSCLC). Late diagnosis and the aggressive nature of NSCLC pose a significant threat. Studying the clinic pathological properties of NSCLC proteins is a potential alternative for developing treatment strategies. Towards this, 35 downregulated actin cytoskeletal proteins on NSCLC prognosis and treatment were studied by examining their protein-protein interactions, gene ontology enrichment terms, and signaling pathways. Using PubMed, various proteins in NSCLC were identified. The protein-protein interactions and functional associations of these proteins were examined using the STRING database. The focal adhesion signaling pathway was selected from all available KEGG and Wiki pathways because of its role in regulating gene expression, facilitating cell movement and reproduction, and significantly impacting NSCLC. The protein-protein interaction network of the 35 downregulated actin cytoskeleton proteins revealed that ACTG1, ACTR2, ACTR3, ANXA2, ARPC4, FLNA, TLN1, CALD1, MYL6, MYH9, MYH10, TPM1, TPM3, TPM4, PFN1, IQGAP1, MSN, and ZXY exhibited the highest number of interactions. Whereas HSPB1, CTNNA1, KRT17, KRT7, FLNB, SEPT2, and TUBA1B displayed medium interactions, while UTRN, TUBA1B, and DUSP23 had relatively fewer interactions. It was discovered that focal adhesions are critical in connecting membrane receptors with the actin cytoskeleton. In addition, protein kinases, phosphatases, and adapter proteins were identified as key signaling molecules in this process, greatly influencing cell shape, motility, and gene expression. Our analysis shows that the focal adhesion pathway plays a crucial role in NSCLC and is essential for developing effective treatment strategies and improving patient outcomes.

关键词： Non-Small Cell Lung Cancer NSCLC Actin Actin Cytoskeletal Proteins Focal Adhesion KEEG Pathway

Deep Learning-Based Speech Emotion Recognition: Leveraging Diverse Datasets and Augmentation Techniques for Robust Modeling

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Journal of Harbin Institute of Technology(New series) 2024年

作者： Ayush Porwal praveen Kumar Tyagi Ajay Sharma Dheeraj Kumar Agarwal Department of Electronics and Instrumentation Engineering Shri G.S.Institute of Technology and Science Department of Electronics and Communication Engineering Maulana Azad National Institute of Technology School of Computing Science and Engineering VIT Bhopal University

In recent years， Speech Emotion Recognition (SER) has developed into an essential instrument for interpreting human emotions from auditory data. The proposed research focused on the development of a SER system employing deep learning and multiple datasets containing samples of emotive speech. The primary objective of this research endeavor is to investigate the utilization of Convolutional Neural Networks (CNNs) in the process of sound feature extraction. Stretching， pitch manipulation， and noise injection are a few of the techniques utilized in this study to improve the data quality. The investigation includes coverage of these methods. Feature extraction methods including Zero Crossing Rate， Chroma＿stft， MFCC， RMS， and MelSpectogram are used to train a model. By using these techniques， audio signals can be transformed into recognized features that can be utilized to train the model. Ultimately， the study will produce a thorough evaluation of the model’s performance. When this method was applied， the model achieved an impressive accuracy of 94.57% on the test dataset. Proposed work also validated on EMO-BD and IEMOCAP dataset. These consist of further data augmentation， feature engineering， and hyperparameter optimization. By following these development paths， SER systems will be able to be implemented in real-world scenarios with greater accuracy and resilience.

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Cardiac implications in myasthenia gravis

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World Journal of Clinical Cases 2024年第26期12卷 5863-5867页

作者： praveen Reddy Elmati Gowthami Sai Kogilathota Jagirdhar Salim Surani Department of Anesthesiology Saint Clair HospitalDoverNJ 07801United States Department of Medicine Saint Michaels Medical CenterNewarkNJ 07107United States Department of Medicine and Pharmacology Texas A&M UniversityCollege StationTX 77843United States

This editorial aimed to consolidate the current evidence in literature on the association between myasthenia gravis(MG)and cardiac involvement,focusing on the impact of thymoma,antistriational antibodies,and late-onset ***,the study aimed to explore the influence of genetic differences among populations on the association with cardiac *** conducted a review of existing literature in PubMed and Google Scholar to find relevant studies on cardiac involvement in *** created search criteria using a combination of free text words,including MG,antistriational antibodies,thymectomy,cardiomyopathy,myocarditis,arrhythmias,autonomic *** articles published in English language were analyzed and *** findings indicate a strong association between thymoma,myasthenic crisis,antistriational antibodies,and late-onset MG with cardiac *** study also revealed that genetic differences among populations influence the risk of cardiac disease and electrocardiography(ECG)abnormalities in MG *** dysfunctions altered cardiac autonomic response and increased susceptibility to arrhythmias and sudden cardiac death in MG *** study supports the significance of thymoma,antistriational antibodies,and late-onset MG as key factors associated with cardiac involvement in MG *** emphasizes the importance of ECG as the initial test in managing MG patients,particularly in the perioperative period,to identify and genetic testing if needed to address their cardiac risk effectively.

关键词： Myasthenia gravis Antistriational antibodies Thymectomy Cardiomyopathy Myocarditis Arrhythmias Autonomic dysfunction