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Study of hsCRP, adiponectin, NF-κB in low bodyweight, standard bodyweight and obese subjects with type 2 diabetes mellitus in India

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Journal of Diabetes Mellitus 2012年第4期2卷 386-392页

作者： Sidhartha Das Durga Prasanna Misra pratima kumari sahu Department of Biochemistry Sriram Chandra Bhanj Medical College Cuttack India Department of Medicine Sriram Chandra Bhanj Medical College Cuttack India

Introduction: Low bodyweight type 2 DM is a distinct clinical entity having many inherent peculiarities seen in India and developing countries, constituting 11% to 25% of type 2 diabetic subjects. Our study aimed at assessing the prevalence of inflammatory markers like hsCRP, adiponectin and NF-κB expression in peripheral blood mononuclear cells in subjects with type 2 DM in relation to BMI. Materials and Methods: 57 consecutive type 2 diabetics were recruited for study, classified as Low Bodyweight (A = BMI < 18.5), Standard weight (B = BMI 18.5 - 24.99) and Obese (C = BMI ≥ 25). Group D comprised 14 healthy controls. They were evaluated for clinical parameters, FBG, 2hrPPBG, HbA1c, lipid profile and above mentioned inflammatory markers. Results: Serum hsCRP was significantly higher in all group of diabetics as compared to Group D but was lowest in Group A. Adiponectin levels were highest in Group D, similar in Groups B and C but lowest in Group A. NF-κB expression, though higher in diabetic subjects than controls (OD = 0.041 ± 0.006), was least in Group A (OD = 0.045 ± 0.005). Discussion and Conclusion: Our study revealed that Indians with type 2DM are in a pro-inflamematory state. Low bodyweight type 2 diabetics had the least pro-inflammatory load. This further supported the earlier observation of lesser macrovascular disease load and testifying that Low Bodyweight type2DM constitutes a distinct entity.

关键词： Low Bodyweight Type 2 DM hsCRP NF-κB Adiponectin

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Removal of Chromium(III) from the Waste Solution of an Indian Tannery by Amberlite IR 120 Resin

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International Journal of Nonferrous Metallurgy 2012年第3期1卷 32-41页

作者： pratima Meshram Sushanta Kumar sahu Banshi Dhar Pandey Vinay Kumar Tilak Raj Mankhand Department of Metallurgical Engineering IIT BHU Varanasi India Metal Extraction & Forming Division CSIR-National Metallurgical Laboratory Jamshedpur India

The extraction of chromium(III) from a model waste solution and also from a waste solution of an Indian tannery with Amberlite IR 120 resin is described, and the performance of this resin is compared with other similar resins. The parameters that were optimized include effect of mixing time, pH, loading and elution behaviours of chromium(III) for this resin. Sorption of chromium(III) on Amberlite IR 120 followed Freundlich isotherm and Langmuir isotherm model, and the maximum sorption capacity was determined to be 142.86 mg Cr(III)/g of the resin. Higher Freundlich constant (Kf) values (6.30 and 13.46 for aqueous feed of 500 and 1000 ppm Cr(III)) indicated strong chemical interaction through ion exchange mechanism of the metal ion with the resin. The kinetic data showed good fit to the Lagergren first order model for extraction of chromium(III). Desorption of chromium(III) from the loaded resin increased with the increase in concentration of eluent (5-20% H2SO4). With 20% (v/v) sulphuric acid solution 94% chromium(III) was eluted in three stages. Elution of the Cr(III) in the column experiments was however, found to be lower (82%) than that of the shake flask data. In case of Indian tannery’s waste solution, it was observed that almost total chromium was extracted in four stages with Amberlite IR 120.

关键词： Chromium(III) Ion exchange Amberlite IR 120 Tannery Waste Solution

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