检索结果-南通市图书馆

Comparison of efficacy of metformin and D-chiro-inositol on clinical biomarkers in patients with polycystic ovarian syndrome:an open label study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Health Journal 2023年第3期7卷 147-152页

作者： Gaurika Aggarwal Shikha Gupta Ojus Sardana Harleen pratima kumari Rupinder Kaur Thakur Gurjeet Singh Amit Sharma Ravinder Singh Neelam Hospital Near Chitkara UniversityRajpuraPunjab 140401India Department of Pharmacy Practice Chitkara College of PharmacyChitkara UniversityRajpuraPunjab 140401India Department of Pharmacy Practice ISF College of PharmacyMogaPunjab 142001India

Objective:Polycystic ovary syndrome(Pcos)is a pathophysiological disorder affecting reproductive and metabolic indices in *** present study was designed to compare the efficacy of metformin and D-chiroinositol in PcoS ***:In a tertiary care hospital in North India,prospective observational research was undertaken on 1o0 patients with PCOS,which was diagnosed based on European Society of Human Reproduction and Embryology Guidelines and ultrasound of lower *** study involves various clinical characteristics into consideration for the determination of statistical significance(P<0.05)in PCOS ***'s t-test along with the association between PCOS and patients taking metformin and D-chiro-inositol,as well as their impact on various biochemical parameters,were investigated finally using Pearson Correlation ***:This study comprises 50 patients taking metformin and 50 patients taking D-chiro-inositol in women suffering from *** mass index(BMI)and waist-to-hip ratio(WHR)were statistically significant(P<0.05)within the groups of both metformin and *** parameters such as luteinizing hormone(LH),follicle stimulating hormone(FSH),anti-mullerian hormone(AMH)and glycated hemoglobin(HbA1c)were found to be statistically significant(P<0.05)in both ***,FSH and AMH(14.40±0.52;14.28±0.53;1.99±0.10)were comparatively lower in patients taking D-chiro-inositol as compared to metformin group(14.17±0.42;19.88±1.01;2.61±0.04).HbA1c(3.71±0.08)with P<0.05 was found to be decreased more in metformin group as compared to patients taking D-chiro-inositol(4.90±0.09).A positive correlation was found between HbAlc and LH in metformin,&HbAlc and FSH in D-chiro-inositol groups,***:The results indicate that D-chiro-inositol shows better results in reducing clinical variables involved in causing PCOS as compared to metformin whereas metformin has better glycemic control in PCOS patients.

关键词： PCOS Metformin D-chiro-inositol HbA1c Correlation

Study of hsCRP, adiponectin, NF-κB in low bodyweight, standard bodyweight and obese subjects with type 2 diabetes mellitus in India

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Diabetes Mellitus 2012年第4期2卷 386-392页

作者： Sidhartha Das Durga Prasanna Misra pratima kumari Sahu Department of Biochemistry Sriram Chandra Bhanj Medical College Cuttack India Department of Medicine Sriram Chandra Bhanj Medical College Cuttack India

Introduction: Low bodyweight type 2 DM is a distinct clinical entity having many inherent peculiarities seen in India and developing countries, constituting 11% to 25% of type 2 diabetic subjects. Our study aimed at assessing the prevalence of inflammatory markers like hsCRP, adiponectin and NF-κB expression in peripheral blood mononuclear cells in subjects with type 2 DM in relation to BMI. Materials and Methods: 57 consecutive type 2 diabetics were recruited for study, classified as Low Bodyweight (A = BMI < 18.5), Standard weight (B = BMI 18.5 - 24.99) and Obese (C = BMI ≥ 25). Group D comprised 14 healthy controls. They were evaluated for clinical parameters, FBG, 2hrPPBG, HbA1c, lipid profile and above mentioned inflammatory markers. Results: Serum hsCRP was significantly higher in all group of diabetics as compared to Group D but was lowest in Group A. Adiponectin levels were highest in Group D, similar in Groups B and C but lowest in Group A. NF-κB expression, though higher in diabetic subjects than controls (OD = 0.041 ± 0.006), was least in Group A (OD = 0.045 ± 0.005). Discussion and Conclusion: Our study revealed that Indians with type 2DM are in a pro-inflamematory state. Low bodyweight type 2 diabetics had the least pro-inflammatory load. This further supported the earlier observation of lesser macrovascular disease load and testifying that Low Bodyweight type2DM constitutes a distinct entity.

关键词： Low Bodyweight Type 2 DM hsCRP NF-κB Adiponectin

Purification, characterization and evaluation of insecticidal activity of trypsin inhibitor from Albizia lebbeck seeds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2012年第1期23卷 131-137页

作者： pratima Sharma Amarjit K Nath Reena kumari SV Bhardwaj Department of Biotechnology UHFNauniSolanIndia

A Bowman-Birk inhibitor with activity against gut proteases of Helicoverpa armigera was extracted in 0.I M sodium phosphate buffer from defatted seed flour of Albizia lebbeck. It was purified to 29.62 folds with 51.43% recovery using ammonium sulfate precipitation, gel filtration chromatography on Sephadex G-100 column and ion ex- change chromatography on DEAE-Sephadex As0. The purified protein had a molecular weight of 12,303 daltons as determined by SDS-PAGE. It was found to be heat stable up to 60~C and had two pH optima of 7.5 and 9.0. The inhibitor exhibited non-competitive pattern of inhibition with a low Ki value of 0.2 ~tM. The inhibitoi- was found to be susceptible to varying concentrations of reducing agents like DTT and 2- mercaptoethanol, thereby indicating the role of disulphide bridges in maintaining its three dimensional structure and stability. The purified inhibitor caused mortality and suppressed larval growth ofPieris brassi- cae larvae. It was also found to be effective against gut trypsin extracted from Spodoptera littoralis. The sequence of the genes encoding for such inhibitors can be determined and the genes expressing protease inhibitors can be used in vegetable crops to confer resistance against insect pests and other plant pathogens.

关键词： Albizia lebbeck trypsin inhibitor insecticidal activity purifi-cation Pieris brassicae

Essential role of monocytes and macrophages in the progression of acute pancreatitis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第32期16卷 3995-4002页

作者： pratima Shrivastava Madhav Bhatia Department of Pharmacology National University of SingaporeSingapore 117597Singapore Department of Pathology University of OtagoChristchurch 8140New Zealand

Acute pancreatitis(AP) is an inflammatory condition of the pancreas caused by an imbalance in factors involved in maintaining cellular *** events in AP occur within acinar cells accompanied by other principal contributors to the inflammatory response *** endothelial cells,immunocytes(granulocytes,monocytes/macrophages,lymphocytes) and ***/macrophages are important inflammatory mediators,involved in the pathophysiology of AP,known to reside in the peritoneal cavity(in the vicinity of the pancreas) and in peripancreatic *** studies suggested that impaired clearance of injured acini by macrophages is associated with an altered cytokine reaction which may constitute a basis for progression of *** review focuses on the role of monocytes/macrophages in progression of AP and discusses f indings on the inflammatory process involved.

关键词： Acute pancreatitis Monocytes Peritoneal macrophages Alveolar macrophages Kupffer cells

Glacier-Glacial Lake Interactions and Glacial Lake Development in the Central Himalaya,India(1994–2017)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Earth Science 2021年第6期32卷 1563-1574页

作者： pratima Pandey Sheikh Nawaz Ali Prashant Kumar Champati Ray Indian Institute of Remote Sensing DehradunIndia Birbal Sahni Institute of Palaeosciences LucknowIndia

Despite several regional glacier and glacier lake inventories, the relationship between receding glacier, glacial lake evolution(glacial-lake interactions) and their sensitivity to different forcing factors have not been properly understood yet. To better understand these processes, we used satellite images collected in 1994, 2015 and 2017 to monitor the spatially-explicit evolution of glacial lakes and glacier changes. The results show a total of 1 353 glacial lakes covering an area of 7.96 km;in the year 2015. Out of these, a total of 137 glacial lakes having an area of >0.01 km;and located within 2 km periphery of mother glacier have been selected for the monitoring of spatial development between 1994 and 2017. We found an increase in the total lake area from ~4.9 to ~7.73 km;between 1994 and 2017,corresponding to an overall expansion of ~57%. The total area covered by the glaciers associated with these lakes reduced from ~365 km;in 1994 to ~358 km^(2) in 2017, accounting for a glacier loss of ~7 km^(2) and corresponding to ~1.92% reduction. Our study results are in agreement with global glacier behavior, revealing a rapid glacier recession and accelerated glacial lake expansion under an unprecedented climate change scenario. In addition, the results suggest a significant reduction in the glacier area and a close relationship between the glacier melting and lake changes.

关键词： glacial lake expansion glacier change glacier-lake interaction Central Himalaya climate

Characterization of Black Carbon in the Ambient Air of Agra,India:Seasonal Variation and Meteorological Influence

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2017年第9期34卷 1082-1094页

作者： pratima GUPTA Shalendra Pratap SINGH Ashok JANGID Ranjit KUMAR Department of Chemistry Faculty of ScienceDayalbagh Educational Institute (Deemed University) Department of Physics and Computer Science Faculty of ScienceDayalbagh Educational Institute (Deemed University)

This study characterizes the black carbon in Agra, India home to the Taj Mahal--and situated in the lndo-Gangetic basin. The mean black carbon concentration is 9.5 μg m-3 and, owing to excessive biomass/fossil fuel combustion and automobile emissions, the concentration varies considerably. Seasonally, the black carbon mass concentration is highest in winter, probably due to the increased fossil fuel consumption for heating and cooking, apart from a low boundary layer. The nocturnal peak rises prominently in winter, when the use of domestic heating is excessive. Meanwhile, the concentration is lowest during the monsoon season because of the turbulent atmospheric conditions and the process of washout by precipitation. The ratio of black carbon to brown carbon is less than unity during the entire study period, except in winter （December）. This may be because that biomass combustion and diesel exhaust are major black carbon contributors in this region, while a higher ratio in winter may be due to the increased consumption of fossil fuel and wood for heating purposes. ANOVA reveals significant monthly variation in the concentration of black carbon; plus, it is negatively correlated with wind speed and temperature. A high black carbon mass concentration is observed at moderate （1-2 m s-1） wind speed, as compared to calm or turbulent atmospheric conditions.

关键词： black carbon aerosol seasonal variation diurnal variation meteorological parameter,

Three-dimensional aspects of formulation excipients in drug discovery:a critical assessment on orphan excipients,matrix effects and drug interactions

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2020年第6期10卷 522-531页

作者： Vijayabhaskar Veeravalli Hanumanth Srikanth Cheruvu pratima Srivastava Lakshmi Mohan Vamsi Madgula Syngene International Limited Biocon ParkSEZBommasandra Industrial Area-Phase-IV Bommasandra-Jigani Link RoadBangalore560099India GVK BIO Pvt Ltd NacharamHyderabadTelangana500076India

Formulation/pharmaceutical excipients play a major role in formulating drug candidates,with the objectives of ease of administration,targeted delivery and complete *** excipients used in pharmaceutical formulations are orphanized in preclinical drug *** orphan excipients could enhance formulatability of highly lipophilic ***,they are safe in preclinical species when used below the LD50 ***,when the excipients are used in formulating compounds with diverse physico-chemical properties,they pose challenges by modulating study results through their bioanalytical matrix *** invariably present in study samples and not in the calibration curve standards cause over-/under-estimation of ***,the mechanism by which excipients cause matrix effects and strategies to nullify these effects needs to be ***,formulation excipients cause drug interactions by moderating the pathways of drug metabolizing enzymes and drug transport *** it is not possible to get rid of excipient driven interactions,it is always advised to be aware of these interactions and apply the knowledge to draw meaningful conclusions from study *** this review,we will comprehensively discuss a)orphan excipients that have wider applications in preclinical formulations,b)bioanalytical matrix effects and possible approaches to mitigating these effects,and c)excipient driven drug interactions and strategies to alleviate the impacts of drug interactions.

关键词： Formulation excipients Preclinical Drug discovery Matrix effects Drug interactions Bioanalysis Pharmacokinetics Formulation development

Controlled release of FK506 from micropatterned PLGA films:potential for application in peripheral nerve repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第7期13卷 1247-1252页

作者： Brett Davis Susan Wojtalewicz pratima Labroo Jill Shea Himanshu Sant Bruce Gale Jayant Agarwal Department of Bioengineering University of Utah Department of Surgery University of Utah Department of Mechanical Engineering University of Utah

After decades of research,peripheral nerve injury and repair still frequently results in paralysis,chronic pain and neuropathies leading to severe disability in *** clinically available nerve conduits only provide crude guidance of regenerating axons across nerve gap without additional ***506（Tacrolimus）,an FDA approved immunosuppressant,has been shown to enhance peripheral nerve regeneration but carries harsh side-effects when delivered *** objective of this study was to develop and evaluate a bioresorbable drug delivery system capable of local extended delivery of FK506 that also provides topological guidance cues to guide axon growth via *** was used to create micropatterned poly（lactide-co-glycolic acid）（PLGA） films embedded with ***-patterned,10/10 μm（ridge/groove width）,and 30/30 μm patterned films loaded with 0,1,and 3 μg/cm2 FK506 were manufactured and *** vitro FK506 rate of release testing indicated that the films are capable of an extended（at least 56 days）,controlled,and scalable release of *** extension bioactivity assay indicated that FK506 released from the films（concentration of samples tested ranged between 8.46–19.7 ng/m L） maintained its neural bioactivity and promoted neurite extension similar to control FK506 dosages（10 ng/m L FK506）.The multi-functional FK506 embedded,micropatterned poly（lactide-co-glycolic acid） films developed in this study have potential to be used in the construction of peripheral nerve repair devices.

关键词： nerve regeneration FK506 controlled release micropatterns topological cues PLGA

Regional representation of glaciers in Chandra Basin region,western Himalaya,India

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2017年第4期8卷 841-850页

作者： pratima Pandey S.Nawaz Ali AL.Ramanathan P.K.Champati ray G.Venkataraman Geosciences and Geohazards Department Indian Institute of Remote Sensing Birbal Sahni Institute of Paleosciences School of Environmental Science Jawaharlal Nehru University Centre of Studies in Resource Engineering Indian Institute of Technology

Hamtah and Chhota Shigri are two nearby,well monitored glaciers of western Himalaya,lying in the same climatic zone and driven by the same climatic *** this study,topographical characteristics of both the glacier have been explored to understand the role of topography in controlling the glacier ***,their topographical characteristics and possible response towards climatic variations have been compared with each other and also with that of the other glaciers in the basin to find out the suitability of these two glaciers to be considered as representative of the *** sensor and multi temporal remote sensing data have been used to carry out to fulfill the *** is found that being in the same climatic zone,the mean accumulation area ratio of Chhota Shigri is 54%and Hamtah is 11%between 1980 and *** comparison to Hamtah,Chhota Shigri glacier has a small upslope area,low compactness ratio indicating the ability of the glacier to receive direct precipitation and solar *** analysis revealed that the Chhota Shigri glacier has a closer resemblance with the other glaciers in the region than Hamtah ***,the topographical settings of Chhota Shigri glacier are suitable for recording and reflecting year-to-year climatic variations.

关键词： Himalaya Glacier Regional representation Topography Remote sensing