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Curcumin-loaded polymeric nanoparticles for neuro-protection in neonatal rats with hypoxic-ischemic encephalopathy

Nano Research 2018年第10期11卷 5670-5688页

作者： Andrea Joseph Thomas Wood Chih-Chung Chen Kylie Corry Jessica M. Snyder Sandra E. Juul pratik parikh Elizabeth Nance Department of Chemical Engineering University of Washington Seattle WA 98195 USA Division of Neonatology Department of Pediatrics University of Washington Seattle WA 98195 USA Department of Comparative Medicine University of Washington Seattle WA 98195 USA Department of Radiology University of Washington Seattle WA 98195 USA

Hypoxic-ischemic encephalopathy is the leading cause of permanent brain injury in term newborns and currently has no cure. Inflammatory processes play a key role in the progression of this disease and may be amenable to a targeted pharmaceutical intervention. Curcumin is a dietary compound with potent anti-inflammatory, antioxidant, and antiapoptotic properties but is limited in therapeutic applications due to its low aqueous solubility, low bioavailability, and rapid first-pass hepatic metabolism. To address these limitations, loading curcumin into poly（lactic-co-glycolic acid）-poly（ethylene glycol）（PLGA-PEG） nanoparticles may increase relevant pharmacokinetic parameters and allow for effective drug delivery to the brain. Using the Vannucci model of unilateral hypoxic-ischemic brain injury in neonatal rats, we studied the in vivo effect of curcumin-loaded PLGA-PEG nanoparticles on brain uptake and diffusion of curcumin and on neuroprotection. The curcumin-loaded nanoparticles were able to overcome the impaired blood-brain barrier, diffuse effectively through the brain parenchyma, localize in regions of injury, and deliver a protective effect in the injured neonatal brain. The application of curcumin and PLGA-PEG nanoparticle-mediated delivery to a clinically relevant model of neonatal brain injury provides greater opportunities for clinical translation of targeted therapies for hypoxic-ischemic encephalopathy.

关键词： drug delivery neuroprotection brain penetrating neonatal hypoxia-ischemia curcumin nanotherapeutics

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Effect of westernization on oral health among college students of Udaipur City,India

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Journal of Medical Colleges of PLA(China) 2016年第4期31卷 194-201页

作者： Piyush Pujara Neeraj Sharma Rujul Jayeshkumar parikh Maitri Shah Shachi parikh Vivek Vadera Manpreet Kaur Isha Makkar Mayur Parmar pratik Rupakar Shrikant Patel Department of Public Health Dentistry Pacific Dental College and Hospital Airport Road Debari Udaipur Rajasthan India Department of Prosthodontics Modern Dental College and Research Centre Indore India Dr.D.y.Patil Dental College and Hospital Pune India. Faculty of Dental Science Ndaiad Gujarat India Department of Oral Medicine Karnavati School of Dentistry Ahmedabad India Pacific Dental College and Hospital Udaikpur India Pacific Medical College and Hospital Udaipur India Senior Lecturer Department of PeriodonticsGoenka Research Institute of Dental Science Piplaj Gandhinagar India Department of Dentistry Gujarat Adani Institute of Medical Science Bhuj Kutch Gujarat India Senior Lecturer Department of Oral PathologyPacific Dental College and Hospital Udaipur India.

Background:There is overwhelming evidence that periodontal disease and dental caries affect the majority of populations and that western culture and lifestyle may have a profound influence on oral health,especially in *** present study was performed to determine the effect of westernization on the oral health of college students of Udaipur City,***:A descriptive cross-sectional study was conducted among students attending various professional and non-professional bachelor's degree colleges of Udaipur City,Rajasthan,India,from March 2013 to May *** hundred students were selected based on a two-stage random sampling *** was assessed by a self-administered structured *** status,dental caries status and malocclusion were assessed according to World Health Organization(WHO) criteria(1997).Statistical analysis was performed using Chi-square and Multivariate logistic *** confidence level and level of significance were set at 95% and 5%,***:The present study suggested that adverse habits,listening to English music and preferring English food had a significant association with dental caries and periodontal *** also showed a significant relationship with consuming English food for snacks and *** analysis revealed a significantly greater odds ratio(OR) for periodontal disease and dental caries among those who preferred English food for ***:Based on the results of the present study,there is an association between westernization and oral health.

关键词： Westernization Periodontal disease Dental caries Food

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