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Changes in body composition in relation to estimated glomerular filtration rate and physical activity in predialysis chronic kidney disease

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Chronic Diseases and Translational Medicine 2022年第4期8卷 305-313页

作者： prathiksha r.bhat Asna Urooj Srinivas Nalloor Department of Studies in Food Science and Nutrition ManasagangotriUniveristy of MysoreMysuruKarnatakaIndia Department of Nephrology Apollo BGS hospitalsMysuruKarnatakaIndia

Background: Early body composition changes, associated with physical inactivity and disease advancement are devastating for patient-related outcomes in predialysis chronic kidney disease (CKD), thus warranting a detailed analysis of body composition beyond conventional measures.Methods: The study included 40 subjects diagnosed with CKD;recruited between January to May 2021. Body composition was measured using the multifrequency analyzer, InBody 770. International Physical Activity Questionnaire-Short Form was used to assess physical activity. Suitable statistical analyses were performed using SPSS 21.0.results: The mean age of the subjects was 58.68 ± 12.24 years. Sarcopenic obesity was prevalent in 62.5% of the subjects. Body mass index under identified obesity by 15% compared to percent body fat, especially in subjects with low muscle mass. The decline in a unit of estimated glomerular filtration rate (eGFr) significantly correlated with a decrease in weight (p = 0.02), body fat mass (p = 0.05), visceral fat area (p = 0.05), and phase angle (p = 0.01) with marginal changes in waist–hip ratio and extracellular water/total body water. The effect of physical activity on skeletal muscle mass was homogeneous between low and moderate levels, but significantly different from high activity level.Conclusion: Changes in fat and fluid compartment were associated with eGFr decline, whereas higher physical activity positively affected body composition.

关键词： body composition electric impedance exercise glomerular filtration rate malnutrition

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