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Phenolic Profile,Antioxidant,Antihyperlipidemic and Cardiac Risk Preventive Effect of Pigmented Black Rice Variety Chakhao poireiton in High-Fat High-Sugar Induced Rats

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Rice science 2023年第6期30卷 641-651页

作者： Raja CHAKRABORTY pratap kalita Saikat SEN Faculty of Pharmaceutical Science Assam down town UniversityAssam 781026India Institute of Pharmacy Assam Don Bosco UniversityAssam 782402India Pratiksha Institute of Pharmaceutical Sciences GuwahatiAssam 781026India

The present study aimed to investigate the hypolipidemic,antioxidant and cardiac risk-suppressing effects of Chakhao poireiton(CP),a GI-tagged pigmented black rice from *** vitro and ex vivo studies confirmed that whole rice extracts of CP have potent antioxidant,3-hydroxy-3-methylglutaryl-CoA reductase,cholesterol esterase inhibitory,and antilipase *** in vivo study was conducted to evaluate the effects of the ethanol extracts of CP on high-fat high-sugar induced hyperlipidemic *** ethanol extract significantly ameliorated lipid parameters and liver enzymes to *** of lactate dehydrogenase,creatine kinase-N-acetyl cysteine,C-reactive protein,and lipoprotein a were significantly lower in the extract-treated groups than those in the disease control group.A marked reduction of ApoB/ApoA1 and other atherogenic indices were observed in extract-treated *** phenolic compounds,*** acid,gallic acid,protocatechuic acid etc.,were quantified in *** study provided the first evidence of the antihyperlipidemic and cardiac risk inhibitory effects of CP,which would be beneficial in preventing and managing hyperlipidemia,associated oxidative stress,and cardiac complications.

关键词： antioxidant cardiac risk high fat high sugar hypolipidemic phenolic compound pigmented rice whole rice

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Diabetes mellitus and COVID-19:Understanding the association in light of current evidence

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World Journal of Clinical Cases 2021年第28期9卷 8327-8339页

作者： Saikat Sen Raja Chakraborty pratap kalita Manash Pratim Pathak Faculty of Pharmaceutical Science Assam down town UniversityGuwahati 781026AssamIndia Department of Pharmaceutical Technology School of Medical SciencesADAMAS UniversityKolkata 700126West BengalIndia Department of Pharmacy Pratiksha Institute of Pharmaceutical SciencesGuwahati 781026AssamIndia

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections have posed a problematic healthcare situation worldwide since December *** mellitus is associated with an increased risk and severity of coronavirus disease 2019(COVID-19).While interacting with various other risk factors,high blood sugar was found to reduce immunity and increase the replication of SARS�*** stress and the release of pro-inflammatory cytokines are greater in diabetic individuals than in healthy people,worsening the outcome of SARS�CoV-2 infection in *** expression of furin and angiotensin converting enzyme 2(ACE-2)receptor in the hyperglycemic environment may promote the entry of SARS-CoV-2 in the host ***-19 infection primarily modulates immune and inflammatory responses,and may cause a cytokine storm,resulting in possible lethal outcomes in *** experimental report suggests that ACE expressed in the pancreas and the SARS-CoV-2 virus invariably destroyβ-cells which contain ACE-2 receptors and results in acute ***,COVID-19 also causes hyperglycemia in an individual with diabetes which may be related to insulin resistance and destruction ofβ-cells during SARS-CoV-2 *** observations also suggest a correlation between oral hypoglycemic agents and the risk of *** review focused on the possible cause and mechanism involved in SARS-CoV-2 infection in diabetics and the role of antidiabetic drugs in COVID-19.

关键词： Diabetes mellitus SARS-CoV-2 COVID-19 Angiotensin converting enzyme

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