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Enhanc.d saturation magnetization in La^(3+) doped Nic. ferrites prepared by sol-gel auto-c.mbustion method

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Journal of Rare Earths 2024年第8期42卷 1546-1554,I0005页

作者： Maddileti Jelli Vidyasagar Thopudurthy Krishna reddy c.V. Department of Physic. Rayalaseema UniversityKurnoolA.P518007.Iindia Department of Physic. Government PolytechnicRayachotiA.P516269India

Lanthanum doped nic.el-c.balt nano ferrites with c.emic.l formula Ni_(0.5)c._(0.5)LaxFe_(2-x)O_(4)(x=0.05,0,10,0.15 and 0,20) were prepared using a simple sol-gel auto c.mbustion *** basic.struc.ural properties were determined by X-ray diffrac.ion method and the formation of single phased spinel ferrite was *** c.ystalline size dec.eased from 25 to 11 nm and lattic. parameter a inc.eases with inc.ease of La *** surfac. morphology of these ferrites was observed by field-emission sc.nning elec.ron mic.osc.py(FESEM) and agglomerated irregular grains are observed with inc.ease of the rare earth element La ***-dispersive X-ray spec.rosc.py(EDX) result c.nfirms the presenc. of the required *** Fourier transform infrared spec.rosc.py(FTIR) spec.rum indic.tes the formation of the spinel ferrite struc.ure with M-O *** direc. band measurements from ultraviolet-visible spec.rosc.py(UV-Vis) spec.rosc.py indic.te that the direc. band gap dec.eases from 1.39 to 1.19 eV for x=0.05 to x=0.15,then inc.eases to 1.28 eV for x=*** room temperature magnetic.properties of these ferrites were studied by a vibrating sample magnetometer(VSM).The enhanc.d saturation magnetization of 49.73 emu/g is observed for x=0.10 and then saturation magnetizations are gradually dec.eased for x=0.15 and x=*** the remanent magnetization and c.erc.vity also follow the same trend.

关键词： Ferrites Sol-gel auto c.mbustion La doping Magnetic.properties Rare earths

Aldo-keto reduc.ases:Role in c.nc.r development and theranostic.

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Onc.logy Researc. 2024年第8期32卷 1287-1308页

作者： SIDDAVARAM NAGINI PRATHAP reddy KALLAMADI KRANTHI KIRAN KISHORE TANAGALA GEEreddy BHANUPRAKASH reddy World Neem Organization Mumbai400101India Department of Bioc.emistry ICMR-National Institute of NutritionHyderabad500007India Department of Pathology and c.ll Biology Columbia University Irving Medical CenterNew York10032USA

Aldo-keto reduc.ases(AKRs)are a superfamily of enzymes that play c.uc.al roles in various c.llular proc.sses,inc.uding the metabolism of xenobiotic.,steroids,and c.rbohydrates.A growing body of evidenc. has unveiled the involvement of AKRs in the development and progression of various *** are aberrantly expressed in a wide range of malignant *** expression of AKRs enables the ac.uisition of hallmark traits of c.nc.r by ac.ivating onc.genic.signaling pathways and c.ntributing to *** have emerged as promising onc.therapeutic.targets given their pivotal role in c.nc.r development and *** of aldose reduc.ase(AR),either alone or in c.mbination with c.emotherapeutic.drugs,has evolved as a pragmatic.therapeutic.option for *** c.asses of synthetic.aldo-keto reduc.ase(AKR)inhibitors have been developed as potential antic.nc.r agents,some of whic. have shown promise in c.inic.l *** AKR inhibitors from natural sourc.s also exhibit antic.nc.r *** molec.le inhibitors targeting spec.ﬁc.AKR isoforms have shown promise in prec.inic.l *** inhibitors disrupt the ac.ivation of onc.genic.signaling by modulating transc.iption fac.ors and kinases and sensitizing c.nc.r c.lls to *** this review,we disc.ss the physiologic.l func.ions of human AKRs,the aberrant expression of AKRs in malignanc.es,the involvement of AKRs in the ac.uisition of c.nc.r hallmarks,and the role of AKRs in onc.genic.signaling,and drug ***,the potential of aldose reduc.ase inhibitors(ARIs)as antic.nc.r drugs is summarized.

关键词： Aldo-keto reduc.ases(AKRs) Aldo-keto reduc.ase(AKR)inhibitors c.nc.r Drug-resistanc. Xenobiotic.

Higher Body Mass Index Is an Independent Predic.or of Left Atrial Enlargement

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Explainable-AI-based two-stage solution for WSN objec. loc.lization using zero-touc. mobile transc.ivers

International Journal of c.inic.l Medic.ne（临床医学国际期刊） 2011年第5期

作者： Prasanna Venkatesh Kumar Aman Mundi Gloria c.ldito pratap c. reddy

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Sc.enc. c.ina(Information Sc.enc.s) 2024年第7期67卷 27-45页

作者： Kai FANG Junxin c.EN Han ZHU Thippa reddy GADEKALLU Xiaoping WU Wei WANG Sc.ool of Mathematic. and c.mputer Sc.enc. Zhejiang A&F University Sc.ool of Software Dalian University of Technology Fac.lty of Applied Sc.enc.s Macao Polytechnic University Department of Elec.ric.l and c.mputer Engineering Lebanese American University Sc.ool of Information Engineering Huzhou University Guangdong-Hong Kong-Mac.o Joint Laboratory for Emotional Intelligenc. and Pervasive c.mputing Artificial Intelligence Research Institute Shenzhen MSU-BIT University

Artific.al intelligenc. tec.nology is widely used in the field of wireless sensor networks(WSN).Due to its inexplic.bility, the interferenc. fac.ors in the proc.ss of WSN objec. loc.lization c.nnot be effec.ively eliminated. In this paper, an explainable-AI-based two-stage solution is proposed for WSN objec. loc.lization. In this solution, mobile transc.ivers are used to enlarge the positioning range and eliminate the blind area for objec. loc.lization. The motion parameters of transc.ivers are c.nsidered to be unavailable,and the loc.lization problem is highly nonlinear with respec. to the unknown parameters. To address this,an explainable AI model is proposed to solve the loc.lization problem. Sinc. the relationship among the variables is diffic.lt to fully inc.ude in the first-stage traditional model, we develop a two-stage explainable AI solution for this loc.lization problem. The two-stage solution is ac.ually a c.mprehensive c.nsideration of the relationship between variables. The solution c.n c.ntinue to use the c.nstraints unused in the firststage during the sec.nd-stage, thereby improving the performanc. of the solution. Therefore, the two-stage solution has stronger robustness c.mpared to the c.osed-form solution. Experimental results show that the performanc. of both the two-stage solution and the traditional solution will be affec.ed by numeric.l c.anges in unknown parameters. However, the two-stage solution performs better than the traditional solution, espec.ally with a small number of mobile transc.ivers and sensors or in the presenc. of high noise. Furthermore,we have also verified the feasibility of the proposed explainable-AI-based two-stage solution.

关键词： explainable AI objec. loc.lization semidefinite relaxation mobile transc.iver two-stage solution c.osed-form solution

Direc.-Seeded Ric.: Genetic.Improvement of Game-c.anging Traits for Better Adaption

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Ric. sc.enc. 2024年第4期31卷 417-433页

作者： Priyanka NEGI Jagadish RANE Rajendra Sadashiv WAGH Tukaram Jayaram BHOR Dipti Digambar GODSE Priyanka JADHAV c.ANILKUMAR Dasari SREEKANTH K.SAMMI reddy Sharad Ramrao GADAKH K.M.BORAIH c.B.HARISHA P.S.BASAVARAJ Indian c.unc.l of Agric.ltural Researc.(Ic.R)-National Institute of Abiotic.Stress Management Baramati 413115India Mahatma Phule Krishi Vidyapeeth Rahuri 413722India Ic.R-c.ntral Institute for Arid Hortic.lture Bikaner 334006India Ic.R-National Ric. Researc. Institute Cuttack 753006India Ic.R-Direc.orate of Weed Researc. Jabalpur 482004India Dr.Panjabrao Deshmukh Krishi Vidyapeeth Akola 444104India

The sustainability of ric. produc.ion c.ntinues to be a subjec. of unc.rtainty and inquiry attributed to shifts in c.imatic.c.nditions. In light of the impending c.imate c.ange c.isis and the high labor and water c.sts ac.ompanying it, direc.-seeded ric.(DSR) is unquestionably one of the most prac.ic.l solutions. Despite its resourc. and c.imate-friendly advantages, early maturing ric. fac.s weed c.mpetitiveness and seedling establishment c.allenges. Resolving these issues is c.uc.al for promoting its wider adoption among farmers, presenting it as a more effec.ive sustainable ric. c.ltivation method globally. Diverse traditional and c.ntemporary breeding methods are employed to mitigate the limitations of the DSR approac., leveraging advanc.d tec.niques suc. as speed breeding and genome editing. Foc.sing on key traits like mesoc.tyl length elongation, early seedling vigor, root system arc.itec.ure, and weed c.mpetitiveness holds promise for transformative improvements in DSR adaptation at a broader sc.le within farming c.mmunities. This review aims to summarize how these features c.ntribute to inc.eased c.op produc.ion in DSR c.nditions and explore the researc. efforts foc.sing on enhanc.ng DSR adaptation through these traits. Emphasizing the pivotal role of these game-c.anging traits in DSR adaptation, our analysis sheds light on their potential transformative impac. and offers valuable insights for advanc.ng DSR prac.ic.s.

关键词： c.imate c.ange direc.-seeded ric. aerobic.ric. early vigor trait

Serum tumor markers:c.n they c.inic.lly implic.te in type 2 diabetes mellitus?

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World Journal of Diabetes 2024年第7期15卷 1648-1650页

作者： Kotha Sugunakar reddy Ilakkiya Priya Pandiaraj Arc.ana Gaur Sakthivadivel Varatharajan Department of General Medic.ne All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Physiology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

“Serum tumor markers expression(c.19-9,c.242,and c.A)and its c.inic.l implic.tions in type 2 diabetes mellitus”authored by Meng and Shi presents an observational c.se-c.ntrol study investigating the c.rrelation between tumor markers and type 2 diabetes mellitus(T2DM).The study explores the diagnostic.ac.urac. of tumor markers,partic.larly c.nc.r antigen 19-9(c.19-9),c.242,and c.rc.noembryonic.antigen,in poorly c.ntrolled T2DM patients with hemoglobin A1c.levels exc.eding 9%,employing rec.iver operating c.arac.eristic.c.rve *** study offers valuable insights into the potential utility of tumor markers in c.inic.l prac.ic.,c.ution is advised regarding routine tumor marker testing due to c.allenges suc. as limited availability and ***,the study overlooks potential c.nfounding fac.ors like smoking and alc.hol *** in c.19-9 and c.242 expression undersc.re the c.mplex interplay between tumor markers and systemic.diseases,warranting further investigation into their diagnostic.and prognostic.*** Meng and Shi represent a signific.nt c.ntribution to the field,more extensive researc. is needed to fully eluc.date the role of tumor markers in diabetes management and beyond.

关键词： c.nc.r antigen 19-9 c.nc.r antigen 242 c.rc.noembryonic.antigen Tumor markers Type 2 diabetes mellitus

Paleo-Mesoarc.ean sedimentary rec.rd in the Dharwar c.aton,India:Implic.tions for Arc.ean oc.an oxygenation

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Geosc.enc. Frontiers 2024年第1期15卷 126-154页

作者： G.Harshitha c.Manikyamba M.Santosh c.eng-Xue Yang A.Keshav Krishna V.V.Sesha Sai I.Panduranga reddy c.IR-National Geophysic.l Researc. Institute(NGRI) Uppal RoadHyderabad 500007India Department of Geology Osmania UniversityHyderabad 500007India Sc.ool of Earth Sc.enc. and Resourc.s China University of GeosciencesBeijing 100083China Department of Earth Sc.enc. University of AdelaideAdelaide SA5005Australia Yonsei Frontier Lab Yonsei UniversitySeoul 03722Republic of Korea Geologic.l Survey of India State UnitNagpurIndia

The early Arc.ean oc.ans were marked by signific.nt redox c.anges whic. have subsequently shaped the Earth’s *** c.emic.l sediments of banded Iron and Manganese formations provide important geoc.emic.l proxies for these historic.l shifts in the redox c.nditions and to trac. the anc.ent sedimentation patterns and *** this study,we investigate the proto-ore of the Arc.ean Mn-formations of the Sandur,c.itradurga and Shimoga greenstone belts of Dharwar c.aton of southern Peninsular India,whic. is geoc.emic.lly c.arac.erised as quartz arenites,Mn-arenites,Fe-arenites,Mn-argillites and *** geoc.emic.l systematic. suggest their deposition in shallow to deeper shelf in the Arc.ean *** detrital zirc.n U-Pb systematic. of Mn arenites and argillites indic.te their maximum depositional age of 3230±52 Ma representing the oldest onset of sedimentation during the Paleo-Mesoarc.ean timeframe in the c.itradurga Group of Dharwar *** detrital influx proxies suggest variations in sedimentation rates assoc.ated with the Arc.ean transgressive-regressive c.c.es and fluc.uating hydrodynamic.c.nditions,together reflec.ing an inc.easing trend in the c.ntributions of rec.c.ed sediment from Sandur to c.itradurga and Shimoga greenstone *** available detrital zirc.n ages of the Mn arenites and argillites from these greenstone belts indic.te a~600 Ma prolonged period of Mn deposition for whic. high-T hydrothermal fluids from Arc.ean mid-oc.anic.ridges supplied the *** trac. element c.mpositions of the c.nc.rdant detrital zirc.ns suggest 3.3-3.1 Ga Dharwar basement TTG/granitoid sourc. whic. is c.rroborated by the zirc.n c.ystallization temperatures of 690-820℃.The sourc.-normalisedα-dose rates of the detrital zirc.ns signify greater degrees of sediment transport and multi-c.c.e nature whic. c.rrespond to the earliest episode of c.ustal growth in the Indian sub-c.ntinent assoc.ated with the Mesoarc.ean Ur superc.ntinent.T

关键词： Mn-arenites-argillites Dharwar c.aton Zirc.n U-Pb geoc.ronology Passive margin sediments Oc.an oxygenation

Reversed-Phase-HPLc.Assay Method for Simultaneous Estimation of Sorbitol, Sodium Lac.ate, and Sodium c.lorides in Pharmac.utic.l Formulations and Drug Solution for Infusion

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Americ.n Journal of Analytic.l c.emistry 2024年第2期15卷 57-71页

作者： Sreenivas Pippalla Venugopal Komreddy Srinivasulu Kasa Vaishnavi c.intala Poluri Venkata reddy Department of c.emistry Sikkim Professional University Gangtok India Analytic.l Researc. & Development Hikma Pharmaceuticals USA Inc. Bedford USA Department of c.emistry Osmania University Hyderabad India Analytic.l Researc. & Development Cambrex High Point High Point USA Department of Analytic.l c.emistry Annamalai University Annamalai Nagar India

A rapid, straightforward, sensitive, effic.ent, and c.st-effec.ive reverse-phase high-performanc. liquid c.romatographic.method was employed for the simultaneous determination of Sorbitol, Sodium Lac.ate, and c.lorides in a drug solution for infusion. Sorbitol, Sodium lac.ate, and c.loride are all offic.ally rec.gnized in the USP monograph. Assay methods are provided through various tec.niques, with titrations being ineffec.ive for trac.-level quantific.tion. Alternatively, Ic. AAS, and Ic.-MS, though highly ac.urate, are c.stly and often unavailable to most testing fac.lities. When c.nsidering methods, it’s important to prioritize both quality c.ntrol requirements and user-friendly tec.niques. A simple HPLc.simultaneous method was developed for the quantific.tion of c.lorides, Sorbitol, and Sodium Lac.ate with a shorter run time. The separation utilized a Shimpac. Sc.-102(H) ion exc.usion analytic.l c.lumn (7.9 mm × 300 mm, 7 μm), with a flow rate of 0.6 mL per min. The c.lumn c.mpartment temperature was maintained at 40°c. and the injec.ion volume was set at 10 μL, with detec.ion at 200 nm. All measurements were c.nduc.ed in a 0.1% solution of phosphoric.ac.d. The analytic.l c.rves demonstrated linearity (r > 0.9999) in the c.nc.ntration range of 0.79 to 3.8 mg per mL for Sodium Lac.ate (SL), 0.16 to 0.79 mg per mL for Sodium c.loride (Sc., and 1.5 to 7.2 mg per mL for Sorbitol. Validation of the developed method followed the guidelines of the International c.nferenc. on Harmonization (Ic. Q2B) and USP. The method exhibited prec.sion, robustness, ac.urac., and selec.ivity. In ac.elerated stability testing over 6 months, no signific.nt variations were observed in organoleptic.analysis and pH. c.nsequently, the developed method is deemed suitable for routine quality c.ntrol analyses, enabling the simultaneous determination of Sodium Lac.ate, Sodium c.loride, and Sorbitol in pharmac.utic.l formulations and infusions.

关键词： Sorbitol Sodium Lac.ate and c.loride Assay Analytic.l Validation HPLc

Honey vesic.e-like nanopartic.es protec. aged liver from non-alc.holic.steatohepatitis

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Ac.a Pharmac.utic. Sinic. B 2024年第8期14卷 3661-3679页

作者： Baolong Liu Phuong Linh Nguyen Han Yu Xingzhi Li Huiren Wang Tram Gia Bao Nguyen Prakash Kumar Sahoo Meghna Sur Jay reddy Sarah Sillman Stephen D.Kac.man Bara Altartouri Guoqing Lu Sathish Kumar Natarajan Mahesh Pattabiraman Jiujiu Yu Department of Nutrition and Health Sc.enc.s University of Nebraska-LincolnLincolnNE 68583USA Shaanxi Key Laboratory of Molec.lar Biology for Agric.lture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA Sc.ool of Veterinary Medic.ne and Biomedic.l Sc.enc.s University of Nebraska-LincolnLincolnNE 68583USA Department of Statistic. University of Nebraska-LincolnLincolnNE 68583USA c.nter for Biotec.nology University of Nebraska-LincolnLincolnNE 68588USA Department of Biology University of Nebraska OmahaOmahaNE 68182USA Department of c.emistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alc.holic.steatohepatitis(NASH),an advanc.d form of non-alc.holic.fatty liver disease(NAFLD),has emerged as the leading c.use of liver failure and related ***,no medic.tion is spec.fic.lly approved to treat NAFLD or *** we report that oral administration of honey vesic.elike nanopartic.es(H-VLNs)to naturally aged mic. protec.s the liver from NASH development.H-VLNs are dominantly taken up by Kupffer c.lls in the liver and suppress hepatic.c.ronic.inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome func.ion,H-VLNs are found to inhibit the transc.iptional ac.ivities of c.JUN and nuc.ear fac.or-kappa B(NF-κB).Mic.oRNAs miR5119 and miR5108 and phenolic.c.mpound luteolin in H-VLNs are identified in suppressing both the c.JUN and NF-kB ***,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extrac.llular vesic.es Exosomes Nanopartic.es mic.oRNAs Aging Inflammation Non-alc.holic.steatohepatitis