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Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis

World Journal of Hepatology 2020年第7期12卷 363-377页

作者： Naruemon Klaikeaw Jutamas Wongphoom Duangporn Werawatganon Maneerat Chayanupatkul prasong siriviriyakul Department of Pathology Faculty of MedicineChulalongkorn UniversityBangkok 10330Thailand Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases Research Unit Department of PhysiologyFaculty of MedicineChulalongkorn UniversityBangkok 10330Thailand

BACKGROUND Aloe vera exerts several biological activities,such as,anti-inflammatory,antioxidant,and antimicrobial *** was recently shown to reduce insulin resistance and triglyceride *** hypothesized that aloe vera would have beneficial effects in alleviating non-alcoholic steatohepatitis(NASH)in *** To examine the therapeutic effects of aloe vera in NASH *** All rats were randomly divided into 3 groups(n=6 in each group).Rats in the control group were fed ad libitum with a standard diet for 8 *** in the NASH group were fed ad libitum with a high-fat high-fructose diet(HFHFD)for 8 *** in the aloe vera group were fed ad libitum with a HFHFD and aloe vera in dimethylsulfoxide(50 mg/kg)by gavage daily for 8 *** samples were collected at the end of the treatment *** Hepatic malondialdehyde(MDA)levels increased significantly in the NASH group as compared with the control group(377±77 nmol/mg vs 129±51 nmol/mg protein,respectively,P<0.001).Glutathione(GSH)levels were significantly lower in the NASH group than the control group(9±2 nmol/mg vs 24±8 nmol/mg protein,respectively,P=0.001).The expression of interleukin-18 (IL-18), nuclear factor-kappa β, and caspase-3 increased, while peroxisomeproliferator-activated receptor gamma decreased in the NASH group comparedwith the controls. Following aloe vera administration, MDA levels decreased (199± 35 nmol/mg protein) and GSH increased (18 ± 4 nmol/mg protein) ***, hepatocyte ballooning, lobular inflammation and increased hepatocyteapoptosis were observed in the NASH group. Aloe vera treatment attenuatedthese changes in liver *** vera attenuated oxidative stress, hepatic inflammation and hepatocyteapoptosis, thus improving liver pathology in rats with NASH.

关键词： Non-alcoholic steatohepatitis Aloe vera Oxidative stress Hepatic inflammation Hepatocyte apoptosis Peroxisome proliferator-activated receptor

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