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Euphorbia neriifolia L.:Review on botany,ethnomedicinal uses,phytochemistry and biological activities

Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 408-417页

作者： prashant Y.mali Shital S.Panchal Department of Pharmacology Institute of PharmacyNirma UniversityAhmedabadGujaratIndia

The present review is intended to provide information on botany,ethnomedicinal uses,phytochemistry and biological activities of various parts of Euphorbia neriifolia(E. neriifolia). E. neriifolia has several ethnomedicinal uses. The latex of E. neriifolia is used as laxative,purgative,rubefacient,carminative and expectorant as well as in treatment of whooping cough,gonorrhea,leprosy,asthma,dyspepsia,jaundice,enlargement of the spleen,tumors,stone in the bladder,abdominal troubles and leucoderma. Leaves are brittle,heating,carminative,and good for improving the appetite and treatment of tumors,pains,inflammations,abdominal swellings and bronchial infections. Roots are used as symptomatic treatment of snake bite,scorpion sting and antispasmodic. Various plant parts or whole E. neriifolia extract and its isolates have been reported scientifically using various in-vivo and in-vitro experimental methods for anaesthetic,analgesic,anti-anxiety,anti-convulsant,anti-psychotic,anti-arthritis,anti-carcinogenic,antidiabetic,anti-diarrhoeal,anti-inflammatory,anti-thrombotic,antimicrobial,antioxidant,antiulcer,cytotoxic,death-receptor expression enhancing,dermal irritation,diuretic,hemolytic,immunomodulatory,radioprotective,scorpion venom and wound healing properties. It is reported to have chemical constituents like,neriifolin-S,neriifolin,neriifoliene,euphol,neriifolione,cycloartenol,nerifoliol,lectin,euphonerins A–G,3-O-acetyl-8-O-tigloylingol,taraxerol,antiquorin,etc. Identified chemical constituents are still required to be explored for their advanced isolation techniques and biological activities.

关键词： Euphorbia neriifolia Botany Ethnomedicinal uses Phytochemistry Anti-cancer

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Euphorbia tirucalli L.:Review on morphology,medicinal uses,phytochemistry and pharmacological activities

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Asian Pacific Journal of Tropical Biomedicine 2017年第7期7卷 603-613页

作者： prashant Y. mali Shital S. Panchal Department of Pharmacology Institute of Pharmacy Nirma University Ahmedabad Gujarat India

The intention of current review is to make available up-to-date information on morphology, ecological biodiversity, medicinal uses, phytochemistry and pharmacolog-ical activities on different parts of Euphorbia tirucalli (E. tirucalli). This plant has a number of medicinal uses. Latex of E. tirucalli is vesicant and rubefacient which is used for rheumatism, warts, cough, asthma, ear-ache, tooth-ache and neuralgia. It acts as a purgative in small doses while in big doses it is bitter irritant and emetic. Milky juice is alexiteric, carminative and purgative. It is useful in whooping cough, gonorrhea, asthma, leprosy, dropsy, dyspepsia, enlargement of spleen, colic, jaundice and stone in bladder. The fresh milky juice is good alternative in syphilis and a good application in neuralgia. A decoction of branches is used in gastralgia and colic. Bark is used in treatment of fractures. Poultices prepared from the stem are useful to repair the broken bones. Boiled root liquid acts as an emetic in cases of snake-bite and for infertility in women. The wood is used for rafters, toys and veneering purposes. It is also useful against leprosy and foot paralysis subsequent to childbirth. E. tirucalli is reported to have euphol, β-sitosterol, euphorbol hexacosonate, cycloeuphordenol, cyclotirucanenol, tirucalicine, tri-methyl ellagic acid, gallic acids, terpenic alcohol, isoeuphorol, taraxasterol, tirucallol, euphor-one, euphorcinol, euphorbins, 12-deoxy-4β-hydroxyphorbol-13-phenyl acetate-20-acetate, 12, 20-dideoxyphorbol-13-isobutyrate, glut-5-en-3-β-ol, 3,3′-di-O-methylellagic acid, euphorbin-A (polyphenol), tirucallin-A (7) (tannin), tirucallin-B (11), euphorbin-F (14) (dimers), cycloartenol, 24-methylenecycloartenol, ingenol triacetate, 12-deoxy-4β-hydroxyphorbol-13-phenyl acetate-20-acetate, taraxerone, euphorginol, taraxerol, cam-pesterol, stigmasterol, palmitic acid, linoleic acid,β-amyrin, etc. active phytoconstituents. E. tirucalli have possessed activity in human-lymphocy

关键词： Euphorbia tirucalli Morphology Ecological biodiversity Medicinal uses Phytochemistry Anticancer

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Promoting human embryonic stem cell renewal or differentiation by modulating Wnt signal and culture conditions

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Cell Research 2007年第1期17卷 62-72页

作者： Betty Ying Zhou prashant mali USA. Whitehead institute for Biomedical Research CambridgeMA 02142USAThe Institute for Cell EngineeringDepartment of Gynecology & Obstetricsthe Johns Hopkins University School of MedicineBaltimoreMD Program of Biomedical Engineeringthe Johns Hopkins UniversiOSchool of MedicineBaltimoreMD 21205USA

We previously showed that Wnt3a could stimulate human embryonic stem (hES) cell proliferation and affect cell *** the absence of feeder cell-derived factors,hES cells cultured under a feeder-free condition survivedand proliferated *** recombinant Wnt3a in the absence of feeder cell derived-factors stimulated hES cellproliferation but also *** the present study,we further extended our analysis to other Wnt ligands such asWntl and *** Wntl displayed a similar effect on hES cells as Wnt3a,Wnt5a had little effect in this ***3a and Wntl enhanced proliferation of undifferentiated hES cells when feeder-derived self-renewal factors andbFGF are also *** explore the possibility to promote the proliferation of undifferentiated hES cells by activatingthe Wnt signaling,we overexpressed Wnt3a or Wntl gene in immortalized human adult fibroblast (HAFi) cells that aresuperior in supporting long-term growth of undifferentiated hES cells than primary mouse embryonic *** with or without a Wnt transgene can be propagated ***-expression of the Wnt3a gene significantlyenhanced the ability of HAFi feeder cells to support the undifferentiated growth of 3 different hES cell lines we ***-expression of three commonly-used drug selection genes in Wnt3a-overpressing HAFi cells further enabled us toselect rare hES clones after stable transfection or *** immortalized engineered feeder cells (W3R) thatco-express growth-promoting genes such as Wnt3a and three drug selection genes should empower us to efficiently makegenetic modified hES cell lines for basic and translational research.

关键词： WNT human embryonic stem cells stem cell renewal stem cell differentiation transgene

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Nat Methods:利用CRISPR-Cas9组合筛选发现癌症弱点

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现代生物医学进展 2017年第17期17卷 I0001-I0001页

作者： John Paul Shen, Ana Bojorquez-Gomez, Katherine Licon, Kristin Klepper, Daniel Pekin, Alex N Beckett, Kyle Salinas Sanchez, Jason F Kreisberg, Trey Ideker John Paul Shen, Trey Ideker, prashant mali John Paul Shen, Dongxin Zhao, Dan Du, Assen Roguev, Jason F Kreisberg, Nevan Krogan, Lei Qi, Trey Ideker, prashant mali Dongxin Zhao, Chih-Chung Kuo, prashant mali Roman Sasik, Amanda Birmingham, Aaron N Chang, Trey Ideker Jens Luebeck, Alex Thomas Alex Thomas, Chih-Chung Kuo, Nathan E Lewis Dan Du Assen Roguev, Nevan Krogan Nathan E Lewis Lei Qi Department of Medicine Division of Genetics University of California San Diego La Jolla California USA Moores UCSD Cancer Center La Jolla California USA The Cancer Cell Map Initiative (CCMI) La Jolla and San Francisco California USA Department of Bioengineering University of California San Diego La Jolla California USA Center for Computational Biology & Bioinformatics University of California San Diego La Jolla California USA Bioinformatics & Systems Biology Program University of California San Diego La Jolla California USA Novo Nordisk Center for Biosustainability at the University of California San Diego La Jolla California USA Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research Department of Cell and Tissue Biology University of California San Francisco San Francisco California USA Department of Cellular and Molecular Pharmacology University of California San Francisco San Francisco California USA Department of Pediatrics University of California San Diego La Jolla California USA Department of Bioengineering Stanford University Stanford California USA.

导致癌症的基因突变也会削弱癌细胞，从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性（synthetic lethality）”，这是因为这些药物仅对发生突变的（或者说合成的）细胞是致命性的。在... 详细信息

导致癌症的基因突变也会削弱癌细胞，从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性（synthetic lethality）”，这是因为这些药物仅对发生突变的（或者说合成的）细胞是致命性的。在一项新的研究中。来自美国加州大学圣地亚哥分校、加州大学旧金山分校、斯坦福大学和癌细胞图谱项目（Cancer Cell Map Initiative）的研究人员开发出一种新的方法来寻找合成致死性的基因组合。

关键词：组合筛选癌症美国加州大学利用基因突变斯坦福大学癌细胞正常细胞

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