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Ayurveda and in silico Approach: A Challenging Proficient Confluence for Better Development of Effective Traditional Medicine Spotlighting Network Pharmacology

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Chinese Journal of Integrative Medicine 2023年第5期29卷 470-480页

作者： Rashmi Sahu prashant Kumar gupta Amit Mishra Awanish Kumar Department of Balroga Shri NPA Govt.Ayurveda CollegeRaipur(492010)ChhattisgarhIndia Ayurinformatics Lab Department of KaumarabhrityaAll India Institute of AyurvedaSarita ViharNew Delhi(110076)India Cellular and Molecular Neurobiology Unit Indian Institute of TechnologyJodhpur(342037)RajasthanIndia Department of Biotechnology National Institute of TechnologyRaipur(492010)ChhattisgarhIndia

Coalescence of traditional medicine Ayurveda and in silico technology is a rigor for supplementary development of future-ready effective traditional medicine. Ayurveda is a popular traditional medicine in South Asia, emanating worldwide for the treatment of metabolic disorders and chronic illness. Techniques of in silico biology are not much explored for the investigation of a variety of bioactive phytochemicals of Ayurvedic herbs. Drug repurposing, reverse pharmacology, and polypharmacology in Ayurveda are areas in silico explorations that are needed to understand the rich repertoire of herbs, minerals, herbo-minerals, and assorted Ayurvedic formulations. This review emphasizes exploring the concept of Ayurveda with in silico approaches and the need for Ayurinformatics studies. It also provides an overview of in silico studies done on phytoconstituents of some important Ayurvedic plants, the utility of in silico studies in Ayurvedic phytoconstituents/formulations, limitations/challenges, and prospects of in silico studies in Ayurveda. This article discusses the convergence of in silico work, especially in the least explored field of Ayurveda. The focused coalesce of these two domains could present a predictive combinatorial platform to enhance translational research magnitude. In nutshell, it could provide new insight into an Ayurvedic drug discovery involving an in silico approach that could not only alleviate the process of traditional medicine research but also enhance its effectiveness in addressing health care.

关键词： Ayurveda in silico approach conﬂuence challenge effective therapeutics

Development of Siliconized Epoxy Resins and Their Application as Anticorrosive Coatings

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Advances in Chemical Engineering and Science 2011年第3期1卷 133-139页

作者： prashant gupta Madhu Bajpai 不详

The present work involves the development of siliconized epoxy resin to overcome the drawback of epoxy resin like poor impact strength, high rigidity and moisture absorbing nature because of which they are not applied as corrosion resistant coating. By embedding silicone into the back bone of polymeric resin the above drawback can be reduced to substantial level. For achieving this, siliconised epoxy resins were prepared by reacting amine terminated silicone resin with novolac epoxy resin and meta-phenylenediamine was used as curing agent. The applied films of coating were baked at 150oC. Cured films were evaluated for their thermal, mechanical, chemical and corrosion resistance properties to ascertain the commercial utility of these eco-friendly resin for use in anti corrosive formulations. The siliconized epoxy resins system was found to exhibit good thermal and anticorrosive properties.

关键词： Epoxy Resin Silicone Resin Anticorrosive Coatings

Posterior Capsular Rent: Risk Factors, Diagnosis and Management

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Surgical Science 2014年第5期5卷 224-226页

作者： Nimmi Rani prashant gupta Aravind Eye Hospital Madurai India Cataract Services at Aravind Eye Hospital Madurai India

In spite of a steady improvement in the safety of cataract surgery since the inception of phacoemulsification, diagnosing and managing posterior capsular rent still remains a challenge. Identification of the pre-existing risk factors is of utmost importance so that precautionary modifications are done in the surgery to prevent this complication. Once it happens, timely realization and appropriate management can have excellent outcomes.

关键词： Posterior Capsular Rent Vitreous Loss Traumatic Cataract Small Pupil Pseudoexfoliation Vitrectomy Triamcinolone Acetonide

Pharmacological, Ethnomedicinal, and Evidence-Based Comparative Review of Moringa oleifera Lam.(Shigru) and Its Potential Role in the Management of Malnutrition in Tribal Regions of India, Especially Chhattisgarh

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World Journal of Traditional Chinese Medicine 2022年第3期8卷 314-338页

作者： Kishor Sonewane Sharda Swaroop Chouhan Mariappan Rajan Nagendra Singh Chauhan Om Prakash Rout Awanish Kumar Gyanendra Singh Baghel prashant Kumar gupta Department of Kaumarabhritya-Balaroga Shri NPA Government Ayurveda CollegeRaipurChhattisgarhIndia Department of Natural Chemistry Madurai Kamraj UniversityMaduraiTamil NaduIndia Drug Testing Lab Avam Anushandhan Kendra Department of AYUSHChhattisgarhIndia Department of Dravya Guna Shri NPA Government Ayurveda CollegeRaipurChhattisgarhIndia Department of Biotechnology National Institute of TechnologyRaipurChhattisgarhIndia

Moringa oleifera Lam.(Shigru)(Moringaceae family) is a traditional medicine used for control of diabetes, obesity, asthma, and cardiac,liver, gastrointestinal, infective, and brain disorders, such as depression and Alzheimer's disease. In Ayurvedic literature, Shigru is among few drugs having Balya(nourishing) as well as Medohara(antiobesity) property. This review focuses on valid connections between the properties documented in ancient literature and current pharmacological knowledge of Moringa, including pharmacological actions, phytochemistry,botanical description, and how Moringa can tackle malnutrition in India, especially Chhattisgarh. All information about M. oleifera was obtained from electronic scientific databases such as PubMed, Web of Science, Scopus, ScienceDirect, Elsevier, Google Scholar, Traditional Knowledge Digital Library, and Indian Traditional Books(Ancient Ayurveda literatures, The Wealth of India, and The Ayurvedic Formulary of India), postgraduate/doctoral thesis, and googling the keyword M. oleifera. M. oleifera have anti-oxidant, antimicrobial, anti-diabetic,anti-obesity, anti-inflammatory, cardioprotective, hepatoprotective, neuroprotective, gastroprotective, wound-healing properties and it can potentially tackle malnutrition. This review describes the key information related to botanical description of M. oleifera, phytochemistry,pharmacological actions, clinical studies, toxicological studies, better utilization as food therapeutics, and ethnobotanical and evidence-based comparative review of M. oleifera. M. oleifera can effectively tackle malnutrition in India, especially Chhattisgarh. The authors emphasize the need for future in-depth ethnopharmacological lead-based research and clinical studies to expand M. oleifera pharmacological activities,clinical efficacy, and safety.

关键词： Ethnobotanical practices ethnomedicine Moringa oleifera phytochemicals pharmacological action

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一文读懂智能体

机器人产业 2017年第6期 40-44页

作者： prashant gupta

根据我们希望实现的目标以及衡量其成功的标准,我们可以采用多种方法来创建人工智能.它涵盖的范围极其广泛,从自动驾驶和机器人这样非常复杂的系统,到诸如人脸识别、机器翻译和电子邮件分类这些我们日常生活的常见部分,都可以划为人工... 详细信息

根据我们希望实现的目标以及衡量其成功的标准,我们可以采用多种方法来创建人工智能.它涵盖的范围极其广泛,从自动驾驶和机器人这样非常复杂的系统,到诸如人脸识别、机器翻译和电子邮件分类这些我们日常生活的常见部分,都可以划为人工智能的领域范畴之内.

关键词：智能体人工智能自动驾驶人脸识别邮件分类机器翻译机器人

基于RAPD-PCR标记的印度亚麻品种遗传多样性和指纹图谱分析(英文)

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广西农业科学 2010年第3期41卷 201-206页

作者： prashant Shekhar gupta Sangeeta Srivastava Manoj Kumar Srivastava Abhilash gupta 印度国家甘蔗研究所作物改良室印度勒克瑙226002 广西作物遗传改良生物技术重点开放实验室南宁530007 阿拉哈巴德农业研究所遗传与植物育种室印度阿拉哈巴德211007

栽培的亚麻(***)通常为亚麻籽,以其油分和纤维而被认为是具有较高经济价值的作物之一。开发亚麻遗传资源并进一步进行遗传改良,须了解其遗传变异的范围和结构。位于坎普尔的C.S.农业科技大学种质管理单位保存有广泛收集而来的2772份栽... 详细信息

栽培的亚麻(***)通常为亚麻籽,以其油分和纤维而被认为是具有较高经济价值的作物之一。开发亚麻遗传资源并进一步进行遗传改良,须了解其遗传变异的范围和结构。位于坎普尔的C.S.农业科技大学种质管理单位保存有广泛收集而来的2772份栽培和野生亚麻资源。从中选出23份不同基因型栽培亚麻品种包括5份两用品种、4份种用品种、14份具有不同形态和经济特性的引进种用品种以及1份野生品系(***),采用RAPD标记进行遗传多样性分析。20条随机引物共产生242条带,每条引物扩增带数为1～20条,平均为10.95条。所有基因型和位点的RAPD多态性比例为90.49%。DICE系数相似矩阵分析揭示其遗传相似性为0.63～0.97,平均相似系数为82%,说明这些亚麻品种(系)的遗传背景较窄。采用UPGMA法以及NTSYS-pc软件的SAHN聚类分析模型对遗传相似矩阵进行聚类分析,发现属于***的所有栽培品种在X轴上可聚为一类,而***野生种单独在Y轴上聚为一类。主成分分析结果表明,除了Shekha(r优良种用品种)和野生种***广泛分布外,其他所有种用品种、两用品种和外来品种聚类很近。由于亚麻栽培品种的遗传关系相近,须对亚麻种质的各种基因型进行鉴定,以拓宽今后育种计划中的遗传基础。

关键词：亚麻籽 RAPD 亚麻种用品种两用品种

Development of Siliconized Epoxy Resins and Their Application as Anticorrosive Coatings

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Momordica charantia trypsin inhibitor Ⅱ inhibits growth and development of Helicoverpa armigera

Advances in Chemical Engineering and Science（化学工程与科学期刊） 2011年第3期

作者： prashant gupta Madhu Bajpai

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Insect Science 2009年第5期16卷 371-379页

作者： Manasi Alok Telang prashant Pyati Mohini Sainani Vidya Shrikant gupta Ashok Prabhakar Giri Plant Molecular Biology Unit Division of Biochemical Sciences National Chemical Laboratory Dr. Homi Bhabha Road Pune 411 008(M. S.) India

Bitter gourd （Momordica charantia L.） seeds contain several squash-type serine proteinase inhibitors （PIs）, which inhibit the digestive proteinases of the polyphagous insect pest Helicoverpa armigera. In the present work isolation of a DNA sequence encoding the mature peptide of a trypsin inhibitor McTI-Ⅱ, its cloning and expression as a recombinant protein using Pichia pastoris have been reported. Recombinant McTI-Ⅱ inhibited bovine trypsin at 1 ： 1 molar ratio, as expected, but did not inhibit chymotrypsin or elastase. McTI-Ⅱ also strongly inhibited trypsin-like proteinases （81% inhibition） as well as the total proteolytic activity of digestive proteinases （70% inhibition） from the midgut of H. armigera larvae. The insect larvae fed with McTI-Ⅱ-incorporated artificial diet suffered over 70% reduction in the average larval weight after 12 days of feeding. Moreover, ingestion of McTI-Ⅱ resulted in 23% mortality in the larval population. The strong antimetabolic activity of McTI-Ⅱ toward H. armigera indicates its probable use in developing insect tolerance in susceptible plants.

关键词： antimetabolic activity bitter gourd (Momordica charantia) digestive gut proteinases Helicoverpa armigera insect resistance squash family proteinase inhibitor

Artefacts in cone beam CT

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Open Journal of Stomatology 2013年第5期3卷 292-297页

作者： prashant P. Jaju Mayuri Jain Ajita Singh Akanksha gupta Rishi Raj College of Dental Sciences and Research Centre Bhopal India

Cone beam computed tomography (CBCT) is the modern third dimension applied in the field of oral maxillofacial region. With lower radiation dose compared to conventional CT, its applications in dentistry has increased tremendously. Artefacts can seriously degrade the quality of computed tomographic (CBCT) images, sometimes to the point of making them diagnostically unusable. To optimize image quality, it is necessary to understand why artifacts occur and how they can be prevented or suppressed. CT artifacts originate from a range of sources;physical based, scanner based and patient based. This article highlights the causes of artefacts on CBCT images and methods to avoid them.

关键词： CBCT Artefacts Metal Artefacts