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Magnification:The game changer in dentistry

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World Journal of Methodology 2025年第2期15卷 74-82页

作者： Sachin Chauhan Radha Chauhan prashant Bhasin Meenu Bhasin Department of Conservative Dentistry and Endodontics Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002India Department of Prosthodontics and Crown and Bridge and Oral Implantology Mahatma Gandhi Dental College and HospitalJaipur 302022India Department of Periodontics Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002India

During dental examinations and treatments,many dentists are using magni-fication to improve their *** dental operating microscope serves as the most effective tool for this purpose,enhancing the quality,longevity,and outcome of clinical *** review will explore the latest research and data on the importance of magnification devices in dentistry,including diagnostic methods,treatment options and ergonomics in specialities such as restorative dentistry,endodontics,pedodontics,periodontics,and *** review aims to provide insights into the optimal magnification for different clinical situations,the specific benefits of dental operating microscopes for each dental branch,and their limitations.

关键词： Magnification Vision Endodontics Dentistry Dental operating microscope

Present status and future directions:Apexification

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World Journal of Methodology 2025年第1期15卷 26-32页

作者： Sachin Chauhan Radha Chauhan prashant Bhasin Bhavna G Sharaf Department of Conservative Dentistry and Endodontics Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002HaryanaIndia Department of Prosthodontics and Crown and Bridge and Oral Implantology Mahatma Gandhi Dental College&HospitalJaipur 302022RajasthanIndia Department of Pedodontics and Preventive Dentistry Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002HaryanaIndia

The success rate of apexification is primarily determined by multiple factors,including the material used,the size of the open apex compared to the length of the root,and the technique used in each *** main objective of this review was to provide an update on the present management of open apex to identify factors and circumstances that may influence the success of apexification using different materials and *** research on apexification should focus on how to treat open apices with wide periapical lesions without ***,the predictability of these parameters with non-surgical procedures was uncertain,but now,with the use of a dental operating microscope,it has become more *** reason could be that extra visits are no longer required due to major advances in the armamentarium and materials used for apexification.

关键词： Bioceramics Magnification Biodentine Mineral trioxide aggregate Apexification Open apex

Comparative efficacy of hyperbaric bupivacaine vs hyperbaric ropivacaine in spinal anesthesia for cesarean section:A metaanalysis

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World Journal of Methodology 2025年第2期15卷 154-165页

作者： Rishi Anand Deb Sanjay Nag Roushan Patel prashant Sharma Vamsi Krishna Uppalapati Umesh Kumar Singh Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JhārkhandIndia

BACKGROUND Intrathecal bupivacaine is the traditional anesthetic drug used in spinal anesthesia for caesarean sections(CSs),but ropivacaine has emerged as a potential *** meta-analysis compares the efficacy and safety of intrathecal hyper-baric bupivacaine vs hyperbaric ropivacaine for cesarean *** To systematically evaluate and compare the efficacy and safety of intrathecal hyperbaric bupivacaine and hyperbaric ropivacaine for spinal anesthesia in *** A thorough search of electronic databases was carried out to find pertinent randomized controlled trials(RCTs)comparing intrathecal hyperbaric ropi-vacaine and hyperbaric bupivacaine during ***,Cochrane database,Google Scholar,and Scopus were searched,and papers from January 2000 to January 2024 were deemed eligible and filtered using predetermined inclusion and exclusion *** were assessed for methodological quality,and data were extracted for time to adequate anesthesia(sensory and motor blockade),duration of sensory and motor block,hemodynamic changes and side effect *** standardized mean difference with 95%CI was used for continuous *** variables were assessed using the Mantel-Haenszel test and the random effect model to compute the odds *** Total 8 RCTs were selected from a pool of 119 search results for *** meta-analysis evaluated pooled effect sizes and assessed heterogeneity among the *** primary objective was to compare key outcomes to identify any significant variances in efficacy and safety profiles between two local *** analysis revealed that the difference in the onset of sensory blockade between the two local anesthetics was statistically insignificant(P=0.1586).However,the onset of motor blockade appeared to be faster with bupivacaine(P=0.03589).Additionally,the regression of sensory and motor blockade occurred earlier in the ropivacaine ***,the duration of the first analgesic

关键词： Ropivacaine Bupivacaine Anesthesia Spinal Cesarean section Meta-analysis

Liver transplantation and resection in patients with hepatocellular cancer and portal vein tumor thrombosis: Feasible and effective?

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 123-128页

作者： prashant Bhangui Institute of Liver Transplantation and Regenerative Medicine Medanta–The MedicitySector 38GurgaonDelhi NCR 122001India

Patients with locally advanced hepatocellular cancer(HCC)and portal vein tumor thrombosis(PVTT)have a dismal prognosis since limited treatment options are available for *** recent years,effective systemic therapy,and advances in the understanding of technicalities and effectiveness of ablative therapies especially radiotherapy,have given some hope to prolong survival in *** review summarized recent evidence in literature regarding the possible role of liver resection(LR)and liver transplantation(LT)in patients with locally advanced HCC and PVTT with no extrahepatic *** therapies have helped make curative resection or LT a reality in selected *** review emphasizes on the key points to focus on when considering surgery in these patients,who are usually relegated to palliative systemic therapy *** patient selection based on tumor biology,documented downstaging based on imaging and decrease in tumor marker levels,and an adequate waiting period to demonstrate stable disease,may help obtain satisfactory long-term outcomes post LR or LT in an intention to treat strategy in patients with HCC and PVTT.

关键词： Hepatocellular carcinoma Portal vein tumour thrombosis Downstaging therapies Living donor liver transplantation and resection Outcomes

Polymer Nanocomposites in Sensor Applications: A Review on Present Trends and Future Scope

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Chinese Journal of Polymer Science 2021年第6期39卷 665-691,I0005页

作者： prashant Shukla Pooja Saxena Amity Institute for Advanced Research and Studies(Materials&Devices) Amity UniversitySector-125Noida 201303India G L Bajaj Institute of Technology and Management Greater Noida-201306Uttar PradeshIndia

Polymers are crucial constituents of modern electronic *** can be used in their pristine,composite or nanocomposite forms for several domestic and industrial applications with innumerable unique *** nanocomposites have gained wide theoretical interest and numerous practical applications in diverse fields of science and technology as they bestow the materials not only with virtuous processability but also with exceptional *** is evidenced that the electrical conductance of polymer nanocomposite is governed by the conductive filler networks within the polymer ***,insignificant variation in the conductive networks can result in noteworthy variations in the output electric signal of polymer *** this stimuli-responsive performance of conductive networks to the physical parameters,polymer nanocomposites can be harnessed to fabricate novel sensitive sensors to detect vital physical parameters ***/stress,pressure,temperature,solvent or *** and phenomenological studies on polymer nanocomposites are still *** explanations are being sought but the mechanisms governing the formation of several polymer nanocomposites are still topics of debate in the material science *** in-depth investigation requires copious scientific *** review analytically sketches the synthesis,microstructures,physiochemical properties and the underlying mechanisms for stimuli-responsiveness to the physical parameters of the polymer nanocomposites as well as their applications in various sensitive sensors and ***,it became evocative for this review to focus on their processing methodologies,physiochemical physiognomies,classification and probable potentials of polymer *** review primarily presents the current literature survey on polymer composites and the gap areas in the study encourages the objective of the present review ***,the status,perspec

关键词： Polymers Polymer nanocomposites Sensors CNT Graphene

Boundary Element Modeling of Multiconnected Ocean Basin in Visakhapatnam Port Under the Resonance Conditions

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China Ocean Engineering 2021年第5期35卷 662-675页

作者： prashant KUMAR Prachi PRIYA RAJNI Department of Applied Sciences National Institute of Technology DelhiDelhi 110040India Jindal Global Business School O P Jindal Global UniversitySonipatHaryana 131001India

A mathematical model has been developed to analyze the influence of extreme water waves over multiconnected regions in Visakhapatnam Port,India by considering an average water depth in each multiconnected *** addition,partial reflection of incident waves on coastal boundary is also *** domain of interest is divided mainly into two regions,i.e.,open sea region and harbor region namely as Region-I and Region-II,***,Region-II is divided into multiple connected *** 2-D boundary element method(BEM)including the Chebyshev point discretization is utilized to solve the Helmholtz equation in each region separately to determine the wave *** numerical convergence is performed to obtain the optimum numerical accuracy and the validation of the current numerical approach is also conducted by comparing the simulation results with existing *** four key spots based on the moored ship locations in Visakhapatnam Port are identified to perform the numerical *** wave amplification at these locations is estimated for monochromatic incident waves,considering approximate water depth and different reflection coefficients on the wall of port under the resonance *** addition,wave field analysis inside the Visakhapatnam Port is also conducted to understand resonance *** current numerical model provides an efficient tool to analyze the amplification on any realistic ports or harbors.

关键词： boundary element method amplification factor Helmholtz equation reflection coefficient Visakhapatnam Port

Spatio-temporal assessment of soil salinization utilizing remote sensing derivatives,and prediction modeling:Implications for sustainable development

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Geoscience Frontiers 2024年第6期15卷 22-36页

作者： prashant Kumar Prasoon Tiwari Arkoprovo Biswas prashant Kumar Srivastava Department of Geology Centre of Advanced StudyInstitute of ScienceBanaras Hindu UniversityVaranasi 221005U.P.India Institute of Environment and Sustainable Development Banaras Hindu UniversityVaranasi 221005U.P.India

This study aims to investigate the combined use of multi-sensor datasets(Landsat 4–5&8 OLI satellite imagery,spatial resolution=30 m)coupled with field studies to evaluate spatio-temporal dynamics of soil salinization along the coastal belt in West Bengal,*** study assesses soil salinization by mapping the salinity and electrical conductivity of saturation extract(ECe)and utilizing spectral signatures for estimating soil *** SI change(%)was analyzed(2021–1995),categorizing increases in salinity levels into 5%,10%,and 50%changes possibly due to salt encrustation on the soil *** land use land cover(LULC)change map(2021–1995)demonstrates that the study area is continuously evolving in terms of ***,in the study area,soil salinity ranges from 0.03 ppt to 3.87 ppt,and ECe varies from 0.35 dSm^(-1)to 52.85 dSm^(-1).Additionally,vulnerable saline soil locations were further *** of soil salinity based on ECe reveals that 26%of samples fall into the nonsaline category,while the rest belong to the saline *** Spectral signatures of the soil samples(n=19)acquired from FieldSpec hand spectrometer show significant absorption features around 1400,1900,and 2250 nm and indicate salt *** results of reflectance spectroscopy were crossvalidated using X-ray fluorescence and scanning electron *** study also employed partial least square regression(PLSR)approach to predict ECe(r^(2)=0.79,RMSE=3.29)and salinity parameters(r^(2)=0.75,RMSE=0.51),suggesting PLSR applicability in monitoring salt-affected soils *** study’s conclusion emphasizes that remote sensing data and multivariate analysis can be crucial tools for mapping spatial variations and predicting soil *** has also been concluded that saline groundwater used for irrigation and aqua-cultural activities exacerbates soil *** study will help policymakers/farmers identify the salt degradation problem more effectivel

关键词： Hyperspectral remote sensing Scanning electron microscopy X-ray fluorescence Partial least square regression Soil salinity Salinity index

A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against cell death in yeast

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Neural Regeneration Research 2020年第10期15卷 1931-1936页

作者： prashant Bharadwaj Ralph Martins Centre of Excellence for Alzheimer’s Disease Research and Care School of Medical and Health SciencesEdith Cowan UniversityWestern AustraliaAustralia School of Pharmacy and Biomedical Sciences Curtin Health and Innovation Research Institute(CHIRI)Faculty of Health SciencesCurtin UniversityWestern AustraliaAustralia School of Psychiatry and Clinical Neuroscience.University of Western Australia Western AustraliaAustralia School of Biomedical Science Macquarie UniversitySydneyNSWAustralia

Multiple lines of evidence show that soluble oligomer forms of amyloidβprotein(Aβ42)are the most neurotoxic species in the brain and correlates with the degree of neuronal loss and cognitive deficit in Alzheimer’s *** many studies have used mammalian cells to investigate oligomer Aβ42 toxicity,the use of more simple eukaryotic cellular systems offers advantages for large-scale screening *** have previously established and validated budding yeast,Saccharomyces cerevisiae to be a simple and a robust model to study the toxicity of Aβ.Using colony counting based methods,oligomeric Aβ42 was shown to induce dose-dependent cell death in *** have adapted this method for high throughput screening by developing an absorbance-based growth *** further validated the assay with treatments previously shown to protect oligomer Aβ42 induced cell death in mammalian and yeast *** assay offers a platform for studying underlying mechanisms of oligomer Aβ42 induced cell death using gene deletion/overexpression libraries and developing novel agents that alleviate Aβ42 induced cell death.

关键词： Alzheimer’s disease amyloid toxicity autophagy Aβ42 oligomer high-throughput screening latrepirdine neuroprotection yeast model

Mathematical Modeling of Moored Ship Motion in Arbitrary Harbor utilizing the Porous Breakwater

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China Ocean Engineering 2023年第5期37卷 738-752页

作者： Prachi Priya prashant Kumar Gulshan Rajni Government Model Sanskriti Senior Secondary School Ganaur Sonipat 131101India Department of Applied Sciences(Mathematics) National Institute of TechnologyDelhi 110036India JindalGobal Business School O.P.Jindal Global UniversitySonepat 131001India

The motion of the moored ship in the harbor is a classical hydrodynamics problem that still faces many challenges in naval operations,such as cargo transfer and ship pairings between a big transport ship and some small ships.A mathematical model is presented based on the Laplace equation utilizing the porous breakwater to investigate the moored ship motion in a partially absorbing/reflecting *** motion of the moored ship is described with the hydrodynamic forces along the rotational motion(roll,pitch,and yaw)and translational motion(surge,sway,and heave).The efficiency of the numerical method is verified by comparing it with the analytical study of Yu and Chwang(1994)for the porous breakwater,and the moored ship motion is compared with the theoretical and experimental data obtained by Yoo(1998)and Takagi et al.(1993).Further,the current numerical scheme is implemented on the realistic Visakhapatnam Fishing port,India,in order to analyze the hydrodynamic forces on moored ship motion under resonance *** model incorporates some essential strategies such as adding a porous breakwater and utilizing the wave absorber to reduce the port’s *** has been observed that these tactics have a significant impact on the resonance inside the port for safe maritime ***,the current numerical model provides an efficient tool to reduce the resonance within the arbitrarily shaped ports for secure anchoring.

关键词： boundary element method Laplace equation porous breakwater partially reflecting/absorbing harbor wall moored ship motion