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Pharmacological and Immunological Aspects of Phage Therapy

Infectious Microbes & Diseases 2019年第2期1卷 34-42页

作者： prasanth manohar Ashok.J.Tamhankar Sebastian Leptihn Nachimuthu Ramesh Antibiotic Resistance and Phage Therapy Laboratory Department of Biomedical SciencesSchool of Biosciences and TechnologyVellore Institute of Technology(VIT)Vellore 632014Tamil NaduIndia Global Health Health Systems and Policy:Medicines-focusing AntibioticsDepartment of Public Health SciencesKarolinska InstitutetStockholmSweden Indian Initiative for Management of Antibiotic resistance Department of Environmental MedicineRuxmaniben Deepchand Gardi Medical CollegeUjjainIndia Zhejiang University School of Medicine Zhejiang University-Edinburgh University(ZJU-UoE)InstituteInternational CampusZhejiang UniversityHainingZhejiang 314400China Department of Infectious Diseases Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouChina.

Bacteriophages,or viruses of microbes,when used as a medical strategy,might be able to solve the current crisis mankind faces with the increasing number of pathogens being antibiotic-resistant,where chemical drugs seized to show any therapeutic *** socalled phage therapy may be one of the most promising alternatives to treat infections caused by antibiotic-resistant bacteria,which are killed after infection by a *** phages that destroy the host by lysis are chosen for therapy,many pharmacological and immunological aspects of phages as medicines have not been established so *** immune system plays an important role in a process called phage acceptance where both,innate and adaptive immune responses of the host are ***,not only medical aspects but also social ones such as lacking public awareness or acceptance,and lack of structured regulatory guidelines are challenges that have to be addressed in the near future to establish phage therapy as a reliable and safe alternative for the treatment of *** review focuses on the unique pharmacological and immunological aspects of phages used in therapy.

关键词： phage therapy phage immune response phage stability bacteriophages phage

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Will the Overuse of Antibiotics During the Coronavirus Pandemic Accelerate Antimicrobial Resistance of Bacteria?

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Infectious Microbes & Diseases 2020年第3期2卷 87-88页

作者： prasanth manohar Belinda Loh Sebastian Leptihn Zhejiang University-University of Edinburgh(ZJU-UoE)Institute Zhejiang UniversityInternational CampusHainingZhejiangChina Department of Infectious Diseases Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiangChina University of Edinburgh Medical School Biomedical SciencesCollege of Medicine&Veterinary MedicineThe University of EdinburghEdinburghUnited Kingdom.

The coronavirus pandemic is one of mankind's biggest challenges of modern *** can cause deadly pandemics,yet another enemy should not be forgotten:Bacterial *** a biomedical perspective,bacterial infections should be easier to control,as prokaryotes exhibit structures and biochemical processes that differ from humans,and thus are easier to ***,however,employ human cells to propagate and are,therefore,more complicated to target by drugs.

关键词： drugs demic Bacteria

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