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Ground level utility of Access, Watch, Reserve classification: Insights from a tertiary care center in North India

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World Journal of Experimental Medicine 2023年第5期13卷 123-133页

作者： Gunjita Negi Arjun KB prasan kumar panda Department of Medicine All India Institute of Medical SciencesRishikeshRishikesh 249203India

BACKGROUND The overuse and misuse of antimicrobials contribute significantly to antimicrobial resistance(AMR),which is a global public health *** has particularly high rates of AMR,posing a threat to effective *** World Health Or-ganization(WHO)Access,Watch,Reserve(AWaRe)classification system was introduced to address this issue and guide appropriate antibiotic ***,there is a lack of studies examining the prescribing patterns of antimi-crobials using the AWaRe classification,especially in North ***,this study aimed to assess the prescribing patterns of antimicrobials using the WHO AWaRe classification in a tertiary care centre in North ***,Obstetrics and Gynecology).Metronidazole and ceftriaxone were the most prescribed *** to the AWaRe classification,57.61%of antibiotics fell under the Access category,38.27%in Watch,and 4.11%in *** Access antibiotics were prescribed within the Medicine department,and the same department also exhibited a higher frequency of Watch antibiotics *** questionnaire survey showed that only a third of participants were aware of the AWaRe classification,and there was a lack of knowledge regarding AMR and the potential impact of AWaRe *** The research was carried out in accordance with the methodology presented in Figure 1.A total of n=123 patients were enrolled in this study,with each of them receiving antibiotic *** majority of these prescriptions were issued to inpatients(75.4%),and both the Medicine and Surgical departments were equally represented,accounting for 49.6%and 50.4%,*** the healthcare providers responsible for prescribing antibiotics,72%were Junior Residents,18.7%were Senior Residents,and 9.3%were *** findings have been summarized in Table *** prescriptions included 27 different antibiotics,with metronidazole being the most prescribed(19%)followed by ceftriaxone(17%).Th

关键词： Antimicrobial resistance AWaRe classification Access Watch Reserve Daily defined dose Questionnaire based survey

Study on good clinical practices among researchers in a tertiary healthcare institute in India

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World Journal of Methodology 2023年第5期13卷 466-474页

作者： Harshita Harshita prasan kumar panda Medical School All India Institute of Medical SciencesRishikesh 249203UttarakhandIndia Department of Medicine All India Institute of Medical SciencesRishikesh 249203UttarakhandIndia Department of Medicine College BlockAll India Institute of Medical SciencesRishikesh 249203UttarakhandIndia

BACKGROUND Good clinical practice(GCP)is put in place to protect human participants in clinical trials as well as to ensure the quality of ***-adherence to these guidelines can produce research that may not meet the standards set by the scientific ***,it must be ensured that researchers are wellversed in the *** not much is known about the knowledge and practices of the GCP in the medical colleges of North *** To assess the knowledge and practices of researchers about GCP and analyze these with respect to the demographics of *** This is a cross-sectional study.A self-structured questionnaire about GCP,after expert validations,was circulated among researchers,at a tertiary healthcare institute,All India Institute of Medical Sciences(AIIMS),Rishikesh.A total of 59 individuals,who were selected by universal sampling,participated in the *** healthcare workers who have been investigators of Institutional Ethics Committee-approved research projects,except residents and faculty,and are still a part of the institute have been included in the *** study was approved by the Institutional Ethics Committee of AIIMS,*** used descriptive analysis and the Chi-squared test to analyze data.P value<0.05 was considered *** Out of 59 participants,only 11(18.6%)were certified for *** of the participants(64.4%)had“Average”knowledge,33.9%had“Good”knowledge and 1.7%had“Poor”*** 49%of participants had satisfactory practices related to *** was a significant difference in the knowledge based on the current academic position for the items assessing knowledge of institutional review board(P=0.010),confidentiality&privacy(P=0.011),and participant safety&adverse events(P<0.001).There was also a significant difference in knowledge of research misconduct(P=0.024)and participant safety&adverse events(P=0.011)based on certification of *** was a notable difference in the practices relate

关键词： Clinical trial Ethics Good clinical practice Knowledge Research Research subjects

Hypereosinophilic syndrome presenting as eosinophilic gastroenteritis disorder and splinter hemorrhages:A case report

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2022年第2期13卷 23-29页

作者： Ankith Bhasi Itish Patnaik prasan kumar panda Ashok Singh Department of Internal Medicine All India Institute of Medical SciencesRishikesh 249203UttarakhandIndia Department of Gastroenterology All India Institute of Medical SciencesRishikesh 249203India Department of Pathology All India Institute of Medical SciencesRishikesh 249203India

BACKGROUND Eosinophilia and related organ damage are extensively studied hot topics among rare *** addition to the cohort of available case reports of the same will be adding knowledge for better management of this less known *** SUMMARY In this article,we describe a 27-year-old Indo-Aryan man who presented with abdominal pain,abdominal distension,and loose stools for variable *** had splinter hemorrhages in the majority of *** was diagnosed with predominant eosinophilic gastrointestinal involvement with bowel obstruction and ascites,and was managed with intravenous *** was subsequently treated with oral low dose steroid therapy and responded *** Our experience is evidence that prompt management of this hypereosinophilic lethal gastrointestinal(all three layers)infiltrative disease provides a cure and avoids *** nail hemorrhages may be seen in the same disease.

关键词： Ascites Diarrhea Eosinophilia Intravenous immunoglobulin Leucoproliferative disorder Case report

Correlation of serum SARS-CoV-2 IgM and IgG serology and clinical outcomes in COVID-19 patients:Experience from a tertiary care centre

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World Journal of Biological Chemistry 2023年第2期14卷 52-61页

作者： Mohan Suresh Pratap kumar prasan kumar panda Vikram Jain Rohit Raina Sarama Saha Subbiah Vivekanandhan Balram Ji Omar Department of Internal Medicine All India Institute of Medical SciencesRishikesh 249203India Department of Biochemistry All India Institute of Medical SciencesRishikesh 249203India Department of Microbiology All India Institute of Medical SciencesRishikesh 249203India

BACKGROUND The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus has become a pandemic for the last 2 *** response to the virus leads to organ dysfunction and *** the severity of inflammatory response helps in managing critical patients using serology tests IgG and *** To investigate the correlation of the serology(IgM and IgG)with reverse transcriptase polymerase chain reaction(RT-PCR)status,disease severity[mild to critical],intensive care unit(ICU)admission,septic shock,acute kidney injury,and in-hospital *** We conducted a longitudinal study to correlate serum SARS-CoV-2 immunoglobulin M(IgM)and immunoglobulin G(IgG)serology with clinical outcomes in coronavirus disease 2019(COVID-19)*** analyzed patient data from March to December 2020 for those who were admitted at All India Institute of Medical Sciences *** and laboratory data of these patients were collected from the e-hospital portal and analyzed.A correlation was seen with clinical outcomes and was assessed using MS Excel 2010 and SPSS *** Out of 494 patients,the mean age of patients was 48.95±16.40 years and there were more male patients in the study(66.0%).The patients were classified as mild-moderate 328(67.1%),severe 131(26.8%),and critical 30(6.1%).The mean duration from symptom onset to serology testing was 19.87±30.53 ***-hospital mortality was observed in 25.1%of *** seropositivity rate(i.e.,either IgG or IgM>10 AU)was 50%.IgM levels(AU/mL)(W=33428.000,P≤0.001)and IgG levels(AU/mL)(W=39256.500,P≤0.001),with the median IgM/IgG levels(AU/mL),were highest in the RT-PCR-Positive group compared to RT-PCR-Negative clinical *** was no significant difference between the two groups in terms of all other clinical outcomes(disease severity,septic shock,ICU admission,mechanical ventilation,and mortality).CONCLUSION The study showed that serology levels are high in RT-PCR positive group compared

关键词： Inflammatory response Reverse transcription polymerase chain reaction SARS-CoV-2 Serology IgM and IgG

Marine Predators Algorithm with Deep Learning-Based Leukemia Cancer Classification on Medical Images

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 893-916页

作者： Sonali Das Saroja kumar Rout Sujit kumar panda Pradyumna kumar Mohapatra Abdulaziz S.Almazyad Muhammed Basheer Jasser Guojiang Xiong Ali Wagdy Mohamed Department of Computer Science&Engineering Gandhi Institute for TechnologyBPUTBhubaneswar752054India Department of Information Technology Vardhaman College of Engineering(Autonomous)Hyderabad501218TelanganaIndia Department of Electronic&Communication Engineering Vedang Institute of TechnologyBhubaneswar752010India Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia Department of Computing and Information Systems School of Engineering and TechnologySunway UniversityJalan UniversitiBandar SunwaySelangor Darul Ehsan47500Malaysia Research Centre for Human-Machine Collaboration(HUMAC) School of Engineering and TechnologySunway UniversityJalan UniversitiBandar SunwaySelangor Darul Ehsan47500Malaysia Guizhou Key Laboratory of Intelligent Technology in Power System College of Electrical EngineeringGuizhou UniversityGuiyang550025China Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Applied Science Research Center Applied Science Private UniversityAmman11931Jordan

In blood or bone marrow,leukemia is a form of cancer.A person with leukemia has an expansion of white blood cells(WBCs).It primarily affects children and rarely affects *** depends on the type of leukemia and the extent to which cancer has established throughout the *** leukemia in the initial stage is vital to providing timely patient *** image-analysis-related approaches grant safer,quicker,and less costly solutions while ignoring the difficulties of these invasive *** can be simple to generalize Computer vision(CV)-based and image-processing techniques and eradicate human *** researchers have implemented computer-aided diagnosticmethods andmachine learning(ML)for laboratory image analysis,hopefully overcoming the limitations of late leukemia detection and determining its *** study establishes a Marine Predators Algorithm with Deep Learning Leukemia Cancer Classification(MPADL-LCC)algorithm onMedical *** projectedMPADL-LCC system uses a bilateral filtering(BF)technique to pre-process medical *** MPADL-LCC system uses Faster SqueezeNet withMarine Predators Algorithm(MPA)as a hyperparameter optimizer for feature ***,the denoising autoencoder(DAE)methodology can be executed to accurately detect and classify leukemia *** hyperparameter tuning process using MPA helps enhance leukemia cancer classification *** results are compared with other recent approaches concerning various measurements and the MPADL-LCC algorithm exhibits the best results over other recent approaches.

关键词： Leukemia cancer medical imaging image classification deep learning marine predators algorithm

Determination of the time of refractive stability after uneventful phacoemulsification in Indian eyes

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World Journal of Experimental Medicine 2024年第2期14卷 89-96页

作者： Ashok kumar Nanda Bijnya Birajita panda Asish Swain Logesh Balakrishnan Department of Ophthalmology Kar Vision Eye HospitalBhubaneswar 751013OdishaIndia Department of Ophthalmology All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Optometry Kar Vision Eye HospitalBhubaneswar 751013OdishaIndia Department of Statistics Apollo HospitalsChennai 823104India

BACKGROUND Knowledge about refractive stabilization and the accuracy of postoperative refractive error measurements are crucial for improved patient outcomes after *** guidelines typically recommend waiting 4-6 wk before prescribing corrective *** research focused on identifying factors that influence refractive errors in the early stages of post-cataract surgery,thus contributing to the existing literature on this *** To investigate the time required for refraction stability after uneventful phacoemulsification *** We compared the variation and statistical significance of the difference in spherical,cylindrical components,and the spherical equivalent between the 1-and 6-wk follow-up period in a group of 257 eyes that underwent uneventful phacoemulsification with foldable intraocular lens implantation,all performed by a single experienced *** Wilcoxon-Signed Rank Test was utilized to assess the magnitude of the change and determine its statistical *** refractive stability was defined as the point at which the change in spherical equivalent was within±0.5 dioptres for two consecutive *** The average age of the patients was 64.9±8.9 *** differences observed in both the visits in spherical power(0.1±0.2),cylinder power(0.3±0.4),and spherical equivalent(0.2±0.2)were minimal and not statistically *** majority of eyes(93.4%)achieved refractive stability within 6 wk after the *** cylindrical power differed between age groups at the 6th wk post-operative and the difference was statistically significant(P value 0.013).There were no significant differences in refractive stability when considering sex and axial *** Phacoemulsification with foldable intraocular lens implantation results in no significant changes in refraction for the majority of cases during the 6-wk follow-up ***,a spectacle prescription can be given at the completion of 1 wk.

关键词： Cataract surgery Phacoemulsification Refraction stability Visual acuity Spherical equivalent

Optimized protoplast isolation and transfection with a breakpoint:accelerating Cas9/sgRNA cleavage efficiency validation in monocot and dicot

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aBIOTECH 2024年第2期5卷 151-168页

作者： Debasmita panda Subhasis Karmakar Manaswini Dash Swagat kumar Tripathy Priya Das Sagar Banerjee Yiping Qi Sanghamitra Samantaray Pradipta kumar Mohapatra Mirza J.Baig Kutubuddin A.Molla ICAR National Rice Research Institute CuttackOdisha 753006India Department of Botany Ravenshaw UniversityCuttackOdisha 753003India Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA

The CRISPR-Cas genome editing tools are revolutionizing agriculture and basic biology with their simplicity and precision ability to modify target genomic ***-predicted guide RNAs(gRNAs)often fail to induce efficient cleavage at target *** target loci are inaccessible due to complex chromatin ***,there is no suitable tool available to predict the architecture of genomic target sites and their ***,significant time and resources are spent on performing editing experiments with inefficient *** in vitro-cleavage assay could provide a rough assessment of gRNA efficiency,it largely excludes the interference of native genomic *** in-vivo testing gives a proper assessment of the cleavage ability of editing reagents in a native genomic ***,we developed a modified protocol that offers highly efficient protoplast isolation from rice,Arabidopsis,and chickpea,using a sucrose gradient,transfection using PEG(polyethylene glycol),and validation of single guide RNAs(sgRNAs)cleavage efficiency of *** have optimized various parameters for PEG-mediated protoplast transfection and achieved high transfection efficiency using our protocol in both monocots and *** introduced plasmid vectors containing Cas9 and sgRNAs targeting genes in rice,Arabidopsis,and chickpea *** dual sgRNAs,our CRISPRdeletion strategy offers straightforward detection of genome editing success by simple agarose gel *** sequencing of PCR products confirmed the editing efficiency of specific ***,we demonstrated that isolated protoplasts can be stored for up to 24/48 h with little loss of viability,allowing a pause between isolation and *** high-efficiency protocol for protoplast isolation and transfection enables rapid(less than 7 days)validation of sgRNA cleavage efficiency before proceeding with stable *** isolation and transfection method can als

关键词： Protoplast Genome editing Transgene-free edited plants Rice Chickpea

Emerging leishmaniasis in southern Himalayas:A mini-review

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World Journal of Clinical Infectious Diseases 2023年第2期13卷 11-23页

作者： Ashwani Sharma Santosh kumar prasan kumar panda Sweety Yadav Deepjyoti Kalita Department of Community and Family Medicine All India Institute of Medical SciencesRishikesh 249203India Department of Medicine All India Institute of Medical SciencesRishikesh 249203India Department of Internal Medicine All India Institute of Medical SciencesRishikesh 249203India Department of Microbiology All India Institute of Medical SciencesRishikesh 249203India

Leishmaniasis is a vector-borne parasitic disease affecting millions of people ***,in the last decade,the number of cases has been reduced from well-documented endemic parts,but sporadic cases have been reported widely from various non-endemic areas,especially from the southern Himalayan *** raises concerns about the emergence of new ecological *** warrants a critical evaluation of key factors causing this rapid spread and possibly indigenous *** mini-review article is aimed to briefly address the parasite,the vector,and the environmental aspects in the transmission of leishmaniasis in these new foci against a background of worldwide endemic leishmaniasis with a special focus on the southern Himalayan *** the lack of knowledge about the causative parasites,vectors,reservoir hosts,atypical presentations,and their management make the problem serious and may lead to the emergence of public health *** present works also reviewed the existing information regarding clinical variations,diagnostic methods,treatment,its outcome,and ignite for further research in these aspects of the disease.

关键词： Anthroponosis Kala azar sandfly Sporadic transmission Southern Himalaya

A Review on Robust and Adaptive Control Schemes for Microgrid

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Journal of Modern Power Systems and Clean Energy 2023年第4期11卷 1027-1040页

作者： Swagat kumar panda Bidyadhar Subudhi School of Electrical Sciences Indian Institute of Technology GoaGoaIndia

Several challenges are encountered while integrating microgrids(MGs)with an existing utility *** are low inertia,intermittent nature of renewable energy resources(RESs),sensor and actuator faults,unbalanced and nonlinear loads,supply-demand mismatch,and uncertain switching functions of the power electronic *** control is fully dependent on the communication network,which is also susceptible to different types of failures such as noise in communication links,communication delay,limited bandwidth,packet dropout,and various malicious cyber *** few papers are available in the literature that focus on the review of control schemes for ***,this paper presents a comprehensive review of different robust and adaptive control schemes that address the challenges encountered due to communication constraints,uncertainties,and disturbances for different MG topologies such as AC,DC,and hybrid AC/DC MGs,as well as the current research trends in the field of robust and adaptive *** can be concluded that to achieve control objectives of MG and overcome the existing challenges,robust and adaptive controllers show significantly improved performance in terms of transient and steady-state behavior and robustness as compared to traditional controllers.

关键词： Microgrid distributed energy resource robust control adaptive control distributed control