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Computational Identification of Sweet Wormwood (Artemisia annua) microRNA and Their mRNA Targets

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Genomics, Proteomics & Bioinformatics 2011年第6期9卷 200-210页

作者： Alok Pani Rajani Kanta Mahapatra Niranjan Behera pradeep kumar Naik School of Biotechnology Kalinga Institute of Industrial Technology (KIIT) UniversityBhubaneswar Odisha 751024 India School of Biotechnology Kalinga Institute of Industrial Technology (KIIT) University Bhubaneswar Odisha 751024 India School of Life Sciences Sambalpur UniversityBurla Odisha 768019 India Department of Biotechnology &Bioinformatics Jaypee University of Information TechnologySolan Himachal Pradesh 173215 India

Despite its efficacy against malaria, the relatively low yield （0.01%-0.8%） of artemisinin in Artemisia annua is a serious limitation to the commercialization of the drug. A better understanding of the biosynthetic pathway of artemisinin and its regulation by both exogenous and endogenous factors is essential to improve artemisinin yield. Increasing evidence has shown that microRNAs （miRNAs） play multiple roles in various biological processes. In this study, we used previously known miRNAs from Arabidopsis and rice against expressed sequence tag （EST） database of A. annua to search for potential miRNAs and their targets in A. annua. A total of six potential rniRNAs were predicted, which belong to the miR414 and miR1310 families. Furthermore, eight potential target genes were identified in this species. Among them, seven genes encode proteins that play important roles in artemisinin biosynthesis, including HMG-CoA reductase （HMGR）, amorpha-4,11-diene synthase （ADS）, farnesyl pyrophosphate synthase （FPS） and cytochrome P450. In addition, a gene coding for putative AINTEGUMENTA, which is involved in signal transduction and development, was also predicted as one of the targets. This is the first in silico study to indicate that miRNAs target genes encoding enzymes involved in artemisinin biosynthesis, which may help to understand the miRNA-mediated regulation of artemisinin biosynthesis in A. annua.

关键词： artemisinin microRNA EST computational prediction Artemisia annua

Antidiabetic claims of Tinospora cordifolia(Willd.)Miers:critical appraisal and role in therapy

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Asian Pacific Journal of Tropical Biomedicine 2015年第1期5卷 68-78页

作者： Rohit Sharma Hetal Amin Galib pradeep kumar Prajapati Department of Rasashastra and Bhaishajya Kalpana Including Drug Research I.P.G.T.& R.A.Gujarat Ayurved University Department of Basic Principles including Drug Research I.P.G.T.& R.A.Gujarat Ayurved University

Currently,available conventional options for diabetes mellitus have certain limitations of their own,and options from medicinal plants with antihyperglycemic activities are being searched to meet the *** properties of Tmospora cordifolia are highly appreciated in Ayurveda and even in recent modern *** studies on its extracts(viz,***,*** regulator etc.) and isolated phytoconstituents(like tinosporin,*** etc.) have reported that it is a preventive and curative antidiabetic herb,which are substantiated by clinical *** information pertaining to antidiabetic potential of Tmospora is *** review encompasses(i) in-depth information of reported antidiabetic activities of the plant in light of available experimental and clinical studies,and(ii) understanding on the possible mechanism of its action in combating the complex pathology of diabetes.

关键词： Diabetes mellitus Guduchi Herbal remedies Tinospora cordifolia Traditional medicine

Development of a PCR methodology to distinguish species members of Culex vishnui subgroup （Diptera： Culicidae）, based on DNA Barcodes

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Insect Science 2017年第2期24卷 336-340页

作者： N. pradeep kumar A. R. Rajavel P. Jambulingam Vector Control Research Centre Field Station (ICMR) Kottayam Kerala India Vector Control Research Centre (ICMR) Indira Nagar Puducherry India

Dear Editor, ＂DNA Barcoding＂ has emerged as a very efficient tool for species identification of diverse group of animals and plants （Stoeckle ＆ Hebert, 2008）. This methodology was proposed as a universal approach... 详细信息

关键词： PCR方法双翅目条形码 DNA 蚊科库蚊物种

Altered Host Resistance to Listeria monocytogenes In Mice Exposed to 1-Chloroacetophenone (CN) Vapours

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Biomedical and Environmental Sciences 1992年第2期5卷 142-148页

作者： pradeep kumar PRAVIN kumar K.ZACHARIAH G.P.RAI R.VIJAYRAGHAVAN Defence Research and Development Establishment Tansen RoadDefence Research and Development Establishment Tansen RoadDefence Research and Development Establishment Tansen RoadDefence Research and Development Establishment Tansen RoadDefence Research and Development Establishment Tansen Road Gwalior 474002 India Gwalior 474002 India Gwalior 474002 IndiaGwalior 474002 IndiaGwalior 474002 India

Short term repeated exposure of 1-chloroacetophenone (CN) vapours at a concentration of 0.153 mg per litre for 15 minutes daily on 10 consecuitve days in Swiss albino male mice resulted in increased mortality to Listeria monocytogenes. Significantly elevated bacterial growth was observed in the spleen and liver of the CN exposed animals. The increased bacterial count in these organs was evident within 4-6 days post challenge as compared to vehicle exposed infected and unexposed infected animals. Increased susceptibility to infection has been considered to be the function of immune alteration due to cumulative short term effects ofCN vapour inhalation. This may be attributed to immunotoxic effects of CN on Tcells mediated macrophage functions.

关键词： CN Vapours Altered Host Resistance to Listeria monocytogenes In Mice Exposed to 1-Chloroacetophenone

First contact investigations and compliance to treatment in patients with uveitis

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1820-1826页

作者： Anuja Patil Sanjeev Gupta pradeep Venkatesh Mousumi Banerjee Vinod kumar Rohan Chawla Shorya Vardhan Azad Atul kumar Dr.Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical SciencesNew Delhi 110029India

AIM:To ascertain the pattern of investigations at first contact in uveitic patients and evaluate compliance to ***:An observational study comprised of 201 uveitic patients presenting for the first time to our centre from January 2019 to June *** information regarding systemic investigations undertaken by specialists at the time of first contact and the cost of these investigations were reviewed on the first visit to our *** with the treatment was determined and reasons behind non-compliance were evaluated on the first follow-up in patients who had no improvement in clinical signs and ***:The mean age of the study group was 35.35±14.1y and gender composition was 59.7%males and 40.3%*** uveitis was observed in 45.3%of patients,intermediate uveitis in 31.8%of patients,posterior uveitis in 14.9%of patients and panuveitis in 8.0%of *** with a systemic disease was evident in 17.9%of *** compared with standard guidelines and uveitis patterns,systemic investigations were identified to be relevant only in 38.3%of ***-compliance to treatment was documented in 22.4%of *** reasons for non-compliance were inadequate counselling by the treating physician about treatment in 26.7%of patients and a busy schedule at work/school in 22.2%of ***:Significant number of investigations performed at first contact is found to be contrary to standard guidelines and are not contributory to the *** a quarter of patients in this study are found to be non-compliant with the *** is more challenging to achieve in school-going children and working *** availability of comprehensive,periodically updated,evidence-based guidelines on the role of investigations and the use of trained counsellors may help to channelize proper evaluation and improve compliance to treatment,respectively,in patients with uveitis.

关键词： uveitis compliance investigations first contact

Multi-Objective Grey Wolf Optimization Algorithm for Solving Real-World BLDC Motor Design Problem

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Computers, Materials & Continua 2022年第2期70卷 2435-2452页

作者： M.Premkumar pradeep Jangir B.Santhosh kumar Mohammad A.Alqudah Kottakkaran Sooppy Nisar Department of Electrical and Electronics Engineering GMR Institute of TechnologyRajam532127Andhra PradeshIndia Rajasthan Rajya Vidyut Prasaran Nigam Sikar332025RajasthanIndia Department of Computer Science and Engineering GMR Institute of TechnologyRajam532127Andhra PradeshIndia German Jordanian University Amman11180Jordan Department of Mathematics College of Arts and SciencesPrince Sattam Bin Abdulaziz UniversityWadi Aldawaser11991Saudi Arabia

The first step in the design phase of the Brushless Direct Current(BLDC)motor is the formulation of the mathematical framework and is often used due to its analytical ***,the BLDC motor design problem is considered to be an optimization *** this paper,the analytical model of the BLDC motor is presented,and it is considered to be a basis for emphasizing the optimization *** analytical model used for the experimentation has 78 non-linear equations,two objective functions,five design variables,and six non-linear constraints,so the BLDC motor design problem is considered as highly non-linear in electromagnetic ***-objective optimization becomes the forefront of the current research to obtain the global best solution using metaheuristic *** bio-inspired multi-objective grey wolf optimizer(MOGWO)is presented in this paper,and it is formulated based on Pareto optimality,dominance,and archiving *** performance of theMOGWO is verified on standard multi-objective unconstraint benchmark functions and applied to the BLDC motor design *** results proved that the proposedMOGWO algorithm could handle nonlinear constraints in electromagnetic optimization *** performance comparison in terms of Generational Distance,inversion GD,Hypervolume-matrix,scattered-matrix,and coverage metrics proves that the MOGWO algorithm can provide the best solution compared to other selected *** source code of this paper is backed up with extra online support at https://***/mysite and https://***/matlabcentral/fileexchange/75259-multiobjective-non-sorted-grey-wolf-mogwo-nsgwo.

关键词： BLDC motor electromagnetics metaheuristic multi-objective grey wolf optimizer

Generating A New Shilling Attack for Recommendation Systems

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Computers, Materials & Continua 2022年第5期71卷 2827-2846页

作者： pradeep kumar Singh Pijush Kanti Dutta Pramanik Madhumita Sardar Anand Nayyar Mehedi Masud Prasenjit Choudhury Department of Computer Science&Engineering National Institute of TechnologyDurgapurIndia Graduate School Duy Tan UniversityDa NangVietnam Faculty of Information Technology Duy Tan UniversityDa NangVietnam Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

A collaborative filtering-based recommendation system has been an integral part of e-commerce and *** keep the recommendation systems reliable,authentic,and superior,the security of these systems is very *** the existing shilling attack detection methods in collaborative filtering are able to detect the standard attacks,in this paper,we prove that they fail to detect a new or unknown *** develop a new attack model,named Obscure attack,with unknown features and observed that it has been successful in biasing the overall top-N list of the target users as *** Obscure attack is able to push target items to the top-N list as well as remove the actual rated items from the *** proposed attack is more effective at a smaller number of k in top-k similar user as compared to other existing *** effectivity of the proposed attack model is tested on the MovieLens dataset,where various classifiers like SVM,J48,random forest,and naïve Bayes are utilized.

关键词： Shilling attack recommendation system collaborative filtering top-N recommendation biasing shuffling hit ratio

Magnesium based surface metal matrix composites by friction stir processing

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Journal of Magnesium and Alloys 2016年第1期4卷 52-61页

作者： B.Ratna Sunil G.pradeep kumar Reddy Hemendra Patle Ravikumar Dumpala Department of Mechanical Engineering Rajiv Gandhi University of Knowledge Technologies(AP-IIIT)Nuzvid 520202India Department of Mechanical Engineering Vignana Bharathi Institute of TechnologyHyderabad 501301India Department of Mechanical Engineering Visvesvaraya National Institute of TechnologyNagpur 440010India

Surface metal matrix composites(MMCs)are a group of modern engineered materials where the surface of the material is modified by dispersing secondary phase in the form of particles or fibers and the core of the material experience no change in chemical composition and *** potential applications of the surface MMCs can be found in automotive,aerospace,biomedical and power ***,friction stir processing(FSP)technique has been gaining wide popularity in producing surface composites in solid state *** and its alloys being difficult to process metals also have been successfully processed by FSP to fabricate surface *** aim of the present paper is to provide a comprehensive summary of state-of-the-art in fabricating magnesium based composites by *** of the secondary phase particles and grain refinement resulted from FSP on the properties of these composites is also discussed.

关键词： Surface composites Friction stir processing Hardness Light weight Magnesium alloys Biomedical implants

Insights on antioxidant therapeutic strategies in type 2 diabetes mellitus:A narrative review of randomized control trials

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World Journal of Diabetes 2023年第6期14卷 919-929页

作者： Dharmsheel Shrivastav pradeep kumar Dabla Jitender Sharma Aroop Viswas Rashid Mir Amity Institute of Biotechnology Amity University RajasthanJaipur 303002India Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchDelhi 110002India Department of Medical Lab Technology Faculty of Applied Medical SciencesUniversity of TabukTabuk 71491Saudi Arabia

BACKGROUND Type 2 diabetes mellitus(T2DM)is a metabolic disease of impaired glucose *** in generation and elimination of free radicals generate oxidative stress which modulates glucose metabolism and insulin regulation,resulting in the occurrence and progression of diabetes and associated *** supplements in T2DM can be seen as a potential preventive and effective therapeutic *** To compare randomized controlled trials(RCTs)in which antioxidants have been shown to have a therapeutic effect in T2DM *** We systematically searched the electronic database PubMed by *** evaluating the effect of antioxidant therapy on glycaemic control as well as oxidant and antioxidant status as primary outcomes were *** outcomes considered were:A reduction in blood glucose;changes in oxidative stress and antioxidant ***-length papers of the shortlisted articles were assessed for the eligibility criteria and 17 RCTs were *** The administration of fixed-dose antioxidants significantly reduces fasting blood sugar and glycated hemoglobin and is associated with decreased malondialdehyde,advanced oxidation protein products,and increased total antioxidant *** Antioxidant supplements can be a beneficial approach for the treatment of T2DM.

关键词： Diabetes Antioxidants Oxidative stress Malondialdehyde Polyphenols Antioxidant therapy