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Current methods for the maturation of induced pluripotent stem cellderived cardiomyocytes

World Journal of Stem Cells 2019年第1期11卷 33-43页

作者： pranav Machiraju Steven C Greenway Departments of Pediatrics and Cardiac Sciences Alberta Children’s Hospital Research Institute Libin Cardiovascular Institute of Alberta Cumming School of MedicineUniversity of Calgary Departments of Pediatrics Cardiac Sciences Biochemistry & Molecular Biology Alberta Children’s Hospital Research Institute Libin Cardiovascular Institute of Alberta Cumming School of Medicine University of Calgary

Induced pluripotent stem cells(iPSCs) were first generated by Yamanaka and colleagues over a decade ago. Since then, iPSCs have been successfully differentiated into many distinct cell types, enabling tissue-, disease-, and patientspecific in vitro modelling. Cardiovascular disease is the greatest cause of mortality worldwide but encompasses rarer disorders of conduction and myocardial function for which a cellular model of study is ideal. Although methods to differentiate iPSCs into beating cardiomyocytes(iPSC-CMs) have recently been adequately optimized and commercialized, the resulting cells remain largely immature with regards to their structure and function,demonstrating fetal gene expression, disorganized morphology, reliance on predominantly glycolytic metabolism and contractile characteristics that differ from those of adult cardiomyocytes. As such, disease modelling using iPSC-CMs may be inaccurate and of limited utility. However, this limitation is widely recognized, and numerous groups have made substantial progress in addressing this problem. This review highlights successful methods that have been developed for the maturation of human iPSC-CMs using small molecules,environmental manipulation and 3-dimensional(3 D) growth approaches.

关键词： Induced pluripotent stem cells Induced pluripotent stem cell-derived cardiomyocytes Regenerative medicine Stem cell biology Translational research

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Mechanism of Action of Natural Products Used in the Treatment of Diabetes Mellitus

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Chinese Journal of Integrative Medicine 2011年第8期17卷 563-574页

作者： pranav Kumar Prabhakar Mukesh Doble Department of Biotechnology Indian Institute of Technology Madras

Diabetes mellitus（DM） is a metabolic disorder caused by insufficient or inefficient insulin secretary response and it is characterized by increased blood glucose levels（hyperglycemia）.DM is a heterogonous group of *** is the main energy source for the body,and in the case of DM,management of glucose becomes *** are three key defects in the onset of hyperglycemia in DM,namely increased hepatic glucose production,diminished insulin secretion, and impaired insulin *** drugs treat diabetes by improving insulin sensitivity,increasing insulin production and/or decreasing the amount of glucose in *** article provides a comprehensive review of the mode of action of most popular hypoglycemic herbs,such as ginseng,bitter melon,fenugreek,banaba, Gymnema sylvestre and Coptis *** herbs act by increasing insulin secretion,enhancing glucose uptake by adipose and skeletal muscle tissues,inhibiting intestinal glucose absorption and inhibiting hepatic glucose *** evidence from animals and humans consistently supports the therapeutic effect of these phytomedicines,multicenter large-scale clinical trials have not been conducted to evaluate the safety and efficacy of these herbal medicines and their interaction with conventional drugs when administered simultaneously.

关键词： hyperglycemia medicinal plants ginseng bitter melon fenugreek banaba

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A simulation-based proposed high-k heterostructure AlGaAs/Si junctionless n-type tunnel FET

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Journal of Semiconductors 2014年第11期35卷 59-63页

作者： Shiromani Balmukund Rahi Bahniman Ghosh pranav Asthana Department of Electrical Engineering Indian Institute of Technology Kanpur Microelectronics Research Center 10100Burnet RoadBldg.160University of Texas at Austin

We propose a heterostructure junctionless tunnel field effect transistor （HJL-TFET） using AIGaAs/Si. In the proposed HJL-TFET, low band gap silicon is used in the source side and higher band gap AlGaAs in the drain side. The whole AlGaAs/Si region is heavily doped n-type. The proposed HJL-TFET uses two isolated gates （named gate, gatel ） with two different work functions （gate = 4.2 eV, gatel = 5.2 eV respectively）. The 2-D nature of HJL-TFET current flow is studied. The proposed structure is simulated in Silvaco with different gate dielectric materials. This structure exhibits a high on current in the range of 1.4 × 10^-6 A/μm, the off current remains as low as 9.1 × 10^-14 A/μm. So /ON/OFF ratio of 10^8 is achieved. Point subthreshold swing has also been reduced to a value of 41 mV/decade for TiO2 gate material.

关键词： band-to-band tunneling (BTBT) TFET heterostructure junctionless tunnel field effect transistor (HJL-TFET) ION/ION/IOFF ratio subthreshold slope VLSI

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Dynamic threshold voltage operation in Si and SiGe source junctionless tunnel field effect transistor

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Journal of Semiconductors 2014年第11期35卷 32-39页

作者： Shibir Basak pranav Kumar Asthana Yogesh Goswami Bahniman Ghosh Department of Electrical Engineering Indian Institute of Technology Kanpur Microelectronics Research Center 10100Burnet RoadBldg.160University of Texas at Austin

We propose a dynamic threshold voltage j unctionless tunnel FET （DT-JLTFET） in wnlcn me mresnolu voltage can be dynamically adjusted, resulting in higher ON-current. Through 2D numerical simulations, it is presented that the threshold voltage in the DT-JLTFET can be adjusted by applying a voltage to the adjust gate. The impact of the threshold voltage shift on the overall performance of the device is also studied. A comparison is made between the dynamic threshold voltage characteristics of a silicon JLTFET and a Sio.7Geo.3 source JLTFET.

关键词： SiGe tunnel field effect transistor ON-current

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Characterization of Intracellular Gold Nanoparticles Synthesized by Biomass of Aspergillus terreus

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Acta Metallurgica Sinica(English Letters) 2014年第4期27卷 569-572页

作者： Baskar Gurunathan pranav Vasanthi Bathrinarayanan Vasanth Kumar Muthukumarasamy Dilliganesh Thangavelu Department of Biotechnology St.Joseph’s College of EngineeringChennai 600 119India

Greener synthesis of nanoparticle is a revolutionizing area in research *** method of reduction of metal ions is often preferred because they are clean,safe,biocompatible,and environmentally acceptable than physical,chemical,and mechanical *** wet biomass of Aspergillus terreus（***） was utilized for the intracellular synthesis of gold *** nanoparticles were produced when an aqueous solution of chloroauric acid was reduced by *** biomass as the reducing *** of gold nanoparticles was confirmed by the color change of biomass from yellow to pinkish *** produced nanoparticles were then characterized by FT-IR,SEM,EDS,and *** SEM images revealed that the nanoparticles were spherical,irregularly shaped with no definite *** size of the biosynthesized gold nanoparticles was 186 *** presence of the gold nanoparticle was confirmed by EDS *** nature of synthesized gold nanoparticle was confirmed by XRD pattern.

关键词： Gold nanoparticles Biosynthesis Characterization Scanning electron microscope Energy dispersive spectroscopy

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Systematic review and meta-analysis of augmented reality in medicine, retail, and games

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Visual Computing for Industry,Biomedicine,and Art 2020年第1期3卷 227-246页

作者： pranav Parekh Shireen Patel Nivedita Patel Manan Shah Department of Computer Engineering Nirma UniversityAhmedabadGujarat 382481India Department of Chemical Engineering School of TechnologyPandit Deendayal Petroleum UniversityGandhinagarGujaratIndia

This paper presents a detailed review of the applications of augmented reality(AR)in three important fields where AR use is currently *** objective of this study is to highlight how AR improves and enhances the user experience in entertainment,medicine,and *** authors briefly introduce the topic of AR and discuss its differences from virtual *** also explain the software and hardware technologies required for implementing an AR system and the different types of displays required for enhancing the user *** growth of AR in markets is also briefly *** the three sections of the paper,the applications of AR are *** use of AR in multiplayer gaming,computer games,broadcasting,and multimedia videos,as an aspect of entertainment and gaming is *** in medicine involves the use of AR in medical healing,medical training,medical teaching,surgery,and post-medical *** in retail was discussed in terms of its uses in advertisement,marketing,fashion retail,and online *** authors concluded the paper by detailing the future use of AR and its advantages and disadvantages in the current scenario.

关键词： Augmented reality Software Medicine Gaming

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Efficacy and safety of ivermectin for COVID-19:A systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2021年第10期14卷 440-450页

作者： Alok Singh pranav G Sheth Suryaprakash Dhaneria Dhyuti Gupta Department of Pharmacology All India Institute of Medical SciencesRaipur 492099 ChhattisgarhIndia

Objective:To critically evaluate the trials that have assessed the efficacy and safety of ivermectin COVID-19 and to validate the rationality of using this drug in the management of COVID-19 either as a prophylactic or therapeutic ***:The authors conducted a systematic search through various databases,i.e.,Cochrane library,Pub Med,***,and preprint servers,for publications from 2020 to May *** keywords used for the search were:"COVID-19 and ivermectin"(with filter set for"trials").All the trials assessing efficacy in prophylaxis and treatment of COVID-19 were included for *** primary outcome was the proportion of patients showing disease *** outcomes were mean duration of hospitalization and resolution of symptoms,the proportion of patients testing positive on day 5-7,the mortality rate in severe cases,incidence of serious adverse events,and contacts of COVID-19 positive patients who turned RT-PCR positive after prophylaxis ***:A total of 17 clinical trials were included for the *** proved to be a beneficial add-on therapy,as it reduced the risk of disease progression(OR 0.47,95%CI 0.30-0.74,P=0.001),led to early resolution of symptoms(MD-1.16,95%CI-1.52--0.81,P<0.001),and had less duration of hospitalization(MD-2.21,95%CI-3.23--1.19,P<0.001).In addition,ivermectin was better in providing effective prophylaxis(OR 0.13,95%CI 0.05-0.30,P<0.001).The incidence of serious adverse events was ***:As an adjunct to standard care,ivermectin has shown its efficacy and safety in treating and prophylaxis in COVID-19 *** results should be interpreted cautiously as these trials had significant shortcomings.

关键词： Ivermectin SARS-CoV-2 COVID-19 Drug repurposing WHO

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Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

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Animal Models and Experimental Medicine 2021年第3期4卷 243-248页

作者： pranav Nayak B Minaz Nathani Khadar Pasha Pharmacology Department and Al-Ameen College of Pharmacy and Rajiv Gandhi University BangaloreIndia

Diabetic neuropathy is a disorder which affects various regions of the nervous sys-tem and there is no specific treatment available for ***,the present study eval-uated protective effect of molsidomine in diabetic neuropathy in *** was induced in male Wistar rats by administrating streptozotocin(52 mg/kg i.p).Diabetic rats were administered with molsidomine 5 mg/kg p.o,and 10mg/kg *** *** 8 weeks of treatment,Motor coordination,Mechanical allodynia,Mechanical hyperalgesia,Nerve conduction velocity,Glycosylated hemoglobin were *** animals were sacrificed and sciatic nerve was *** was used for reduced glutathione,lipid peroxidation and for *** with molsidomine significantly improved motor coordination,paw withdrawal threshold,mechanical threshold and nerve conduction ***,mol-sidomine treatment also reduced malondialdehyde levels and prevented depletion of reduced glutathione in sciatic nerve *** shows molsid-omine treatment maintained normal architecture of sciatic *** results of our study strengthens the alterative use of molsidomine in diabetic neuropathy.

关键词： diabetic neuropathy molsidomine streptozotocin Wistar rats

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Influence of Unbalance on Classification Accuracy of Tyre Pressure Monitoring System Using Vibration Signals

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Structural Durability & Health Monitoring 2021年第3期15卷 261-279页

作者： P.S.Anoop pranav Nair V.Sugumaran School of Mechanical Engineering Vellore Institute of TechnologyChennai CampusChennai600127India School of Electrical Engineering Vellore Institute of TechnologyChennai CampusChennai600127India

Tyre Pressure Monitoring Systems(TPMS)are installed in automobiles to monitor the pressure of the *** pressure is an important parameter for the comfort of the travelers and the safety of the *** methods have been researched and reported for *** them,vibration-based indirect TPMS using machine learning techniques are the recent *** literature reported the results for a perfectly balanced ***,if there is a small unbalance,which is very common in automobile wheels,‘What will be the effect on the classification accuracy?’is the question on *** paper attempts to study the effect of unbalance of the wheel on the classification accuracy of an indirect TPMS *** tyres filled with air are considered with different pressure values to represent puncture,normal,under pressure and overpressure *** vibration signals of each condition were acquired and processed using machine learning *** procedure is carried out with perfectly balanced wheels and known unbalanced *** results are compared and presented.

关键词： Tyre pressure monitoring system wheel unbalance random committee classifier machine learning

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A novel sub 20 nm single gate tunnel field effect transistor with intrinsic channel for ultra low power applications

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Journal of Semiconductors 2016年第5期37卷 30-34页

作者： pranav Kumar Asthana Yogesh Goswami Bahniman Ghosh Department of Electrical Engineering Indian Institute of Technology Kanpur Microelectronics Research Center University of Texas at Austin

We propose a nanoscale single gate ultra thin body intrinsic channel tunnel field effect transistor using the charge plasma concept for ultra low power applications. The characteristics of TFETs （having low leakage） are improved by junctionless TFETs through blending advantages of Junctionless FETs （with high on current）. We further improved the characteristics, simultaneously simplifying the structure at a very low power rating using an InAs channel. We found that the proposed device structure has reduced short channel effects and parasitics and provides high speed operation even at a very low supply voltage with low leakage. Simulations resulted in Iovv of - 9 × 10-16A/um, IoN of ,-20uA/um, ION/IoFF of--2× 1010, threshold voltage of 0.057 V, subthreshold slope of 7 mV/dec and DIBL of 86 mV/V for PolyGate/HfO2/InAs TFET at a temperature of 300 K, gate length of 20 nm, oxide thickness of 2 nm, film thickness of 10 nm, low-k spacer thickness of 10 nm and VDD of 0.2 V.

关键词： band-to-band tunneling (BTBT) tunnel field effect transistor (TFET) junctionless tunnel field effecttransistor (JLTFET) ION/IOFF ratio low power

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