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Effect of FFD-410 (HiOwna-Jr.), a Balanced Herbal Nutritional Supplement on Biochemical, Hematological, Immunological and Cognitive Parameters of Wistar Rats

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Food and Nutrition Sciences 2013年第6期4卷 660-667页

作者： Suryakanth Dattatraya Anturlikar Mohamed Rafiq Gollapalle Laksminarayanashastry Viswanatha Mohammed Azeemuddin Agadi Hiremath Thippeswamy Uday Kumar Veeranna Kanni pralhad sadashiv patki Department of Pharmacology R&D Center The Himalaya Drug Company Bangalore India Department of Pharmacology R&D Center The Himalaya Drug Company Bangalore India.

Present study was aimed to evaluate the effect HiOwna-Jr. (FFD-410) on vital biochemical, hematological, immunological and cognitive functions in rats;also in vitro antioxidant studies were carried out to evaluate the antioxidant capacity of FFD-410. Animals of respective groups were treatment with FFD-410 for 90 days and blood samples were collected for the estimation of biochemical, hematological parameters and serum immunoglobulin levels;haemoagglutination assay was carried out using Sheep Red blood cells (SRBC’s). In addition, effect of FFD-410 on cognition and memory was evaluated by modified elevated plus maze test. Apart from in vivo studies, in vitro studies such as DPPH radical scavenging assay, reducing power assay and ORAC assays were carried out to evaluate the free radical scavenging and antioxidant activity of FFD-410. Pretreatment with FFD-410 for 90 days did not bring about any change in serum biochemical and hematological parameters and relative organ weights etc., which could account for its wide safety margin at tested dose levels (2.5 and 5.0 g/kg, p.o.). However, FFD-410 showed potent immunostimulant activity by elevating the serum immunoglobulins and haemoagglutination titer values, also the pretreatment with FFD-410 showed dose dependent improvement in short-term cognition and memory in elevated plus maze test. Furthermore, in vitro antioxidant studies FFD-410 exhibited significant and dose dependent free radical scavenging and antioxidant activity as assessed by DPPH (IC50 value of 1162.6 μg/ml), reducing power and ORAC assays (Trolox equivalence/g of 76.1). These findings suggest that, FFD-410 possess very good antioxidant, cognition improving and potent immunostimulant properties. Also, there was no significant change in the serum biochemical and hematological parameters and relative organ weights were observed after 90 days treatment with FFD-410, which could account for its wide safety of margin at tested dose levels (2.5 and5.0 g/kg. p.o

关键词： HiOwna-Jr. Herbal Nutritional Supplement Antioxidants ORAC Assay Hematology Immunomodulator Cognition Improvement

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Clinical Evaluation of Efficacy and Safety of a Herbal Formulation in Benign Prostatic Hyperplasia: A Single Blind, Randomized, Placebo-Controlled Study

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Open Journal of Urology 2012年第3期2卷 157-163页

作者： Ramanathan Jeyaraman pralhad S. patki Department of Urology Madras Medical College Chennai India The Himalaya Drug Company Bangalore India

Benign prostatic hyperplasia (BPH) is a condition intimately related to ageing. Currently available treatment options for the management of BPH have various limitations and associated adverse effects. A polyherbal formulation is claimed to be beneficial in patients with benign prostatic hyperplasia. This single blind, placebo-controlled study evaluated the clinical efficacy and safety of polyherbal formulation in BPH. Material and Methods: A total of 60 patients who were diagnosed as BPH and who were willing to give informed consent were included in the study. At the randomization visit, a detailed medical history was obtained and the patients underwent a thorough systemic examination and digital rectal examination. Routine blood analysis, urinalysis and serum levels of prostate specific antigen were carried out. Abdominal pelvic ultrasonography was done at entry and after completing the study. The severity of the urinary parameters was evaluated using American Urological Association symptom score. All the patients were randomized using random table into either polyherbal group (n = 30) or placebo (n = 30). Each patient received either polyherbal formulation or placebo in a dose of 2 capsules twice a day with meals for two months. All adverse events reported by the patients or observed by investigators were recorded. Statistical analysis was done according to the intention-to-treat principles. Analysis was performed between the groups using Fisher's exact test or unpaired 't' test (Independent t-test). Results: Fifty-six patients completed the study. There was a significant improvement in the mean AUA symptom score, PVR urine volume urinary hesitancy, intermittent flow, straining during urination, sense of incomplete micturition and frequency of night-time urination, in the polyherbal formulation group. Four patients from the placebo group withdrew from the study due to lack of benefit to the treatment. Conclusion: The beneficial clinical efficacy of polyherbal form

关键词： Phytotherapy Ayurveda Clinical Evaluation

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草药复方Bresol抵抗化合物48/80诱导的肥大细胞脱颗粒及组胺释放:促使肥大细胞稳定的一种非免疫机制(英文)

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中西医结合学报 2012年第6期10卷 690-694页

作者： Yathiraj Ashwini Mohamed Rafiq Gollapalle L.Viswanatha Subbanna Rajesh Selvam Senthilraja Mohammed Azeemuddin Suryakanth D.Anturlikar Paramesh Rangesh pralhad S.patki Department of Pharmacology Research and Development Centerthe Himalaya Drug CompanyBangalore 562123KarnatakaIndia

目的:研究一种草药复方制剂Bresol对于肥大细胞脱颗粒以及组胺释放的保护作用。方法:使用大鼠腹膜内肥大细胞,在体外经化合物48/80诱导肥大细胞脱颗粒及组胺释放,评估Bresol稳定肥大细胞的作用。结果:显微镜下正常对照组涂片显示较多完... 详细信息

目的:研究一种草药复方制剂Bresol对于肥大细胞脱颗粒以及组胺释放的保护作用。方法:使用大鼠腹膜内肥大细胞,在体外经化合物48/80诱导肥大细胞脱颗粒及组胺释放,评估Bresol稳定肥大细胞的作用。结果:显微镜下正常对照组涂片显示较多完整的肥大细胞,有极少量的脱颗粒肥大细胞和微量的组胺释放。阳性对照组中用化合物48/80培养的肥大细胞出现了显著的肥大细胞脱颗粒现象以及高浓度的组胺释放。而100mg/L浓度的Bresol明显抑制了化合物48/80诱导的肥大细胞脱颗粒。此外,Bresol可有效抑制化合物48/80诱导的组胺释放,且抑制效果与剂量有关。结论:Bresol能够在体外抑制化合物48/80诱导的肥大细胞脱颗粒和组胺释放。本研究的发现可解释Bresol对多种过敏疾病有效可能是通过一种非免疫机制。

关键词：医学印度传统植物药用化合物48/80 肥大细胞细胞脱颗粒组胺释放体外研究

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