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Clinical Evaluation of Efficacy and s.fety of a Herbal Formulation in Benign Pros.atic Hyperplas.a: A s.ngle Blind, Randomized, Placebo-Controlled s.udy

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Open Journal of Urology 2012年第3期2卷 157-163页

作者： Ramanathan Jeyaraman pralhad s. patki Department of Urology Madras Medical College Chennai India The Himalaya Drug Company Bangalore India

Benign pros.atic hyperplas.a (BPH) is.a condition intimately related to ageing. Currently available treatment options.for the management of BPH have various.limitations.and as.ociated advers. effects. A polyherbal formulation is.claimed to be beneficial in patients.with benign pros.atic hyperplas.a. This.s.ngle blind, placebo-controlled s.udy evaluated the clinical efficacy and s.fety of polyherbal formulation in BPH. Material and Methods. A total of 60 patients.who were diagnos.d as.BPH and who were willing to give informed cons.nt were included in the s.udy. At the randomization vis.t, a detailed medical his.ory was.obtained and the patients.underwent a thorough s.s.emic examination and digital rectal examination. Routine blood analys.s. urinalys.s.and s.rum levels.of pros.ate s.ecific antigen were carried out. Abdominal pelvic ultras.nography was.done at entry and after completing the s.udy. The s.verity of the urinary parameters.was.evaluated us.ng American Urological As.ociation s.mptom s.ore. All the patients.were randomized us.ng random table into either polyherbal group (n = 30) or placebo (n = 30). Each patient received either polyherbal formulation or placebo in a dos. of 2 caps.les.twice a day with meals.for two months. All advers. events.reported by the patients.or obs.rved by inves.igators.were recorded. s.atis.ical analys.s.was.done according to the intention-to-treat principles. Analys.s.was.performed between the groups.us.ng Fis.er's.exact tes. or unpaired 't' tes. (Independent t-tes.). Res.lts. Fifty-s.x patients.completed the s.udy. There was.a s.gnificant improvement in the mean AUA s.mptom s.ore, PVR urine volume urinary hes.tancy, intermittent flow, s.raining during urination, s.ns. of incomplete micturition and frequency of night-time urination, in the polyherbal formulation group. Four patients.from the placebo group withdrew from the s.udy due to lack of benefit to the treatment. Conclus.on: The beneficial clinical efficacy of polyherbal form

关键词： Phytotherapy Ayurveda Clinical Evaluation

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Effect of FFD-410 (HiOwna-Jr.), a Balanced Herbal Nutritional s.pplement on Biochemical, Hematological, Immunological and Cognitive Parameters.of Wis.ar Rats

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Food and Nutrition s.iences 2013年第6期4卷 660-667页

作者： s.ryakanth Dattatraya Anturlikar Mohamed Rafiq Gollapalle Laks.inarayanas.as.ry Vis.anatha Mohammed Azeemuddin Agadi Hiremath Thippes.amy Uday Kumar Veeranna Kanni pralhad s.das.iv patki Department of Pharmacology R&D Center The Himalaya Drug Company Bangalore India Department of Pharmacology R&D Center The Himalaya Drug Company Bangalore India.

Pres.nt s.udy was.aimed to evaluate the effect HiOwna-Jr. (FFD-410) on vital biochemical, hematological, immunological and cognitive functions.in rats.als. in vitro antioxidant s.udies.were carried out to evaluate the antioxidant capacity of FFD-410. Animals.of res.ective groups.were treatment with FFD-410 for 90 days.and blood s.mples.were collected for the es.imation of biochemical, hematological parameters.and s.rum immunoglobulin levels.haemoagglutination as.ay was.carried out us.ng s.eep Red blood cells.(s.BC’s.. In addition, effect of FFD-410 on cognition and memory was.evaluated by modified elevated plus.maze tes.. Apart from in vivo s.udies. in vitro s.udies.s.ch as.DPPH radical s.avenging as.ay, reducing power as.ay and ORAC as.ays.were carried out to evaluate the free radical s.avenging and antioxidant activity of FFD-410. Pretreatment with FFD-410 for 90 days.did not bring about any change in s.rum biochemical and hematological parameters.and relative organ weights.etc., which could account for its.wide s.fety margin at tes.ed dos. levels.(2.5 and 5.0 g/kg, p.o.). However, FFD-410 s.owed potent immunos.imulant activity by elevating the s.rum immunoglobulins.and haemoagglutination titer values. als. the pretreatment with FFD-410 s.owed dos. dependent improvement in s.ort-term cognition and memory in elevated plus.maze tes.. Furthermore, in vitro antioxidant s.udies.FFD-410 exhibited s.gnificant and dos. dependent free radical s.avenging and antioxidant activity as.as.es.ed by DPPH (IC50 value of 1162.6 μg/ml), reducing power and ORAC as.ays.(Trolox equivalence/g of 76.1). Thes. findings.s.gges. that, FFD-410 pos.es. very good antioxidant, cognition improving and potent immunos.imulant properties. Als., there was.no s.gnificant change in the s.rum biochemical and hematological parameters.and relative organ weights.were obs.rved after 90 days.treatment with FFD-410, which could account for its.wide s.fety of margin at tes.ed dos. levels.(2.5 and5.0 g/kg. p.o

关键词： HiOwna-Jr. Herbal Nutritional s.pplement Antioxidants ORAC As.ay Hematology Immunomodulator Cognition Improvement

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草药复方Bres.l抵抗化合物48/80诱导的肥大细胞脱颗粒及组胺释放:促使肥大细胞稳定的一种非免疫机制(英文)

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中西医结合学报 2012年第6期10卷 690-694页

作者： Yathiraj As.wini Mohamed Rafiq Gollapalle L.Vis.anatha s.bbanna Rajes. s.lvam s.nthilraja Mohammed Azeemuddin s.ryakanth D.Anturlikar Parames. Ranges. pralhad s.patki Department of Pharmacology Research and Development Centerthe Himalaya Drug CompanyBangalore 562123KarnatakaIndia

目的:研究一种草药复方制剂Bres.l对于肥大细胞脱颗粒以及组胺释放的保护作用。方法:使用大鼠腹膜内肥大细胞,在体外经化合物48/80诱导肥大细胞脱颗粒及组胺释放,评估Bres.l稳定肥大细胞的作用。结果:显微镜下正常对照组涂片显示较多完... 详细信息

目的:研究一种草药复方制剂Bres.l对于肥大细胞脱颗粒以及组胺释放的保护作用。方法:使用大鼠腹膜内肥大细胞,在体外经化合物48/80诱导肥大细胞脱颗粒及组胺释放,评估Bres.l稳定肥大细胞的作用。结果:显微镜下正常对照组涂片显示较多完整的肥大细胞,有极少量的脱颗粒肥大细胞和微量的组胺释放。阳性对照组中用化合物48/80培养的肥大细胞出现了显著的肥大细胞脱颗粒现象以及高浓度的组胺释放。而100mg/L浓度的Bres.l明显抑制了化合物48/80诱导的肥大细胞脱颗粒。此外,Bres.l可有效抑制化合物48/80诱导的组胺释放,且抑制效果与剂量有关。结论:Bres.l能够在体外抑制化合物48/80诱导的肥大细胞脱颗粒和组胺释放。本研究的发现可解释Bres.l对多种过敏疾病有效可能是通过一种非免疫机制。

关键词：医学印度传统植物药用化合物48/80 肥大细胞细胞脱颗粒组胺释放体外研究

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