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Penoscrotal defect:a functional,esthetic,and psychological challenge

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Plastic and Aesthetic Research 2016年第1期3卷 64-67页

作者： Durga Karki Pankaj Kumar Patel Ravi prakash narayan Department of Burns Plastic and Maxillofacial SurgerySafdarjung HospitalNew Delhi 110029India

Aim:Penoscrotal defects may be caused by a variety of *** of the penoscrotal region is required not only for aesthetic appearance but also for functional and psychological *** techniques have been described for penoscrotal reconstruction reflecting the challenge and complexity of the region *** suggests that no single method is satisfactory for all types and degrees of tissue *** prospective study was conducted in a tertiary care hospital in India,over a period of 5 ***:Eighteen patients with penoscrotal defects of varying etiology were included in the study and underwent different surgical *** of the patients ranged from 20 to 60 *** etiology of penoscrotal defect was Fournier’s gangrene in 12 cases,trauma in 4 cases,and burn in 2 *** patients with Fournier’s gangrene were initially treated by debridement,drainage,and *** penoscrotal defects were treated with local flap advancement with skin grafting(n=7),pedicled anterolateral thigh flap(n=4),gracilis muscle flap with split skin grafting(n=4),and medial thigh flap(n=3).Results:There was complete healing in 16 patients with minor complications in the form of partial skin graft loss(n=1)and wound dehiscence(n=1).Results were highly satisfactory in 6 patients,satisfactory in 8 patients,and not satisfactory in 4 *** at the donor site was limited and ***:The vast arsenal of options for penoscrotal defect coverage ranges from skin grafting to flaps,and every case needs a customized approach with regard to its feasibility,outcome,and complication *** should be the preferred choice over the skin grafts because of the superior functional and aesthetic results and better compliance.

关键词： Anterolateral thigh flap gracilis muscle flap penoscrotal defect

Anti-steatotic and anti-fibrotic effects of the KCa3.1 channel inhibitor, Senicapoc, in non-alcoholic liver disease

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World Journal of Gastroenterology 2017年第23期23卷 4181-4190页

作者： latha paka david e smith dawoon jung siobhan mccormack ping zhou bin duan jing-song li jiaqi shi yong-jie hao kai jiang michael yamin itzhak d goldberg prakash narayan Department of Research and Development Angion Biomedica Corp.

To evaluate a calcium activated potassium channel (KCa3.1) inhibitor attenuates liver disease in models of non-alcoholic fatty liver disease (NAFLD).METHODSWe have performed a series of in vitro and in vivo studies using the KCa3.1 channel inhibitor, Senicapoc. Efficacy studies of Senicapoc were conducted in toxin-, thioacetamide (TAA) and high fat diet (HFD)-induced models of liver fibrosis in rats. Efficacy and pharmacodynamic effects of Senicapoc was determined through biomarkers of apoptosis, inflammation, steatosis and *** of KCa3.1 expression was recorded in TAA-induced and high fat diet-induced liver disease. Treatment with Senicapoc decreased palmitic acid-driven HepG2 cell death. (P < 0.05 vs control) supporting the finding that Senicapoc reduces lipid-driven apoptosis in HepG2 cell cultures. In animals fed a HFD for 6 wk, co-treatment with Senicapoc, (1) reduced non-alcoholic fatty liver disease (NAFLD) activity score (NAS) (0-8 scale), (2) decreased steatosis and (3) decreased hepatic lipid content (Oil Red O, P < 0.05 vs vehicle). Randomization of TAA animals and HFD fed animals to Senicapoc was associated with a decrease in liver fibrosis as evidenced by hydroxyproline and Masson’s trichrome staining (P < 0.05 vs vehicle). These results demonstrated that Senicapoc mitigates both steatosis and fibrosis in liver fibrosis *** data suggest that Senicapoc interrupts more than one node in progressive fatty liver disease by its anti-steatotic and anti-fibrotic activities, serving as a double-edged therapeutic sword.

关键词： High fat diet Liver Steatosis Fibrosis KCa3.1 channel Senicapoc Inflammation

A small molecule fibrokinase inhibitor in a model of fibropolycystic hepatorenal disease

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World Journal of Nephrology 2018年第5期7卷 96-107页

作者： Prani Paka Brian Huang Bin Duan Jing-Song Li Ping Zhou Latha Paka Michael A Yamin Scott L Friedman Itzhak D Goldberg prakash narayan Department of Research and Development Angion Biomedica Corp.UniondaleNY 11553United States Icahn School of Medicine 1 Gustave L.Levy PlaceNew YorkNY 10029United States

AIM To evaluate the novel platelet-derived growth factor receptor and vascular endothelial growth factor receptor dual kinase inhibitor ANG3070 in a polycystic kidney disease-congenital hepatic fibrosis *** At 6 wk of age, PCK rats were randomized to vehicle or ANG3070 for 4 wk. At 10 wk, 24 h urine and left kidneys were collected and rats were continued on treatment for 4 wk. At 14 wk, 24 h urine was collected, rats were sacrificed, and liver and right kidneys were collected for histological evaluation. For Western blot studies, PCK rats were treated with vehicle or ANG3070 for 7 d and sacrificed approximately 30 min after the last *** Compared to the wild-type cohort, the PCK kidney(Vehicle cohort) exhibited a marked increase in kidney and liver mass, hepato-renal cystic volume, hepato-renal fibrosis and hepato-renal injury biomarkers. Intervention with ANG3070 in PCK rats decreased kidney weight, reduced renal cystic volume and reduced total kidney hydroxyproline, indicating significantly reduced rental interstitial fibrosis compared to the PCK-Vehicle cohort. ANG3070 treatment also mitigated several markers of kidney injury, including urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, cystatin C and interleukin-18 levels. In addition, this treatment attenuated key indices of renal dysfunction, including proteinuria, albuminuria and serum blood urea nitrogen and creatinine, and significantly improved renal function compared to the PCK-Vehicle cohort. ANG3070 treatment also significantly decreased liver enlargement, hepatic lesions, and liver fibrosis, and mitigated liver dysfunction compared to the PCK-Vehicle *** These results suggest that ANG3070 has the potential to slow disease, and may serve as a bridge toward hepato-renal transplantation in patients with fibropolycystic disease.

关键词： Congenital hepatic fibrosis Cyst Fibrosis Autosomal recessive polycystic kidney disease Kidney Liver Therapy

Structural and electrical properties of ferroelectric BiFeO_(3)/HfO_(2) gate stack for nonvolatile memory applications

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Journal of Advanced Dielectrics 2018年第5期8卷 57-63页

作者： Nitish Yadav Kamal prakash Pandey Pramod narayan Tripathiy Department of Electronics and Communication Engineering Shambhunath Institute of Engineering and TechnologyAllahabadUttar Pradesh 211015India Department of Electronics and Communication Engineering Indian Institute of Information TechnologyAllahabadUttar Pradesh 211015India

Difficulties in the fabrication of direct interface of ferroelectric BiFeO_(3)/HfO_(2) on the gate of ferroelectric field effect transistor(FeFET)is well *** paper reports the optimization and fabrication of ferroelectric/dielectric(BiFeO_(3)/HfO_(2))gate stack for the FeFET *** magnetron sputtering has been used for the deposition of BiFeO_(3),HfO_(2) films and their stack.X-Ray diffraction(XRD)analysis of BiFeO_(3) shows the dominant perovskite phase of(104),(110)orientation at 2θ=32°at the annealing temperature of 500℃.XRD analysis also confirms the amorphous nature of the HfO2 film at annealing temperature of 400℃,500℃ and 600℃.Multiple angle analysis shows the variation ion the refractive index between 2.98–3.0214 for BiFeO_(3) and 2.74–2.9 for the HfO2 film with the annealing ***/Ferroelectric/Silicon(MFS),Metal/Ferroelectric/Metal(MFM),Metal/Insulator/Silicon(MIS),and Metal/Ferroelectric/Insulator/Silicon(MFIS)structures have been fabricated to obtain the electric characteristic of the ferroelectric,dielectric and their *** characteristics of the MFIS structure show the memory improvement from 2.7 V for MFS structure to 4.65 V for MFIS structure with 8 nm of buffer dielectric *** structure also shows the breakdown voltage of 40 V with data retention capacity greater than 9×10^(9)iteration cycles.

关键词： Endurance ferroelectric high-k dielectric memory window MFIS.

Saponin synthesis and cotton growth is antagonistically regulated by solar UV-B radiation

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Journal of Cotton Research 2018年第3期1卷 30-40页

作者： DEHARIYA Priti KATARIA Sunita GURUPRASAD Kadur narayan PANDEY Govind prakash School of Life Sciences Devi Ahilya University School of Biochemistry Devi Ahilya University Shri Vaishnav Vidyapeeth Vishwavidyalaya

Background: Earlier we have reported that the exclusion of solar UV-B increased the growth and yield of cotton plants as compared with ambient UV-B. The UV-B radiation effects on the saponins and the impact of ambient and reduced UV-B on the accumulation of saponins has not been investigated yet. Thus a field experiment was conducted to study the influence of solar UV-B on the growth response and saponin synthesis in cotton(Gossypium hirsutum) var. Vikram plants by the exclusion of UV-B. The cotton plants were grown in specially designed iron chambers, wrapped with filters that excluded UV-B(<315 nm), or transmitted ambient ***: Exclusion of ambient UV-B enhanced the growth of cotton plants in terms of plant height and leaf *** plant height in UV-B excluded plants was due to elongated internode and more number of *** in growth was accompanied by a decrease in the accumulation of saponins, which was quantified by the spectrophotometric, TLC and HPLC methods. Solvent extraction of saponins from the internodes and leaves were used for the bioassay of Amaranthus hypocotyl growth and expansion of cucumber cotyledons. Extracts obtained from the UV-B excluded plants(leaves and internodes) promoted the growth to a larger extent as compared with the extracts obtained from ambient grown ***: The result indicates that solar UV-B may possibly suppress the plant growth by regulating the synthesis of natural growth inhibitor’s like saponin.

关键词： Bioassay Cotton Growth Inhibitor Saponin UV radiation

Preclinical animal studies in ischemic stroke:Challenges and some solutions

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Animal Models and Experimental Medicine 2021年第2期4卷 104-115页

作者： Sunil K.narayan Simy Grace Cherian prakash Babu Phaniti Saravana Babu Chidambaram A.Hannah Rachel Vasanthi Murugesan Arumugam Comprehensive Stroke Care and Neurobiology Centre Department of NeurologyJawaharlal Institute of Postgraduate Medical Education and ResearchPuducherryIndia Department of Biotechnology&School of Medical Sciences University of HyderabadHyderabadIndia Department of Pharmacology JSS Medical CollegeMysoreIndia Department of Biotechnology School of Life scienceUniversity of PondicherryPondicherryIndia

Despite the impressive efficacies demonstrated in preclinical research,hundreds of potentially neuroprotective drugs have failed to provide effective neuroprotec-tion for ischemic stroke in human clinical *** of a powerful animal model for human ischemic stroke could be a major reason for the failure to develop successful neuroprotective drugs for ischemic *** review recapitulates the available cerebral ischemia animal models,provides an anatomical comparison of the circle of Willis of each species,and describes the functional assessment tests used in these ischemic stroke *** distinct differences between human ischemic stroke and experimental stroke in available animal models is *** animal models more closely resembling human strokes,better techniques in functional out-come assessment and better experimental designs generating clearer and stronger evidence may help realise the development of truly neuroprotective drugs that will benefit human ischemic stroke *** may involve use of newer molecules or revisiting earlier studies with new experimental *** of any resultant successes may then be tested in human clinical trials with greater confidence and optimism.

关键词： cerebral ischemia circle of Willis focal ischemic models functional assessment tests neuroprotection preclinical model