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Prostate-associated gene 4 （PAGE4）, an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer

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Asian Journal of Andrology 2016年第5期18卷 695-703页

作者： prakash Kulkarni A Keith Dunker Keith Weninge John Orban Institute for Bioscience and Biotechnology Research University of Maryland Rockville MD 20850 USA Center for Computational Biology and Bioinformatics Department of Biochemistry and Molecular Biology Indiana University School of Medicine and Informatics Indianapolis IN 46202 USA Department of Physics North Carolina State University Raleigh NC 27695 USA Department of Chemistry and Biochemistry University of Maryland College Park MD 20742 USA.

Prostate-associated gene 4 （PAGE4） is a remarkably prostate-specific Cancer/Testis Antigen that is highly upregulated in the human fetal prostate and its diseased states but not in the adult normal gland. PAGE4 is an intrinsically disordered protein （IDP） that functions as a stress-response protein to suppress reactive oxygen species as well as prevent DNA damage. In addition, PAGE4 is also a transcriptional regulator that potentiates transactivation by the oncogene c-Jun, c-Jun forms the AP-1 complex by heterodimerizing with members of the Fos family and plays an important role in the development and pathology of the prostate gland, underscoring the importance of the PAGE4/c-Jun interaction. HIPK1, also a component of the stress-response pathway, phosphorylates PAGE4 at T51 which is critical for its transcriptional activity. Phosphorylation induces conformational and dynamic switching in the PAGE4 ensemble leading to a new cellular function. Finally, bioinformatics evidence suggests that the PAGE4 mRNA could be alternatively spliced resulting in four potential isoforms of the polypeptide alluding to the possibility of a range of conformational ensembles with latent functions. Considered together, the data suggest that PAGE4 may represent the first molecular link between stress and prostate cancer （PCa）. Thus, pharmacologically targeting PAGE4 may be a novel opportunity for treating and managing patients with PCa, especially patients with low-risk disease.

关键词： prostate-associated Gene 4 cancer/testis antigen intrinsically disordered protein prostate cancer c-Jun AP-1 proteininteraction networks homeodomain-interacting protein 1

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Data-Driven Approaches to Integrated Disaster Risk Management Special Issue of the 9th Conference of the International Society for Integrated Disaster Risk Management

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International Journal of Disaster Risk Science 2020年第6期11卷 693-695页

作者： Vincent Lemiale Mahesh prakash Ana Maria Cruz CSIRO Data61 Clayton SouthVIC 3169Australia Disaster Prevention Research Institute Kyoto UniversityKyoto 611-0011Japan

The 9 th Conference of the International Society for Integrated Disaster Risk Management(IDRiM)was held in Sydney on 2–4 October *** event was hosted by Data61,the data innovation hub of Australia’s National Science Agency *** IDRiM annual conference series traditionally brings together researchers and practitioners across all disciplines of disaster risk management(DRM)and the Australian instalment was no exception.

关键词： disaster traditionally Sydney

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Antidiabetic and anti-lipemic effects of Cassia siamea leaves extract in streptozotocin induced diabetic rats

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Asian Pacific Journal of Tropical Medicine 2010年第11期3卷 871-873页

作者： S Kumar V Kumar Om prakash Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetra -136119HaryanaIndia

Objective:To investigate the antidiabetic and anti-lipemic effects of Cassia siamea methanolic leaves ***:The antidiabetic study was performed by measuring blood glucose level with elegance glucometer at weekly intervals i.e.0,7,14 and 21 in normal and streptozotocin induced diabetic *** cholesterol,triglyceride and HDL-cholesterol were determined in normal and streptozotocin induces diabetic rats by *** was used as a reference drug at a dose of 10 mg/***:After the oral administration of extracts at doses of 250 mg/kg and 500 mg/kg for three weeks,blood glucose levels and body weights were significantly improved(P<0.01).Daily oral treatment with the extract also resulted in significantly reduction of serum cholesterol and ***-cholesterol level was found to be improved to(P<0.01).Conclusions:The Cassia siamea leaf extract is useful in controlling blood glucose level as well as improving lipid metabolism and body weight in rats with induced diabetes.

关键词： Cassia siamea Antidiabetic Anti-lipemic Rat Streptozotocin

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High temperature tribological behaviour of PVD coated tool steel and aluminium under dry and lubricated conditions

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Friction 2021年第4期9卷 802-821页

作者： Justine DECROZANT-TRIQUENAUX Leonardo PELCASTRE Cedric COURBON Braham prakash Jens HARDELL Division of Machine Elements Lulea University of TechnologySE-97187Sweden Universite de Lyon CNRSEcole Nationale d'lngenieurs de Saint-EtienneLTDS UMR5513F-42023France Department of Mechanical Engineering Tsinghua UniversityBeijing100084 China

Aluminium alloys are commonly used as lightweight materials in the automotive *** non-ferrous family of metallic alloys offers a high versatility of properties and *** reduce weight and improve safety,high strength-to-weight ratio alloys(e.g.6XXX and 7XXX),are increasingly implemented in ***,these alloys exhibit low formability and experience considerable springback during cold forming,and are therefore hot *** forming,severe adhesion(***)of aluminium onto the die surface takes *** phenomenon has a detrimental effect on the surface properties,geometrical tolerances of the formed parts and maintenance of the *** effect of surface engineering as well as lubricant chemistry on galling has not been sufficiently ***-like carbon(DLC)and CrN physical vapour deposition(PVD)coated steel have been studied to reduce aluminium ***,the interaction between lubricants and PVD coatings during hot forming of aluminium alloys is not yet fully *** present study thus aims to characterise the high temperature tribological behaviour of selected PVD coatings and lubricants during sliding against aluminium *** objectives are to first select promising lubricant-coating combinations and then to study their tribological response in a high-temperature reciprocating friction and wear *** and lubricated tests were carried out at 300℃ using a commercial polymer *** using DLC,CrN,CrTiN,and CrAIN coated tool steel were compared to uncoated tool steel reference *** initial and worn test specimen surfaces were analysed with a 3-dimensional(3D)optical profiler,scanning electron microscope(SEM)and energy dispersive X-ray spectroscope(EDS)as to understand the wear *** results showed formation of tribolayers in the contact zone,reducing both friction and *** stability of these layers highly depends on both the coatings'roughness and chemical affinity towards

关键词： high temperature tribology aluminium lubrication physical vapour deposition(PVD)coatings material transfer adhesion

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A numerical simulation for the control of radiative heat energy and thermophoretic effects on MHD micropolar fluid with heat source

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Journal of Ocean Engineering and Science 2022年第1期7卷 92-98页

作者： Ram prakash Sharma S.R.Mishra Department of Mechanical Engineering National Institute of TechnologyArunachal PradeshYupia 791112Papum Pare DistrictArunachal Pradesh Department of Mathematics Siksha‘O’Anusandhan Deemed to be UniversityBhubaneswar 751030OdishaIndia

The current paper explores the behavior of the thermal radiation on the time-independent flow of mi-cropolar fluid past a vertical stretching surface with the interaction of a transverse magnetic *** ef-fect of thermo-diffusion(Soret)along with the heat source is incorporated to enhance the thermal ***,the convective solutal condition is considered that affects the mass transfer *** transformed equations are modeled using suitable similarity ***,the complex cou-pled equations are handled mathematically employing the Runge-Kutta-Felhberg *** behavior of characterizing parameters on the flow phenomena as well as the engineering coefficients are displayed via graphs and the validation of the current outcome is reported with the previously published results in particular cases.

关键词： Magnetohydrodynamic Thermal radiation Heat source Thermo-diffusion Chemical reaction Runge-Kutta-Felhberg method

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An insight on established retinal injury mechanisms and prevalent retinal stem cell activation pathways in vertebrate models

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Animal Models and Experimental Medicine 2021年第3期4卷 189-203页

作者： Rinchen Doma Sherpa Subhra prakash Hui S.N.Pradhan Centre for Neurosciences University of CalcuttaKolkataIndia

Implementing different tools and injury mechanisms in multiple animal models of retina regeneration,researchers have discovered the existence of retinal stem/pro-genitor *** they appear to be distributed uniformly across the vertebrate lineage,the reparative potential of the retina is mainly restricted to lower *** repair post-injury requires the creation of a proliferative niche,vital for proper stem cell activation,propagation,and lineage *** seems to be lacking in ***,in this review,we first discuss the many forms of retinal injuries that have been generated using animal ***,we discuss how they are utilized to stimulate regeneration and mimic eye disease *** key to driving stem cell activation in mammals relies on the information we can gather from these ***,we present a brief update about the genes,growth factors,and signaling pathways that have been brought to light using these models.

关键词： animal models retina injury retina regeneration retinal stem cells zebrafish

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Hepatoprotective and cytoprotective properties of Hyptis suaveolens against oxidative stress-induced damage by CCl_4 and H_2O_2

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Asian Pacific Journal of Tropical Medicine 2012年第11期5卷 868-874页

作者： Hadi Ghaffari Behrouz Jalali Ghassam HS prakash Department of Studies in Biotechnology University of MysoreManasagangotriMysore570006KarnatakaIndia

Objective:To investigate capacity of Hyptis suaveolens(***) methanol extract as an antioxidant to protect against carbon tetrachloride(CCl_4)-indueed oxidative stress,hepatotoxicitv in Albino Wistar rats and cytoprotective effect of hydrogen peroxide(H_2O_2) induced cell death in HepG_2 cell ***:Two different doses of methanol extract of *** were evaluated for the hepatoprotective activity against carbon tetrachloride(CCl_4) induced hepatotoxicitv in *** in GroupⅠ:served as control,groupⅡ:***(100 mL/ kg b.w),groupⅢ:***(50 mL/kg b.w) + CCl_4(1 mg/kg),groupⅣ:***(100 mL/kg b.w) + CCl_4(1 ml/kg)and groupⅤ:CCl_4(1 mL/kg).Histopathologic changes of liver were also *** was also determined by 3,(4,5-dimethylthiazol-2-yl)2,5-diphenyl-tetrazolium bromide(MTT) ***:Oral sigle dose treatment of CCl_4 produced a marked elevation in the serum levels of aspartate transaminase(AST),alanine transaminase(ALT), alkaline phosphatase(ALP) and Lactate dehydrogenase(LDH).Histopathological analysis of the liver of CCl_4-induced rats revealed marked liver cell necrosis with inflammatory collections that were conformed to increase in the levels of SOD,GSH,GST,GR and *** with H_2O_2 significantly induced death of HepG_2 *** with *** methanol extract inhibited or attenuated H_2O_2 induced ***:This study shows that *** methanol extract can be proposed to protect the liver against CCl_4-induced oxidative damage in rats and protect the cells against H_2O_2-induced oxidative damage in HepG_2 *** hepatoprotective and cytoprotective effects might be correlated with its antioxidant and free radical scavenger effects.

关键词： Hyptis suaveolens Antioxidant enzymes Lipid peroxidation HepG_2 cell line Hydrogen peroxide MTT assay

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Camelina sativa,a short gestation oilseed crop with biofuel potential:Opportunities for Indian scenario

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Oil Crop Science 2021年第3期6卷 114-121页

作者： Ankur Agarwal Om prakash Madhu Bala Defence Institute of Bio-Energy Research Defence R&D OrganizationGoraparaoP.O.ArjunpurHaldwaniUttarakhand263139India

Camelina is an oilseed crop which is being commercially produced globally as feedstock for *** a non-edible oil bearing low input crop owing to its low fertilizer and water requirement,fits well for biofuel *** India,targets for biofuel blending has been set by New Biofuel Policy-2018 and to meet these targets efforts are being made to harness the potential of available feedstock in the *** these feedstock,contribution of short gestation oilseed bearing crop has been very *** has been introduced in India during 2009–10 as experimental crop by DIBER,*** then various efforts have made to standardize the production technology of this crop under various agro-climatic regions of the country,crop improvement,oil quality analysis and development of high energy *** has various advantages to offer for Indian biofuel *** paper reviews the potential of this crop for Indian Biofuel scenario.

关键词： Camelina False flax Production Agro-technology Crop improvement Economics

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Optimal generation mix for frequency response adequacy in future power system

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能源与人工环境(英文) 2021年第3期2卷 243-250页

作者： Vivek prakash Kailash Chand Sharma Rohit Bhakar School of Automation Banasthali VidyapithRajasthanIndia Department of Electrical Engineering NIT JalandharIndia Department of Electrical Engineering Malaviya National Institute of TechnologyJaipurIndia

Strict enforcement of government policies to integrate high generation share from renewable energy sources(RES)like wind and PV would create inevitable operational challenges for the utilities to deliver Frequency Response(FR)*** RES generation characteristics would worsen the situation for SO,to detain initial frequency deviation following the largest generation *** necessitates investigation of optimal generator combination for securing PFR adequacy with simultaneous characterization of *** this regard,this paper proposes a novel Modified Interval(MI)based optimal generation mix formulation for operation cost minimization and FR *** uncertainty is characterised by forecasted upper and lower bound,while hourly ramp needs are based on the net load *** model is assessed on one area IEEE reliability test *** of change of frequency(ROCOF)and frequency deviation are considered as network security limits to obtain optimal generation *** obtained provide,overall cost performance,PFR and optimal generation mix,without violating system security *** model would certainly assist SO,to enhance system’s inertia and PFR adequacy at short-term system operations and could be extended for long-term planning framework.

关键词： Frequency response Generation mix Inertial response Net load Primary frequency response System security Unit commitment

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Light meson spectrum and their leptonic decay widths in the frame work of constituent quark models

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Chinese Physics C 2010年第9期34卷 1396-1398页

作者： K.B.Vijaya Kumar Antony prakash Monteiro Department of Physics Mangalore University

The phenomenological non-relativistic quark model has been employed to obtain the ground state masses of light vector mesons and their radially excited states and their decay *** full hamiltonian used in the investigation has kinetic energy,the confinement potential and the one-gluon-exchange potential.A good agreement is obtained with the experimental masses and their leptonic decay widths.

关键词： meson spectrum leptonic decay width constituent quark model OGEP

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