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The biochemical pathways of central nervous system neural degeneration in niacin deficiency

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Neural Regeneration Research 2014年第16期9卷 1509-1513页

作者： Linshan Fu Venkatesh Doreswamy Ravi prakash Department of Neurosurgery the First People’s Hospital of Yancheng Department of Physiology M.S.Ramaiah Medical College

Neural degeneration is a very complicated process. In spite of all the advancements in the molecular chemistry, there are many unknown aspects of the phenomena of neurodegeneration which need to be put together. It is a common sequela of the conditions of niacin deficiency. Neural degeneration in Pellagra manifests as chromatolysis mainly in pyramidal followed by other neurons and glial cells. However, there is a gross lack of understanding of biochemi- cal mechanisms of neurodegeneration in niacin deficiency states. Because of the necessity of niacin or its amide derivative NAD in a number of biochemical pathways, it is understandable that several of these pathways may be involved in the common outcome of neural degener- ation. Here, we highlight five pathways that could be involved in the neuraldegeneration for which evidence has accumulated through several studies. These pathways are： 1） the trypto- phan-kyneurenic acid pathway, 2） the mitochondrial ATP generation related pathways, 3） the poly （ADP-ibose） polymerase （PARP） pathway, 4） the BDNF-TRKB Axis abnormalities, 5） the genetic influences of niacin deficiency.

关键词： Niacin deficiency neural degeneration chromatolysis biochemical pathways ofdegeneration kyneurenic acid BDNF- TRKB pathway

An efficient hybrid computational technique for the time dependent Lane-Emden equation of arbitrary order

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Journal of Ocean Engineering and Science 2022年第2期7卷 131-142页

作者： Manish Goyal Amit prakash Dumitru Baleanu Department of Mathematics Institute of Applied Sciences and HumanitiesGLA UniversityMathuraIndia Department of Mathematics National Institute of TechnologyKurukshetraIndia Department of Mathematics Faculty of Arts and SciencesCankaya UniversityEtimesgutTurkey Institute of Space Sciences Magurele-BucharestRomania

The study of dynamic behaviour of nonlinear models that arise in ocean engineering play a vital role in our daily *** are many examples of ocean water waves which are nonlinear in *** shallow water,the linearization of the equations imposes severe conditions on wave amplitude than it does in deep water,and the strong nonlinear effects are *** this paper,q-homotopy analysis Laplace transform scheme is used to inspect time dependent nonlinear Lane-Emden type equation of arbitrary *** offers the solution in a fast converging *** uniqueness and convergence analysis of the considered model is *** given examples confirm the competency as well as accuracy of the presented *** behavior of obtained solution for distinct orders of fractional derivative is dis-cussed through *** auxiliary parameter¯h offers a suitable mode of handling the region of *** outcomes reveal that the q-HATM is attractive,reliable,efficient and very effective.

关键词： Fractional differential equations(FDE) Time dependent Lane-Emden type differential equation Caputo derivative of arbitrary order q-homotopy analysis transform scheme(q-HATM) Laplace transform

Oxygen Fugacity and Water Activity during Thermal Peak and Retrogression of Granulites around the Sarvapuram Area, Karimnagar Granulite Terrane, Andhra Pradesh, India

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Acta Geologica Sinica(English Edition) 2019年第6期93卷 1900-1908页

作者： P.Chandra SINGH D.prakash Department of Earth Sciences Indian Institute of TechnologyPowaiMumbai400076India Centre of Advanced Study in Geology Banaras Hindu UniversityVaranasi221005India

The investigated area around Sarvapuram represents a part of the Karimnagar granulite terrane of the Eastern Dharwar Craton, India. Garnet–bearing gneiss is hosted as enclaves, pods within granite gneiss and charnockite. It is largely made up of garnet, orthopyroxene, cordierite, biotite, plagioclase, K–feldspar, sillimanite and quartz. The peak metamorphic stage is represented by the equilibrium mineral assemblage i.e. garnet, orthopyroxene, cordierite, biotite, plagioclase, sillimanite and quartz. Breakdown of the garnet as well as preservation of the orthopyroxene–cordierite symplectite, formation of cordierite with the consumption of the garnet + sillimanite + quartz represents the decompressional event. The thermobarometric calculations suggest a retrograde P–T path with a substantial decompression of c. 3.0 kbar. The water activity(XH2 O) conditions obtained with the win TWQ program for core and symplectite compositions from garnet–bearing gneiss are 0.07–0.14 and 0.11–0.16 respectively. The quantitative estimation of oxygen fugacity in garnet–bearing gneiss reveal log f O2 values ranging from-11.38 to-14.05. This high oxidation state could be one of the reasons that account for the absence of graphite in these rocks.

关键词： metamorphic conditions oxygen fugacity water activity garnet–bearing gneisses Karimnagar granulite terrane India

Inter laminar shear strength behavior of acid,base and silane treated E-glass fibre epoxy resin composites on drilling process

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Defence Technology（防务技术） 2017年第1期13卷 40-46页

作者： V.R.Arun prakash A.Rajadurai Department of Production Technology MITAnna UniversityChennai 600 044India Faculty Department of Production TechnologyMITAnna UniversityChennai 600 044India

In this present work siliconized e-glass fibre reinforced epoxy resin composite has been prepared and compared with acid and base treated e-glass fibre epoxy composites to know the significant advantage of silane treatment on fibre. The composites were fabricated by laying 20, 30 and 40vol% of e-glass fibre into epoxy resin matrix. The e-glass fibre woven mat was surface treated by an amine functional coupling agent 3-Aminopropyletrimethoxysilane(APTMS). The fibres were surface treated by aqueous solution method and thermo assisted to create silinol groups. Similarly for acid treatment H_2SO_4 and base treatment Na OH with 1N concentration was used for surface treating the fibres. Effectiveness of silane treatment on glass fibre was compared by inter laminar shear strength test according to ASTM D *** process with varying diameter drill bit and varying cutting speed was applied to check the composites for their delamination resistance while machining. Maximum improvement of 15%, 12.5% and9%(20, 30 and 40 vol %) on ILSS was achieved for siliconized e-glass fibre reinforced epoxy *** scanning electron microscopy images revealed that no fibre pull out was present on fractured surfaces of composites which contains siliconized e-glass fibre. Similarly better dimensional accuracy was achieved on drilling process for composites contains siliconized e-glass fibre.

关键词： Polymer matrix composites Surface treatment ILSS SEM

Cancer/testis antigens： novel tools for discerning aggressive and non-aggressive prostate cancer

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Asian Journal of Andrology 2012年第3期14卷 400-404,I0006页

作者： Takumi Shiraishi Robert H Getzenberg prakash Kulkarni Department of Urology James Buchanan Brady Urological Institute Baltimore M D 21287 USA Department of Urology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan Department of Oncology James Buchanan Brady Urological Institute Baltimore MD 21287 USA pharmacology and Molecular Sciences The Johns Hopkins University School of Medicine Baltimore MD 21287 USA

The introduction of serum prostate-specific antigen （PSA） in the 1980s has dramatically altered and benefited the initial diagnosis of prostate cancer. However, the widespread use of PSA testing has resulted in overdetection and overtreatment of potentially indolent disease. Thus, a clinical dilemma today in the management of prostate cancer is to discern men with aggressive disease who need definitive treatment from men whose disease are not lethal. Although several serum and tissue biomarkers have been evaluated during the past decade, improved markers are still needed to enhance the accuracy, with which patients at risk can be discerned and treated more aggressively. The cancer/testis antigens （CTAs） are a group of proteins that are restricted to the testis in the normal adult, but are aberrantly expressed in several types of cancers. Because of their restricted expression pattern, the CTAs represent attractive biomarker candidates for cancer diagnosis/prognosis. Furthermore, several studies to date have reported the differential expression of CTAs in prostate cancer. Here, we review recent developments that demonstrate the potential of the CTAs as biomarkers to discern the a^ressive Dhenotvoe of orostate cancer.

关键词： cancer/testis antigens DNA microarrays prostate cancer prostate carcinoma tumor antigen

GIS-based Frequency Ratio and Logistic Regression Modelling for Landslide Susceptibility Mapping of Debre Sina Area in Central Ethiopia

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Journal of Mountain Science 2015年第6期12卷 1355-1372页

作者： Matebie METEN Netra prakash BHANDARY Ryuichi YATABE Geo-Disaster Research Laboratory Graduate School of Science and Engineering Ehime University

Ethiopia has a mountainous landscape which can be divided into the Northwestern and Southeastern plateaus by the Main Ethiopian Rift and Afar Depression. Debre Sina area is located in Central Ethiopia along the escarpment where landslide problem is frequent due to steep slope, complex geology, rift tectonics, heavy rainfall and seismicity. In order to tackle this problem, preparing a landslide susceptibility map is very important. For this, GISbased frequency ratio(FR) and logistic regression(LR) models have been applied using landslide inventory and the nine landslide factors(i.e. lithology, land use, distance from river & fault, slope, aspect, elevation, curvature and annual rainfall). Database construction, weighting each factor classes or factors, preparing susceptibility map and validation were the major steps to be undertaken. Both models require a rasterized landslide inventory and landslide factor maps. The former was classified into training and validation landslides. Using FR model, weights for each factor classes were calculated and assigned so that all the weighted factor maps can be added to produce a landslide susceptibility map. In the case of LR model, the entire study area is firstly divided into landslide and non-landslide areas using the training landslides. Then, these areas are changed into landslide and non-landslide points so as to extract the FR maps of the nine landslide factors. Then a linear relationship is established between training landslides and landslide factors in SPSS. Based on this relationship, the final landslide susceptibility map is prepared using LR equation. The success-rate and prediction-rate of FR model were 74.8% and 73.5%, while in case of LR model these were 75.7% and 74.5% respectively. A close similarity in the prediction and validation rates showed that the model is acceptable. Accuracy of LR model is slightly better in predicting the landslide susceptibility of the area compared to FR model.

关键词： Landslide susceptibility GIS Frequency Ratio Logistic Regression Debre Sina Ethiopia

On Almost Armendariz Ring

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Algebra Colloquium 2020年第2期27卷 199-212页

作者： Om prakash Sushma Singh K.P.Shum Department of Mathematics Indian Institute of Technology Patna PatnaBihar 801106India Department of Mathematics John Fulton Center The Chinese University of Hong KongShatinN.T.Hong KongChina

In this paper,we introduce the notion of an almost Armendariz ring,which is a generalization of an Armendariz ring,and discuss some of its *** has been found that every almost Armendariz ring is weak Armendariz but the converse is not *** prove that a ring R is almost Armendariz if and only if R[x]is almost *** is also shown th at if R/I is an almost Armendariz ring and I is a semicommutative ideal,then H is an almost Armendariz ***,the class of minimal non-commutative almost Armendariz rings is completely determined,up to isomorphism(minimal means having smallest cardinality).

关键词： Armendariz ring almost Armendariz ring weak Armendariz ring lower nil radical reduced ring semicommutative ring

Hierarchical Data Aggregation with Data Offloading Scheme for Fog Enabled IoT Environment

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Computer Systems Science & Engineering 2023年第3期44卷 2033-2047页

作者： P.Nalayini R.Arun prakash Department of Computer Science and Engineering Kings College of EngineeringPunalkulam613303TamilnaduIndia Department of Computer Science and Engineering University College of EngineeringAriyalur621704TamilnaduIndia

Fog computing is a promising technology that has been emerged to handle the growth of smart devices as well as the popularity of latency-sensitive and location-awareness Internet of Things(IoT)*** the emergence of IoT-based services,the industry of internet-based devices has *** number of these devices has raised from millions to billions,and it is expected to increase further in the near ***,additional challenges will be added to the traditional centralized cloud-based architecture as it will not be able to handle that growth and to support all connected devices in real-time without affecting the user *** data aggregation models for Fog enabled IoT environ-ments possess high computational complexity and communication ***-fore,in order to resolve the issues and improve the lifetime of the network,this study develops an effective hierarchical data aggregation with chaotic barnacles mating optimizer(HDAG-CBMO)*** HDAG-CBMO technique derives afitness function from many relational matrices,like residual energy,average distance to neighbors,and centroid degree of target ***,a chaotic theory based population initialization technique is derived for the optimal initial position of ***,a learning based data offloading method has been developed for reducing the response time to IoT user requests.A wide range of simulation analyses demonstrated that the HDAG-CBMO technique has resulted in balanced energy utilization and prolonged lifetime of the Fog assisted IoT networks.

关键词： Internet of things fog computing barnacles mating optimizer data offloading data aggregation

Corrosion Inhibition of Leucaena Leucocephala Pod on Mild Steel in Sulphuric Acid Solution

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Acta Metallurgica Sinica(English Letters) 2013年第4期26卷 416-424页

作者： P.Muthukrishnan B.Jeyaprabha P.prakash Department of Chemistry Thiagarajar College Department of Civil Engineering Fatima Michael College of Engineering & Technology

The corrosion of the mild steel in i mol/L H2SO4 was investigated using Leucaena leucocephala pod extract （LLPE） as corrosion inhibitor by weight loss and electrochemical techniques. Inhibition efficiency of 95% was achieved with 500×10^-6 of LLPE at 308 K. The polarization studies showed that LLPE acted as mixed type inhibitor. The adsorption of the studied inhibitor on mild steel obeyed Langmuir adsorption isotherm. Protective film formation against acid attack was confirmed by FT-IR, XRD and SEM techniques.

关键词： Mild steel Polarization SEM Acid corrosion XRD