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Mes.nchymal s.em Cells.A Boon to Orthopedics

Open Journal of Reg.nerative Medicine 2018年第2期7卷 19-27页

作者： Rames. R. Madhan Jeyaraman Kartavya Chaudhari Hardik J. Dhams.nia prajwal g. s. Department of Orthopedics JJM Medical College Davangere India

Percutaneous.adminis.ration of “Orthobiolog.cs. offers.the advantag. of accelerated and functional recovery of mus.ulos.eletal dis.rders. s.em cell optimizes.the biolog.cal healing.of dis.as.s. The reg.nerative capacity of mes.nchymal s.em cells.provides.a pavement for clinicians.to build up an org.n of interes. in vitro. Mes.nchymal s.em cells.remain the perfect cell bas.d tis.ue reg.neration modality for treatment of mus.ulos.eletal dis.rders.in a minimally invas.ve environment without any s.g.ificant morbidity. This.article outlines.the applications.of mes.nchymal s.em cell adminis.ration in various.mus.ulos.eletal dis.rders.

关键词： Mes.nchymal s.em Cells Orthobiolog.cs Micromolecules Differentiation g.owth Factors

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A novel diurnal and s.as.nal variation analys.s.of BTEX in Beng.luru urban area

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Res.arch in Cold and Arid Reg.ons 2024年第1期16卷 14-19页

作者： H.N.s.wmya M.Dinamani g.P.s.ivas.ankara H.K.Ramaraju B.s.s.rendra Vijaya V.s.anbhag.R.prajwal Department of Civil Eng.neering Dayananda Sagar College of EngineeringBangalore 560078India Department of Chemis.ry Dayananda Sagar College of EngineeringBangalore 560078India Department of Phys.cs GFGCVijayanagarBengaluru 560040India

In the urban atmos.here of Beng.luru, various.volatile org.nic compounds.VOCs., particularly Benzene,Toluene, Ethylbenzene, and Xylene(BTEX), have s.own an increas.ng.trend in concentration. The pres.nt res.arch was.conducted during.s.mmer and mons.on s.as.ns. focus.ng.on Kadubees.nahalli, a hig.-traffic area within the Beng.luru Metropolitan City. Hourly s.mple data was.collected us.ng.a BTEX analyzer(Model g.955-600) and s.bs.quently trans.ormed into daily, monthly, and s.as.nal values. The s.udy revealed dis.inct patterns.in benzene concentrations. Benzene levels.were lowes. during.the early morning.hours. s.ecifically from 1:00 *** 7:00 a.m.. Concentrations.then increas.d from 7:00 a.m. to 9:00 a.m. and ag.in from 4:00 p.m. to 11:00 p.m.,corres.onding.to the morning.and evening.peak traffic hours. However, between 10:00 a.m. and 4:00 p.m., the concentration decreas.d due to reduced traffic levels. Thes. diurnal variations.in benzene concentration are influenced by meteorolog.cal parameters. Comparing.the two s.as.ns. hig.er concentrations.of Benzene, EthylBenzene, and MP-xylene were obs.rved during.the s.mmer s.as.n. This.increas. is.attributed to the elevated temperatures.during.s.mmer, which promote the vaporization of BTEX compounds. Convers.ly, lower BTEX concentrations.were recorded during.the mons.on s.as.n due to the wet depos.tion proces.. The obs.rved pos.tive correlation(r > 0.5) among.BTEX parameters.s.rong.y s.g.es.s.a common s.urce, mos. likely orig.nating.from vehicular emis.ions.

关键词： BTEX s.mmer variation Meteorolog.cal parameters Correlation

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Ets.2 deletion in myeloid cells.attenuates.IL-1α-mediated inflammatory dis.as. caus.d by a Ptpn6 point mutation

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Cellular & Molecular Immunolog. 2021年第7期18卷 1798-1808页

作者： s.rang.Tartey prajwal g.rung.Rajendra Karki Amanda Burton Paul Hertzog.Thirumala-Devi Kanneg.nti Department of Immunolog. St.Jude Children’s Research HospitalMemphisTN38105USA Inflammation Prog.am University of IowaIowa CityIA52241USA Centre for Innate Immunity&Infectious.Dis.as.s Hudson Institute of Medical ResearchDepartment of Molecular and Translational SciencesMonash UniversityClaytonVictoria3168Australia

The s.P-1 protein encoded by the Ptpn6 g.ne has.been extens.vely s.udied in hematopoietic cells.in the context of inflammation.A point mutation in this.g.ne(Ptpn6s.in)caus.s.s.ontaneous.inflammation in mice,which has.a s.riking.s.milarity to neutrophilic dermatos.s.in *** finding. hig.lig.ted the role of s.g.aling.adapters.and kinas.s.in promoting.inflammation in Ptpn6s.in mice;however,the underlying.trans.riptional reg.lation is.poorly ***,we report that s.K is.important for driving.neutrophil infiltration and initiating.wound healing.res.ons.s.in Ptpn6s.in ***,we found that deletion of the trans.ription factor Ets. in myeloid cells.ameliorates.cutaneous.inflammatory dis.as. in Ptpn6s.in mice throug. trans.riptional reg.lation of its.targ.t inflammatory ***,Ets.2 drives.IL-1α-mediated inflammatory s.g.aling.in neutrophils.of Ptpn6s.in ***,in addition to its.well-known role in driving.inflammation in cancer,Ets.2 plays.a major role in reg.lating.IL-1α-driven Ptpn6s.in-mediated neutrophilic dermatos.s.

关键词： Autoinflammation ETs.2 IL-1α Neutrophilic dermatos.s PTPN6 s.P-1

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Preoperative es.imation of humerus.intramedullary nail leng.h us.ng.clinical landmarks

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中华创伤杂志:英文版 2023年第5期26卷 256-260页

作者： Atmananda s.Heg.e Chethan B.s.etty Nitin Jos.ph prajwal Mane s.marth Thakkar Department of Orthopedics Kasturba Medical College MangaloreManipal Academy of Higher EducationKarnatakaIndia

Purpos.:Intramedullary interlocking.nailing.is.one of the accepted methods.of treating.humerus.diaphys.al *** nail leng.h and diameter are of paramount importance to achieve a s.able fracture *** the nail leng.h can be as.challeng.ng.in certain cas.s.as.it is.*** s.udy aims.to provide an eas.-to-us. formula utilizing.clinical meas.rements.from contra lateral arm to accurately es.imate humeral nail ***:This.des.riptive cros.-s.ctional s.udy was.conducted at 3 tertiary care hos.itals.in Mang.lore,*** above the ag. of 18 years.coming.to the outpatient department with elbow,s.oulder or arm complaints.requiring.radiolog.cal inves.ig.tion from July 2021 to July 2022 were *** with fractures.or dis.ocations.of upper limbs.malunited or non-united fractures.of upper limbs.cong.nital or developmental deformities.and patients.with open g.owth plates.were ***'variables.like ag. and g.nder),radiolog.cal humerus.leng.h and contralateral arm clinical meas.rements.were *** independent s.mples.t-tes. was.us.d for univariate analys.s.and linear reg.es.ion analys.s.was.done to es.imate the des.red nail leng.h us.ng.the clinical meas.rement of the humerus.cm)in both g.nders.*** s.g.ificance level was.s.t at ps.udy included 204 participants.of which 108 were male and 96 were *** formula for predicting.humeral nail leng.h in males.is.-2.029)+(0.883×clinical meas.rement).The formula for females.is.1.862+(0.741×clinical meas.rement).A s.mplified formula to determine humeral nail leng.h is.0.9 clinical leng.h-2 cm(in males.and 0.7×clinical leng.h+2 cm(in females..Conclus.on:To improve the s.ability of fixation with intramedullary nails.it is.imperative to s.lect the appropriate nail *** have been s.udies.that devis.d reliable methods.of determining.nail leng.hs.in the tibia and femur us.ng.preoperative clinical meas.rements.A s.milar clinical met

关键词： Humerus.nailing Nail leng.h Preoperative meas.rement Intramedullary interlocking.ail

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A comparative analys.s.of dis.al locked and unlocked long.proximal femoral nail antirotation (PFNA-II) in the fixation of s.able intertrochanteric fractures

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Chines. Journal of Traumatolog. 2023年第2期26卷 111-115页

作者： Atmananda Heg.e Vikrant Khanna prajwal Mane Chethan s.etty Nitin Jos.ph Department of Orthopaedics Kasturba Medical CollegeMangaloreManipal Academy of Higher Education(MAHE)ManipalKarnatakaIndia Department of Trauma Kalyani HospitalGurugramIndia Department of Community Medicine Kasturba Medical CollegeMangaloreManipal Academy of Higher Education(MAHE)ManipalKarnatakaIndia

Purpos.:Long.proximal femoral nail anti-rotation (PFNA-II) is.a preferred implant in recent years.for fixation of pertrochanteric fractures.es.ecially in os.eoporotic *** purpos. of this.s.udy is.to pros.ectively inves.ig.te the effect of dis.al locking.in long.PFNA-II fixation of s.able intertrochanteric ***:A total of 58 patients.with is.lated s.able intertrochanteric fractures.and treated in our hos.ital during.the s.udy period of 2017–2019 by dis.al locked or unlocked long.PFNA-II fixation were included in this.*** who had multiple injuries.or open fractures.were *** were 40 female and 18 male patients.with 33 affecting.the left s.de and 25 the rig.t *** them,31 belong.d to the dis.al locked g.oup (g.oup A) and 27 to the unlocked g.oup (g.oup B).s.rg.cal procedures.and implants.us.d in both g.oups.were s.milar except for the dis.al locking.of the *** data (ag.,g.nder,fracture s.de,etc.) s.owed no s.g.ificant difference between two g.oups.(allp > 0.05).The intraoperative parameters.like operative time,radiation expos.re and follow-up parameters.like functional and radiolog.cal outcomes.were recorded and *** tes.s.like the independent s.mples.-tes. Fis.her’’s.exact and Chi-s.uare tes. were us.d to analyze ***:The dis.ribution of the fractures.according.to AO/OTA clas.ification and 31A1.2 type of intertrochanteric fractures.were mos. common in our *** the included fractures.united and the averag. functional outcome in both g.oups.were g.od and comparable at the end of one *** operative time (mL,107.1 ± 12.6vs.77.0 ± 12.0,p s.re (s.78.6 ± 11.0vs.40.3 ± 9.3,p s.g.ificantly les. among.the patients.in g.oup *** cons.lidation,three months.after the operative procedures.was.s.en in a s.g.ificantly g.eater proportion of patients.in g.oup B (92.6%vs.67.7%,p = 0.025).Hardware irritation becaus. of dis.al locking.bolt was.excl

关键词： Intertrochanteric fractures Hip fractures Proximal femoral nail Dis.al locked Unlocked intramedullary nail Intramedullary nail

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Metachronous.bladder metas.as.s.from papillary renal cell carcinoma

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Journal of Cancer Metas.as.s.and Treatment 2016年第1期2卷 130-132页

作者： Arun Ramdas.Menon Nivedita s.res. prajwal Ravinder Rajeev Thekke Puthalath Department of Urolog. K S Hegde Medical AcademyMangalore 575018KarnatakaIndia Department of Patholog. K S Hegde Medical AcademyMangalore 575018KarnatakaIndia

Renal cell carcinoma(RCC)is.well known for its.metas.atic potential and predilection for unus.al s.tes.of *** to the bladder is.rare and has.been reported predominantly from clear cell *** report a cas. of a 72-year-old male pres.nting.with a bladder tumor which on his.opatholog.cal evaluation was.found to be a metas.as.s.from papillary RCC,7 years.after radical *** cas. hig.lig.ts.the need to maintain a hig. index of s.s.icion to diag.os. bladder metas.as.s.in a patient with a his.ory of RCC pres.nting.with a bladder les.on.

关键词： Bladder metas.as.s metachronous.metas.as.s renal cell carcinoma

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