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Antileishmanial potential of a marine sponge Haliclona oculata against experimental visceral leishmaniasis

Journal of Coastal Life Medicine 2015年第3期3卷 187-192页

作者： Vijai Lakshmi Prashant Khare pragya misra Mahendra Nath Srivastava Anuradha Dube Divisions of Medicinal&Process Chemistry CSIR-Central Drug Research InstituteLucknow-226001India Divisions of Parasitology CSIR-Central Drug Research InstituteLucknow-226001India Divisions of Botany CSIR-Central Drug Research Institute Lucknow-226001India

Objective:To evaluate the antileishmanial activity of a marine spongeHaliclona ***:The crude methanol extract was prepared from the freshly collected sponge and its three fractions were also prepared by maceration *** antileishmanial activity of these extract and fractions was tested againstLeishmania ***:The antileishmanial activity was tested bothin vitroand in *** crude methanol extract exerted almost complete inhibition of promastigotes(81.0%±6.9%)and 78.8%±5.2%inhibition of intracellular amastigotes at 100μg/mL with IC_(50)values of 29.5μg/mL and 40.6μg/mL,*** treatment of 500 mg/kg(p.o.)of the crude methanol extract for 5 d for Leishmania donovani infected hamsters resulted in 78.35%±10.20%inhibition of intracellular *** a lower dose(250 mg/kg),it exhibited poor *** the fractions,highestin vitro(>75%)and in vivo(84.3%±10.2%)antileishmanial activity was observed in n-chloroform fraction with IC_(50)values of 54.2μg/mL and 61μg/mL against promastigotes and intracellular amastigotes,*** fraction andn-butanol(both insoluble and soluble)fractions were found inactivein vitroand in ***:Our findings indicate that this marine sponge has the potential to provide new insight toward development of an effective antileishmanial agent and,hence,more exhaustive studies are needed for exploiting the vast marine resources of the world to combat the scourge of several parasitic diseases.

关键词： Antileishmanial activity In vitroand in vivo Marine sponge Haliclona oculata Leishmania donovani

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