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Nimotuzumab with Concurrent Chemoradiation in Inoperable Locally Advanced Squamous Cell Carcinoma of Head and Neck: An Indian Experience

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Journal of Cancer Therapy 2018年第1期9卷 89-100页

作者： Ankur Bahl Komal Singh pragati choudhary A. K. Anand Amal Roy Chaoudhoory Harit Chaturvedi Biswajyoti Hazarika Dilip Pawar Medical Oncology Max Super Specialty Hospital Saket New Delhi India Radiation Oncology Max Super Specialty Hospital Saket New Delhi India Surgical Oncology Max Super Specialty Hospital Saket New Delhi India Medical Affairs & Clinical Development Biocon Banglore India

Background: The prognosis of patients with Epidermal Growth Factor Receptor (EGFR) overexpression in inoperable Locally Advanced Squamous Cell Carcinoma of Head and Neck (LASCCHN) remains poor. Nimotuzumab is an Anti EGFR humanized monoclonal antibody approved for treatment of LASCCHN, with concurrent chemoradiation. Objective: To assess the efficacy and safety of nimotuzumab with concurrent chemoradiation in inoperable LASCCHN patients. Methodology: This is a single-centre, single arm, retrospective study evaluating 35 patients with histologically confirmed inoperable LASCCHN (stages III-IV). The patients were administered IV cisplatin 50 mg/m2 and IV nimotuzumab 200 mg for 6 - 7 weeks, along with radiotherapy of 6600 - 7000 cGy over 35 fractions. Patients were evaluated over response evaluation criteria in solid tumors (RECIST) criteria 12 weeks after the last cycle of chemotherapy. They were also followed up for overall survival and relapse free survival. Results: The median duration of follow-up was 20 months. The most common site of cancer was oropharynx (68.6%). One patient was lost to follow up. Objective Response Rate (ORR) was observed in 97% of the patients with 17 patients (48.6%) achieving complete response (CR) and 17 patients (48.6%) achieving partial response (PR). The median overall survival was 22.7 months (95% CI: 21.30, 34.27). The median relapse free survival was 16.7 months (95% CI: 9.80, 24.50). Nimotuzumab was safe and well tolerated with few mild, self-limiting adverse events. Conclusion: Nimotuzumab with chemoradiation is a safe and efficacious option in patients with LASCCHN. Larger studies are needed to verify the same.

关键词： Epidermal Growth Factor Receptor Chemoradiation Locally Advanced Squamous Cell Carcinoma of Head and Neck Humanised Monoclonal Antibody Nimotuzumab

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Variations of the harmonic components of the X-ray pulse profile of PSR B1509–58

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Research in Astronomy and Astrophysics 2015年第1期15卷 28-36页

作者： pragati Pradhan Biswajit Paul Harsha Raichur Bikash Chandra Paul St Joseph’s College Singamari Darjeeling 734104 West Bengal India North Bengal University Raja Rammohanpur District Darjeeling 734013 West Bengal India Raman Research Institute Sadashivnagar Bangalore 560080 India

We used the Fourier decomposition technique to investigate the stability of the X-ray pulse profile of a young pulsar PSR B1509–58 by studying the relative amplitudes and phase differences of its harmonic components with respect to the fundamental using data from the Rossi X-Ray Timing Explorer. Like most young rotation powered pulsars, PSR B1509–58 has a high spin down rate. It also has less timing noise, allowing accurate measurement of higher order frequency derivatives which in turn helps in the study of the physics of pulsar spin down. Detailed investigation of pulse profiles over the years will help us establish any possible connection between the timing characteristics and the high energy emission characteristics for this ***, the study of pulse profiles of short period X-ray pulsars can also be useful when used as a means of interplanetary navigation. The X-ray pulse profile of this source has been analyzed for 15 yr（1996–2011）. The long term average amplitudes of the first, second and third harmonics（and their standard deviation for individual measurements） compared to the fundamental are 36.9%（1.7%）, 13.4%（1.9%） and 9.4%（1.8%） respectively. Similarly, the phases of the three harmonics（and standard deviations） with respect to the fundamental are 0.36（0.06）, 1.5（0.2） and 2.5（0.3） radian respectively. We do not find any significant variation of the harmonic components of the pulse profile in comparison to the fundamental.

关键词： pulsars: individual:(PSR B1509–58) stars: neutron X-rays

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Population and development:impacts on environmental performance

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Chinese Journal of Population,Resources and Environment 2016年第3期16卷 208-214页

作者： Prerna Jain pragati Jain Department of Economics Jaipuria Institute of Management Department of Economics Central University of Rajasthan

Population growth and development patterns have a significant impact on the environmental *** issue of concern is whether population growth or the consumption/production patterns are responsible for environmental *** paper is an attempt to capture the impact of technological development,affluence,and population on environmental performance index,while previous stuthes had captured the impact of these three factors on environment only through CO_*** analysis reveals that technological development and population size have a negative impact on environmental performance,whereas measures to improve affluence have a positive *** development has increased the production of energy efficient products but at the same time consumption of these products has increased manifold leading to environmental *** attributes need specific attention to improve environmental *** paper concludes on some policy reflections on slowing the population growth as well as persuades individuals and economies to relook to their consumption and production patterns and channelize their efforts to protect the environment.

关键词： Population environmental deterioration EnTAP affluence and technology

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Lanthanide doped fluorosilicate glass-ceramics:A review on experimental and theoretical progresses

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Journal of Rare Earths 2022年第2期40卷 169-192,I0001页

作者： Pengcheng Li Xiuxia Xu Junjie Zhao pragati Awasthi Xusheng Qiao Jincheng Du Xianping Fan Guodong Qian State Key Laboratory of Silicon Materials&School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China Department of Materials Science and Engineering University of North TexasDentonTX76203-5017USA

Significant developments have been made in the past few decades for lanthanide(Ln)ions doped fluorosilicate glass-ceramics(Flusi-GCs).As novel generation of luminescence materials with a wide range of applications,Flusi-GCs as a single host combine the advantages of glass and ceramics/crystals as well as fluorides and *** this review,the chemical design principles and experimental procedures of Flusi-GCs are summarized in ***-GCs are categorized as those containing PbxCd_(1-x)F_(2),RF_(3)(R=Y,La,Gd),MF_(2)(M=Ca,Sr,Ba),xMF_(2)-yRF_(3)(R=Y,La-Lu),mAF-nRF_(3)(A=Li,Na,K),KTF_(3)(T=Zn,Mn)and K2 SiF6 nanocrystals(NCs).Theoretical breakthroughs mainly by molecular dynamic(MD)simulation have been recapitulated as efficient routes for composition-design,nano-crystallization-prediction,and performance-optimization of Flusi-GCs containing target fluoride *** research progresses pertaining photonic applications have been made in random lasers,communication amplifiers,optical fibers,spectral converters,white light-emitting-diodes(WLEDs),and thermal *** the end,we propose three future research directions for Flusi-GCs.

关键词： Fluorosilicate glass-ceramics Molecular dynamic simulation Nanocrystallization Luminescence Rare earths Photonic application

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Strengths,weaknesses,opportunities,and threats(SWOT)analysis of supercapacitors:A review

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Journal of Energy Chemistry 2023年第4期79卷 611-638页

作者： pragati A.Shinde Qaisar Abbas Nilesh R.Chodankar Katsuhiko Ariga Mohammad Ali Abdelkareem Abdul Ghani Olabi Sustainable Energy&Power Systems Research Centre RISEUniversity of SharjahP.O.Box 27272SharjahUnited Arab Emirates International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)1-1 NamikiTsukuba 305-0044Japan Department of Energy and Material Engineering Dongguk University-SeoulSeoul 04620Republic of Korea Graduate School of Frontier Sciences The University of Tokyo5-1-5 KashiwanohaKashiwaChiba 277-8561Japan Mechanical Engineering and Design School of Engineering and Applied ScienceAston UniversityAston TriangleBirmingham B47ETUK School of Computing Engineering and Physical SciencesUniversity of The West of ScotlandGlasgowPA12BEUK

The development of clean and sustainable energy sources has received widespread interest in the past few decades due to the rolling energy demands while extenuating the rising tiers of greenhouse gases and environmental *** to their intermittent nature,these green and sustainable sources require appropriate energy storage *** different energy storage technologies,electrochemical energy storage devices,particularly supercapacitors(SCs),have fascinated global attention for their utilization in electric vehicles,power supports,portable electronics,and many others application requiring electric energy devices for their ***,the growth of SCs in the commercial market has squeezed requirements,and further developments are obligatory for their effective *** the meantime,SCs also face technical complications and contests for their introduction in industrial settings because of their low energy density and high Levelized *** present study combines core strengths,weaknesses,opportunities,and threats(SWOT)analysis of SCs with new perspectives and recent *** challenges and the future progressive prospects of SCs are also presented in *** review will afford consistent direction and new superhighways for the further development of SCs as standalone and complementary energy storage systems.

关键词： Supercapacitors Energy storage Strengths Opportunities

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A report on TypeⅡX-ray bursts from SMC X-1

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Research in Astronomy and Astrophysics 2018年第12期18卷 43-52页

作者： Binay Rai pragati Pradhan Bikash Chandra Paul Dept.of Physics North Bengal UniversityDarjeelingWest Bengal734013India Department of Astronomy and Astrophysics Pennsylvania State UniversityPennsylvania16802USA St.Joseph's College Darjeeling-734104West BengalIndia

We study RXTE PCA data for the high mass X-ray binary source SMC X-1 between 2003–10 and 2003–12 when the source was in its high *** source is found to be frequently bursting which can be seen as flares in lightcurves that occur at a rate of one every 800 s, with an average of 4–5 Type Ⅱ X-ray bursts per *** note that typically a burst was short, lasting for a few tens of seconds in addition to a few long bursts spanning more than a hundred seconds that were also *** flares apparently occupied 2.5% of the total observing time of 225.5 *** note a total of 272 flares with mean FWHM of the flare ～21 *** rms variability and aperiodic variability are independent of *** observed, the pulse profiles of the lightcurves do not change their shape, implying that there is no change in the geometry of an accretion disk due to a *** hardness ratio and rms variability of lightcurves exhibit no correlation with the *** flare fraction shows a positive correlation with the peak-to-peak ratio of the primary and secondary peaks of the pulse *** observed hardening or softening of the spectrum cannot be correlated with the flaring rate but may be due to the interstellar absorption of X-rays as evident from the change in hydrogen column density(n_H).It is found that the luminosity of the source increases with the flaring *** that the viscous timescale is equal to the mean recurrence time of flares, we fixed the viscosity parameter α ～ 0.16.

关键词： accretion accretion discs pulsar:individual(SMC X-1) stars:neutron X-rays:binaries X-ray:burst

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Study of Temperature Behaviour on Thermally Induced Vibration of Non-Homogeneous Trapezoidal Plate with Bi-Linearly Varying Thickness

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Journal of Applied Mathematics and Physics 2016年第10期4卷 1936-1948页

作者： Kavita Satish Kumar pragati Sharma Department of Mathematics M. M. University Mullana India Department of Mathematics Haryana College of Technology and Management Kaithal India

The main aim of the present work is to study the linear temperature behaviour of a non-homogeneous trapezoidal plate whose thickness varies linearly in both directions. The temperature behaviour considered linear along the length of the plate. Non-homogeneity in plate arises due to variation in density along the length of the plate. The two-term deflection function with clamped-simply supported-clamped-simply supported boundary condition is taken into consideration. The effect of structural parameters such as taper constants, thermal gradient, non-homogeneity constant and aspect ratio has been studied. Rayleigh-Ritz method is used to solve the governing differential equations and to obtain the fundamental frequencies for the first two modes of vibration. Results are presented in graphical form.

关键词： Vibration Trapezoidal Plate Taper Constants Thermal Gradient Aspect Ratio Non-Homogeneity Thickness Density Frequencies

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Study of Thermally Induced Vibration of Non-Homogeneous Trapezoidal Plate with Parabolically Thickness Variation in Both Directions

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Applied Mathematics 2016年第12期7卷 1283-1296页

作者： Kavita Satish Kumar pragati Sharma Department of Mathematics M. M. University Mullana India Department of Mathematics Haryana College of Technology & Management Kaithal India

The present analysis demonstrates the thermal effect on vibrations of a symmetric, non-homoge- neous trapezoidal plate with parabolically varying thickness in both directions. The variation in Young’s modulus and mass density is the main cause for the occurrence of non-homogeneity in plate’s material. In this consideration, density varies linearly in one direction. The governing differential equations have been derived by Rayleigh-Ritz method in order to attain fundamental frequencies. With C-S-C-S boundary condition, a two term deflection function has been considered. The effect of structural parameters such as taper constants, thermal gradient, aspect ratio and non-homogeneity constant has been investigated for first two modes of vibration. The obtained numerical results have been presented in tabular and graphical form.

关键词： Vibration Trapezoidal Plate Taper Constants Thermal Gradient Aspect Ratio Non-Homogeneity Parabolically Thickness Linearly Density

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Study the Thermal Gradient Effect on Frequencies of a Trapezoidal Plate of Linearly Varying Thickness

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Applied Mathematics 2010年第5期1卷 357-365页

作者： Arun Kumar Gupta pragati Sharma 不详

In this paper, effect of thermal gradient on vibration of trapezoidal plate of varying thickness is studied. Thermal effect and thickness variation is taken as linearly in x-direction. Rayleigh Ritz technique is used to calculate the fundamental frequencies. The frequencies corresponding to the first two modes of vibrations are obtained for a trapezoidal plate for different values of taper constant, thermal gradient and aspect ratio. Results are presented in graphical form.

关键词： Frequencies Trapezoidal Plate Linearly Thickness Thermal Gradient

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Synthesis of Silver Doped TiOz Nanoparticles for the Improved Photocatalytic Degradation of Methyl Orange

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材料科学与工程（中英文B版） 2012年第1期2卷 52-58页

作者： Roshan Nainani pragati Thakur Manohar Chaskar Department of Chemistry University of Pune Pune 411007 India Baburaoji Gholap College Pune India

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