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Multi-scale analysis for transport of fine settling particles through an ice-covered channel in a laminar flow condition

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International Journal of Sediment Research 2022年第6期37卷 794-808页

作者： Subham Dhar nanda Poddar B.S.Mazumder Kajal kumar Mondal Department of Mathematics Cooch Behar Panchanan Barma University Physics and Applied Mathematics Unit Indian Statistical Institute Department of Civil Engineering Indian Institute of Technology Bombay

The current research deals with the dispersion of fine settling particles in a fluid flowing through an icecovered channel under the laminar flow condition. An analytical solution of the two-dimensional convection-diffusion equation, based on the multi-scale homogenization technique, is obtained. To validate the current study, analytical results for the dispersion coefficient are compared with the available earlier research work. Moreover, the proposed analytical solutions for mean concentration distributions of the tracers are compared with the numerical results obtained from the finite difference technique. From the industrial and environmental points of view, the vertical concentration distribution provides a very significant information. The downstream evolution of the concentration distribution also is shown for typical time periods at different values of the settling velocity. The approach to the vertical uniformity shows that it is too slow a process in comparison to that of longitudinal normality. It was found that settling velocities of particles disturb the vertical uniformity and the centroid of the solute cloud rises due to the increase in settling velocity. Results illustrate that in the downstream direction, the vertical concentration distribution increases near the bed surface and it decreases in the proximity of the ice-covered surface of the channel with the increase of settling velocity, but the mean concentration of the solute increases. The current study may play an important role to understand the mechanism of the sedimentation process in a closed channel system.

关键词： Sediment transport Dispersion Ice-covered channel Vertical uniformity Multi-scale analysis

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Metal organic framework modulated nanozymes tailored with their biomedical approaches

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Chinese Chemical Letters 2024年第11期35卷 155-171页

作者： Manoj kumar Sarangi L.D Patel Goutam Rath Sitansu Sekhar nanda Dong Kee Yi Department of Pharmaceutics Amity Institute of PharmacyAmity UniversityLucknow 201313India Department of Pharmaceutics Parul Institute of PharmacyParul UniversityVadodara 391760India Department of Pharmaceutics School of Pharmaceutical SciencesSiksha'O'Anusandhan UniversityBhubaneswar 751030India Department of Chemistry Myongji UniversityYongin 03674Republic of Korea

Nanozymes are the paradigm for bridging inorganic nanomaterials with biology and environment for taking the spontaneous responsibilities to outplay natural ***-organic frameworks(MOFs) are mesoporous materials of inorganic-organic coordination,bearing ampoules of active/target sites and having the tendency to mimic natural *** MOF-based nanozymes(NZs) could be recognized for their tremendous potential for ***,MOFs are of four types namely: modified MOFs,pristine MOFs,MOF-derived materials and MOFs comprised of natural *** MOFs-based NZ modulated via ultrasound,light,and heat revealed diversified *** article is concentrated on different methods for the preparation of MOF-based NZ for mimicking the responses of catalases,multifunctional enzymes,oxidases,superoxide dismutase,hydrolases,and peroxidases,progress and challenges of MOFs/MOF-based materials for exploiting their recent and futuristic approaches in biomedical sector.

关键词： MOF Nanozyme Catalysis Biomedicine Theranostics

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Extensional collapse of the Gondwana orogen: Evidence from Cambrian mafic magmatism in the Trivandrum Block, southern India

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Geoscience Frontiers 2019年第1期10卷 263-284页

作者： Qiong-Yan Yang Sohini Ganguly E.Shaji Yunpeng Dong V.nanda-kumar School of Earth Science and Resources China University of Geosciences Department of Earth Science Goa University Department of Geology University of Kerala State Key Laboratory of Continental Dynamics Department of Geology Northwest University National Center for Earth Science Studies Akkulam Trivandrum India

The assembly of Late Neoproterozoice Cambrian supercontinent Gondwana involved prolonged subduction and accretion generating arc magmatic and accretionary complexes, culminating in collision and formation of high grade metamorphic orogens. Here we report evidence for mafic magmatism associated with post-collisional extension from a suite of gabbroic rocks in the Trivandrum Block of southern Indian Gondwana fragment. Our petrological and geochemical data on these gabbroic suite show that they are analogous to high Fe tholeiitic basalts with evolution of the parental melts dominantly controlled by fractional crystallization. They display enrichment of LILE and LREE and depletion of HFSE with negative anomalies at Zre Hf and Ti corresponding to subduction zone magmatic regime. The tectonic affinity of the gabbros coupled with their geochemical features endorse a heterogeneous mantle source with collective melt contributions from sub-slab asthenospheric mantle upwelling through slab break-off and arc-related metasomatized mantle wedge, with magma emplacement in subduction to post-collisional intraplate settings. The high Nb contents and positive Nbe Ta anomalies of the rocks are attributed to inflow of asthenospheric melts containing ancient recycled subducted slab components and/or fusion of subducted slab materials owing to upwelling of hot asthenosphere. Zircon grains from the gabbros show magmatic crystallization texture with low U and Pb content. The LA-ICPMS analyses show ^(206) Pb/^(238) U mean ages in the range of 507-494 Ma suggesting Cambrian mafic magmatism. The post-collisional mafic magmatism identified in our study provides new insights into mantle dynamics during the waning stage of the birth of a supercontinent.

关键词： Mafic dykes Geochemistry Zircon Ue Pb geochronology Post-collisional extension Gondwana supercontinent

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Cytogenotoxic Effect of Pesticides Induces Variability in Micronucleus and Nucleo-Cytoplasmic Abnormalities in Channa punctatus in vivo

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Journal of Zoological Research 2021年第4期3卷 1-11页

作者： pradipta kumar Sarangi Department of Zoology Indira Memorial CollegeChandiputGajapatiOdisha761017India

Our aim was to study the genotoxic,cytotoxic and clastogenic effect of locally used various groups of agro-pesticides in the protection of crops using fresh water fish Channa punctatus as test model to estimate water pollution by micronucleus(MN)assay in *** different concentrations(MC,MC/2&MC/5)of eight pesticides(Dimethoate,Dichlorovos,chlorpyriphos and Malathion,Methyl parathion,Fenvalerate,Cypermethrin and Carbaryl)at different time periods(5,10,15,20,25 days)were *** blood samples smears of fish were collected and stained with Giemsa,micronuclei and nucleo-cytoplasmic abnormalities were analyzed under Germany made Leitz *** analysis shows the rate of concentration,period,nature and mode of action of different agro-pesticides induces varieties of micronuclei and nucleo-cytoplasmic abnormalities even in the same species of fish Channa punctatus in the context of same/different pesticides in different species.

关键词： Cytogenetics Genotoxicity Pesticides Fish Channapunctatus Micronucleus Pollutants

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Classical Hodgkin＇s Lymphoma Presenting as Acute Hepatic Failure One Case Report

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Clinical oncology and cancer researeh 2010年第6期7卷 373-376页

作者： pradipta Guha Shivesh Shanker Sahai Sekhar Mukherjee Sanjoy kumar Chatterjee Department of cardiology G.B. Pant Hospital New Delhi 110002 India. Department of General Medicine Medica College Kolkata-700073 West Bengal India.

A 20-year-old boy presenting daily febrile episodes was suspected to have developed acute hepatic failure. Serologic tests ruled out infectious and autoimmune causes apart from drug toxicity. During clinical examinations, he was found to have generalized enlarged lymph nodes that were then taken biopsy. It was diagnosed as classical Hodgkin＇s lymphoma based on histological examination of the lymph node. A bone marrow biopsy showed marrow infiltration by Hodgkin＇s lymphoma with hemophagocytosis and secondary myelofibrosis. A percutaneous liver biopsy demonstrated hepatic involvement of the same disease. After an extensive work-up, the cause of liver failure was figure out to be only attributed to the involvement of the lymphoma. Hodgkin＇s lymphoma as a cause of hepatic failure is rare and young patients diagnosed as Hodgkin＇s lymphoma causing hepatic failure has been reported very rarely so far.

关键词： Hodgkin's disease bone marrow liver failure acute.

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Optimized protoplast isolation and transfection with a breakpoint:accelerating Cas9/sgRNA cleavage efficiency validation in monocot and dicot

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aBIOTECH 2024年第2期5卷 151-168页

作者： Debasmita Panda Subhasis Karmakar Manaswini Dash Swagat kumar Tripathy Priya Das Sagar Banerjee Yiping Qi Sanghamitra Samantaray pradipta kumar Mohapatra Mirza J.Baig Kutubuddin A.Molla ICAR National Rice Research Institute CuttackOdisha 753006India Department of Botany Ravenshaw UniversityCuttackOdisha 753003India Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA

The CRISPR-Cas genome editing tools are revolutionizing agriculture and basic biology with their simplicity and precision ability to modify target genomic ***-predicted guide RNAs(gRNAs)often fail to induce efficient cleavage at target *** target loci are inaccessible due to complex chromatin ***,there is no suitable tool available to predict the architecture of genomic target sites and their ***,significant time and resources are spent on performing editing experiments with inefficient *** in vitro-cleavage assay could provide a rough assessment of gRNA efficiency,it largely excludes the interference of native genomic *** in-vivo testing gives a proper assessment of the cleavage ability of editing reagents in a native genomic ***,we developed a modified protocol that offers highly efficient protoplast isolation from rice,Arabidopsis,and chickpea,using a sucrose gradient,transfection using PEG(polyethylene glycol),and validation of single guide RNAs(sgRNAs)cleavage efficiency of *** have optimized various parameters for PEG-mediated protoplast transfection and achieved high transfection efficiency using our protocol in both monocots and *** introduced plasmid vectors containing Cas9 and sgRNAs targeting genes in rice,Arabidopsis,and chickpea *** dual sgRNAs,our CRISPRdeletion strategy offers straightforward detection of genome editing success by simple agarose gel *** sequencing of PCR products confirmed the editing efficiency of specific ***,we demonstrated that isolated protoplasts can be stored for up to 24/48 h with little loss of viability,allowing a pause between isolation and *** high-efficiency protocol for protoplast isolation and transfection enables rapid(less than 7 days)validation of sgRNA cleavage efficiency before proceeding with stable *** isolation and transfection method can als

关键词： Protoplast Genome editing Transgene-free edited plants Rice Chickpea

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Determination of the time of refractive stability after uneventful phacoemulsification in Indian eyes

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World Journal of Experimental Medicine 2024年第2期14卷 89-96页

作者： Ashok kumar nanda Bijnya Birajita Panda Asish Swain Logesh Balakrishnan Department of Ophthalmology Kar Vision Eye HospitalBhubaneswar 751013OdishaIndia Department of Ophthalmology All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Optometry Kar Vision Eye HospitalBhubaneswar 751013OdishaIndia Department of Statistics Apollo HospitalsChennai 823104India

BACKGROUND Knowledge about refractive stabilization and the accuracy of postoperative refractive error measurements are crucial for improved patient outcomes after *** guidelines typically recommend waiting 4-6 wk before prescribing corrective *** research focused on identifying factors that influence refractive errors in the early stages of post-cataract surgery,thus contributing to the existing literature on this *** To investigate the time required for refraction stability after uneventful phacoemulsification *** We compared the variation and statistical significance of the difference in spherical,cylindrical components,and the spherical equivalent between the 1-and 6-wk follow-up period in a group of 257 eyes that underwent uneventful phacoemulsification with foldable intraocular lens implantation,all performed by a single experienced *** Wilcoxon-Signed Rank Test was utilized to assess the magnitude of the change and determine its statistical *** refractive stability was defined as the point at which the change in spherical equivalent was within±0.5 dioptres for two consecutive *** The average age of the patients was 64.9±8.9 *** differences observed in both the visits in spherical power(0.1±0.2),cylinder power(0.3±0.4),and spherical equivalent(0.2±0.2)were minimal and not statistically *** majority of eyes(93.4%)achieved refractive stability within 6 wk after the *** cylindrical power differed between age groups at the 6th wk post-operative and the difference was statistically significant(P value 0.013).There were no significant differences in refractive stability when considering sex and axial *** Phacoemulsification with foldable intraocular lens implantation results in no significant changes in refraction for the majority of cases during the 6-wk follow-up ***,a spectacle prescription can be given at the completion of 1 wk.

关键词： Cataract surgery Phacoemulsification Refraction stability Visual acuity Spherical equivalent

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Iodocyclization of Diallyl-Dihydroxy Naphthalenes Using <i>N</i>-Iodosuccinimide vs Molecular Iodine in Aqueous Micelle

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International Journal of Organic Chemistry 2013年第3期3卷 176-184页

作者： pradipta kumar Basu Amrita Ghosh Department of Chemistry Hooghly Mohsin College Chinsurah India

A number of doubly-fused [1,2] naphthodifurans have been synthesized from the corresponding diallyl-dihydroxy naphthalene precursors involving N-iodosuccinimide in acetonitrile and also by molecular iodine in aqueous micelle using CTAB as surfactant. The electrophilic cyclization occurs regioselectively by a 5-exo-trig mode of cyclization.

关键词： Di-Allyl-Dihydroxy Naphthalene N-Iodosuccinimide CTAB Micelle 5-Exo-Trig Mode Regioselective Cyclization

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Noscapine shows antimalarial activity against Plasmodium falciparum 3D7,its clinical isolate Pf140/SS,and Plasmodium berghei ANKA

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 350-358页

作者： Swaraj kumar Babu Sameer Maharana Satyaranjan Chhatria Dibya Ranjan Sahoo Ashirbad nanda Satish Kanhar Prativa KBehera Sanjib Mohanty Pradeep kumar Naik Praveen Kishore Sahu Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyoti ViharSambalpur OdishaIndia Department of Molecular Biology and Infectious Diseases Community Welfare Society HospitalRourkelaOdishaIndia Molecular&Immunology Laboratory Infectious Disease Biology UnitIspat General HospitalRourkelaOdishaIndia Department of Pharmacy Centurion University of Technology and ManagementBhubaneswarOdishaIndia

Objective:To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain(Pf3D7),its clinical isolate(Pf140/SS),and Plasmodium berghei ANKA(PbA).Methods:Using ring-stage survival assay,phenotypic assessments,and SYBR-green-based fluorescence assay,the antimalarial activities of noscapine were assessed compared with dihydroartemisinin(DHA)in in vivo and in vitro *** addition,hemolysis and cytotoxicity tests were carried out to evaluate its ***-PCR assay was also conducted to determine the effect of noscapine on papain-like cysteine protease Plasmodium falciparum falcipain-2(PfFP-2).Results:The antimalarial efficacy of noscapine against Pf3D7 and Pf140/SS was comparable to DHA,with IC50 values of(7.68±0.88)and(5.57±0.74)nM/mL,respectively,and>95%inhibition of PbA infected *** also showed a safe profile,as evidenced by low hemolysis and cytotoxicity even at high ***,PfFP-2 expression was significantly inhibited in both noscapine-treated Pf3D7 and Pf140/SS(P<0.01).Conclusions:Noscapine has antimalarial properties comparable to standard antimalarial DHA with better safety profiles,which may be further explored as a therapeutic candidate for the treatment of malaria.

关键词： Malaria Plasmodium falciparum Plasmodium berghei Noscapine Antimalarial Dihydroartemisinin Cytotoxicity Falcipain-2

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Non-Classical Hodgkin＇s Lymphoma Presenting As Cauda Equina Syndrome a Rare presentation： One Case Report

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Clinical oncology and cancer researeh 2010年第5期7卷 322-325页

作者： pradipta Guha Debasis Sarkar Indranil Thakur Partha Sardar Sekhar Mukherjee Sanjoy kumar Chatterjee Department of cardiology G.B.Pant HospitalNew Delhi Jawaharlal Nehru Marg 110002New Delhi India. Department of General Medicine Medical College Kolkata 88 College Street Kolkata 700073 West Bengal India. Department of General Medicine Lal Bahadur Shastri Hospital Khichripur New Delhi 110091 India.

Nodular lymphocyte predominant Hodgkin＇s disease occurs in 5% of all cases of Hodgkin＇s disease. It occurs more commonly in male. Only 5% of all Hodgkin＇s lymphoma cases develop spinal cord compression and in only 0.2% cases, spinal cord compression occurs as the initial presentation. So our case is rare both in the form of the unique variety of Hodgkin＇s disease and also in the form of presentation.

关键词： Hodgkin's disease non-classical variety cauda equina syndrome.

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