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International Journal of Ophthalmology(English edition) 2023年第5期16卷 836-836页

作者： Suraj kumar chaurasiya Vishmarika Sharma pradeep Agarwal Department of Optometry and Vision Science C L Gupta Eye InstituteRam Ganga Vihar Phase II(Extn.)Uttar PradeshMoradabad 244001India Department of Paediatric and Neuro Ophthalmology C L Gupta Eye InstituteRam Ganga Vihar Phase II(Extn.)Uttar PradeshMoradabad 244001India

Dear Editor,I would like to congratulate the author on their excellent paper. With great interest, I read Al-Mohaimeed et al’s study[1]“Factors affecting single-step transepithelial photorefractive keratectomy outco... 详细信息

关键词： mild treatment

Comment on: Observation of peripheral refraction in myopic anisometropia in young adults

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1385-1386页

作者： Suraj kumar chaurasiya Mahendra Singh pradeep Agarwal Yu-Qin Du Yue-Hua Zhou Ming-Wei Ding Ming-Xu Zhang Yu-Juan Guo Shan-Shan Ge Department of Optometry and Vision Science CL Gupta Eye InstituteRam Ganga Vihar Phase II(Extn.)MoradabadUttar Pradesh 244001India Department of Paediatric and Neuro Ophthalmology CL Gupta Eye InstituteRam Ganga Vihar Phase II(Extn.)MoradabadUttar Pradesh 244001India Eye School of Chengdu University of TCM Ineye Hospital of Chengdu University of TCMChengdu 610036Sichuan ProvinceChina Beijing Ming Vision and Ophthalmology Beijing 100010China

Dear Editor,We read with great interest the recently published article titled“Observation of peripheral refraction in myopic anisometropia in young adults”by Du et al[1].The study conducted at the InEye Hospital of Chengdu University of TCM provides valuable insights into the relationship between anisometropia and peripheral refraction in myopic young *** commend the authors for their thorough investigation and adherence to ethical *** the study contributes significantly to our understanding of myopic anisometropia,we would like to draw attention to some limitations that merit consideration for a comprehensive interpretation of the findings.

关键词： Observation young insight

Feature Selection with Deep Reinforcement Learning for Intrusion Detection System

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Computer Systems Science & Engineering 2023年第9期46卷 3339-3353页

作者： S.Priya K.pradeep Mohan kumar Department of Computer Science and Engineering SRM Institute of Science and TechnologyRamapuramChennai600089India Department of Computing Technologies SRM Institute of Science and TechnologyKattankulathurChennai603203India

An intrusion detection system(IDS)becomes an important tool for ensuring security in the *** recent times,machine learning(ML)and deep learning(DL)models can be applied for the identification of intrusions over the network *** resolve the security issues,this paper presents a new Binary Butterfly Optimization algorithm based on Feature Selection with DRL technique,called BBOFS-DRL for intrusion *** proposed BBOFSDRL model mainly accomplishes the recognition of intrusions in the *** attain this,the BBOFS-DRL model initially designs the BBOFS algorithm based on the traditional butterfly optimization algorithm(BOA)to elect feature ***,DRL model is employed for the proper identification and classification of intrusions that exist in the ***,beetle antenna search(BAS)technique is applied to tune the DRL parameters for enhanced intrusion detection *** ensuring the superior intrusion detection outcomes of the BBOFS-DRL model,a wide-ranging experimental analysis is performed against benchmark *** simulation results reported the supremacy of the BBOFS-DRL model over its recent state of art approaches.

关键词： Intrusion detection security reinforcement learning machine learning feature selection beetle antenna search

Low-dose metformin and PEN2-dependent lysosomal AMPK activation: benefits outnumber side effects

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2119-2120页

作者： Longlong Liu pradeep kumar Patnana Subbaiah Chary Nimmagadda Department of Medicine A HematologyOncology and PneumologyUniversity Hospital MuensterMuensterGermany

Recent advances demonstrated numerous molecular mechanisms of metformin based on the dosage and duration,yet our understanding is *** a photoactive metformin probe Ma et al.1 identified presenilin enhancer 2(PEN2)as its interaction partner and demonstrated its contribution to AMP-activated protein kinase(AMPK)activation.1 Metformin is a widely used anti-diabetic for managing blood glucose levels in patients with type 2 diabetes mellitus(T2D).Owing to its pleiotropic modes of action,its role in other pathophysiological conditions including metabolic complications,cancer,cardiovascular diseases,inflammation,ageing,gut microbiota,neuroprotection and COVID-19 were *** is widely accepted that metformin inhibits mitochondrial complex I of the electron transport chain and results in a decrease in ATP synthesis stimulating AMPK,inhibiting hepatic gluconeogenesis,increasing insulin sensitivity in the liver and intensifying glucose absorption in the muscles.

关键词： dosage inflammation cardiovascular

Changes in post-keratoplasty astigmatism after suture removal:refraction vs tomography vs aberrometry

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International Journal of Ophthalmology(English edition) 2021年第11期14卷 1707-1713页

作者： Suraj kumar chaurasiya Jagadesh C.Reddy Pravin K.Vaddavalli Christopher J.Rapuano Brien Holden School of Optometry and Vision Sciences L V Prasad Eye Institute(LVPEI)Hyderabad 500034India Cataract and Refractive Surgery Services The Cornea InstituteL V Prasad Eye Institute(LVPEI)Hyderabad 500034India Comea Service Wills Eye HospitalPhiladelphiaPennsylvania 19107USA

AIM:To analyse the changes in magnitude and orientation of astigmatism after suture removal(SR)in keratoplasty eyes as measured by refraction,tomography,and ***:Twenty-six eyes of 25 patients after optical keratoplasty requiring SR to reduce the astigmatism during the follow-up period were prospectively *** with poor quality topography scans or if there were no sutures in the steepest semi meridian were *** distance visual acuity(CDVA),manifest refraction,corneal tomography and aberrometr y were per formed on all patients before and after ***:The mean age of the patients was 40.8±14.4 *** keratoplasty was performed in 23 eyes(89%)and deep anterior lamellar keratoplasty was done in 3 eyes(11%).There was a statistically significant reduction in the magnitude of refractive,tomographic and aberrometry astigmatism after SR(P<0.001)at 2 h after suture *** mean net reduction of the astigmatism was greater as measured by corneal tomography compared to refractive astigmatism(P<0.05).There was no statistically significant change in refractive astigmatism between 2 h and 2 mo after SR(P=0.55).Vector calculations demonstrated a greater amount of undercorrection in the tomography group and the rotational error was more towards counterclockwise *** monocular log MAR CDVA improved from 0.57 D to 0.49 D after SR(P=0.002).CONCLUSION:The net reduction in the magnitude of astigmatism after SR is greater in the tomography and aberrometry *** one episode of SR,there is no difference in the aberration profile.

关键词： keratoplasty astigmatism suture removal

Primary endoscopic stapedotomy using 3 mm nasal endoscope:Audiologic and clinical outcomes

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Journal of Otology 2020年第4期15卷 133-137页

作者： pradeep Pradhan Chappity Preetam Pradipta kumar Parida Department of ENT and Head Neck Surgery All India Institute of Medical SciencesBhubaneswarOdisha751019India

Objective:To report the use of a 3 mm rigid nasal endoscope in primary endoscopic stapedotomy and clinical and audiological *** and methods:Thirty patients diagnosed with primary otosclerosis underwent endoscopic stapedotomy that was performed using a 3 mm nasal endoscope(Karl Storz).At 6 months follow-up,the patients were evaluated for intraoperative findings,postoperative hearing outcomes and ***:Canaloplasty was performed in 2(6.66%)patients,and no curettage of the canal wall was required in 12(40%)*** of the chorda tympani nerve was conducted in 11(36.66%)*** average duration of surgery was 36 min(range 31e65 min).The air-bone gap(ABG)was 35 dB(range 24e50 dB)preoperatively and 14.63 dB(range 9e20 dB)postoperatively(p?0.00).At 6 months follow-up,<20 dB ABG was achieved in 93.33%of the *** major intraoperative/postoperative complications were ***:A 3 mm rigid nasal endoscope can be effectively used in stapedotomy to obtain adequate audiological *** can be considered as a better alternative to the standard microscope or 4 mm endoscope in preserving the posterior canal wall and chorda tympani nerve while minimizing operative time without causing significant complications.

关键词： Endoscope Otosclerosis Outcomes

Aerodynamics of a Tandem-Bladed Axial Compressor Rotor under Circumferential Distortion at Different Rotational Speeds

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Journal of Thermal Science 2024年第4期33卷 1340-1356页

作者： Amit kumar Jerry T.JOHN A.M.pradeep R.A.DAKKERMANS Dragan KOZULOVIC Department of Aerospace Engineering Indian Institute of Technology BombayMumbai400076India Department of Automotive and Aeronautical Engineering Hamburg University of Applied Sciences20099HamburgGermany Institute of Jet Propulsion Bundeswehr University Munich85577NeubibergGermany

For most aircraft engines,inflow distortion is *** distortion is known to degrade the aerodynamic performance and stable operating limits of a *** rotor configuration is an arrangement that effectively controls the growth of the boundary layer over the suction surface of the ***,a higher total pressure rise can be achieved through this unconventional design approach involving the splitting of the blade into forward and aft *** is expected that the effect of inlet flow distortion would be more severe for a tandem-rotor design due to the greater flow turning inherent in such ***,this aspect needs to be thoroughly *** present study discusses the effect of circumferential distortion on the tandem-rotor at different rotational ***-annulus RANS simulations using ANSYS CFX are used in the present *** performance of the rotor at a particular flow coefficient and different rotational speeds is *** total pressure and efficiency are observed to drop at lower mass flow rates under the influence of circumferential *** loss region in each blade passage is mainly associated with the blade wake,tip leakage vortex,secondary flow,and boundary ***,their contribution varies from passage to passage,particularly in the distorted *** the lower span,the wake width is found to be higher than that at a higher *** to the redistribution of the mass flow,the circumferential extent reduces at a higher *** the undistorted sector,the strength of the tip leakage vortex is significantly higher at the design rotational speed than at lower *** distortion near the tip region promotes an early vortex breakdown even at the design operating *** adversely affects the total pressure,efficiency,and stall *** clean flow conditions,this phenomenon is only observed near the stall *** the design operating condition,the breakdown of the forward rotor tip l

关键词： tandem rotor circumferential distortion loss tip leakage vortex vortex breakdown diffusion factor aerodynamics of compressor blade

T_(H)17 cells...Sorting the good out from the bad

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Signal Transduction and Targeted Therapy 2020年第1期5卷 780-781页

作者： Junwei Li Le Jiang Yongxiang Yi pradeep kumar Sacitharan College of Veterinary Medicine Qingdao Agricultural University266109 QingdaoChina Department of General Surgery The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina The Institute of Ageing and Chronic Disease University of LiverpoolLiverpool L78TXUK Xi’an Jiaotong-Liverpool University Department of Biological Sciences#111 Ren’ai RoadSuzhou Industrial Park215123 SuzhouJiangsu ProvinceP.R.China

A recent article by Wu et al.1 demonstrated how targeting inflammatory TH17 cells can be achieved by blocking glycolysis pathway *** findings could lead to potential drugs to selective target“bad”inflammatory TH17 c... 详细信息

关键词： al drugs autoimmune

Identification of optimal composition with superior electrochemical properties along the zero Mn^(3+)line in Na_(0.75)(Mn-Al-Ni)O_(2)pseudo ternary system

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Journal of Energy Chemistry 2024年第9期96卷 206-216页

作者： Hari Narayanan Vasavan Manish Badole Samriddhi Saxena Velaga Srihari Asish kumar Das Pratiksha Gami Neha Dagar Sonia Deswal pradeep kumar Himanshu kumar Poswal Sunil kumar Department of Metallurgical Engineering and Materials Science Indian Institute of Technology IndoreSimrol 453552India High Pressure&Synchrotron Radiation Physics Division Bhabha Atomic Research Centre400085 MumbaiIndia School of Physical Sciences Indian Institute of Technology MandiHimachal Pradesh 175005India Center for Electric Vehicle and Intelligent Transport Systems Indian Institute of Technology IndoreSimrol 453552India

Biphasic layered oxide cathodes,known for their superior electrochemical performance,are prime candidates for commercializing in Na-ion ***,we unveil a series of P3/P2 monophasic and biphasic Al-substituted Na_(3/4)Mn_(5-x/8)Al_(2x/8)Ni_(3-x/8)O_(2)layered oxide cathodes that lie along the‘zero Mn^(3+)line’in the Na_(3/4)(Mn-Al-Ni)O_(2)pseudo-ternary *** structural analysis showed a larger Na^(+)conduction bottleneck area in both P3 and P2 structures with a higher Al3+content,which enhanced their rate *** each composition,the P3/P2 biphasic compound with nearly equal fractions of P3 and P2 phases outperformed their monophasic counterparts in almost all electrochemical performance *** synchrotron XRD measurements obtained for the monophasic P3 and biphasic P2/P3 samples revealed the absence of the O3 phase during *** high structure stability and faster Na^(+)transport kinetics in the biphasic samples underpins the enhancement of electrochemical properties in the Al-substituted P3/P2 *** results highlight fixed oxidation state lines as a novel tool to identify and design layered oxide cathodes for Na-ion batteries in pseudo-ternary diagrams involving Jahn-Teller active cations.

关键词： Layered oxides Biphasic cathode Operando Synchrotron XRD Electrochemical behavior Cyclic performance

Enhanced Energy Efficient with a Trust Aware in MANET for Real-Time Applications

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Computers, Materials & Continua 2023年第4期75卷 587-607页

作者： M.V.Narayana Vadla pradeep kumar Ashok kumar Nanda Hanumantha Rao Jalla Subba Reddy Chavva Department of CSE Guru Nanak Institutions Technical CampusHyderabadRanga Reddy DistrictTelangana501506India Department of CSE B V Raju Institute of TechnologyNarsapurMedakTelangana502313India Department of CSE T.R.R.Government Degree College KandukurKandukurA.P.523105India Department of IT VFST&Research(Deemed to be University)VadlamudiA.P.522213India

Mobile ad hoc networks (MANETs) are subjected to attack detectionfor transmitting and creating new messages or existing message *** attacker on another node evaluates the forging activity in themessage directly or indirectly. Every node sends short packets in a MANETenvironment with its identifier, location on the map, and time through *** attackers on the network broadcast the warning message usingfaked coordinates, providing the appearance of a network collision. Similarly,MANET degrades the channel utilization performance. Performancehighly affects network performance through security algorithms. This paperdeveloped a trust management technique called Enhanced Beacon TrustManagement with Hybrid Optimization (EBTM-Hyopt) for efficient clusterhead selection and malicious node detection. It tries to build trust amongconnected nodes and may improve security by requiring every participatingnode to develop and distribute genuine, accurate, and trustworthy materialacross the network. Specifically, optimized cluster head election is done periodicallyto reduce and balance the energy consumption to improve the lifetimenetwork. The cluster head election optimization is based on hybridizingParticle Swarm Optimization (PSO) and Gravitational Search OptimizationAlgorithm (GSOA) concepts to enable and ensure reliable routing. Simulationresults show that the proposed EBTM-HYOPT outperforms the state-of-thearttrust model in terms of 297.99 kbps of throughput, 46.34% of PDR, 13%of energy consumption, 165.6 kbps of packet loss, 67.49% of end-to-end delay,and 16.34% of packet length.

关键词： MANET malicious nodes clustering trust management beacon message