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智能多媒体监控当前趋势及研究

国外科技新书评介 2015年第3期 20-21页

作者： pradeep K. Atrey 张进兴不详中国科学院空间科学与应用研究中心

目前，智能多媒体监控技术已经逐渐成为处理诸多与安全相关的应用问题必不可缺的工具。智能多媒体监控关注于分析多传感信号输入，包括视频流、音频流及射频识别和深度数据，这些数据在运动的人物、汽车及其他物体的自动探测及跟踪方面... 详细信息

目前，智能多媒体监控技术已经逐渐成为处理诸多与安全相关的应用问题必不可缺的工具。智能多媒体监控关注于分析多传感信号输入，包括视频流、音频流及射频识别和深度数据，这些数据在运动的人物、汽车及其他物体的自动探测及跟踪方面有着广泛的应用。智能多媒体监控技术的初衷是确定运动物体并理解他们的行为，进而检测出可疑或者反常的举动以预防犯罪，尽管这项技术有着诸多益处，但公共安全与个人隐私的冲突成为了此项技术的主要挑战。

关键词：多媒体监控智能监控技术运动物体信号输入深度数据射频识别自动探测

Antimicrobial Activity of Minocycline-Loaded Genipin-Crosslinked Nano-Fibrous Chitosan Mats for Guided Tissue regeneration

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Journal of Biomaterials and Nanobiotechnology 2012年第4期3卷 528-532页

作者： Peter A. Norowski Jegdish Babu pradeep C. Adatrow Franklin Garcia-Godoy Warren O. Haggard Joel D. Bumgardner Department of Biomedical Engineering Herff College of Engineering University of Memphis Memphis USA Department of Bioscience research College of Dentistry University of Tennessee Health Science Center Memphis USA Department of Periodontology College of Dentistry University of Tennessee Health Science Center Memphis USA

Antimicrobial delivery has been advocated for guided tissue regeneration (GTr) or guided bone regeneration (GBr) therapies involving patients with aggressive or unresolved periodontitis/peri-implantitis. Electrospun chitosan membranes demonstrate several advantages over traditional GTr barrier membranes because they stimulate healing, mimic the topology of the extracellular matrix, and allow for diffusion of nutrients and wastes into/out of the graft site, and were shown to stimulate bone formation in a rabbit calvarial criticalsize defect model. Previously, we have shown improvements in mechanical properties and degradation kinetics by crosslinking electrospun membranes with 5 mM or 10 mM genipin. We have also demonstrated the ability of elecrospun chitosan membranes to inhibit lippopolysaccharide (LPS)-induced monocyte activation. In this study, minocycline was incorporated into the chitosan membrane by passive absorption at 5 or 10 mg/mL. The minocycline-loaded membranes and control membranes (carrier only) were tested against Porphyromonas gingivalis (P. gingivalis) by repeated zone of inhibition (ZOI) measurements. Testing showed that uncrosslinked and genipin-crosslinked membranes have similar capacity to absorb aqueous solutions (swelling ratio 1.7 - 2.2). Minocycline loading resulted in bacterial inhibition for up to 8 days from crosslinked membranes (with 11 mm initial ZOI) whereas uncrosslinked membranes loaded with minocycline only inhibited bacteria for 4 days (with 8 mm initial ZOI). These in vitro results suggest that genipin-crosslinked electrospun chitosan membranes loaded with minocycline may be able to reduce early bacterial contamination of GTr graft sites.

关键词： Chitosan Nanofiber Genipin Minocycline Guided Tissue regeneration

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终身学习之路同位素水文学教育与培训

国际原子能机构通报 2001年第1期43卷 38-40页

作者： pradeep K.AGGArWAL DIN D.SOOD IAEA核科学与应用司物理和化学处同位素水文学科

人类的生存和发展取决于能否获得淡水。这一基本需求促使人类养成了一种靠直觉管理水资源的技能——比如收集雨水之类的作法已在不同文明中使用4000多年。如今,由于淡水变得越来越难采集,需要用更先进的科学和系统方法来评估和管理水资源。

关键词： IAEA 同位素水文学教育培训水文学同位素技术

Evaluation of Bone regeneration of Simvastatin Loaded Chitosan Nanofiber Membranes in rodent Calvarial Defects

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Journal of Biomaterials and Nanobiotechnology 2018年第2期9卷 210-231页

作者： Najib Ghadri K. Mark Anderson pradeep Adatrow Sidney H. Stein Hengjie Su Franklin Garcia-Godoy Anastasios Karydis Joel D. Bumgardner Department of Periodontology University of Tennessee Health Science Center College of Dentistry Memphis USA Department of Diagnostic Sciences and Oral Medicine University of Tennessee Health Science Center College of Dentistry Memphis USA Department of Biomedical Engineering University of Memphis Herff College of Engineering Memphis USA Department of Bioscience research University of Tennessee Health Science Center College of Dentistry Memphis USA

Chitosan nanofiber membranes have been known to have a high degree of biocompatibility and support new bone formation with controllable biodegradation. The surface area of these membranes may allow them to serve as local delivery carriers for different biologic mediators. Simvastatin, a drug commonly used for lowering cholesterol, has demonstrated promising bone regenerative capability. The aim of this study was to evaluate simvastatin loaded chitosan nanofiber membranes for guided bone regeneration (GBr) applications and their ability to enhance bone formation in rat calvarial defects. Nanofibrous chitosan membranes with random fiber orientation were fabricated by electrospinning technique and loaded with 0.25 mg of simvastatin under sterile conditions. One membrane was implanted subperiosteally to cover an 8 mm diameter critical size calvarial defect. Two groups: 1) Control: non-loaded chitosan membranes;2) Experimental: chitosan membranes loaded with 0.25 mg of simvastatin were evaluated histologically and via micro-computed tomography (micro-CT) for bone formation at 4 and 8 weeks time points (n = 5/group per time point). Both groups exhibited good biocompatibility with only mild or moderate inflammatory response during the healing process. Histologic and micro-CT evaluations confirmed bone formation in calvarial defects as early as 4 weeks using control and experimental membranes. In addition, newly-formed bony bridges consolidating calvarial defects histologically along with partial radiographic defect coverage were observed at 8 weeks in both groups. Although control and experimental groups demonstrated no significant statistical differences in results of bone formation, biodegradable chitosan nanofiber membranes loaded with simvastatin showed a promising regenerative potential as a barrier material for guided bone regeneration applications.

关键词： Guided Bone regeneration (GBr) Chitosan Simvastatin Calvarial Defect Membrane Nanofiber

Spatial-Temporal Dynamics of runoff Generation Areas in a Small Agricultural Watershed in Southern Ontario

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Journal of Water resource and Protection 2015年第1期7卷 14-40页

作者： Kamran Chapi ramesh P. rudra Syed I. Ahmed Alamgir A. Khan Bahram Gharabaghi William T. Dickinson pradeep K. Goel School of Engineering University of Guelph Guelph Canada Environmental Monitoring and reporting Branch Ministry of the Environment Toronto Canada

The identification of runoff generating areas (rGAs) within a watershed is a difficult task because of their temporal and spatial behavior. A watershed was selected to investigate the rGAs to determine the factors affecting spatio-temporally in southern Ontario. The watershed was divided into 8 fields having a Wireless System Network (WSN) and a V-notch weir for flow and soil moisture measurements. The results show that surface runoff is generated by the infiltration excess mechanism in summer and fall, and the saturation excess mechanism in spring. The statistical analysis suggested that the amount of rainfall and rainfall intensity for summer (r2 = 0.63, 0.82) and fall (r2 = 0.74, 0.80), respectively, affected the rGAs. The analysis showed that 15% area generated 85% of surface runoff in summer, 100% of runoff in fall, and 40% of runoff in spring. The methodology developed has potential for identifying rGAs for protecting Ontario’s water resources.

关键词： Variable Source Area runoff Spatial-Temporal Variability Seasonal Effect

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杂交方法对亚洲棉分离世代中遗传变异的影响

国外作物育种 2004年第3期23卷 33-34页

作者： T．pradeep K．Sumalini 谢国禄

在印度，Gossypium arboreum和Gossypium herbaceum这两个亚洲棉栽培种的种植面积大约占总面积的28％。desi棉非常适应广泛的气候条件；它对刺吸式昆虫和棉铃虫均有耐性，但是与对病虫害高度敏感的hirsutum棉花品种和杂种比较，其产量... 详细信息

在印度，Gossypium arboreum和Gossypium herbaceum这两个亚洲棉栽培种的种植面积大约占总面积的28％。desi棉非常适应广泛的气候条件；它对刺吸式昆虫和棉铃虫均有耐性，但是与对病虫害高度敏感的hirsutum棉花品种和杂种比较，其产量较低。

关键词：杂交方法亚洲棉分离世代遗传变异

Innovative Consortia of Micro and Macro Fungal Systems: Cellulolytic Enzyme Production from Groundnut Shell Biomass and Supportive Structural Analysis

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Journal of Sustainable Bioenergy Systems 2018年第3期8卷 47-66页

作者： Sai Praneeth Thota pradeep Kumar Badiya Yadhu Nadh Guragain Praveen Venkata Vadlani Meera Pandey rajesh Babu Dandamudi Sai Sathish ramamurthy Siva Kumar Belliraj Department of Chemistry Sri Sathya Sai Institute of Higher Learning Prasanthi Nilayam India Bioprocessing and renewable Energy Laboratory Departments of Grain Science and Industry & Chemical Engineering Kansas State University Manhattan KS USA Mushroom Lab Indian Institute Horticulture Research Bangalore India

renewable biomass-derived fuels are essential to meet the blend mandates and the sustainability goals. In our first-to-date study, we investigated individual and synergistic consortia of fungal cultures comprising Pycnoporous sanguineus (PS) in combination with Aspergillus oryzae (AO) and Trichoderma harzianum (TH) for production of cellulolytic enzymes using groundnut shell under solid state and submerged liquid fermentation conditions. The innovative consortia closely align with the microbial ecosystems found in nature;consequently, we anticipate a potent and effective cellulolytic enzyme system, which maximises the breakdown of biomass polymers to sugars. Under ternary combination of cultures, cellulase production was highest at 123.0 ± 1 FPU/gds;β-glucosidase production at 875.6 ± 26.4 IU/g dry substrate (gds);and CMCase at 474.95 ± 45.5 IU/gds. β-glucosidase production was highest on the 2nd day at 987.03 ± 64.2 IU/gds while CMCase peaked at 514.97 ± 21.4 IU/gds on 2nd day for PS, maximum cellulase enzyme production was observed on the 6th day at 192.2 ± 0.96 FPU/gds (AO + PS). Present work showed that synergistic combination of fungal cultures for releasing balanced enzyme activities that can efficiently saccharify biomass, such as groundnut shell to sugars, which can subsequently be fermented to various bioproducts and biomaterial monomers. Elaborate characterization studies of enzyme treated groundnut shell revealed prominent physicochemical changes in the hydrolysate, which indicates the changes in biomass are due to the enzymatic action and the growth effects of the consortia;thereby, leading to promising applications for the microbial fortified biomass.

关键词： Mixed Cultures Fermentation Enzymatic Hydrolysis Groundnut Shell Biomass Characterization

Mutations in foregut SOX2^+ cells induce efficient proliferation via CXCr2 pathway

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Protein & Cell 2019年第7期10卷 485-495页

作者： Tomoaki Hishida Eric Vazquez-Ferrer Yuriko Hishida-Nozaki Ignacio Sancho-Martinez Yuta Takahashi Fumiyuki Hatanaka Jun Wu Alejandro Ocampo pradeep reddy Min-Zu Wu Laurie Gerken reuben J. Shaw Concepcion rodriguez Esteban Christopher Benner Hiroshi Nakagawa Pedro Guillen Garcia Estrella Nunez Delicado Antoni Castells Josep M. Campistol Guang-Hui Liu Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Advaneed Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical University Beijing 100053 China National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of the Chinese Academy of Sciences Beijing 100049 China Insitute for Stem Cell and regeneration Chinese Academy of Sciences Beijing 100101 China Beijing Institute for Brain Disorder Beijing 100069 China Universidad Catolica San Antonio de Murcia Campus de los Jeronimos 135 Guadalupe 30107 Spain Molecular and Cell Biology Laboratory Dulbecco Center for Cancer Research Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Howard Hughes Medical Institute Dulbecco Center for Cancer Research Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Integrative Genomics Core Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Division of Gastroenterology Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Abramson Cancer Center University of Pennsylvania Philadelphia PA 19104 USA Department of Traumatology and research Unit Clinica CEMTRO Av. Ventisquero de la Condesa 42 Madrid 28035 Spain Gastroenterology Department Hospital Clinic University of Barcelona IDIBAPS CIBEREHD Barcelona 08036 Spain

Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion. Here, we demonstrate that SOX2^+ foregut epithelial cells are prone to oncogenic transformation upon mutagenic insults, such as Kras^G12D and p53 deletion. GFP-based lineage-tracing experiments indicate that SOX2^+ cells are the cells-of-origin of esophagus and stomach hyperplasia. Our observations indicate distinct roles for oncogenic KrAS mutation and P53 deletion. p53 homozygous deletion is required for the acquisition of an invasive potential, and Kras^G12D expression, but not p53 deletion, suffices for tumor formation. Global gene expression analysis reveals secreting factors upregulated in the hyperplasia induced by oncogenic KrAS and highlights a crucial role for the CXCr2 pathway in driving hyperplasia. Collectively, the array of genetic models presented here demonstrate that stratified epithelial cells are susceptible to oncogenic insults, which may lead to a better understanding of tumor initiation and aid in the design of new cancer therapeutics.

关键词： Sox2 tumor CXCr2 stratified epithelia

Versatility of microbial proteases

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Advances in Enzyme research 2013年第3期1卷 39-51页

作者： Veloorvalappil N. Jisha robinson B. Smitha Selvanesan pradeep Sasidharan Sreedevi Kizhakkepawothail N. Unni Sreedharan Sajith Prakasan Priji Moolakkariyil Sarath Josh Sailas Benjamin Enzyme Technology Laboratory Biotechnology Division Department of Botany University of Calicut Kerala India

Proteases or peptidases constitute the largest group of enzymes in bio-industry with a long array of uses. They play an invincible role in industrial biotechnology, especially in detergent, food and pharmaceutical arena. This focused review encompasses an overview on alkaline proteases, mainly of microbial sources in a handy module. Following an introduction and general classification with evolutionary insight, major sources of proteases (animal, plant and microbial including fungal, bacterial), their general properties with mechanism of action and molecular masses are discussed. Proteases fromBacillusspp. have been given special attention. In addition to this, an overview on the applications of proteases in detergent, tannery, food, metal recovery and waste treatment industries is also addressed briefly.

关键词： review Proteases Classification Sources Bacillus Industrial Uses