检索结果-南通市图书馆

Bird Swarm Algorithm with Fuzzy Min-Max Neural Network for Financial Crisis Prediction

Computers, Materials & Continua 2022年第10期73卷 1541-1555页

作者： K.pradeep Mohan kumar S.Dhanasekaran I.S.Hephzi Punithavathi P.Duraipandy Ashit kumar Dutta Irina V.Pustokhina Denis A.Pustokhin Department of Computing Technologies Associate ProfessorSRM Institute of Science and TechnologyKattankulathur603203India Department of Information Technology Kalasalingam Academy of Research and Education626126India Department of Computer Science and Engineering Sphoorthy Engineering CollegeHyderabadTelangana501510India Department of Electrical and Electronics Engineering J B Institute of Engineering and TechnologyHyderabadTelangana500075India Department of Computer Science and Information System College of Applied SciencesAlMaarefa UniversityRiyadh11597Kingdom of Saudi Arabia Department of Entrepreneurship and Logistics Plekhanov Russian University of Economics117997MoscowRussia Department of Logistics State University of Management109542MoscowRussia

Financial crisis prediction(FCP)models are used for predicting or forecasting the financial status of a company or financial *** is considered a challenging issue in the financial *** and machine learning(ML)models can be employed for the design of accurate FCP *** numerous works have existed in the literature,it is needed to design effective FCP models adaptable to different *** study designs a new bird swarm algorithm(BSA)with fuzzy min-max neural network(FMM-NN)model,named BSA-FMMNN for *** major intention of the BSA-FMMNN model is to determine the financial status of a firm or *** presented BSA-FMMNN model primarily undergoes minmax normalization to transform the data into uniformity ***,k-medoid clustering approach is employed for the outlier removal ***,the classification process is carried out using the FMMNN model,and the parameters involved in it are tuned by the use of *** utilization of proficient parameter selection process using BSA demonstrate the novelty of the *** experimental result analysis of the BSA-FMMNN model is validated using benchmark dataset and the comparative outcomes highlighted the supremacy of the BSA-FMMNN model over the recent approaches.

关键词： Financial crisis predictive model machine learning outlier removal clustering metaheuristics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular docking simulation analysis of the interaction of dietary flavonols with heat shock protein 90

引用

The Journal of Biomedical Research 2016年第1期30卷 67-74页

作者： Salam pradeep Singh Chitta Ranjan Deb Sharif Udin Ahmed Yenisetti Saratchandra Bolin kumar Konwar Bioinformatics Infrastructure Facility Centre Nagaland UniversityLumami 798627NagalandIndia Department of Botany Department of Zoology Nagaland UniversityLumami 798627NagalandIndia Department of Molecular Biology and Biotechnology Tezpur UniversityTezpur-784028AssamIndia

Hsp90 is a major protein involved in the stabilization of various proteins in cancer *** present investigation focused on the molecular docking simulation studies of flavanols as inhibitors of Hsp90 at the high affinity adenosine triphosphate（ATP）binding site and analyzed absorption,distribution,metabolism,excretion and toxicity（ADME-toxicity）.The molecular docking analysis revealed that the flavanols showed competitive inhibition with ATP molecule at the active site and enhanced pharmacological parameters.

关键词： flavonols cancer molecular docking Hsp90 ATP binding site

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparative analysis of Nε-carboxymethyl-lysine and inflammatory markers in diabetic and non-diabetic coronary artery disease patients

引用

World Journal of Diabetes 2023年第12期14卷 1754-1765页

作者： Dharmsheel Shrivastav Desh Deepak Singh Rashid Mir Pratishtha Mehra Vimal Mehta pradeep kumar Dabla Amity Institute of Biotechnology Amity UniversityJaipur 303002RajasthanIndia Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchDelhi 110002India Department of Medical Lab Technology Faculty of Applied Medical SciencesUniversity of TabukTabuk 71491India Department of Cardiology Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchDelhi 110002India

BACKGROUND Coronary artery disease(CAD)is a major cause of death worldwide,and India contributes to about one-fifth of total CAD *** development of CAD has been linked to the accumulation of Nε-carboxymethyl-lysine(CML)in heart muscle,which correlates with *** To assess the impact of CML and inflammatory markers on the biochemical and cardiovascular characteristics of CAD patients with and without *** We enrolled 200 consecutive CAD patients who were undergoing coronary angiography and categorized them into two groups based on their serum glycosylated hemoglobin(HbA1c)levels(group I:HbA1c≥6.5;group II:HbA1c<6.5).We analyzed the levels of lipoproteins,plasma HbA1c levels,CML,interleukin-6(IL-6),tumor necrosis factor alpha(TNF-α),and nitric *** Group I (81 males and 19 females) patients had a mean age of 54.2 ± 10.2 years, with a mean diabetes duration of4.9 ± 2.2 years. Group II (89 males and 11 females) patients had a mean age of 53.2 ± 10.3 years. Group I had moresevere CAD, with a higher percentage of patients with single vessel disease and greater stenosis severity in the leftanterior descending coronary artery compared to group II. Group I also exhibited a larger left atrium *** I patients exhibited significantly higher levels of CML, TNF-α, and IL-6 and lower levels of nitric oxide ascompared with group II patients. Additionally, CML showed a significant positive correlation with IL-6 (r = 0.596,P = 0.001) and TNF-α (r = 0.337, P = 0.001) and a negative correlation with nitric oxide (r=-4.16, P = 0.001). Oddsratio analysis revealed that patients with CML in the third quartile (264.43-364.31 ng/mL) were significantlyassociated with diabetic CAD at unadjusted and adjusted levels with covariates.

关键词： Coronary artery disease Diabetes Nε-carboxymethyl-lysine Inflammatory markers Interleukin-6 Tumor necrosis factor alpha Nitric oxide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Production and Characterization of Monoclonal Antibodies to Bluetongue Virus

引用

Virologica Sinica 2011年第1期26卷 8-18页

作者： Veerakyathappa Bhanuprakash Madhusudhan Hosamani Vinayagamurthy Balamurugan pradeep Narayan Gandhale Gnanavel Venkatesan Raj kumar Singh Division of Virology Indian Veterinary Research Institute Indian Veterinary Research Institute Project Directorate on Animal Disease Monitoring And Surveillance National Research Centre on Equines and Veterinary Type Culture Centre

In the present study,a total of 24 MAbs were produced against bluetongue virus (BTV) by polyethyleneglycol (PEG) mediated fusion method using sensitized lymphocytes and myeloma cells. All these clones were characterized for their reactivity to whole virus and recombinant BTV-VP7 protein,titres,isotypes and their reactivity with 24 BTV-serotype specific sera in cELISA. Out of 24 clones,a majority of them (n = 18) belong to various IgG subclasses and the remaining (n = 6) to the IgM class. A panel of eight clones reactive to both whole BTV and purified rVP7 protein were identified based on their reactivity in iELISA. For competitive ELISA,the clone designated as 4A10 showed better inhibition to hyperimmune serum of BTV serotype 23. However,this clone showed a variable percent of inhibition ranging from16.6% with BTV 12 serotype to 78.9% with BTV16 serotype using 24 serotype specific sera of BTV originating from guinea pig at their lowest dilutions. From the available panel of clones,only 4A10 was found to have a possible diagnostic application.

关键词： Bluetongue virus Competitive ELISA Enzyme-linked immunosorbent assay Monoclonal antibody India.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Detection of Bluetongue Virus Group-specific Antigen Using Monoclonal Antibody Based Sandwich ELISA

引用

Virologica Sinica 2010年第6期25卷 390-400页

作者： pradeep Narayan Gandhale Veerakyathappa Bhanuprakash Vinayagamurthy Balamurugan Madhusudhan Hosamani Gnanavel Venkatesan Raj kumar Singh Division of Virology Indian Veterinary Research Institute Project Directorate on Animal Disease Monitoring And Surveillance Indian Veterinary Research Institute National Research Centre on Equines

A monoclonal antibody (MAb) specific for the bluetongue virus (BTV) group specific antigen (VP7) was characterized for its reactivity with purified virus and recombinant BTV VP7 (rVP7) protein and its suitability for use in the sandwich *** MAb,designated as 5B5 was specific to VP7 and belongs to IgG2a subclass and was selected for the development of the sELISA in this *** MAb had a titer of 1:25 with BTV and 1:2 with the rVP7 *** sELISA is based on capturing of BTV antigen with VP7 specific MAb followed by detection using BTV polyclonal antiserum raised in *** assay was evaluated with six cell culture adapted serotypes of BTV that have been isolated from India,1,2,15,17,18 and *** assay could detect BTV antigen as early as day 8 in *** was also successfully applied for the detection of BTV group specific antigen in clinical samples of blood,washed RBCs,buffy coat and plasma.A total of 102 field samples from animals,suspected of being infected with BTV,were tested and 29.42% were *** blood samples were also amplified in cell culture which improved the sensitivity of the *** confirmed that the sELISA is rapid and specific.

关键词： Bluetongue Diagnosis ELISA Monoclonal antibody Sandwich ELISA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular exposition of broad‑spectrum antibacterial efficacy by p‑coumaric acid from an edible mushroom Termitomyces heimii:in vitro and in silico approach

引用

Systems Microbiology and Biomanufacturing 2023年第4期3卷 750-764页

作者： Krishanu Singha Amrita Banerjee Arijit Jana Poushali Bandyopadhyay Smarajit Maiti Bikas Ranjan Pati pradeep kumar Das Mohapatra Department of Microbiology Vidyasagar UniversityMidnaporeWest Bengal 721102India Department of Biotechnology Oriental Institute of Science and TechnologyMidnaporeWest Bengal 721102India Department of Chemical Engineering IIT RoorkeeUttarakhand 247667India Department of Microbiology Raiganj UniversityRaiganjWest Bengal 733134India

P-Coumaric acid was previously reported to contain antioxidant,antidiabetic,anti-inflammatory,antiplatelet,antiulcer and anticancer *** with these,the present work has been conducted to study the antibacterial activity of p-coumaric *** could be used to control broad-spectrum microbiome-based inflammation or in cancer *** analysis of methanolic extract from the mushroom Termitomyces heimii has exhibited a rich fraction of p-coumaric acid(p-CA),which in the pure form showed significant bactericidal *** predict the molecular interactions associated with the bactericidal mechanism of p-CA,the transmembrane protein sequences of Staphylococcus aureus and Escherichia coli were retrieved from the IMG–JGI database,screened and then aligned using Clustal X2 and PHYLIP 3.69 *** common sequences were subjected to tertiary structure prediction using Phyre2 server,followed by quality assessment through the Ramachandran ***,the 3D molecular structure of p-CA was downloaded from PubChem and docked with the selected tertiary structures using Patchdock and showed higher affinity towards 12 common transmembrane protein structures,amongst which CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyl transferase(PgsA)exhibited best dock-ing with p-CA on the basis of ACE value(–249 kcal/mol).This fact revealed that p-CA can block the normal functioning of membrane-bound enzyme PgsA,consequently leading to the interruption in the synthesis and recycling of an essential membrane component phosphatidylglycerol(PG),resulting in membrane disruption followed by cell ***,for the first time we reported the molecular insights and fundamental biochemical events underlying the bactericidal action by p-CA,to explore new perspective to combat multidrug-resistant bacteria.

关键词： p-Coumaric acid Bactericidal Docking ACE value PgsA Lysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two types of uranium mineralization in Gulcheru quartzite:Fracture-controlled in Ambakapalle area and litho-controlled in Tummalapalle area,Cuddapah Basin,Andhra Pradesh,India

引用

China Geology 2019年第2期2卷 142-156页

作者： Sukanta Goswami pradeep kumar Upadhyay Bhaskaran Saravanan V Natarajan Mohan Babu Verma Atomic Minerals Directorate for Exploration and Research Department of Atomic EnergyBangalore 560072India Atomic Minerals Directorate for Exploration and Research Department of Atomic Energy BegumpetHyderabad 500016India

The Cuddapah Basin in southern India has a potential for uranium mineralization due to some favorable factors such as its temporal, stratigraphic and tectonic settings. Systematic exploration program conducted by the Atomic Minerals Directorate for Exploration and Research (AMD) within the Cuddapah Basin resulting in the recognition of distinct types of uranium mineralization, viz., strata bound type, fracture/shear-controlled type and tabular type. The Gulcheru Formation which is the lowermost unit of the Cuddapah Basin is dominantly arenitic in nature. During the exploration works, a number of uranium anomalies were identified with dimensions ranging from 1 m to 1.5 km. Gulcheru quartzite hosted uranium mineralization is intermittent and inconsistent in nature. The anomalous outcrops are distributed over a strike length of ca. 60 km between Gandi in the SE and Ambakapallein the NW. Presently, two different types of uranium mineralization are characterized on the basis of field observations, mapping and structural interpretation, petro-mineralogy and geochemistry. Although the host rock is same for both types, the mechanism of uranium enrichment is totally different. The Ambakapalle uranium mineralization is controlled by fault zone and associated hydrothermal activity. Whereas, the Tummalapalle uranium mineralization is litho-controlled in nature influenced by suitable four ‘P’ factors, i.e., provenance, porositypermeability, precipitation and preservation. The geochemical characterization of Gulcheru quartzite suggest a passive margin type of provenance setting. Petro-mineralogically the quartz arenite suggests enough textural as well as mineralogical maturity. Ambakapalle quartzite is slightly strained and deformed due to faulting. Analysis of selected samples recorded 0.01% to 0.048% U3O8 and <0.01% ThO2. Petrographic observation revealed that the anomalies were appeared due to secondary uranium minerals occurring as surficial encrustations, fracture filling an

关键词： Uranium mineralization Fracture-controlled mineralization Litho-contralled mineralization Gulcheru quartzite Hydrothermal alteration Andhra Pradesh India

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Demand Elasticity of Capacity Offered for Urban Rail Transport

引用

Journal of Transportation Technologies 2016年第4期6卷 163-168页

作者： pradeep kumar Sarkar Jain Amit kumar Transport Planning School of Planning & Architecture New Delhi India Traffic Department Northern Railways New Delhi India

The high peak hour demand in Urban Rail Transport (URT) is usually met by supply side measures such as pushing more number of trains/cars in peak hour by the operator. This additional capacity generates more demand due to a positive elasticity of demand with respect to services. Delhi Metro Rail Corporation (DMRC), India has converted its fleet from 4 cars per train to 6 cars per train and finally to 8 cars per train on its Broad Gauge section. The ridership of the system has also witnessed double digit growth during this conversion period. The demand elasticity w.r.t services for the passengers of DMRC has been estimated as 0.512 on the basis of growth of demand and increase in capacity after adjusting for natural growth. So a 10% increase in supply results into 5% increase in capacity. A simple service elasticity model has been developed to estimate demand with increase in supply. The model has been applied to Line 2 (yellow line), the busiest line of DMRC, to estimate the demand for different level of services (trains/hour). The efficacy of supply side measures is limited by the design capacity of the system beyond which any increase in supply would require disproportionate investment. An optimum combination of supply and demand side measures would perhaps be the best way to address peak hour congestion in Urban Rail Transport.

关键词： Congestion Demand Elasticity Supply Urban Rail Transport

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nitric-oxide enriched plasma-activated water inactivates 229E coronavirus and alters antiviral response genes in human lung host cells

引用

生物活性材料(英文) 2023年第1期19卷 569-580页

作者： Nagendra kumar Kaushik pradeep Bhartiya Neha Kaushik Yungoh Shin Linh Nhat Nguyen Jang Sick Park Doyoung Kim Eun Ha Choi Department of Electrical and Biological Physics Plasma Bioscience Research CenterKwangwoon UniversitySeoul01897Republic of Korea Department of Biotechnology College of EngineeringThe University of SuwonHwaseong-si18323Republic of Korea

The ongoing pandemic caused by the novel coronavirus,SARS-CoV-2,is influencing global ***,there is a major threat of future coronaviruses affecting the entire world in a similar,or even more dreadful,***,effective and biocompatible therapeutic options against coronaviruses are urgently *** address this challenge,medical specialists require a well-informed and safe approach to treating human coronaviruses(HCoVs).Herein,an environmental friendly approach for viral inactivation,based on plasma technology,was considered.A microwave plasma system was employed for the generation of the high amount of gaseous nitric oxide to prepare nitric oxide enriched plasma-activated water(NO-PAW),the effects of which on coronaviruses,have not been reported to *** determine these effects,alpha-HCoV-229E was used in an experimental *** found that NO-PAW treatment effectively inhibited coronavirus infection in host lung cells,visualized by evaluating the cytopathic effect and expression level of spike ***,NO-PAW showed minimal toxicity towards lung host cells,suggesting its potential for therapeutic ***,this new approach resulted in viral inactivation and greatly improved the gene levels involved in host antiviral ***,our findings provide evidence of an initiation point for further progress toward the clinical development of antiviral treatments,including such coronaviruses.

关键词： Nitric oxide enriched plasma-activated water Microwave plasma Coronavirus Virus inactivation Gene expression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MHD Slip Flow past a Shrinking Sheet

引用

Applied Mathematics 2013年第3期4卷 574-581页

作者： Santosh Chaudhary pradeep kumar Malaviya National Institute of Technology Jaipur Rajasthan India

An analysis is made for the steady two-dimensional laminar boundary layer flow of a viscous, incompressible, electrically conducting fluid near a stagnation point past a shrinking sheet with slip in the presence of a magnetic field. The governing boundary layer equations are transformed to ordinary differential equations by taking suitable similarity variables and solved numerically by Shooting method. The effects of the various parameters such as velocity ratio parameter, slip parameter, Prandtl number, Eckert number and magnetic parameter for velocity and temperature distributions have been discussed in detail through graphical representation.

关键词： MHD Boundary Layer Slip Flow Shrinking Sheet

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：